ICD-10-CM Diagnosis Code R53.1 - Weakness (original) (raw)
ICD List 2025-2026 Edition
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- 2026 ICD-10-CM Code R53.1
Weakness
ICD-10-CM Code:
R53.1
ICD-10 Code for:
Weakness
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Not chronic
Code Navigator:
R53.1 is a billable diagnosis code used to specify a medical diagnosis of weakness. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2025 through September 30, 2026.
According to ICD-10-CM guidelines this code should not to be used as a principal diagnosis code when a related definitive diagnosis has been established.
- Code Information
- Approximate Synonyms
- Clinical Classification
- Clinical Information
- Tabular List of Diseases and Injuries
- Index to Diseases and Injuries References
- Diagnostic Related Groups Mapping
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- Other Codes Used Similar Conditions
- Code History
- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
R00–R99
The following list of clinical terms are approximate synonyms, alternative descriptions, or common phrases that might be used by patients, healthcare providers, or medical coders to describe the same condition. These synonyms and related diagnosis terms are often used when searching for an ICD-10 code, especially when the exact medical terminology is unclear. Whether you're looking for lay terms, similar diagnosis names, or common language alternatives, this list can help guide you to the correct ICD-10 classification.
- Asthenia
- Asthenia
- Asthenia
- Asthenia due to disease
- Asthenia due to disease
- Attacks of weakness
- Fatigue due to and following cerebrovascular accident
- Focal motor weakness
- Weakness as a late effect of stroke
Clinical Classifications group individual ICD-10-CM diagnosis codes into broader, clinically meaningful categories. These categories help simplify complex data by organizing related conditions under common clinical themes.
They are especially useful for data analysis, reporting, and clinical decision-making. Even when diagnosis codes differ, similar conditions can be grouped together based on their clinical relevance. Each category is assigned a unique CCSR code that represents a specific clinical concept, often tied to a body system or medical specialty.
CCSR Code: SYM007
Inpatient Default: Y - Yes, default inpatient assignment for principal diagnosis or first-listed diagnosis.
Outpatient Default: Y - Yes, default outpatient assignment for principal diagnosis or first-listed diagnosis.
Asthenia
clinical sign or symptom manifested as debility, or lack or loss of strength and energy.
Neurocirculatory Asthenia
a clinical syndrome characterized by palpitation, shortness of breath, labored breathing, subjective complaints of effort and discomfort, all following slight physical exertion. other symptoms may be dizziness, tremulousness, sweating, and insomnia. neurocirculatory asthenia is most typically seen as a form of anxiety disorder.
Bilateral Vestibular Weakness|Bilateral loss of labyrinthine reactivity
a reduction or absence of vestibular function occurring in both inner ears.
EORTC QLQ-CLL17 - Muscle Weakness|EOR29-Muscle Weakness|EOR29-Muscle Weakness|EOR2931
european organization for the research and treatment of cancer quality of life questionnaire - chronic lymphocytic leukemia 17 items (eortc qlq-cll17) have you had muscle weakness?
Feel Weakness in Arm or Hand Question|Does your arm or hand feel weak|Feel Weakness in Arm or Hand
a question about whether an individual has or had weakness in their arm or hand.
Grade 1 Facial Muscle Weakness, CTCAE|Grade 1 Facial muscle weakness
mild symptoms; clinical or diagnostic observations only; intervention not indicated
Grade 2 Facial Muscle Weakness, CTCAE|Grade 2 Facial muscle weakness
moderate symptoms; limiting instrumental adl or mild/moderate impact on age-appropriate normal daily activity (pediatric)
Grade 2 Generalized Muscle Weakness, CTCAE|Grade 2 Generalized muscle weakness
symptomatic; evident on physical exam; limiting instrumental adl or mild/moderate impact on age-appropriate normal daily activity (pediatric)
Grade 2 Muscle Weakness Lower Limb, CTCAE|Grade 2 Muscle weakness lower limb
symptomatic; evident on physical exam; limiting instrumental adl or mild/moderate impact on age-appropriate normal daily activity (pediatric)
Grade 2 Muscle Weakness Trunk, CTCAE|Grade 2 Muscle weakness trunk
symptomatic; evident on physical exam; limiting instrumental adl or mild/moderate impact on age-appropriate normal daily activity (pediatric)
Grade 2 Muscle Weakness Upper Limb, CTCAE|Grade 2 Muscle weakness upper limb
symptomatic; evident on physical exam; limiting instrumental adl or mild/moderate impact on age-appropriate normal daily activity (pediatric)
Grade 2 Pelvic Floor Muscle Weakness, CTCAE|Grade 2 Pelvic floor muscle weakness
symptomatic, not interfering with bladder, bowel, or vaginal function; limiting instrumental adl or mild/moderate impact on age-appropriate normal daily activity (pediatric)
Grade 3 Facial Muscle Weakness, CTCAE|Grade 3 Facial muscle weakness
severe symptoms; limiting self-care adl or severe impact on age-appropriate normal daily activity (pediatric)
Grade 3 Generalized Muscle Weakness, CTCAE|Grade 3 Generalized muscle weakness
limiting self-care adl or severe impact on age-appropriate normal daily activity (pediatric)
Grade 3 Muscle Weakness Lower Limb, CTCAE|Grade 3 Muscle weakness lower limb
limiting self-care adl or severe impact on age-appropriate normal daily activity (pediatric)
Grade 3 Muscle Weakness Trunk, CTCAE|Grade 3 Muscle weakness trunk
limiting self-care adl or severe impact on age-appropriate normal daily activity (pediatric)
Grade 3 Muscle Weakness Upper Limb, CTCAE|Grade 3 Muscle weakness upper limb
limiting self-care adl or severe impact on age-appropriate normal daily activity (pediatric)
Grade 3 Pelvic Floor Muscle Weakness, CTCAE|Grade 3 Pelvic floor muscle weakness
severe symptoms; limiting self-care adl or severe impact on age-appropriate normal daily activity (pediatric)
Have Difficulty Climbing Stairs or Getting Out of Chair Because of Weakness in Legs Question|Did you have difficulty climbing stairs or getting up out of a chair because of weakness in your legs|Have Difficulty Climbing Stairs or Getting Out of Chair Because of Weakness in Legs
a question about whether an individual has or had difficulty climbing stairs or getting up out of a chair because of weakness in their legs.
Have Difficulty Opening a Jar or Bottle Because of Weakness in Hands Question|Did you have difficulty opening a jar or bottle because of weakness in your hands|Have Difficulty Opening a Jar or Bottle Because of Weakness in Hands
a question about whether an individual has or had difficulty opening a jar or bottle because of weakness in their hands.
Have Felt Unusual Weakness Question|Have Felt Unusual Weakness|Have Felt Unusual Weakness
a question about whether an individual feels or felt unusual weakness.
Have Weakness in Legs Question|Have Leg Weakness|Have Weakness in Legs|I have weakness in my legs|My legs feel weak
a question about whether an individual has or had weakness in their legs.
Have Weakness in Limbs Question|Did you feel weak in your arms and legs|Feel Weak in Arms and Legs|Have Weakness in Limbs|I have weakness in my arms or legs
a question about whether an individual has or had weakness in their arms or legs.
Have Weakness of Both Legs Question|Did you have weakness of both legs|Have Weakness of Both Legs
a question about whether an individual has or had weakness of both legs.
Have Weakness on One Side of Body Question|Did you have weakness on one side of your body|Have Weakness on One Side of Body
a question about whether an individual has or had weakness on one side of the body.
How Much Bothered by Arm Weakness in Affected Arm Question|Arm weakness|How Much Bothered by Arm Weakness in Affected Arm
a question about how bothered an individual is by arm weakness in their affected arm.
How Often Experienced Difficulty Doing Everyday Activities Because of Abdominal Muscle Weakness Question|Difficulty doing everyday activities because of abdominal muscle weakness (e.g. making your bed)|How Often Experienced Difficulty Doing Everyday Activities Because of Abdominal Muscle Weakness
a question about how often an individual has or had experienced difficulty doing everyday activities because of abdominal muscle weakness (e.g.making their bed).
How Often Experienced Difficulty Sitting up Because Abdominal Muscle Weakness Question|Difficulty sitting up because of abdominal muscle weakness (e.g. getting out of bed)|How Often Experienced Difficulty Sitting up Because Abdominal Muscle Weakness
a question about how often an individual has or had experienced difficulty sitting up because of abdominal muscle weakness (e.g.getting out of bed).
Weakness in Arms and/or Legs at its Worst Question|Weakness in Arms and/or Legs at its Worst|Your weakness in the arms and/or legs at its worst
a question about an individual's weakness in their arms and/or legs at its worst.
Weakness on One Side of the Body at its Worst Question|Weakness on One Side of the Body at its Worst|Weakness on one side of the body at its worst
a question about an individual's weakness on one side of the body at its worst.
Eye Muscle Weakness
a reduction in the strength of the eye muscles.
Facial Muscle Weakness, CTCAE|Facial Muscle Weakness|Facial muscle weakness
a disorder characterized by a reduction in the strength of the facial muscles.
Facial Muscle Weakness|Facial muscle weakness
a reduction in the strength of the facial muscles.
Facial Weakness following Cerebral Infarction|Facial weakness following cerebral infarction
evidence of facial weakness following cerebral infarction.
Facial Weakness following Other Cerebrovascular Disease|Facial weakness following other cerebrovascular disease
evidence of facial weakness following other cerebrovascular disease.
Facial Weakness following Unspecified Cerebrovascular Disease|Facial weakness following unspecified cerebrovascular disease
evidence of facial weakness following unspecified cerebrovascular disease.
FACIT-Searchable Item Library Adult Version - Have Weakness in My Arms or Legs|FSIL-Have Weakness in My Arms or Legs|FSIL-Have Weakness in My Arms or Legs|FSIL0100
functional assessment of chronic illness therapy-searchable item library adult version (facit-searchable item library adult version) i have weakness in my arms or legs.
FACIT-Searchable Item Library Adult Version - I Have Weakness in My Legs|FSIL-I Have Weakness in My Legs|FSIL-I Have Weakness in My Legs|FSIL0495
functional assessment of chronic illness therapy-searchable item library adult version (facit-searchable item library adult version) i have weakness in my legs.
FBRSI - Have Weakness in My Arms or Legs|FAC029-Have Weakness in My Arms or Legs|FAC029-Have Weakness in My Arms or Legs|FAC02903
functional assessment of cancer therapy-brain symptom index (fbrsi) i have weakness in my arms or legs.
Feel Weakness in Arm or Hand|Does your arm or hand feel weak
a question about whether an individual has or had weakness in their arm or hand.
Focal Motor Weakness|Focal motor weakness
impairments of brain function, the nerve or spinal cord that affect a specific region of the body.
Generalized Muscle Weakness, CTCAE|Generalized Muscle Weakness|Generalized muscle weakness
a disorder characterized by a reduction in the strength of muscles in multiple anatomic sites.
Generalized Muscle Weakness|Generalized muscle weakness
a reduction in the strength of muscles in multiple anatomic sites.
Grade 1 Facial Muscle Weakness, CTCAE|Grade 1 Facial muscle weakness
asymptomatic; clinical or diagnostic observations only; intervention not indicated
Grade 1 Generalized Muscle Weakness, CTCAE|Grade 1 Generalized muscle weakness
symptomatic; perceived by patient but not evident on physical exam
Grade 1 Muscle Weakness Left-Sided, CTCAE|Grade 1 Muscle weakness left-sided
symptomatic; perceived by patient but not evident on physical exam
Grade 1 Muscle Weakness Lower Limb, CTCAE|Grade 1 Muscle weakness lower limb
symptomatic; perceived by patient but not evident on physical exam
Grade 1 Muscle Weakness Right-Sided, CTCAE|Grade 1 Muscle weakness right-sided
symptomatic; perceived by patient but not evident on physical exam
Grade 1 Muscle Weakness Trunk, CTCAE|Grade 1 Muscle weakness trunk
symptomatic; perceived by patient but not evident on physical exam
Grade 1 Muscle Weakness Upper Limb, CTCAE|Grade 1 Muscle weakness upper limb
symptomatic; perceived by patient but not evident on physical exam
Grade 1 Pelvic Floor Muscle Weakness, CTCAE|Grade 1 Pelvic floor muscle weakness
asymptomatic; clinical or diagnostic observations only; intervention not indicated
Grade 2 Facial Muscle Weakness, CTCAE|Grade 2 Facial muscle weakness
moderate symptoms; limiting instrumental adl
Grade 2 Generalized Muscle Weakness, CTCAE|Grade 2 Generalized muscle weakness
symptomatic; evident on physical exam; limiting instrumental adl
Grade 2 Muscle Weakness Left-Sided, CTCAE|Grade 2 Muscle weakness left-sided
symptomatic; evident on physical exam; limiting instrumental adl
Grade 2 Muscle Weakness Lower Limb, CTCAE|Grade 2 Muscle weakness lower limb
symptomatic; evident on physical exam; limiting instrumental adl
Grade 2 Muscle Weakness Right-Sided, CTCAE|Grade 2 Muscle weakness right-sided
symptomatic; evident on physical exam; limiting instrumental adl
Grade 2 Muscle Weakness Trunk, CTCAE|Grade 2 Muscle weakness trunk
symptomatic; evident on physical exam; limiting instrumental adl
Grade 2 Muscle Weakness Upper Limb, CTCAE|Grade 2 Muscle weakness upper limb
symptomatic; evident on physical exam; limiting instrumental adl
Grade 2 Pelvic Floor Muscle Weakness, CTCAE|Grade 2 Pelvic floor muscle weakness
symptomatic, not interfering with bladder, bowel, or vaginal function; limiting instrumental adl
Grade 3 Facial Muscle Weakness, CTCAE|Grade 3 Facial muscle weakness
severe symptoms; limiting self care adl
Grade 3 Generalized Muscle Weakness, CTCAE|Grade 3 Generalized muscle weakness
limiting self care adl
Grade 3 Muscle Weakness Left-Sided, CTCAE|Grade 3 Muscle weakness left-sided
limiting self care adl
Grade 3 Muscle Weakness Lower Limb, CTCAE|Grade 3 Muscle weakness lower limb
limiting self care adl
Grade 3 Muscle Weakness Right-Sided, CTCAE|Grade 3 Muscle weakness right-sided
limiting self care adl
Grade 3 Muscle Weakness Trunk, CTCAE|Grade 3 Muscle weakness trunk
limiting self care adl
Grade 3 Muscle Weakness Upper Limb, CTCAE|Grade 3 Muscle weakness upper limb
limiting self care adl
Grade 3 Pelvic Floor Muscle Weakness, CTCAE|Grade 3 Pelvic floor muscle weakness
severe symptoms; limiting self care adl
Have Difficulty Climbing Stairs or Getting Out of Chair Because of Weakness in Legs|Did you have difficulty climbing stairs or getting up out of a chair because of weakness in your legs
a question about whether an individual has or had difficulty climbing stairs or getting up out of a chair because of weakness in their legs.
Have Difficulty Opening a Jar or Bottle Because of Weakness in Hands|Did you have difficulty opening a jar or bottle because of weakness in your hands
a question about whether an individual has or had difficulty opening a jar or bottle because of weakness in their hands.
Have Felt Unusual Weakness
a question about whether an individual feels or felt unusual weakness.
Have Weakness in Legs|Have Leg Weakness|I have weakness in my legs|My legs feel weak
a question about whether an individual has or had weakness in their legs.
Have Weakness in Limbs|Did you feel weak in your arms and legs|Feel Weak in Arms and Legs|I have weakness in my arms or legs
a question about whether an individual has or had weakness in their arms or legs.
Have Weakness of Both Legs|Did you have weakness of both legs
a question about whether an individual has or had weakness of both legs.
Have Weakness on One Side of Body|Did you have weakness on one side of your body
a question about whether an individual has or had weakness on one side of the body.
How Much Bothered by Arm Weakness in Affected Arm|Arm weakness
a question about how bothered an individual is by arm weakness in their affected arm.
How Often Experienced Difficulty Doing Everyday Activities Because of Abdominal Muscle Weakness|Difficulty doing everyday activities because of abdominal muscle weakness (e.g. making your bed)
a question about how often an individual has or had experienced difficulty doing everyday activities because of abdominal muscle weakness (e.g.making their bed).
How Often Experienced Difficulty Sitting up Because Abdominal Muscle Weakness|Difficulty sitting up because of abdominal muscle weakness (e.g. getting out of bed)
a question about how often an individual has or had experienced difficulty sitting up because of abdominal muscle weakness (e.g.getting out of bed).
KFSS - Weakness Interferes With Testing|KFSS1-Weakness Interferes With Testing|KFSS1-Weakness Interferes With Testing|KFSS102A
kurtzke functional systems scores (kfss) record number 1 in small box when weakness (grade 3 or worse on pyramidal) interferes with testing.
Kurtzke Functional System Scores KFSS103 Original Result - Severe nystagmus, marked extraocular weakness, or moderate disability of other cranial nerves|KFSS103-Severe nystagmus, marked extraocular weakness, or moderate disability of other cranial nerves|Severe nystagmus, marked extraocular weakness, or moderate disability of other cranial nerves
kurtzke functional system scores kfss103 original result - severe nystagmus, marked extraocular weakness, or moderate disability of other cranial nerves.
Muscle Weakness
a reduction in the strength of one or more muscles.
Muscle Weakness Left-Sided, CTCAE|Muscle Weakness Left-Sided|Muscle weakness left-sided
a disorder characterized by a reduction in the strength of the muscles on the left side of the body.
Muscle Weakness Left-Sided|Muscle weakness left-sided
a reduction in the strength of the muscles in the left side of the body.
Muscle Weakness Lower Limb, CTCAE|Muscle Weakness Lower Limb|Muscle weakness lower limb
a disorder characterized by a reduction in the strength of the lower limb muscles.
Muscle Weakness Lower Limb|Muscle weakness lower limb
a reduction in the strength of the lower limb muscles.
Muscle Weakness Right-Sided, CTCAE|Muscle Weakness Right-Sided|Muscle weakness right-sided
a disorder characterized by a reduction in the strength of the muscles on the right side of the body.
Muscle Weakness Right-Sided|Muscle weakness right-sided
a reduction in the strength of the muscles in the right side of the body.
Muscle Weakness Trunk, CTCAE|Muscle Weakness Trunk|Muscle weakness trunk
a disorder characterized by a reduction in the strength of the trunk muscles.
Muscle Weakness Trunk|Muscle weakness trunk
a reduction in the strength of the trunk muscles.
Muscle Weakness Upper Limb, CTCAE|Muscle Weakness Upper Limb|Muscle weakness upper limb
a disorder characterized by a reduction in the strength of the upper limb muscles.
Muscle Weakness Upper Limb|Muscle weakness upper limb
a reduction in the strength of the upper limb muscles.
Muscle Weakness/Atrophy
a reduction in the strength and/or mass of one or more muscles.
NCCN-FACT FBRSI-24 Version 2 - Have Weakness in My Arms or Legs|FAC030-Have Weakness in My Arms or Legs|FAC030-Have Weakness in My Arms or Legs|FAC03005
national comprehensive cancer network/functional assessment of cancer therapy-brain symptom index-24 version 2 (nccn-fact fbrsi-24 version 2) i have weakness in my arms or legs.
NCCN-FACT-FPSI 17 Version 2 - I Have Weakness in My Legs|FAC052-I Have Weakness in My Legs|FAC052-I Have Weakness in My Legs|FAC05207
national comprehensive cancer network/functional assessment of cancer therapy-prostate symptom index 17 version 2 (nccn-fact-fpsi 17 version 2) i have weakness in my legs.
Pain or Weakness in Shoulder has Caused Work Change|Pain or weakness in my shoulder has caused me to change my work
a response indicating that an individual has or had shoulder pain or weakness that has caused a work change.
Pelvic Floor Muscle Weakness, CTCAE|Pelvic Floor Muscle Weakness|Pelvic floor muscle weakness
a disorder characterized by a reduction in the strength of the muscles of the pelvic floor.
Pelvic Floor Muscle Weakness|Pelvic floor muscle weakness
a reduction in the strength of the muscles of the pelvic floor.
Weakness
the property of lacking physical strength.
Weakness in Arms and/or Legs at its Worst|Your weakness in the arms and/or legs at its worst
a question about an individual's weakness in their arms and/or legs at its worst.
Weakness on One Side of the Body at its Worst|Weakness on one side of the body at its worst
a question about an individual's weakness on one side of the body at its worst.
Early-Onset Progressive Encephalopathy with Brain Atrophy and Thin Corpus Callosum|Early-Onset Progressive Diffuse Brain Atrophy-Microcephaly-Muscle Weakness-Optic Atrophy Syndrome|PEBAT
an autosomal recessive condition caused by mutation(s) in the tbcd gene, encoding tubulin-specific chaperone d. it is characterized by encephalopathy, cerebellar and cerebral atrophy, and a thin corpus callosum.
MT-ATP6 wt Allele|ATP Synthase 6 Gene|ATP6|ATPASE-6|ATPase-6|ATPase6|Complex V, ATP Synthase, Subunit ATPase6 Gene|MTATP6|Mitochondrially Encoded ATP Synthase Gene|Mitochondrially Encoded ATP Synthase Membrane Subunit 6 wt Allele|Mitochondrially Encoded ATP Synthase Membrane Subunit A Gene|Spicular Retinitis Pigmentosa with Dementia, Seizures, Ataxia, Proximal Muscle Weakness and Sensory Deficit Gene|Su6m
human mt-atp6 wild-type allele is located within the circular mitochondrial (mt) chromosome and is approximately 681 bases in length. this allele, which encodes atp synthase subunit a protein, plays a role in proton-transport and atp synthesis. mutation of the gene is associated with neuropathy, ataxia, and retinitis pigmentosa (narp); leber hereditary optic neuropathy (lhon); leigh syndrome (ls); mitochondrial infantile bilateral striatal necrosis (mibsn); myopathy, lactic acidosis, and sideroblastic anemia 3 (mlasa3); adult-onset ataxia and polyneuropathy (apao); infantile hypertrophic cardiomyopathy (cmhi); and mitochondrial complex v (atp synthase) deficiency mitochondrial type 1 (mc5dm1).
Muscle Weakness, Ped-PRO-CTCAE|Muscle weakness|Ped-PRO-CTCAE, Muscle Weakness
weakness of muscles as recorded on the ped-pro-ctcae questionnaire.
The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).
- - Asthenia, asthenic - R53.1
- - Weak, weakening, weakness (generalized) - R53.1
References found for this diagnosis code in the External Cause of Injuries Index:
- Asthenia, asthenic
- Weak, weakening, weakness(generalized)
Below are the ICD-9 codes that most closely match this ICD-10 code, based on the General Equivalence Mappings (GEMs). This ICD-10 to ICD-9 crosswalk tool is helpful for coders who need to reference legacy diagnosis codes for audits, historical claims, or approximate code comparisons.
ICD-9-CM: 780.79
Approximate Flag - The approximate mapping means this ICD-10 code does not have an exact ICD-9 equivalent. The matched code is the closest available option, but it may not fully capture the original diagnosis or clinical intent.
Muscle Disorders
Your muscles help you move and help your body work. Different types of muscles have different jobs. There are many problems that can affect muscles. Muscle disorders can cause weakness, pain or even paralysis.
Causes of muscle disorders include:
- Injury or overuse, such as sprains or strains, cramps or tendinitis
- A genetic disorder, such as muscular dystrophy
- Some cancers
- Inflammation, such as myositis
- Diseases of nerves that affect muscles
- Infections
- Certain medicines
Sometimes the cause of muscle disorders is unknown.
FY 2026 - No Change, effective from 10/1/2025 through 9/30/2026
FY 2025 - No Change, effective from 10/1/2024 through 9/30/2025
FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.
