ICD-10-CM Diagnosis Code O26.643 - Intrahepatic cholestasis of pregnancy, third trimester (original) (raw)

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ICD List 2025-2026 Edition

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  6. 2026 ICD-10-CM Code O26.643

Intrahepatic cholestasis of pregnancy, third trimester

ICD-10-CM Code:

O26.643

ICD-10 Code for:

Intrahepatic cholestasis of pregnancy, third trimester

Is Billable?

Yes - Valid for Submission

Chronic Condition Indicator: [1]

Not chronic

Code Navigator:

O26.643 is a billable diagnosis code used to specify a medical diagnosis of intrahepatic cholestasis of pregnancy, third trimester. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2025 through September 30, 2026.

The code O26.643 is applicable to female patients aged 12 through 55 years inclusive. It is clinically and virtually impossible to use this code on a non-female patient outside the stated age range.

ICD-10-CM Codes Adjacent to O26.643

  1. Code Information
  2. Clinical Classification
  3. Tabular List of Diseases and Injuries
  4. Code Edits
  5. Diagnostic Related Groups Mapping
  6. Replacement Code
  7. Patient Education
  8. Other Codes Used Similar Conditions
  9. Code History

Code Classification

Pregnancy, childbirth and the puerperium (O00-O9A)

Clinical Classification

Clinical Classifications group individual ICD-10-CM diagnosis codes into broader, clinically meaningful categories. These categories help simplify complex data by organizing related conditions under common clinical themes.

They are especially useful for data analysis, reporting, and clinical decision-making. Even when diagnosis codes differ, similar conditions can be grouped together based on their clinical relevance. Each category is assigned a unique CCSR code that represents a specific clinical concept, often tied to a body system or medical specialty.

Other specified and unspecified liver disease

CCSR Code: DIG019

Inpatient Default: N - Not default inpatient assignment for principal diagnosis or first-listed diagnosis.

Outpatient Default: N - Not default outpatient assignment for principal diagnosis or first-listed diagnosis.

Other specified complications in pregnancy

CCSR Code: PRG028

Inpatient Default: Y - Yes, default inpatient assignment for principal diagnosis or first-listed diagnosis.

Outpatient Default: Y - Yes, default outpatient assignment for principal diagnosis or first-listed diagnosis.

Code Edits

The Medicare Code Editor (MCE) detects errors and inconsistencies in ICD-10-CM diagnosis coding that can affect Medicare claim validity. These Medicare code edits help medical coders and billing professionals determine when a diagnosis code is not appropriate as a principal diagnosis, does not meet coverage criteria. Use this list to verify whether a code is valid for Medicare billing and to avoid claim rejections or denials due to diagnosis coding issues.

Maternity diagnoses

The Medicare Code Editor detects inconsistencies in maternity cases by checking a patient's age and any diagnosis on the patient's record. The maternity code edits apply to patients age ange is 9–64 years inclusive (e.g., diabetes in pregnancy, antepartum pulmonary complication).

MS-DRG Mapping for ICD-10-CM Code O26.643

Diagnosis-Related Groups (DRGs) are used to classify hospital cases for billing and healthcare management. They help standardize how hospitals and other providers are reimbursed for inpatient care. Patients are grouped based on their principal diagnosis into broader categories called Major Diagnostic Categories (MDCs).

Once assigned to a DRG, the hospital receives a set payment for the patient’s care, regardless of the actual services provided. This fixed rate is intended to cover the typical cost of treating patients within that group. The payment amount depends on the DRG's relative weight, which reflects the expected complexity and cost of care based on the severity of the patient’s condition.

Diagnostic related groups encourage healthcare providers to focus on quality and efficiency in patient care while managing costs effectively. The diagnosis code is present in the following groups for version MS-DRG V43.0 applicable from 10/01/2025 through 09/30/2026.

Other Antepartum Diagnoses with O.R. Procedures with MCC

MS-DRG: 817

MDC: 14 - Pregnancy, Childbirth & the Puerperium

**Relative Weight:**1.688

Other Antepartum Diagnoses with O.R. Procedures with CC

MS-DRG: 818

MDC: 14 - Pregnancy, Childbirth & the Puerperium

**Relative Weight:**1.0542

Other Antepartum Diagnoses with O.R. Procedures without CC/MCC

MS-DRG: 819

MDC: 14 - Pregnancy, Childbirth & the Puerperium

**Relative Weight:**0.8599

Other Antepartum Diagnoses without O.R. Procedures with MCC

MS-DRG: 831

MDC: 14 - Pregnancy, Childbirth & the Puerperium

**Relative Weight:**1.2025

Other Antepartum Diagnoses without O.R. Procedures with CC

MS-DRG: 832

MDC: 14 - Pregnancy, Childbirth & the Puerperium

**Relative Weight:**0.7216

Other Antepartum Diagnoses without O.R. Procedures without CC/MCC

MS-DRG: 833

MDC: 14 - Pregnancy, Childbirth & the Puerperium

**Relative Weight:**0.5229

Replacement Code

O26643 replaces the following previously assigned ICD-10-CM code(s):

Other ICD-10-CM Codes Commonly Used for Similar Conditions

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Code History