Meisam Fadaei-kenarsary | Kerman University of Medical Sciences (original) (raw)

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Papers by Meisam Fadaei-kenarsary

Research paper thumbnail of Maternal Substance Use and Early-Life Adversity: Inducing Drug Dependence in Offspring, Interactions, Mechanisms, and Treatments

Addiction and health., Feb 29, 2024

Research paper thumbnail of Chronic Maternal Morphine Exposure and Early-Life Adversity Induce Impairment in Synaptic Plasticity of Adolescent Male Rats

Research paper thumbnail of Review of: "A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications

Research paper thumbnail of Chronic maternal morphine exposure and early-life adversity induce impairment in synaptic plasticity of adolescent male rats

Neuroscience Letters, Aug 1, 2023

Research paper thumbnail of Chronic morphine exposure and maternal separation induce impairments in cognition and locomotor activity of male adolescent rats

International Journal of Developmental Neuroscience

Research paper thumbnail of Chronic Maternal Morphine Exposure and Early-Life Adversity Induce Impairment in Synaptic Plasticity of Adolescent Male Rats

Research paper thumbnail of • Effect of Venlafaxine on Depression Induced Relapse to Morphine Dependence after Chronic Methadone Administration in Rat (Poster presentation). Fadaei-kenarsary M, *Fathi Moghaddam H, Farbood Y, Mansouri SMT. 7th National Congress on Addiction Science, Tehran-Iran, 11 September 2013

Research paper thumbnail of • A Novel Depressive State after Chronic Venlafaxine Administration in Chronic Methadone Received Rats (Poster presentation). Fadaei-kenarsary M, *Farbood Y, Fathi Moghaddam H, Mansouri SMT. 2nd Basic & Clinical Neuroscience Congress, Tehran-Iran, 18-20 December 2013 (National)

Research paper thumbnail of • Multidimensional Comparison of Addiction, Cardiovascular Diseases, Cancer, Brain Stroke and Trauma: a review (Poster presentation). Soltani largani H, Gholamy F, *Fadaei-kenarsary M. 10th National Congress on Addiction Science, Tehran-Iran, 16 September 2016

Research paper thumbnail of • Effects of Methadone, Depression and Venlafaxine on Morphine Withdrawal Syndrome in Rats (Poster presentation). Fadaei kenarsary M, *Fathi Moghaddam H, Farbood Y, Mansouri SMT. 21th international congress of Iranian physiology and pharmacology, Tabriz-Iran, 26 August 2013

Research paper thumbnail of Administration of venlafaxine after chronic methadone detoxification blocks post-depression relapse in rats

Brazilian Archives of Biology and Technology, 2017

Research paper thumbnail of Effects of Venlafaxine and Methadone Alone and in Combination with Spontaneous Morphine withdrawal Syndrome and Pain Sensation in Rats

Autonomic neuroscience: basic & clinical

Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitat... more Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. On the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. Therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in drinking water, 7 days), venlafaxine (80 mg/kg/day, intraperitoneally, 7 days) and their combinations with the spontaneous morphine withdrawal syndrome and pain sensitivity. Methods: Twenty eight young male Sprague-Dawley rats were randomly divided into 4 groups: control, venlafaxine treated, methadone treated and venlafaxine + methadone treated. Morphine sulfate (10 mg/kg/day, subcutaneously, 4 days) was injected to all animals. Then primary withdrawal behaviours and tail flick test were performed. The test was then followed by methadone or its vehicle administration. Second intervention was venlafax...

Research paper thumbnail of Effects of Venlafaxine & Methadone Alone and in Combination with Spontaneous Morphine withdrawal Syndrome & Pain Sensation in Rats

Basic and Clinical Neuroscience, 2015

Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitat... more Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. On the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. Therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in drinking water, 7 days), venlafaxine (80 mg/kg/day, intraperitoneally, 7 days) and their combinations with the spontaneous morphine withdrawal syndrome and pain sensitivity. Methods: Twenty eight young male Sprague-Dawley rats were randomly divided into 4 groups: control, venlafaxine treated, methadone treated and venlafaxine + methadone treated. Morphine sulfate (10 mg/kg/day, subcutaneously, 4 days) was injected to all animals. Then primary withdrawal behaviours and tail flick test were performed. The test was then followed by methadone or its vehicle administration. Second intervention was venlafax...

Research paper thumbnail of Effects of Venlafaxine & Methadone Alone and in Combination with Spontaneous Morphine withdrawal Syndrome & Pain Sensation in Rats

Basic and clinical neuroscience, 2015

Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine wi... more Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. On the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. Therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in drinking water, 7 days), venlafaxine (80 mg/kg/day, intraperitoneally, 7 days) and their combinations with the spontaneous morphine withdrawal syndrome and pain sensitivity. Twenty eight young male Sprague-Dawley rats were randomly divided into 4 groups: control, venlafaxine treated, methadone treated and venlafaxine + methadone treated. Morphine sulfate (10 mg/kg/day, subcutaneously, 4 days) was injected to all animals. Then primary withdrawal behaviours and tail flick test were performed. The test was then followed by methadone or its vehicle administration. Second intervention was venlafaxine or its vehicle inje...

Research paper thumbnail of Administration of Venlafaxine after Methadone Detoxification Reduces Spontaneous Freezing Withdrawal Behavior in Rats: Positive Correlation with Hyperalgesia

Background and Aim Methadone has been used as a drug to detoxify opioid tolerance. Naloxane-preci... more Background and Aim
Methadone has been used as a drug to detoxify opioid tolerance.
Naloxane-precipitated morphine withdrawal behaviors were attenuated
by venlafaxine as an antidepressant. In contrary, after detoxifying
the opioids, spontaneous withdrawal syndrome may be
occurred with pain sensitivity. Therefore the present study aimed
to examine the effects of chronic methadone (70 mg/kg, in drinking
water, 7 days), venlafaxine (80 mg/kg/day, intraperitoneally,
7 days) and their sequential administrations on the spontaneous
morphine withdrawal syndrome and pain sensitivity. ...

Research paper thumbnail of Administration of venlafaxine after chronic methadone detoxification blocks post-depression relapse in rats

Relapse is highly prevalent after detoxification and depression. Due to the advantages of venlafa... more Relapse is highly prevalent after detoxification and depression. Due to the advantages of venlafaxine compared with other antidepressants, it is expected that venlafaxine administration may reduce relapse after detoxification and depression. This study aimed to evaluate the effects of venlafaxine on depression-induced relapse to morphine dependence after methadone detoxification. ...

Research paper thumbnail of Fadaei-kenarsary et al..pdf

Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitat... more Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant.
On the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. Therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in drinking water, 7 days), venlafaxine (80 mg/kg/day, intraperitoneally, 7 days) and their combinations with the spontaneous morphine withdrawal syndrome and pain sensitivity.

Research paper thumbnail of Effects of Venlafaxine & Methadone Alone and in Combination with Spontaneous Morphine withdrawal Syndrome & Pain Sensation in Rats

Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitat... more Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. On the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. Therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in drinking water, 7 days), venlafaxine (80 mg/kg/day, intraperitoneally, 7 days) and their combinations with the spontaneous morphine withdrawal syndrome and pain sensitivity. ...

Research paper thumbnail of Administration of venlafaxine after chronic methadone detoxification blocks post-depression relapse in rats

Relapse is highly prevalent after detoxification and depression. Due to the advantages of venlafa... more Relapse is highly prevalent after detoxification and depression. Due to the advantages of venlafaxine compared with other antidepressants, it is expected that venlafaxine administration may reduce relapse after detoxification and depression. This study aimed to evaluate the effects of venlafaxine on depression-induced relapse to morphine dependence after methadone detoxification. ...

Research paper thumbnail of Maternal Substance Use and Early-Life Adversity: Inducing Drug Dependence in Offspring, Interactions, Mechanisms, and Treatments

Addiction and health., Feb 29, 2024

Research paper thumbnail of Chronic Maternal Morphine Exposure and Early-Life Adversity Induce Impairment in Synaptic Plasticity of Adolescent Male Rats

Research paper thumbnail of Review of: "A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications

Research paper thumbnail of Chronic maternal morphine exposure and early-life adversity induce impairment in synaptic plasticity of adolescent male rats

Neuroscience Letters, Aug 1, 2023

Research paper thumbnail of Chronic morphine exposure and maternal separation induce impairments in cognition and locomotor activity of male adolescent rats

International Journal of Developmental Neuroscience

Research paper thumbnail of Chronic Maternal Morphine Exposure and Early-Life Adversity Induce Impairment in Synaptic Plasticity of Adolescent Male Rats

Research paper thumbnail of • Effect of Venlafaxine on Depression Induced Relapse to Morphine Dependence after Chronic Methadone Administration in Rat (Poster presentation). Fadaei-kenarsary M, *Fathi Moghaddam H, Farbood Y, Mansouri SMT. 7th National Congress on Addiction Science, Tehran-Iran, 11 September 2013

Research paper thumbnail of • A Novel Depressive State after Chronic Venlafaxine Administration in Chronic Methadone Received Rats (Poster presentation). Fadaei-kenarsary M, *Farbood Y, Fathi Moghaddam H, Mansouri SMT. 2nd Basic & Clinical Neuroscience Congress, Tehran-Iran, 18-20 December 2013 (National)

Research paper thumbnail of • Multidimensional Comparison of Addiction, Cardiovascular Diseases, Cancer, Brain Stroke and Trauma: a review (Poster presentation). Soltani largani H, Gholamy F, *Fadaei-kenarsary M. 10th National Congress on Addiction Science, Tehran-Iran, 16 September 2016

Research paper thumbnail of • Effects of Methadone, Depression and Venlafaxine on Morphine Withdrawal Syndrome in Rats (Poster presentation). Fadaei kenarsary M, *Fathi Moghaddam H, Farbood Y, Mansouri SMT. 21th international congress of Iranian physiology and pharmacology, Tabriz-Iran, 26 August 2013

Research paper thumbnail of Administration of venlafaxine after chronic methadone detoxification blocks post-depression relapse in rats

Brazilian Archives of Biology and Technology, 2017

Research paper thumbnail of Effects of Venlafaxine and Methadone Alone and in Combination with Spontaneous Morphine withdrawal Syndrome and Pain Sensation in Rats

Autonomic neuroscience: basic & clinical

Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitat... more Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. On the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. Therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in drinking water, 7 days), venlafaxine (80 mg/kg/day, intraperitoneally, 7 days) and their combinations with the spontaneous morphine withdrawal syndrome and pain sensitivity. Methods: Twenty eight young male Sprague-Dawley rats were randomly divided into 4 groups: control, venlafaxine treated, methadone treated and venlafaxine + methadone treated. Morphine sulfate (10 mg/kg/day, subcutaneously, 4 days) was injected to all animals. Then primary withdrawal behaviours and tail flick test were performed. The test was then followed by methadone or its vehicle administration. Second intervention was venlafax...

Research paper thumbnail of Effects of Venlafaxine & Methadone Alone and in Combination with Spontaneous Morphine withdrawal Syndrome & Pain Sensation in Rats

Basic and Clinical Neuroscience, 2015

Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitat... more Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. On the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. Therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in drinking water, 7 days), venlafaxine (80 mg/kg/day, intraperitoneally, 7 days) and their combinations with the spontaneous morphine withdrawal syndrome and pain sensitivity. Methods: Twenty eight young male Sprague-Dawley rats were randomly divided into 4 groups: control, venlafaxine treated, methadone treated and venlafaxine + methadone treated. Morphine sulfate (10 mg/kg/day, subcutaneously, 4 days) was injected to all animals. Then primary withdrawal behaviours and tail flick test were performed. The test was then followed by methadone or its vehicle administration. Second intervention was venlafax...

Research paper thumbnail of Effects of Venlafaxine & Methadone Alone and in Combination with Spontaneous Morphine withdrawal Syndrome & Pain Sensation in Rats

Basic and clinical neuroscience, 2015

Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine wi... more Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. On the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. Therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in drinking water, 7 days), venlafaxine (80 mg/kg/day, intraperitoneally, 7 days) and their combinations with the spontaneous morphine withdrawal syndrome and pain sensitivity. Twenty eight young male Sprague-Dawley rats were randomly divided into 4 groups: control, venlafaxine treated, methadone treated and venlafaxine + methadone treated. Morphine sulfate (10 mg/kg/day, subcutaneously, 4 days) was injected to all animals. Then primary withdrawal behaviours and tail flick test were performed. The test was then followed by methadone or its vehicle administration. Second intervention was venlafaxine or its vehicle inje...

Research paper thumbnail of Administration of Venlafaxine after Methadone Detoxification Reduces Spontaneous Freezing Withdrawal Behavior in Rats: Positive Correlation with Hyperalgesia

Background and Aim Methadone has been used as a drug to detoxify opioid tolerance. Naloxane-preci... more Background and Aim
Methadone has been used as a drug to detoxify opioid tolerance.
Naloxane-precipitated morphine withdrawal behaviors were attenuated
by venlafaxine as an antidepressant. In contrary, after detoxifying
the opioids, spontaneous withdrawal syndrome may be
occurred with pain sensitivity. Therefore the present study aimed
to examine the effects of chronic methadone (70 mg/kg, in drinking
water, 7 days), venlafaxine (80 mg/kg/day, intraperitoneally,
7 days) and their sequential administrations on the spontaneous
morphine withdrawal syndrome and pain sensitivity. ...

Research paper thumbnail of Administration of venlafaxine after chronic methadone detoxification blocks post-depression relapse in rats

Relapse is highly prevalent after detoxification and depression. Due to the advantages of venlafa... more Relapse is highly prevalent after detoxification and depression. Due to the advantages of venlafaxine compared with other antidepressants, it is expected that venlafaxine administration may reduce relapse after detoxification and depression. This study aimed to evaluate the effects of venlafaxine on depression-induced relapse to morphine dependence after methadone detoxification. ...

Research paper thumbnail of Fadaei-kenarsary et al..pdf

Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitat... more Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant.
On the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. Therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in drinking water, 7 days), venlafaxine (80 mg/kg/day, intraperitoneally, 7 days) and their combinations with the spontaneous morphine withdrawal syndrome and pain sensitivity.

Research paper thumbnail of Effects of Venlafaxine & Methadone Alone and in Combination with Spontaneous Morphine withdrawal Syndrome & Pain Sensation in Rats

Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitat... more Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. On the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. Therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in drinking water, 7 days), venlafaxine (80 mg/kg/day, intraperitoneally, 7 days) and their combinations with the spontaneous morphine withdrawal syndrome and pain sensitivity. ...

Research paper thumbnail of Administration of venlafaxine after chronic methadone detoxification blocks post-depression relapse in rats

Relapse is highly prevalent after detoxification and depression. Due to the advantages of venlafa... more Relapse is highly prevalent after detoxification and depression. Due to the advantages of venlafaxine compared with other antidepressants, it is expected that venlafaxine administration may reduce relapse after detoxification and depression. This study aimed to evaluate the effects of venlafaxine on depression-induced relapse to morphine dependence after methadone detoxification. ...