ICD-10-CM Diagnosis Code T65.91XD - Toxic effect of unspecified substance, accidental (unintentional), subsequent encounter (original) (raw)

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  6. 2026 ICD-10-CM Code T65.91XD

Toxic effect of unspecified substance, accidental (unintentional), subsequent encounter

ICD-10-CM Code:

T65.91XD

ICD-10 Code for:

Toxic effect of unsp substance, accidental, subs

Is Billable?

Yes - Valid for Submission

Chronic Condition Indicator: [1]

Not chronic

Code Navigator:

T65.91XD is a billable diagnosis code used to specify a medical diagnosis of toxic effect of unspecified substance, accidental (unintentional), subsequent encounter. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2025 through September 30, 2026. The code is exempt from present on admission (POA) reporting for inpatient admissions to general acute care hospitals.

T65.91XD is a subsequent encounter code, includes a 7th character and should be used after the patient has completed active treatment for a condition like toxic effect of unspecified substance accidental (unintentional). According to ICD-10-CM Guidelines a "subsequent encounter" occurs when the patient is receiving routine care for the condition during the healing or recovery phase of treatment. Subsequent diagnosis codes are appropriate during the recovery phase, no matter how many times the patient has seen the provider for this condition. If the provider needs to adjust the patient's care plan due to a setback or other complication, the encounter becomes active again.

Unspecified diagnosis codes like T65.91XD are acceptable when clinical information is unknown or not available about a particular condition. Although a more specific code is preferable, unspecified codes should be used when such codes most accurately reflect what is known about a patient's condition. Specific diagnosis codes should not be used if not supported by the patient's medical record.

  1. Code Information
  2. Approximate Synonyms
  3. Clinical Classification
  4. Clinical Information
  5. Coding Guidelines
  6. Tabular List of Diseases and Injuries
  7. Diagnostic Related Groups Mapping
  8. Present on Admission (POA)
  9. Convert to ICD-9 Code
  10. Table of Drugs and Chemicals
  11. Patient Education
  12. Other Codes Used Similar Conditions
  13. Code History

The following list of clinical terms are approximate synonyms, alternative descriptions, or common phrases that might be used by patients, healthcare providers, or medical coders to describe the same condition. These synonyms and related diagnosis terms are often used when searching for an ICD-10 code, especially when the exact medical terminology is unclear. Whether you're looking for lay terms, similar diagnosis names, or common language alternatives, this list can help guide you to the correct ICD-10 classification.

Clinical Classifications group individual ICD-10-CM diagnosis codes into broader, clinically meaningful categories. These categories help simplify complex data by organizing related conditions under common clinical themes.

They are especially useful for data analysis, reporting, and clinical decision-making. Even when diagnosis codes differ, similar conditions can be grouped together based on their clinical relevance. Each category is assigned a unique CCSR code that represents a specific clinical concept, often tied to a body system or medical specialty.

CCSR Code: INJ060

Inpatient Default: Y - Yes, default inpatient assignment for principal diagnosis or first-listed diagnosis.

Outpatient Default: Y - Yes, default outpatient assignment for principal diagnosis or first-listed diagnosis.

damage to the ear or its function secondary to exposure to toxic substances such as drugs used in chemotherapy; immunotherapy; or radiation.

separation of nail plate from the underlying nail bed. it can be a sign of skin disease, infection (such as onychomycosis) or tissue injury.

poisoning by staphylococcal toxins present in contaminated food.

poisoning from toxins present in bivalve mollusks that have been ingested. four distinct types of shellfish poisoning are recognized based on the toxin involved.

systemic inflammatory response syndrome with a proven or suspected infectious etiology. when sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. when sepsis is accompanied by hypotension despite adequate fluid infusion, it is called septic shock.

poisoning caused by ingestion of food harboring species of salmonella. conditions of raising, shipping, slaughtering, and marketing of domestic animals contribute to the spread of this bacterium in the food supply.

a condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.

poisoning by the ingestion of plants or its leaves, berries, roots or stalks. the manifestations in both humans and animals vary in severity from mild to life threatening. in animals, especially domestic animals, it is usually the result of ingesting moldy or fermented forage.

poisoning due to exposure to organophosphorus compounds, such as organophosphates; organothiophosphates; and organothiophosphonates.

neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method. this includes conditions caused by biologic, chemical, and pharmaceutical agents.

poisoning caused by the ingestion of mycotoxins (toxins of fungal origin).

poisoning from ingestion of mushrooms, primarily from, but not restricted to, toxic varieties.

a condition caused by the neurotoxin mptp which causes selective destruction of nigrostriatal dopaminergic neurons. clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (parkinson disease, secondary). mptp toxicity is also used as an animal model for the study of parkinson disease. (adams et al., principles of neurology, 6th ed, p1072; neurology 1986 feb;36(2):250-8)

neurologic disorders associated with exposure to inorganic and organic forms of mercury. acute intoxication may be associated with gastrointestinal disturbances, mental status changes, and paraparesis. chronic exposure to inorganic mercury usually occurs in industrial workers, and manifests as mental confusion, prominent behavioral changes (including psychosis), dyskinesias, and neuritis. alkyl mercury poisoning may occur through ingestion of contaminated seafood or grain, and its characteristic features include polyneuropathy; ataxia; vision loss; nystagmus, pathologic; and deafness. (from joynt, clinical neurology, 1997, ch20, pp10-15)

poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of mercury or mercury compounds.

manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. clinical features include confusion; hallucinations; and an extrapyramidal syndrome (parkinson disease, secondary) that includes rigidity; dystonia; retropulsion; and tremor. (adams, principles of neurology, 6th ed, p1213)

neurologic disorders occurring in children following lead exposure. the most frequent manifestation of childhood lead toxicity is an encephalopathy associated with chronic ingestion of lead that usually presents between the ages of 1 and 3 years. clinical manifestations include behavioral changes followed by lethargy; convulsions; hallucinations; delirium; ataxia; and vomiting. elevated intracranial pressure (hypertension, intracranial) and cerebral edema may occur. (from adams et al., principles of neurology, 6th ed, p1210-2)

neurologic conditions in adults associated with acute or chronic exposure to lead or any of its salts. the most common lead related neurologic syndrome in adults consists of a polyneuropathy involving motor fibers. this tends to affect distal nerves and may present as wrist drop due to radial neuropathy. additional features of chronic lead exposure include anemia; constipation; colicky abdominal pain; a bluish lead line of the gums; interstitial nephritis (nephritis, interstitial); and saturnine gout. an encephalopathy may rarely occur. (from adams et al., principles of neurology, 6th ed, p1212)

injury to the nervous system secondary to exposure to lead compounds. two distinct clinical patterns occur in children (lead poisoning, nervous system, childhood) and adults (lead poisoning, nervous system, adult). in children, lead poisoning typically produces an encephalopathy. in adults, exposure to toxic levels of lead is associated with a peripheral neuropathy.

poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of lead or lead compounds.

conditions associated with damage or dysfunction of the nervous system caused by exposure to heavy metals, which may cause a variety of central, peripheral, or autonomic nervous system injuries.

poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of heavy metals. acute and chronic exposures can cause anemia; kidney and liver damage; pulmonary edema; memory loss and behavioral changes; bone deformities in children; and miscarriage or premature labor in pregnant people.

poisoning that results from exposure to gases such as carbon monoxide; noble gases; oxygen; or natural gas.

acute illnesses, usually affecting the gastrointestinal tract, brought on by consuming contaminated food or beverages. most of these diseases are infectious, caused by a variety of bacteria, viruses, or parasites that can be foodborne. sometimes the diseases are caused by harmful toxins from the microbes or other chemicals present in the food. especially in the latter case, the condition is often called food poisoning.

damage to the eye or its function (e.g., visual impairment) due to optic nerve damage secondary to toxic substances such as drugs used in chemotherapy; immunotherapy; or radiation.

poisoning by aflatoxins most often associated with nausea, abdominal pain, hepatotoxicity, immunosuppression, hepatocellular carcinoma and sometimes death.

disorders associated with acute or chronic exposure to compounds containing arsenic (arsenicals) which may be fatal. acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as seizures, mental status changes, and coma. chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (mees) lines in the fingernails. (adams et al., principles of neurology, 6th ed, p1212)

poisoning occurring after exposure to cadmium compounds or fumes. it may cause gastrointestinal syndromes, anemia, or pneumonitis.

toxic asphyxiation due to the displacement of oxygen from oxyhemoglobin by carbon monoxide.

poisoning that results from ingestion, injection, inhalation, or skin absorption of carbon tetrachloride.

poisoning caused by ingestion of seafood containing microgram levels of ciguatoxins. the poisoning is characterized by gastrointestinal, neurological and cardiovascular disturbances.

poisoning caused by ingesting ergotized grain or by the misdirected or excessive use of ergot as a medicine.

poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of fluoride compounds.

a solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (merck index, 11th ed)

generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver; biliary tract; pancreas).

a soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol pb.

a genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that utilizes citrate as a sole carbon source. it is pathogenic for humans, causing enteric fevers, gastroenteritis, and bacteremia. food poisoning is the most common clinical manifestation. organisms within this genus are separated on the basis of antigenic characteristics, sugar fermentation patterns, and bacteriophage susceptibility.

a fungal infection of the nail, usually caused by dermatophytes; yeasts; or nondermatophyte molds.

follicular conjunctivitis caused by chlamydia trachomatis, moraxella, borrelia, molluscum contagiosum, or toxicity from eye make-up and eye drops.

neuropathy affecting multiple nerves that is caused by prolonged exposure to toxic substances.

toxicity resulting exposure to the athanasia trifurcata plant.

toxicity resulting from overconsumption or abuse of common cold medication.

poisoning due to exposure to the organophosphate insecticide, demeton.

poisoning due to exposure to the species of the plant genus, dicentra.

poisoning due to exposure to the species of the plant genus, encephalartos.

moderate; minimal, local or noninvasive intervention indicated; limiting instrumental adl or mild/moderate impact on age-appropriate normal daily activity (pediatric)

severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self-care adl or severe impact on age-appropriate normal daily activity (pediatric)

other specified types of injury, poisoning and procedural complications.

injury, poisoning and procedural complications captures adverse events effecting this system organ class as defined and used by meddra and ctcae 6.0.

poisoning due to ingestion of the toxic cardiac glycosides found in plants belonging to species of the moraea (formerly homeria) genus.

poisoning by a derivative of nitrofuran.

evidence of alcohol abuse with intoxication delirium.

evidence of alcohol abuse with intoxication, uncomplicated.

evidence of alcohol abuse with intoxication.

evidence of alcohol dependence with intoxication delirium.

evidence of alcohol dependence with intoxication, uncomplicated.

evidence of alcohol dependence with intoxication.

disturbances in psychophysiological functions and responses as a result of consumption of a beverage containing ethanol.

disturbances in psychophysiological functions and responses as a result of administration or ingestion of a member of the barbiturate class of central nervous system depressants.

evidence of cannabis abuse with intoxication delirium.

onycholysis as recorded on the pro-ctcae questionnaire.

a nonimmunologic, chemically induced type of photosensitivity.

a study of the effect of an agent on the skin or eyes, such that it induces a sensitivity to sunlight or other forms of light.

damage to the inner ear as a result of exposure to drugs or chemicals.

a nail condition characterized by spontaneous separation of a fingernail or toenail from its nail bed.

food poisoning that is caused by staphylococcal infection.

the presence of pathogenic microorganisms in the blood stream causing a rapidly progressing systemic reaction that may lead to shock. symptoms include fever, chills, tachycardia, and increased respiratory rate. it is a medical emergency that requires urgent medical attention.

injury to the body or interference of normal body functions by a substance that is swallowed, inhaled, injected, or absorbed.

chronic toxicity to the body caused by the absorption of lead, which is characterized by fatigue, gastrointestinal symptoms, anemia, a dark line along the gums, and muscular paralysis or weakness of limbs.

a class of disorders that encompasses conditions resulting from an injury, poisoning or procedure.

death

life-threatening consequences; urgent intervention indicated

severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care adl

moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental adl

asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated

any disorder that results from the consumption of food contaminated with an infectious agent or toxin.

nephropathy due to hypoperfusion of the kidney.

thermal or caustic injury to the esophagus.

polyneuropathy that is caused by exposure to toxins.

a disorder characterized by the acute and sudden development of changes in attention, memory, language and/or perception that can be etiologically linked to the direct physiological consequences of substance intoxication.

evidence of sedative, hypnotic or anxiolytic induced dependence with intoxication.

evidence of sedative, hypnotic or anxiolytic induced dependence with intoxication, uncomplicated.

evidence of sedative, hypnotic or anxiolytic induced dependence with intoxication delirium.

evidence of sedative, hypnotic or anxiolytic abuse with intoxication.

evidence of sedative, hypnotic or anxiolytic abuse with intoxication, uncomplicated.

evidence of sedative, hypnotic or anxiolytic abuse with intoxication delirium.

evidence of other stimulant dependence with intoxication not specified elsewhere.

evidence of other uncomplicated stimulant dependence with intoxication that is not specified elsewhere.

evidence of other stimulant dependence with intoxication with perceptual disturbance not specified elsewhere.

evidence of other stimulant dependence with intoxication delirium not specified elsewhere.

evidence of other stimulant abuse with intoxication not specified elsewhere.

evidence of other stimulant abuse with intoxication, uncomplicated not specified elsewhere.

evidence of other stimulant abuse with intoxication with perceptual disturbance not specified elsewhere.

evidence of other stimulant abuse with intoxication delirium not specified elsewhere.

evidence of other psychoactive substance dependence with intoxication not specified elsewhere.

evidence of other psychoactive substance dependence with intoxication, uncomplicated not specified elsewhere.

evidence of other psychoactive substance dependence with intoxication with perceptual disturbance not specified elsewhere.

evidence of other psychoactive substance dependence with intoxication delirium not specified elsewhere.

evidence of other psychoactive substance abuse with intoxication not specified elsewhere.

evidence of other psychoactive substance abuse with intoxication, uncomplicated not specified elsewhere.

evidence of other psychoactive substance abuse with intoxication with perceptual disturbance not specified elsewhere.

evidence of other psychoactive substance abuse with intoxication delirium not specified elsewhere.

evidence of opioid dependence with intoxication.

evidence of opioid dependence with intoxication, uncomplicated.

evidence of opioid dependence with intoxication with perceptual disturbance.

evidence of opioid dependence with intoxication delirium.

evidence of opioid abuse with intoxication.

evidence of opioid abuse with intoxication, uncomplicated.

evidence of opioid abuse with intoxication with perceptual disturbance.

evidence of opioid abuse with intoxication delirium.

disturbances in psychophysiological functions and responses as a result of administration or ingestion of a psychoactive substance.

evidence of inhalant dependence with intoxication.

evidence of inhalant dependence with intoxication, uncomplicated.

evidence of inhalant dependence with intoxication delirium.

evidence of inhalant abuse with intoxication.

evidence of inhalant abuse with intoxication, uncomplicated.

evidence of inhalant abuse with intoxication delirium.

evidence of hallucinogen dependence with intoxication.

evidence of hallucinogen dependence with intoxication, uncomplicated.

evidence of hallucinogen dependence with intoxication with delirium.

evidence of hallucinogen abuse with intoxication.

evidence of hallucinogen abuse with intoxication, uncomplicated.

evidence of hallucinogen abuse with intoxication with perceptual disturbance.

evidence of hallucinogen abuse with intoxication with delirium.

evidence of cocaine dependence with intoxication.

evidence of cocaine dependence with intoxication, uncomplicated.

evidence of cocaine dependence with intoxication with perceptual disturbance.

evidence of cocaine dependence with intoxication delirium.

evidence of cocaine abuse with intoxication.

evidence of cocaine abuse with intoxication, uncomplicated.

evidence of cocaine abuse with intoxication with perceptual disturbance.

evidence of cocaine abuse with intoxication with delirium.

children affected by toxins may be due to silicone breast implants and their effects on unborn children and from breastfeeding.

evidence of cannabis dependence with intoxication.

evidence of cannabis dependence with intoxication, uncomplicated.

evidence of cannabis dependence with intoxication with perceptual disturbance.

evidence of cannabis dependence with intoxication delirium.

evidence of cannabis abuse with intoxication.

evidence of cannabis abuse with intoxication, uncomplicated.

evidence of cannabis abuse with intoxication with perceptual disturbance.

amblyopia due to exposure to a toxin.

non-scarring alopecia arising during the growth (anagen) phase of the hair cycle. it may be associated with chemotherapy, exposure to radiation or heavy metals, poor nutrition, or various autoimmune conditions.

human poisoning due to exposure to toad toxins.

poisoning resulting from consuming solanum nigrum, black nightshade.

poisoning due to overexposure to profenamine, a medication used to treat parkinson disease and the extrapyramidal signs associated with certain antipsychotic medications.

toxic effects of phosdrin exposure.

poisoning by the seeds of the peganum harmala plant, which is a traditional medicine used as to treat menstrual flow or aid in abortion.

excessive amounts of oxytocin in the body.

poisoning by inhalation, ingestion or dermal contact with members of the osteospermum species.

deleterious effects due to excessive amounts of the bronchodilator metaproterenol in an individual.

The appropriate 7th character is to be added to each code from block Toxic effect of other and unspecified substances (T65). Use the following options for the aplicable episode of care:

T65.91XD is exempt from POA reporting - The Present on Admission (POA) indicator is used for diagnosis codes included in claims involving inpatient admissions to general acute care hospitals. POA indicators must be reported to CMS on each claim to facilitate the grouping of diagnoses codes into the proper Diagnostic Related Groups (DRG). CMS publishes a listing of specific diagnosis codes that are exempt from the POA reporting requirement. Review other POA exempt codes here.

CMS POA Indicator Options and Definitions

POA Indicator: Y

Reason: Diagnosis was present at time of inpatient admission.

CMS Pays CC/MCC DRG? YES

POA Indicator: N

Reason: Diagnosis was not present at time of inpatient admission.

CMS Pays CC/MCC DRG? NO

POA Indicator: U

Reason: Documentation insufficient to determine if the condition was present at the time of inpatient admission.

CMS Pays CC/MCC DRG? NO

POA Indicator: W

Reason: Clinically undetermined - unable to clinically determine whether the condition was present at the time of inpatient admission.

CMS Pays CC/MCC DRG? YES

POA Indicator: 1

Reason: Unreported/Not used - Exempt from POA reporting.

CMS Pays CC/MCC DRG? NO

Below are the ICD-9 codes that most closely match this ICD-10 code, based on the General Equivalence Mappings (GEMs). This ICD-10 to ICD-9 crosswalk tool is helpful for coders who need to reference legacy diagnosis codes for audits, historical claims, or approximate code comparisons.

ICD-9-CM: V58.89

Approximate Flag - The approximate mapping means this ICD-10 code does not have an exact ICD-9 equivalent. The matched code is the closest available option, but it may not fully capture the original diagnosis or clinical intent.

The parent code T65.91 of the current diagnosis code is referenced in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents.

According to ICD-10-CM coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.

Filter table of drugs and chemicals:

Substance Poisoning Accidental (unintentional) Poisoning Accidental (self-harm) Poisoning Assault Poisoning Undetermined Adverse effect Underdosing
Aerosol spray NEC T65.91 T65.92 T65.93 T65.94
Agricultural agent NEC T65.91 T65.92 T65.93 T65.94
Air contaminant (s), source/type NOS T65.91 T65.92 T65.93 T65.94
Antifreeze T65.91 T65.92 T65.93 T65.94
Antifreeze »alcohol T65.91 T65.92 T65.93 T65.94
Antifreeze »ethylene glycol T65.91 T65.92 T65.93 T65.94
Chemical substance NEC T65.91 T65.92 T65.93 T65.94
Horticulture agent NEC T65.91 T65.92 T65.93 T65.94
Horticulture agent NEC »with pesticide T65.91 T65.92 T65.93 T65.94
Ingested substance NEC T65.91 T65.92 T65.93 T65.94
Poison NEC T65.91 T65.92 T65.93 T65.94
Solid substance T65.91 T65.92 T65.93 T65.94
Solid substance »specified NEC T65.91 T65.92 T65.93 T65.94
Spray (aerosol) T65.91 T65.92 T65.93 T65.94
Spray (aerosol) »cosmetic T65.91 T65.92 T65.93 T65.94
Spray (aerosol) »medicinal NEC T65.91 T65.92 T65.93 T65.94
Spray (aerosol) »pesticides T65.91 T65.92 T65.93 T65.94
Spray (aerosol) »specified content T65.91 T65.92 T65.93 T65.94

Poisoning

A poison is any substance that is harmful to your body. You might swallow it, inhale it, inject it, or absorb it through your skin. Any substance can be poisonous if too much is taken. Poisons can include:

The effects of poisoning range from short-term illness to brain damage, coma, and death. To prevent poisoning it is important to use and store products exactly as their labels say. Keep dangerous products where children can't get to them. Treatment for poisoning depends on the type of poison. If you suspect someone has been poisoned, call your local poison control center at 1-800-222-1222 right away.

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