Raghu solanki | Indian Institute of Technology Gandhinagar (original) (raw)
Papers by Raghu solanki
Medicine in drug discovery, Jul 1, 2024
During the past two decades, significant advances have been made in the discovery and development... more During the past two decades, significant advances have been made in the discovery and development of targeted inhibitors aimed at improving the survival rates of cancer patients. Among the multitude of potential therapeutic targets identified thus far, Receptor Tyrosine Kinases (RTKs) are of particular importance. Dysregulation of RTKs has been implicated in numerous human diseases, particularly cancer, where aberrant signaling pathways contribute to disease progression. RTKs have a profound impact on intra and intercellular communication, and they also facilitate post-translational modifications, notably phosphorylation, which intricately regulates a multitude of cellular processes. Prolonged phosphorylation or the disruption of kinase regulation may lead to significant alterations in cell signaling. The emergence of small molecule kinase inhibitors has revolutionized cancer therapy by offering a targeted and strategic approach that surpasses the efficacy of traditional chemotherapeutic drugs. Over the last two decades, a plethora of targeted inhibitors have been identified or engineered and have undergone clinical evaluation to enhance the survival rates of cancer patients. In this review, we have compared the expression of different RTKs, including Met, KDR/VEGFR2, EGFR, BRAF, BCR, and ALK across different cancer types in TCGA samples. Additionally, we have summarized the recent development of small molecule inhibitors and their potential in treating various malignancies. Lastly, we have discussed the mechanisms of acquired therapeutic resistance with a focus on kinase inhibitors in EGFR mutant and ALK-rearranged non-small cell lung cancer and BCR-ABL positive chronic myeloid leukemia.
Next materials, Oct 1, 2024
Journal of the Science of Food and Agriculture/Journal of the science of food and agriculture, May 31, 2024
International journal of biological macromolecules, May 1, 2024
Plant nano biology, Apr 1, 2024
Scientific reports, Mar 14, 2024
Journal of the Science of Food and Agriculture/Journal of the science of food and agriculture, Feb 28, 2024
Scientific reports, Jan 31, 2024
International Journal of Biological Macromolecules, Jan 31, 2024
Medicine in Drug Discovery, Jan 31, 2024
Exploration of targeted anti-tumor therapy, Oct 9, 2023
International journal of biological macromolecules, Apr 1, 2024
Journal of Drug Delivery Science and Technology, Jun 1, 2023
![Research paper thumbnail of Experimental and Computational Characterisation of p-Sulfocalix[4]Arene Mediated Delivery System for Morin Hydrate](https://attachments.academia-assets.com/112159252/thumbnails/1.jpg)
](This study determines the intrusiveness of endoscopic tools within multiphase flows. A liquid-air... more This study determines the intrusiveness of endoscopic tools within multiphase flows. A liquid-air blast atomiser continuously discharges within a test section of air at atmospheric pressure, with and without a circular cylinder placed 25 diameters (D = 10 mm) downstream of the nozzle. Data was collected using Particle Image Velocimetry (PIV), drop sizing and Computational Fluid Dynamics (CFD). Numerical predictions are compared against the PIV results for wake flow characterisation. Using a non-intrusive droplet sizing technique it has been observed that the average droplet diameter increases when the circular cylinder is introduced and so does the frequency of occurrence of these large particles. Smaller particles are re-circulated, whereas the larger drops continued in the general direction of the spray cone.
Medicine in drug discovery, Jul 1, 2024
During the past two decades, significant advances have been made in the discovery and development... more During the past two decades, significant advances have been made in the discovery and development of targeted inhibitors aimed at improving the survival rates of cancer patients. Among the multitude of potential therapeutic targets identified thus far, Receptor Tyrosine Kinases (RTKs) are of particular importance. Dysregulation of RTKs has been implicated in numerous human diseases, particularly cancer, where aberrant signaling pathways contribute to disease progression. RTKs have a profound impact on intra and intercellular communication, and they also facilitate post-translational modifications, notably phosphorylation, which intricately regulates a multitude of cellular processes. Prolonged phosphorylation or the disruption of kinase regulation may lead to significant alterations in cell signaling. The emergence of small molecule kinase inhibitors has revolutionized cancer therapy by offering a targeted and strategic approach that surpasses the efficacy of traditional chemotherapeutic drugs. Over the last two decades, a plethora of targeted inhibitors have been identified or engineered and have undergone clinical evaluation to enhance the survival rates of cancer patients. In this review, we have compared the expression of different RTKs, including Met, KDR/VEGFR2, EGFR, BRAF, BCR, and ALK across different cancer types in TCGA samples. Additionally, we have summarized the recent development of small molecule inhibitors and their potential in treating various malignancies. Lastly, we have discussed the mechanisms of acquired therapeutic resistance with a focus on kinase inhibitors in EGFR mutant and ALK-rearranged non-small cell lung cancer and BCR-ABL positive chronic myeloid leukemia.
Next materials, Oct 1, 2024
Journal of the Science of Food and Agriculture/Journal of the science of food and agriculture, May 31, 2024
International journal of biological macromolecules, May 1, 2024
Plant nano biology, Apr 1, 2024
Scientific reports, Mar 14, 2024
Journal of the Science of Food and Agriculture/Journal of the science of food and agriculture, Feb 28, 2024
Scientific reports, Jan 31, 2024
International Journal of Biological Macromolecules, Jan 31, 2024
Medicine in Drug Discovery, Jan 31, 2024
Exploration of targeted anti-tumor therapy, Oct 9, 2023
International journal of biological macromolecules, Apr 1, 2024
Journal of Drug Delivery Science and Technology, Jun 1, 2023
This study determines the intrusiveness of endoscopic tools within multiphase flows. A liquid-air... more This study determines the intrusiveness of endoscopic tools within multiphase flows. A liquid-air blast atomiser continuously discharges within a test section of air at atmospheric pressure, with and without a circular cylinder placed 25 diameters (D = 10 mm) downstream of the nozzle. Data was collected using Particle Image Velocimetry (PIV), drop sizing and Computational Fluid Dynamics (CFD). Numerical predictions are compared against the PIV results for wake flow characterisation. Using a non-intrusive droplet sizing technique it has been observed that the average droplet diameter increases when the circular cylinder is introduced and so does the frequency of occurrence of these large particles. Smaller particles are re-circulated, whereas the larger drops continued in the general direction of the spray cone.