Paul Sandoval P - Academia.edu (original) (raw)

Uploads

Papers by Paul Sandoval P

Immunology, Endocrine & Metabolic Agents - Medicinal Chemistry (formerly Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents), 2009

One principal process driving fatty acid transport is vectorial acylation, where fatty acids trav... more One principal process driving fatty acid transport is vectorial acylation, where fatty acids traverse the membrane concomitant with activation to CoA thioesters. Current evidence is consistent with the proposal that specific fatty acid transport (FATP) isoforms alone or in concert with specific long chain acyl CoA synthetase (Acsl) isoforms function to drive this energy-dependent process. Understanding the details of vectorial acylation is of particular importance as disturbances in lipid metabolism many times lead to elevated levels of circulating free fatty acids, which in turn increases fatty acid internalization and ectopic accumulation of triglycerides. This is associated with changes in fatty acid oxidation rates, accumulation of reactive oxygen species, the synthesis of ceramide and ER stress. The correlation between chronically elevated plasma free fatty acids and triglycerides with the development of obesity, insulin resistance and cardiovascular disease has led to the hypothesis that decreases in pancreatic insulin production, cardiac failure, arrhythmias, and hypertrophy are due to aberrant accumulation of lipids in these tissues. To this end, a detailed understanding of how fatty acids traverse the plasma membrane, become activated and trafficked into downstream metabolic pools and the precise roles provided by the different FATP and Acsl isoforms are especially important questions. We review our current understanding of vectorial acylation and the contributions by specific FATP and Acsl isoforms and the identification of small molecule inhibitors from high throughput screens that inhibit this process and thus provide new insights into the underlying mechanistic basis of this process.

This Letter presents the results of a direct search with the ATLAS detector at the LHC for a Stan... more This Letter presents the results of a direct search with the ATLAS detector at the LHC for a Standard Model Higgs boson of mass 110 ≤ m H ≤ 130 GeV produced in association with a W or Z boson and decaying to bb. Three decay channels are considered: ZH → ℓ + ℓ − bb, W H → ℓνbb and ZH → ννbb, where ℓ corresponds to an electron or a muon. No evidence for Higgs boson production is observed in a dataset of 7 TeV pp collisions corresponding to 4.7 fb −1 of integrated luminosity collected by ATLAS in 2011. Exclusion limits on Higgs boson production, at the 95% confidence level, of 2.5 to 5.5 times the Standard Model cross section are obtained in the mass range 110-130 GeV. The expected exclusion limits range between 2.5 and 4.9 for the same mass interval.

Physical Review B, 2004

We present the results of electrical resistivity and Hall effect measurements on single crystals ... more We present the results of electrical resistivity and Hall effect measurements on single crystals of HfNiSn, TiPtSn, and TiNiSn. Semiconducting behavior is observed in each case, involving the transport of a small number of highly compensated carriers. Magnetization measurements suggest that impurities and site disorder create both localized magnetic moments and extended paramagnetic states, with the susceptibility of the latter increasing strongly with reduced temperature. The magnetoresistance is sublinear or linear in fields ranging from 0.01 - 9 Tesla at the lowest temperatures. As the temperature increases, the normal quadratic magnetoresistance is regained, initially at low fields, and at the highest temperatures extending over the complete range of fields. The origin of the vanishingly small field scale implied by these measurements remains unknown, presenting a challenge to existing classical and quantum mechanical theories of magnetoresistance.

Journal of Clinical Pharmacology, 2002

It has been suggested that aging enhances the pharmacologic effect of warfarin, but there is litt... more It has been suggested that aging enhances the pharmacologic effect of warfarin, but there is little information about the effects of warfarin in aging minority populations. The authors examine the response of an aging Hispanic population to warfarin. Charts in their anticoagulation clinic were retrospectively examined for the following information: age, sex, weight, duration of anticoagulant therapy, number of medical problems, number of medications, number of minor or major bleeding episodes, prothrombin time, warfarin dose, and international normalized ratio (INR). The dose-adjusted prothrombin time ratio (PTR) and dose-adjusted INR were calculated by dividing the PTR and INR by the mean warfarin dose. Four groups were compared by age: < 50, 50 to 59, 60 to 69, and > or = 70. A total of 243 charts were reviewed: 113 female, 130 male; 90% were Hispanic. The most common indication for anticoagulation was atrial fibrillation. Elderly patients had more medical problems (3.1 vs. 2.4) and took more medications (3.4 vs. 2.4) than younger patients. The dose-adjusted PTR and dose-adjusted INR increased with aging (0.59 vs. 0.38 and 0.85 vs. 0.59, p < .05 ANOVA). In a multiple linear regression analysis, only age remained significantly associated with the anticoagulant effect. These results are consistent with previous reports on the effect of warfarin in aging patients and extend these data to the Hispanic population.

Immunology, Endocrine & Metabolic Agents - Medicinal Chemistry (formerly Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents), 2009

One principal process driving fatty acid transport is vectorial acylation, where fatty acids trav... more One principal process driving fatty acid transport is vectorial acylation, where fatty acids traverse the membrane concomitant with activation to CoA thioesters. Current evidence is consistent with the proposal that specific fatty acid transport (FATP) isoforms alone or in concert with specific long chain acyl CoA synthetase (Acsl) isoforms function to drive this energy-dependent process. Understanding the details of vectorial acylation is of particular importance as disturbances in lipid metabolism many times lead to elevated levels of circulating free fatty acids, which in turn increases fatty acid internalization and ectopic accumulation of triglycerides. This is associated with changes in fatty acid oxidation rates, accumulation of reactive oxygen species, the synthesis of ceramide and ER stress. The correlation between chronically elevated plasma free fatty acids and triglycerides with the development of obesity, insulin resistance and cardiovascular disease has led to the hypothesis that decreases in pancreatic insulin production, cardiac failure, arrhythmias, and hypertrophy are due to aberrant accumulation of lipids in these tissues. To this end, a detailed understanding of how fatty acids traverse the plasma membrane, become activated and trafficked into downstream metabolic pools and the precise roles provided by the different FATP and Acsl isoforms are especially important questions. We review our current understanding of vectorial acylation and the contributions by specific FATP and Acsl isoforms and the identification of small molecule inhibitors from high throughput screens that inhibit this process and thus provide new insights into the underlying mechanistic basis of this process.

This Letter presents the results of a direct search with the ATLAS detector at the LHC for a Stan... more This Letter presents the results of a direct search with the ATLAS detector at the LHC for a Standard Model Higgs boson of mass 110 ≤ m H ≤ 130 GeV produced in association with a W or Z boson and decaying to bb. Three decay channels are considered: ZH → ℓ + ℓ − bb, W H → ℓνbb and ZH → ννbb, where ℓ corresponds to an electron or a muon. No evidence for Higgs boson production is observed in a dataset of 7 TeV pp collisions corresponding to 4.7 fb −1 of integrated luminosity collected by ATLAS in 2011. Exclusion limits on Higgs boson production, at the 95% confidence level, of 2.5 to 5.5 times the Standard Model cross section are obtained in the mass range 110-130 GeV. The expected exclusion limits range between 2.5 and 4.9 for the same mass interval.

Physical Review B, 2004

We present the results of electrical resistivity and Hall effect measurements on single crystals ... more We present the results of electrical resistivity and Hall effect measurements on single crystals of HfNiSn, TiPtSn, and TiNiSn. Semiconducting behavior is observed in each case, involving the transport of a small number of highly compensated carriers. Magnetization measurements suggest that impurities and site disorder create both localized magnetic moments and extended paramagnetic states, with the susceptibility of the latter increasing strongly with reduced temperature. The magnetoresistance is sublinear or linear in fields ranging from 0.01 - 9 Tesla at the lowest temperatures. As the temperature increases, the normal quadratic magnetoresistance is regained, initially at low fields, and at the highest temperatures extending over the complete range of fields. The origin of the vanishingly small field scale implied by these measurements remains unknown, presenting a challenge to existing classical and quantum mechanical theories of magnetoresistance.

Journal of Clinical Pharmacology, 2002

It has been suggested that aging enhances the pharmacologic effect of warfarin, but there is litt... more It has been suggested that aging enhances the pharmacologic effect of warfarin, but there is little information about the effects of warfarin in aging minority populations. The authors examine the response of an aging Hispanic population to warfarin. Charts in their anticoagulation clinic were retrospectively examined for the following information: age, sex, weight, duration of anticoagulant therapy, number of medical problems, number of medications, number of minor or major bleeding episodes, prothrombin time, warfarin dose, and international normalized ratio (INR). The dose-adjusted prothrombin time ratio (PTR) and dose-adjusted INR were calculated by dividing the PTR and INR by the mean warfarin dose. Four groups were compared by age: < 50, 50 to 59, 60 to 69, and > or = 70. A total of 243 charts were reviewed: 113 female, 130 male; 90% were Hispanic. The most common indication for anticoagulation was atrial fibrillation. Elderly patients had more medical problems (3.1 vs. 2.4) and took more medications (3.4 vs. 2.4) than younger patients. The dose-adjusted PTR and dose-adjusted INR increased with aging (0.59 vs. 0.38 and 0.85 vs. 0.59, p < .05 ANOVA). In a multiple linear regression analysis, only age remained significantly associated with the anticoagulant effect. These results are consistent with previous reports on the effect of warfarin in aging patients and extend these data to the Hispanic population.