ICD-10-CM Diagnosis Code C22.1 - Intrahepatic bile duct carcinoma (original) (raw)

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Intrahepatic bile duct carcinoma

ICD-10-CM Code:

C22.1

ICD-10 Code for:

Intrahepatic bile duct carcinoma

Is Billable?

Yes - Valid for Submission

Chronic Condition Indicator: [1]

Chronic

Code Navigator:

C22.1 is a billable diagnosis code used to specify a medical diagnosis of intrahepatic bile duct carcinoma. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2025 through September 30, 2026.

The following anatomical sites found in the Table of Neoplasms reference this diagnosis code given the correct histological behavior: Neoplasm, neoplastic bile or biliary (tract) canaliculi (biliferi) (intrahepatic) ; Neoplasm, neoplastic bile or biliary (tract) canals, interlobular ; Neoplasm, neoplastic bile or biliary (tract) duct or passage (common) (cystic) (extrahepatic) interlobular ; Neoplasm, neoplastic bile or biliary (tract) duct or passage (common) (cystic) (extrahepatic) intrahepatic ; Neoplasm, neoplastic canaliculi, biliary (biliferi) (intrahepatic) ; Neoplasm, neoplastic cholangiole ; Neoplasm, neoplastic gall duct (extrahepatic) intrahepatic ; etc

  1. Code Information
  2. Approximate Synonyms
  3. Clinical Classification
  4. Clinical Information
  5. Tabular List of Diseases and Injuries
  6. Index to Diseases and Injuries References
  8. Diagnostic Related Groups Mapping
  9. Convert to ICD-9 Code
  10. Table of Neoplasms
  11. Patient Education
  12. Other Codes Used Similar Conditions
  13. Code History

The following list of clinical terms are approximate synonyms, alternative descriptions, or common phrases that might be used by patients, healthcare providers, or medical coders to describe the same condition. These synonyms and related diagnosis terms are often used when searching for an ICD-10 code, especially when the exact medical terminology is unclear. Whether you're looking for lay terms, similar diagnosis names, or common language alternatives, this list can help guide you to the correct ICD-10 classification.

Clinical Classifications group individual ICD-10-CM diagnosis codes into broader, clinically meaningful categories. These categories help simplify complex data by organizing related conditions under common clinical themes.

They are especially useful for data analysis, reporting, and clinical decision-making. Even when diagnosis codes differ, similar conditions can be grouped together based on their clinical relevance. Each category is assigned a unique CCSR code that represents a specific clinical concept, often tied to a body system or medical specialty.

CCSR Code: NEO018

Inpatient Default: Y - Yes, default inpatient assignment for principal diagnosis or first-listed diagnosis.

Outpatient Default: Y - Yes, default outpatient assignment for principal diagnosis or first-listed diagnosis.

a cholangiocarcinoma that has metastasized to other anatomic sites.

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

References found for this diagnosis code in the External Cause of Injuries Index:

Below are the ICD-9 codes that most closely match this ICD-10 code, based on the General Equivalence Mappings (GEMs). This ICD-10 to ICD-9 crosswalk tool is helpful for coders who need to reference legacy diagnosis codes for audits, historical claims, or approximate code comparisons.

ICD-9-CM: 155.1

This is a direct match with no additional mapping qualifiers. The absence of a flag generally means the mapping is considered exact or precise. In other words, the ICD-10 code maps cleanly to the ICD-9 code without qualification, approximation, or needing multiple codes.

This code is referenced in the table of neoplasms by anatomical site. For each site there are six possible code numbers according to whether the neoplasm in question is malignant, benign, in situ, of uncertain behavior, or of unspecified nature. The description of the neoplasm will often indicate which of the six columns is appropriate.

Where such descriptors are not present, the remainder of the Index should be consulted where guidance is given to the appropriate column for each morphological (histological) variety listed. However, the guidance in the Index can be overridden if one of the descriptors mentioned above is present.

Filter table of neoplasms:

Neoplasm, neoplastic Malignant Primary Malignant Secondary CaInSitu Benign Uncertain Behavior Unspecified Behavior
»Neoplasm, neoplastic »bile or biliary (tract) »canaliculi (biliferi) (intrahepatic) C22.1 C78.7 D01.5 D13.4 D37.6 D49.0
»Neoplasm, neoplastic »bile or biliary (tract) »canals, interlobular C22.1 C78.89 D01.5 D13.4 D37.6 D49.0
»Neoplasm, neoplastic »bile or biliary (tract) »duct or passage (common) (cystic) (extrahepatic) »interlobular C22.1 C78.89 D01.5 D13.4 D37.6 D49.0
»Neoplasm, neoplastic »bile or biliary (tract) »duct or passage (common) (cystic) (extrahepatic) »intrahepatic C22.1 C78.7 D01.5 D13.4 D37.6 D49.0
»Neoplasm, neoplastic »canaliculi, biliary (biliferi) (intrahepatic) C22.1 C78.7 D01.5 D13.4 D37.6 D49.0
»Neoplasm, neoplastic »cholangiole C22.1 C78.89 D01.5 D13.4 D37.6 D49.0
»Neoplasm, neoplastic »gall duct (extrahepatic) »intrahepatic C22.1 C78.7 D01.5 D13.4 D37.6 D49.0
»Neoplasm, neoplastic »intrahepatic (bile) duct C22.1 C78.7 D01.5 D13.4 D37.6 D49.0

Bile Duct Cancer

Your liver makes a digestive juice called bile. Your gallbladder stores it between meals. When you eat, your gallbladder pushes the bile into tubes called bile ducts. They carry the bile to your small intestine. The bile helps break down fat. It also helps the liver get rid of toxins and wastes.

Bile duct cancer is rare. It can happen in the parts of the bile ducts that are outside or inside the liver. Cancer of the bile duct outside of the liver is much more common. Risk factors include having inflammation of the bile duct, ulcerative colitis, and some liver diseases.

Symptoms can include:

Tests to diagnose bile duct cancer may include a physical exam, imaging tests of the liver and bile ducts, blood tests, and a biopsy.

Treatments include surgery, radiation therapy, and chemotherapy.

NIH: National Cancer Institute

[Learn More in MedlinePlus]

Liver Cancer

Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. Primary liver cancer starts in the liver. Metastatic liver cancer starts somewhere else and spreads to your liver.

Risk factors for primary liver cancer include :

Symptoms can include a lump or pain on the right side of your abdomen and yellowing of the skin. However, you may not have symptoms until the cancer is advanced. This makes it harder to treat. Doctors use tests that examine the liver and the blood to diagnose liver cancer. Treatment options include surgery, radiation, chemotherapy, or liver transplantation.

NIH: National Cancer Institute

[Learn More in MedlinePlus]

Cholangiocarcinoma

Cholangiocarcinoma is a group of cancers that begin in the bile ducts. Bile ducts are branched tubes that connect the liver and gallbladder to the small intestine. They carry bile, which is a fluid that helps the body digest fats that are in food. Bile is made in the liver and stored in the gallbladder before being released in the small intestine after a person eats.

Cholangiocarcinoma is classified by its location in relation to the liver. Intrahepatic cholangiocarcinoma begins in the small bile ducts within the liver. This is the least common form of the disease, accounting for less than 10 percent of all cases. Perihilar cholangiocarcinoma (also known as a Klatskin tumor) begins in an area called the hilum, where the right and left major bile ducts join and leave the liver. It is the most common form of the disease, accounting for more than half of all cases. The remaining cases are classified as distal cholangiocarcinomas, which begin in bile ducts outside the liver. The perihilar and distal forms of the disease, which both occur outside the liver, are sometimes grouped together and called extrahepatic cholangiocarcinoma.

The three types of cholangiocarcinoma do not usually cause any symptoms in their early stages, and this cancer is usually not diagnosed until it has already spread beyond the bile ducts to other tissues. Symptoms often result when bile ducts become blocked by the tumor. The most common symptom is jaundice, in which the skin and whites of the eyes turn yellow. Other symptoms can include extreme tiredness (fatigue), itching, dark-colored urine, loss of appetite, unintentional weight loss, abdominal pain, and light-colored and greasy stools. These symptoms are described as "nonspecific" because they can be features of many different diseases.

Most people who develop cholangiocarcinoma are older than 65. Because this cancer is often not discovered until it has already spread, it can be challenging to treat effectively. Affected individuals can survive for several months to several years after diagnosis, depending on the location of the cancer and how advanced it is.

[Learn More in MedlinePlus]

What is Bile Duct Cancer (Cholangiocarcinoma)?

Learn about bile duct cancer (cholangiocarcinoma) risk factors, symptoms, tests to diagnose, factors affecting prognosis, staging, and treatment.
[Learn More in MedlinePlus]