Fabiano Oliveira | Instituto Federal de Educação, Ciência e Tecnologia do Piauí (original) (raw)

Papers by Fabiano Oliveira

Research paper thumbnail of Disseminated Protothecosis Associated With Diskospondylitis in a Dog

Journal of the American Animal Hospital Association, Sep 23, 2014

A 6 yr old female Labrador retriever was evaluated for an acute onset of difficulty walking and a... more A 6 yr old female Labrador retriever was evaluated for an acute onset of difficulty walking and a head tilt. Initial physical examination revealed bilateral retinal detachment, a left-sided head tilt, positional rotary nystagmus, and lumbar hyperpathia. Pertinent preliminary diagnostic findings included systemic hypertension, bony lysis and adjacent sclerosis of the vertebral endplates of the first and second lumbar vertebrae, and positive urine and blood cultures for a yeast identified as Candida spp. Concerned about disseminated candidiasis after subsequent subretinal aspirates confirmed the presence of a yeast-like organism, therapy with voriconazole was initiated. Because of progressive clinical deterioration and the poor prognosis for recovery, the dog was eventually euthanized. Postmortem histological examination of tissues, including the affected vertebral endplates, revealed numerous intralesional algae compatible with Prototheca spp. To the authors' knowledge, this report is the first to document a case of protothecal diskospondylitis with possible concurrent candidiasis in a dog. Although typically associated with signs referable to the gastrointestinal tract, this report underscores the importance of not excluding protothecosis as a differential diagnosis when such signs are absent. Lastly, the use of voriconazole appears ineffective for reversing the clinical course of late-stage disseminated protothecosis.

Research paper thumbnail of Carboplatin chemotherapy in a cat with a recurrent anal sac apocrine gland adenocarcinoma

Journal of the American Animal Hospital Association

An 8-year-old, castrated male, domestic shorthaired cat was presented for evaluation of a periana... more An 8-year-old, castrated male, domestic shorthaired cat was presented for evaluation of a perianal mass. The mass was incompletely excised, and histological assessment resulted in a diagnosis of anal sac adenocarcinoma. The cat had a partial response to carboplatin therapy but a short overall duration of response. Necropsy confirmed the original diagnosis as well as metastasis to the regional lymph nodes and lungs.

Research paper thumbnail of Prevalence of discordant immunologic and virologic responses in patients with AIDS under antiretroviral therapy in a specialized care center in Brazil

Revista do Instituto de Medicina Tropical de São Paulo

Some patients under antiretroviral therapy (ART) do not reach immune recovery when the viral load... more Some patients under antiretroviral therapy (ART) do not reach immune recovery when the viral load becomes undetectable. This is called discordant immunologic and virologic responses. Its prevalence varies between 8% and 24%. This study describes its prevalence and the characteristics of the affected subjects in the outpatient clinic of a Brazilian specialized-care center. Of 934 patients on ART, 536 had undetectable viral loads. Prevalence was 51/536 or 9% (95% confidence interval: 6.6% to 11.4%). Median age at the beginning of ART was 37 years (interquartile range - IQR: 31 to 45). Male gender and mixed race predominated (76.5% and 47.1% respectively). AIDS-defining illnesses were absent at the beginning of ART in 60.8%. Fifty-one percent were taking protease inhibitors, 43.2% Efavirenz and 5.8% both. Median time on ART was 36 months (IQR: 17-81 months). Irregular treatment was recorded for 21.6%. ART had been modified for 63% prior to the study, and 15.7% had used monotherapy or d...

Research paper thumbnail of Semi-detailed Geomorphological Map of Northeastern Santa Catarina State, Brazil—the Garuva Sheet

Journal of Maps, 2009

Please click here to download the map associated with this article.Geomorphological maps can be d... more Please click here to download the map associated with this article.Geomorphological maps can be documents of restricted use due to the complexity of their content. The research project now presented proposes the geomorphological mapping of the area covered by six official topographic sheets at a scale of 1:50,000, located in the northeastern part of Santa Catarina State, southern Brazil. The

Research paper thumbnail of Disseminated protothecosis associated with diskospondylitis in a dog

Journal of the American Animal Hospital Association

A 6 yr old female Labrador retriever was evaluated for an acute onset of difficulty walking and a... more A 6 yr old female Labrador retriever was evaluated for an acute onset of difficulty walking and a head tilt. Initial physical examination revealed bilateral retinal detachment, a left-sided head tilt, positional rotary nystagmus, and lumbar hyperpathia. Pertinent preliminary diagnostic findings included systemic hypertension, bony lysis and adjacent sclerosis of the vertebral endplates of the first and second lumbar vertebrae, and positive urine and blood cultures for a yeast identified as Candida spp. Concerned about disseminated candidiasis after subsequent subretinal aspirates confirmed the presence of a yeast-like organism, therapy with voriconazole was initiated. Because of progressive clinical deterioration and the poor prognosis for recovery, the dog was eventually euthanized. Postmortem histological examination of tissues, including the affected vertebral endplates, revealed numerous intralesional algae compatible with Prototheca spp. To the authors' knowledge, this repo...

Research paper thumbnail of Factors associated with paradoxical immune response to antiretroviral therapy in HIV infected patients: a case control study

BMC Infectious Diseases, 2011

Background: A paradoxical immunologic response (PIR) to Highly Active Antiretroviral Therapy (HAA... more Background: A paradoxical immunologic response (PIR) to Highly Active Antiretroviral Therapy (HAART), defined as viral suppression without CD4 cell-count improvement, has been reported in the literature as 8 to 42%, around 15% in most instances. The present study aims to determine, in a cohort of HIV infected patients in Brazil, what factors were independently associated with such a discordant response to HAART. Methods: A case-control study (1:4) matched by gender was conducted among 934 HIV infected patients on HAART in Brazil. Cases: patients with PIR, defined as CD4 < 350 cells/mm 3 (hazard ratio for AIDS or death of at least 8.5) and undetectable HIV viral load on HAART for at least one year. Controls: similar to cases, but with CD4 counts ≥ 350 cells/mm 3 . Eligibility criteria were applied. Data were collected from medical records using a standardized form. Variables were introduced in a hierarchical logistic regression model if a p-value < 0.1 was determined in a bivariate analysis. Results: Among 934 patients, 39 cases and 160 controls were consecutively selected. Factors associated with PIR in the logistic regression model were: total time in use of HAART (OR 0.981; CI 95%: 0.96-0.99), nadir CD4-count (OR 0.985; CI 95%: 0.97-0.99), and time of undetectable HIV viral load (OR 0.969; CI 95%: 0.94-0.99). Conclusions: PIR seems to be related to a delay in the management of immunodeficient patients, as shown by its negative association with nadir CD4-count. Strategies should be implemented to avoid such a delay and improve the adherence to HAART as a way to implement concordant responses.

Research paper thumbnail of Sugar cane bagasse drying: a review

International sugar …, 2006

RefDoc Bienvenue - Welcome. Refdoc est un service / is powered by. ...

Research paper thumbnail of O quilombo de Bananal e a questão da identidade histórica

Dimensoes, Dec 20, 2008

O artigo relaciona fatores teóricos e práticos sobre a formação da identidade pessoal dos indivíd... more O artigo relaciona fatores teóricos e práticos sobre a formação da identidade pessoal dos indivíduos nascidos e criados em uma comunidade remanescente de quilombo do interior da Bahia. A partir do aporte sócio-cultural, que desenvolve o conceito de identidade sob alguns pontos de vista complementares, além dos pré-supostos históricos do senso comum que envolvem a vinda dos africanos para a América, faz-se uma descrição dos dados reais advindos de trabalho de campo numa comunidade remanescente de quilombo, a de Bananal, localizada na Chapada Diamantina, como WDPEpP GD DQiOLVH GH PDWHULDO GH IRQWH VHFXQGiULD R ¿OPH GRFXPHQWiULR Quilombos da Bahia de Antonio Olavo. O período de pesquisa foi Janeiro GH DSHQDV H HQYROYHX D SHVTXLVD ELEOLRJUi¿FD R WUDEDOKR GH FDPSR e a análise das fontes secundárias. Palavras-chave: Quilombo; Identidade Histórica; Identidade Pessoal.

Research paper thumbnail of Síndrome do pinçamento aorto-mesentérico: relato de caso

Rev Med Parana, Jun 1, 2004

Resumo: A Sínsdrome da Artéria Mesentérica Superior (SAMS), também chamada de Síndrome de Wilkie,... more Resumo: A Sínsdrome da Artéria Mesentérica Superior (SAMS), também chamada de Síndrome de Wilkie, é uma rara entidade, que tem sintomatologia caracterizada por dor epigátrica, saciedade precoce, desconforto pósprandial (fullness), náuseas, vômitos e ...

Research paper thumbnail of Evolução Das Estruturas De Membrana

The present text brings the evolution of the membrane structures along time. From the prehistory ... more The present text brings the evolution of the membrane structures along time. From the prehistory to nowadays, is shown in a brief way the use and structural aspects of the main types of awnings and hanging roofs. Special attention is dedicated to the evolutionary procexss inside the century XX.

Research paper thumbnail of RUP como Metodologia de Desenvolvimento de Software para Obtenção da Qualidade de Software

The center of interest of our discussion in ensuring the development process appropriate for obta... more The center of interest of our discussion in ensuring the development process appropriate for obtaining quality of software,, examining the method RUP (Rational Unified Process), as an alternative to other solutions that have been submitted for this area. In this paper, we present a conceptual discussion on quality, initially. We discuss the main and relevant aspects of the method RUP,

Research paper thumbnail of A Tendência De Utilização De Embalagens Retornáveis Em Industrias – Um Estudo Exploratório No Brasil

Jovens Pesquisadores Mackenzie, Mar 8, 2010

Research paper thumbnail of Processo de Construção do Plano Diretor de Recursos Hídricos: Caso da Bacia Hidrográfica do Rio Cubatão do Norte ? SC

Revista Brasileira de Recursos Hídricos, 2007

Page 1. RBRH — Revista Brasileira de Recursos Hídricos Volume 12 n.2 Abr/Jun 2007, 147-155 147 Pr... more Page 1. RBRH — Revista Brasileira de Recursos Hídricos Volume 12 n.2 Abr/Jun 2007, 147-155 147 Processo de Construção do Plano Diretor de Recursos Hídricos: Caso da Bacia Hidrográfica do Rio Cubatão do Norte — SC ...

Research paper thumbnail of Febre catarral maligna em bovinos no Rio Grande do Sul: epidemiologia, sinais cl�nicos e patologia

Research paper thumbnail of Molecular Diversity between Salivary Proteins from New World and Old World Sand Flies with Emphasis on Bichromomyia olmeca, the Sand Fly Vector of Leishmania mexicana in Mesoamerica

PLOS Neglected Tropical Diseases, 2016

Sand fly saliva has been shown to have proteins with potent biological activities, salivary prote... more Sand fly saliva has been shown to have proteins with potent biological activities, salivary proteins that can be used as biomarkers of vector exposure, and salivary proteins that are candidate vaccines against different forms of leishmaniasis. Sand fly salivary gland transcriptomic approach has contributed significantly to the identification and characterization of many of these salivary proteins from important Leishmania vectors; however, sand fly vectors in some regions of the world are still neglected, as Bichromomyia olmeca (formerly known as Lutzomyia olmeca olmeca), a proven vector of Leishmania mexicana in Mexico and Central America. Despite the importance of this vector in transmitting Leishmania parasite in Mesoamerica there is no information on the repertoire of B. olmeca salivary proteins and their relationship to salivary proteins from other sand fly species. A cDNA library of the salivary glands of wild-caught B. olmeca was constructed, sequenced, and analyzed. We identified transcripts encoding for novel salivary proteins from this sand fly species and performed a comparative analysis between B. olmeca salivary proteins and those from other sand fly species. With this new information we present an updated catalog of the salivary proteins specific to New World sand flies and salivary proteins common to all sand fly species. We also report in this work the anti-Factor Xa activity of Lofaxin, a salivary anticoagulant protein present in this sand fly species. This study provides information on the first transcriptome of a sand fly from Mesoamerica and adds information to the limited repertoire of salivary transcriptomes from the Americas. This comparative analysis also shows a fast degree of evolution in salivary proteins from New World sand flies as compared with Old World sand flies.

Research paper thumbnail of A34 リーシュマニア原虫媒介サシテョウバエPhlebotomus duboscqi唾液タンパクのトランスクリプトーム解析(一般講演,演題要旨,第58回日本衛生動物学会大会)

Research paper thumbnail of PCR Detection of Leishmania in Bahia @BULLET CID 2003:37 (1 December) @BULLET e149 Clinical Utility of Polymerase Chain Reaction–Based Detection of Leishmania in the Diagnosis of American Cutaneous Leishmaniasis

ABSTRACT We evaluated the use of polymerase chain reaction (PCR) for diagnosis of American cutane... more ABSTRACT We evaluated the use of polymerase chain reaction (PCR) for diagnosis of American cutaneous leishmaniasis (ACL) in an area in Bahia, Brazil, where Leishmania braziliensis is endemic. Leishmania DNA was detected in 50 cases, yielding a positivity rate of 100%, which was higher than the rates for all of the other diagnostic methods studied—namely, the Montenegro skin test, anti-Leishmania serological testing, and microscopic examination of lesion biopsy specimens. These findings have led us to propose guidelines for the diagnosis of ACL that use PCR as the principal means of parasitological confirmation of cases. Leishmania, a protozoan parasite, is the cause of leish-maniasis, a human disease with diverse clinical mani-festations. An estimated 12 million people are currently infected with Leishmania species, whereas another 350 million people live at risk of infection [1]. American cutaneous leishmaniasis (ACL) is characterized by a cutaneous ulcer with elevated borders and a sharp cra-ter, which, when caused by parasites of the Leishmania braziliensis complex, may spontaneously heal, dissem-inate, or metastasize to the nasopharyngeal tract. When metastasis occurs, severe disfigurement and secondary complications may also occur, with a fatal outcome [2]. Therefore, it is important to have an accurate diagnosis of infection to avoid the unnecessary use of drugs that, at this moment, still involve high costs and significant toxicity. Furthermore, it is most important to avoid the development of a long-lasting chronic disease, which

Research paper thumbnail of Survival curves for R. equi samples in 0.9% NaCl irradiated with eBeam doses ranging from 0 to 7 kGy

Research paper thumbnail of Poisoning in sheep from the ingestion of fruits of Erythroxylum argentinum

Veterinary and Human Toxicology, Sep 1, 2004

Epidemiological, clinical and pathological aspects of an unreported plant poisoning are described... more Epidemiological, clinical and pathological aspects of an unreported plant poisoning are described in sheep from southern Brazil. The disease occurred during the summer of 2003/2004 in 173 crossbred sheep with morbidity, mortality and lethality rates respectively of 31.8%, 8.1%, and 25.5%. Affected sheep were reluctant to move; when forced to walk they had stiff uncoordinated gaits, dragged their toes and bumped into objects in their path. When standing they assumed a wide base position with the legs widely spread apart. Increased respiratory rates, laborious breathing and cyanosis were marked in affected sheep that died. The experimental feeding of 2 sheep with the fruits of Eythroxylum argentinum reproduced the clinical disease. Except for consistent findings of distended bladder and the presence of E. argentinum undigested seeds in the abomasum and rumen in 4 necropsied sheep, no significant necropsy and histopathological findings were found. It was concluded that the ingestion of fruits of E. argentinum was the cause of this disease in sheep.

Research paper thumbnail of Spontaneous poisoning by Dodonea viscosa (Sapindaceae) in cattle

Veterinary and Human Toxicology, Jun 1, 2003

This communication reports a southern Brazilian outbreak of acute hepatic insufficiency in which ... more This communication reports a southern Brazilian outbreak of acute hepatic insufficiency in which 14 dairy animals died after consumption of Dodonea viscosa. The clinical course lasted a few hours and was characterized by apathy and staggering disorders. The main postmortem findings occurred in livers as enhanced lobular patterns and hepatocellular necrosis that ranged from centrilobular to massive. Similar clinical and pathological effects were experimentally induced by dosing a heifer with 30 g/kg of the plant&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s green leaves.

Research paper thumbnail of Disseminated Protothecosis Associated With Diskospondylitis in a Dog

Journal of the American Animal Hospital Association, Sep 23, 2014

A 6 yr old female Labrador retriever was evaluated for an acute onset of difficulty walking and a... more A 6 yr old female Labrador retriever was evaluated for an acute onset of difficulty walking and a head tilt. Initial physical examination revealed bilateral retinal detachment, a left-sided head tilt, positional rotary nystagmus, and lumbar hyperpathia. Pertinent preliminary diagnostic findings included systemic hypertension, bony lysis and adjacent sclerosis of the vertebral endplates of the first and second lumbar vertebrae, and positive urine and blood cultures for a yeast identified as Candida spp. Concerned about disseminated candidiasis after subsequent subretinal aspirates confirmed the presence of a yeast-like organism, therapy with voriconazole was initiated. Because of progressive clinical deterioration and the poor prognosis for recovery, the dog was eventually euthanized. Postmortem histological examination of tissues, including the affected vertebral endplates, revealed numerous intralesional algae compatible with Prototheca spp. To the authors&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; knowledge, this report is the first to document a case of protothecal diskospondylitis with possible concurrent candidiasis in a dog. Although typically associated with signs referable to the gastrointestinal tract, this report underscores the importance of not excluding protothecosis as a differential diagnosis when such signs are absent. Lastly, the use of voriconazole appears ineffective for reversing the clinical course of late-stage disseminated protothecosis.

Research paper thumbnail of Carboplatin chemotherapy in a cat with a recurrent anal sac apocrine gland adenocarcinoma

Journal of the American Animal Hospital Association

An 8-year-old, castrated male, domestic shorthaired cat was presented for evaluation of a periana... more An 8-year-old, castrated male, domestic shorthaired cat was presented for evaluation of a perianal mass. The mass was incompletely excised, and histological assessment resulted in a diagnosis of anal sac adenocarcinoma. The cat had a partial response to carboplatin therapy but a short overall duration of response. Necropsy confirmed the original diagnosis as well as metastasis to the regional lymph nodes and lungs.

Research paper thumbnail of Prevalence of discordant immunologic and virologic responses in patients with AIDS under antiretroviral therapy in a specialized care center in Brazil

Revista do Instituto de Medicina Tropical de São Paulo

Some patients under antiretroviral therapy (ART) do not reach immune recovery when the viral load... more Some patients under antiretroviral therapy (ART) do not reach immune recovery when the viral load becomes undetectable. This is called discordant immunologic and virologic responses. Its prevalence varies between 8% and 24%. This study describes its prevalence and the characteristics of the affected subjects in the outpatient clinic of a Brazilian specialized-care center. Of 934 patients on ART, 536 had undetectable viral loads. Prevalence was 51/536 or 9% (95% confidence interval: 6.6% to 11.4%). Median age at the beginning of ART was 37 years (interquartile range - IQR: 31 to 45). Male gender and mixed race predominated (76.5% and 47.1% respectively). AIDS-defining illnesses were absent at the beginning of ART in 60.8%. Fifty-one percent were taking protease inhibitors, 43.2% Efavirenz and 5.8% both. Median time on ART was 36 months (IQR: 17-81 months). Irregular treatment was recorded for 21.6%. ART had been modified for 63% prior to the study, and 15.7% had used monotherapy or d...

Research paper thumbnail of Semi-detailed Geomorphological Map of Northeastern Santa Catarina State, Brazil—the Garuva Sheet

Journal of Maps, 2009

Please click here to download the map associated with this article.Geomorphological maps can be d... more Please click here to download the map associated with this article.Geomorphological maps can be documents of restricted use due to the complexity of their content. The research project now presented proposes the geomorphological mapping of the area covered by six official topographic sheets at a scale of 1:50,000, located in the northeastern part of Santa Catarina State, southern Brazil. The

Research paper thumbnail of Disseminated protothecosis associated with diskospondylitis in a dog

Journal of the American Animal Hospital Association

A 6 yr old female Labrador retriever was evaluated for an acute onset of difficulty walking and a... more A 6 yr old female Labrador retriever was evaluated for an acute onset of difficulty walking and a head tilt. Initial physical examination revealed bilateral retinal detachment, a left-sided head tilt, positional rotary nystagmus, and lumbar hyperpathia. Pertinent preliminary diagnostic findings included systemic hypertension, bony lysis and adjacent sclerosis of the vertebral endplates of the first and second lumbar vertebrae, and positive urine and blood cultures for a yeast identified as Candida spp. Concerned about disseminated candidiasis after subsequent subretinal aspirates confirmed the presence of a yeast-like organism, therapy with voriconazole was initiated. Because of progressive clinical deterioration and the poor prognosis for recovery, the dog was eventually euthanized. Postmortem histological examination of tissues, including the affected vertebral endplates, revealed numerous intralesional algae compatible with Prototheca spp. To the authors' knowledge, this repo...

Research paper thumbnail of Factors associated with paradoxical immune response to antiretroviral therapy in HIV infected patients: a case control study

BMC Infectious Diseases, 2011

Background: A paradoxical immunologic response (PIR) to Highly Active Antiretroviral Therapy (HAA... more Background: A paradoxical immunologic response (PIR) to Highly Active Antiretroviral Therapy (HAART), defined as viral suppression without CD4 cell-count improvement, has been reported in the literature as 8 to 42%, around 15% in most instances. The present study aims to determine, in a cohort of HIV infected patients in Brazil, what factors were independently associated with such a discordant response to HAART. Methods: A case-control study (1:4) matched by gender was conducted among 934 HIV infected patients on HAART in Brazil. Cases: patients with PIR, defined as CD4 < 350 cells/mm 3 (hazard ratio for AIDS or death of at least 8.5) and undetectable HIV viral load on HAART for at least one year. Controls: similar to cases, but with CD4 counts ≥ 350 cells/mm 3 . Eligibility criteria were applied. Data were collected from medical records using a standardized form. Variables were introduced in a hierarchical logistic regression model if a p-value < 0.1 was determined in a bivariate analysis. Results: Among 934 patients, 39 cases and 160 controls were consecutively selected. Factors associated with PIR in the logistic regression model were: total time in use of HAART (OR 0.981; CI 95%: 0.96-0.99), nadir CD4-count (OR 0.985; CI 95%: 0.97-0.99), and time of undetectable HIV viral load (OR 0.969; CI 95%: 0.94-0.99). Conclusions: PIR seems to be related to a delay in the management of immunodeficient patients, as shown by its negative association with nadir CD4-count. Strategies should be implemented to avoid such a delay and improve the adherence to HAART as a way to implement concordant responses.

Research paper thumbnail of Sugar cane bagasse drying: a review

International sugar …, 2006

RefDoc Bienvenue - Welcome. Refdoc est un service / is powered by. ...

Research paper thumbnail of O quilombo de Bananal e a questão da identidade histórica

Dimensoes, Dec 20, 2008

O artigo relaciona fatores teóricos e práticos sobre a formação da identidade pessoal dos indivíd... more O artigo relaciona fatores teóricos e práticos sobre a formação da identidade pessoal dos indivíduos nascidos e criados em uma comunidade remanescente de quilombo do interior da Bahia. A partir do aporte sócio-cultural, que desenvolve o conceito de identidade sob alguns pontos de vista complementares, além dos pré-supostos históricos do senso comum que envolvem a vinda dos africanos para a América, faz-se uma descrição dos dados reais advindos de trabalho de campo numa comunidade remanescente de quilombo, a de Bananal, localizada na Chapada Diamantina, como WDPEpP GD DQiOLVH GH PDWHULDO GH IRQWH VHFXQGiULD R ¿OPH GRFXPHQWiULR Quilombos da Bahia de Antonio Olavo. O período de pesquisa foi Janeiro GH DSHQDV H HQYROYHX D SHVTXLVD ELEOLRJUi¿FD R WUDEDOKR GH FDPSR e a análise das fontes secundárias. Palavras-chave: Quilombo; Identidade Histórica; Identidade Pessoal.

Research paper thumbnail of Síndrome do pinçamento aorto-mesentérico: relato de caso

Rev Med Parana, Jun 1, 2004

Resumo: A Sínsdrome da Artéria Mesentérica Superior (SAMS), também chamada de Síndrome de Wilkie,... more Resumo: A Sínsdrome da Artéria Mesentérica Superior (SAMS), também chamada de Síndrome de Wilkie, é uma rara entidade, que tem sintomatologia caracterizada por dor epigátrica, saciedade precoce, desconforto pósprandial (fullness), náuseas, vômitos e ...

Research paper thumbnail of Evolução Das Estruturas De Membrana

The present text brings the evolution of the membrane structures along time. From the prehistory ... more The present text brings the evolution of the membrane structures along time. From the prehistory to nowadays, is shown in a brief way the use and structural aspects of the main types of awnings and hanging roofs. Special attention is dedicated to the evolutionary procexss inside the century XX.

Research paper thumbnail of RUP como Metodologia de Desenvolvimento de Software para Obtenção da Qualidade de Software

The center of interest of our discussion in ensuring the development process appropriate for obta... more The center of interest of our discussion in ensuring the development process appropriate for obtaining quality of software,, examining the method RUP (Rational Unified Process), as an alternative to other solutions that have been submitted for this area. In this paper, we present a conceptual discussion on quality, initially. We discuss the main and relevant aspects of the method RUP,

Research paper thumbnail of A Tendência De Utilização De Embalagens Retornáveis Em Industrias – Um Estudo Exploratório No Brasil

Jovens Pesquisadores Mackenzie, Mar 8, 2010

Research paper thumbnail of Processo de Construção do Plano Diretor de Recursos Hídricos: Caso da Bacia Hidrográfica do Rio Cubatão do Norte ? SC

Revista Brasileira de Recursos Hídricos, 2007

Page 1. RBRH — Revista Brasileira de Recursos Hídricos Volume 12 n.2 Abr/Jun 2007, 147-155 147 Pr... more Page 1. RBRH — Revista Brasileira de Recursos Hídricos Volume 12 n.2 Abr/Jun 2007, 147-155 147 Processo de Construção do Plano Diretor de Recursos Hídricos: Caso da Bacia Hidrográfica do Rio Cubatão do Norte — SC ...

Research paper thumbnail of Febre catarral maligna em bovinos no Rio Grande do Sul: epidemiologia, sinais cl�nicos e patologia

Research paper thumbnail of Molecular Diversity between Salivary Proteins from New World and Old World Sand Flies with Emphasis on Bichromomyia olmeca, the Sand Fly Vector of Leishmania mexicana in Mesoamerica

PLOS Neglected Tropical Diseases, 2016

Sand fly saliva has been shown to have proteins with potent biological activities, salivary prote... more Sand fly saliva has been shown to have proteins with potent biological activities, salivary proteins that can be used as biomarkers of vector exposure, and salivary proteins that are candidate vaccines against different forms of leishmaniasis. Sand fly salivary gland transcriptomic approach has contributed significantly to the identification and characterization of many of these salivary proteins from important Leishmania vectors; however, sand fly vectors in some regions of the world are still neglected, as Bichromomyia olmeca (formerly known as Lutzomyia olmeca olmeca), a proven vector of Leishmania mexicana in Mexico and Central America. Despite the importance of this vector in transmitting Leishmania parasite in Mesoamerica there is no information on the repertoire of B. olmeca salivary proteins and their relationship to salivary proteins from other sand fly species. A cDNA library of the salivary glands of wild-caught B. olmeca was constructed, sequenced, and analyzed. We identified transcripts encoding for novel salivary proteins from this sand fly species and performed a comparative analysis between B. olmeca salivary proteins and those from other sand fly species. With this new information we present an updated catalog of the salivary proteins specific to New World sand flies and salivary proteins common to all sand fly species. We also report in this work the anti-Factor Xa activity of Lofaxin, a salivary anticoagulant protein present in this sand fly species. This study provides information on the first transcriptome of a sand fly from Mesoamerica and adds information to the limited repertoire of salivary transcriptomes from the Americas. This comparative analysis also shows a fast degree of evolution in salivary proteins from New World sand flies as compared with Old World sand flies.

Research paper thumbnail of A34 リーシュマニア原虫媒介サシテョウバエPhlebotomus duboscqi唾液タンパクのトランスクリプトーム解析(一般講演,演題要旨,第58回日本衛生動物学会大会)

Research paper thumbnail of PCR Detection of Leishmania in Bahia @BULLET CID 2003:37 (1 December) @BULLET e149 Clinical Utility of Polymerase Chain Reaction–Based Detection of Leishmania in the Diagnosis of American Cutaneous Leishmaniasis

ABSTRACT We evaluated the use of polymerase chain reaction (PCR) for diagnosis of American cutane... more ABSTRACT We evaluated the use of polymerase chain reaction (PCR) for diagnosis of American cutaneous leishmaniasis (ACL) in an area in Bahia, Brazil, where Leishmania braziliensis is endemic. Leishmania DNA was detected in 50 cases, yielding a positivity rate of 100%, which was higher than the rates for all of the other diagnostic methods studied—namely, the Montenegro skin test, anti-Leishmania serological testing, and microscopic examination of lesion biopsy specimens. These findings have led us to propose guidelines for the diagnosis of ACL that use PCR as the principal means of parasitological confirmation of cases. Leishmania, a protozoan parasite, is the cause of leish-maniasis, a human disease with diverse clinical mani-festations. An estimated 12 million people are currently infected with Leishmania species, whereas another 350 million people live at risk of infection [1]. American cutaneous leishmaniasis (ACL) is characterized by a cutaneous ulcer with elevated borders and a sharp cra-ter, which, when caused by parasites of the Leishmania braziliensis complex, may spontaneously heal, dissem-inate, or metastasize to the nasopharyngeal tract. When metastasis occurs, severe disfigurement and secondary complications may also occur, with a fatal outcome [2]. Therefore, it is important to have an accurate diagnosis of infection to avoid the unnecessary use of drugs that, at this moment, still involve high costs and significant toxicity. Furthermore, it is most important to avoid the development of a long-lasting chronic disease, which

Research paper thumbnail of Survival curves for R. equi samples in 0.9% NaCl irradiated with eBeam doses ranging from 0 to 7 kGy

Research paper thumbnail of Poisoning in sheep from the ingestion of fruits of Erythroxylum argentinum

Veterinary and Human Toxicology, Sep 1, 2004

Epidemiological, clinical and pathological aspects of an unreported plant poisoning are described... more Epidemiological, clinical and pathological aspects of an unreported plant poisoning are described in sheep from southern Brazil. The disease occurred during the summer of 2003/2004 in 173 crossbred sheep with morbidity, mortality and lethality rates respectively of 31.8%, 8.1%, and 25.5%. Affected sheep were reluctant to move; when forced to walk they had stiff uncoordinated gaits, dragged their toes and bumped into objects in their path. When standing they assumed a wide base position with the legs widely spread apart. Increased respiratory rates, laborious breathing and cyanosis were marked in affected sheep that died. The experimental feeding of 2 sheep with the fruits of Eythroxylum argentinum reproduced the clinical disease. Except for consistent findings of distended bladder and the presence of E. argentinum undigested seeds in the abomasum and rumen in 4 necropsied sheep, no significant necropsy and histopathological findings were found. It was concluded that the ingestion of fruits of E. argentinum was the cause of this disease in sheep.

Research paper thumbnail of Spontaneous poisoning by Dodonea viscosa (Sapindaceae) in cattle

Veterinary and Human Toxicology, Jun 1, 2003

This communication reports a southern Brazilian outbreak of acute hepatic insufficiency in which ... more This communication reports a southern Brazilian outbreak of acute hepatic insufficiency in which 14 dairy animals died after consumption of Dodonea viscosa. The clinical course lasted a few hours and was characterized by apathy and staggering disorders. The main postmortem findings occurred in livers as enhanced lobular patterns and hepatocellular necrosis that ranged from centrilobular to massive. Similar clinical and pathological effects were experimentally induced by dosing a heifer with 30 g/kg of the plant&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s green leaves.