Sodaif Darvish-Moghadam | Kerman University of Medical Sciences (original) (raw)

Papers by Sodaif Darvish-Moghadam

Background: The results reported on the prevalence of colorectal cancer are very disturbing. This... more Background: The results reported on the prevalence of colorectal cancer are very disturbing. This study aimed to address the polyps’ detection rate and their prevalence. In addition, we analyzed some related variables among the patients referred to Afzalipour and Mehregan Hospitals of Kerman in 2015-2016. Methods: Data concerning colonoscopy and pathologic samples of patients aged over 40 years who referred for colonoscopy were collected and analyzed. The polyps’ detection rate and some related variables were assessed. Results: A total of 469 patients older than 40 who underwent colonoscopy were enrolled in this study. One hundred and two cases of polyps were found in which 45.3% of them had adenoma. The bowel preparation (0.03), higher age (0.007) and male gender (0.013) had significant relationship with the detection of polyps. Conclusion: The detection of the polyp / adenoma in this study is comparable with the results of the research carried out in other parts of the world with ...

Background: Improving life is the main goal of therapeutic interventions for chronic diseases. al... more Background: Improving life is the main goal of therapeutic interventions for chronic diseases. although we needed to determine quality of life by various variables. This study aimed to determine quality of life in patients with Irritable Bowel Syndrome (IBS) in Kerman. Materials and Methods: This is a cross sectional study of 143 patients with IBS referred to a specialist, assessed by IBS-QOL.34. Data analyzed by descriptive statistics, Pearson correlation coefficients, t-test and ANOVA, using SPSS software. p.Value <0.05 was considered as statistically significant. Results: In this study from 143 samples, 82 were females (57.3%) and 61 males (42.7%). Quality of life score in patients was 37.16 ± 16.72, and there was significant difference in terms of employment and education level (p.value< 0.05). Conclusion: Among patients with IBS, quality of life is far from desired. Therefore, health care providers should consider psychosocial support alongside medical management for achi...

Background: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are two accessibl... more Background: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are two accessible indices for liver evaluation. Upper limit of normal (ULN) of these tests are important for starting further investigations for persons with high values. In recent years, cut off points for ULN of these tests have been disputed. This study aimed to determine the ULN of ALT and AST in a population-based study. Methods: This cross-sectional study was performed on a randomized clustered sample of people of Kerman city. Demographic, anthropometric, and laboratory data were collected and analyzed. After excluding the recognized risk factors for liver function tests in another group (group 2), data were analyzed in this subgroup. Results:Of 2748 subjects included in this study, 1172 (42.4%) were men, with an age range of 15-85 years. The mean (± SE), median, mode, and 95th percentile were 23.74 ± 0.18, 22, 19, and 37 for AST and 22.37 ± 0.27, 18, 15, and 46 for ALT, respectively. The levels o...

Background: Single nucleotide polymorphisms (SNPs) have been introduced as a new genomic source f... more Background: Single nucleotide polymorphisms (SNPs) have been introduced as a new genomic source for cancer. Therefore, it was decided to conduct a study to evaluate the rs3746444 polymorphism of miR-499 in patients with colon cancer in comparison with healthy subjects. Methods: This case-control study was conducted to investigate rs3746444 polymorphism of miR-499 in blood samples of case and control groups. Patients with a confirmed diagnosis of cancer based on pathologic report were enrolled in the study as the case group and compared with healthy subjects. The level of significance was considered at p< 0.05. Result: The mean of DNA count in samples was 63.17± 23.51 that was significantly higher in the case group. The rs3746444 polymorphism of miR-499 was significantly higher in patients with cancer compared to the healthy subjects (P < 0.05). Conclusion: In this study, rs3746444 polymorphism of miR-499 was significantly higher in patients with colon cancer, which indicated t...

Journal of Molecular Structure, 2019

Recent findings interpret that misfolding, aggregation and accumulation of proteins consequence i... more Recent findings interpret that misfolding, aggregation and accumulation of proteins consequence in some disease. Evidence from different practices intensely support this hypothesis and demonstrate that a common therapy for these pernicious disorders might be possible. However, H syndrome is related to the recessive mutations in SLC29A3, encoding the equilibrative nucleoside transporter Equilibrative nucleoside transporter 3 (hENT3) which is expressed in mitochondria. The aim of this study is to investigate the misfolding and aggregation of ENT3 protein regarding in H syndrome, which can be a potential target for therapeutic interference in this disorder. Therefore, the 3D structure of the ENT3 protein was assumed using the I-TASSER online server and the best-predicted structure with the maximum confidence score (C-Score) was selected. The reliability and quality of the structure were evaluated by Z-score. However, the structural model of the selected mutant was accomplished using the I-TASSER server. The comparison with the corresponding of non-mutated structure and structural difference between mutant and wild-type structures was demonstrated by PyMOL. In the present study, computational models combined with experimental approaches provide new insights into the ENT3 which could lead to expanding new classes of nucleobase analogs for treatment and quintessential therapeutic strategies for H syndrome and some other diseases like cancer and viral infection.

Middle East Journal of Digestive Diseases, 2017

BACKGROUND Many studies have reported an association between periodontal infections and some syst... more BACKGROUND Many studies have reported an association between periodontal infections and some systemic diseases such as respiratory and cardiovascular diseases. Some studies found a direct association between chronic gastritis caused by Helicobacter pylori (HP) infection and poor periodontal health. METHODS In a cross-sectional study from November 2014 to December 2015 in Kerman, the largest province in southeast Iran, patients with dyspepsia who were candidate for diagnostic upper gastrointestinal (GI) endoscopy were included in our study. Decayed, Missing, and Filled Teeth (DMFT) index and Loe plaque index that are two popular indexes in dental epidemiology were used to assess the oral health by a dentist before the upper GI endoscopy. According to the Loe plaque index, score: 0= no plaque, score: 1= a film of plaque attaching to the free gingival border and near area of the tooth, score: 2= moderate reposition of deposits within the gingival pocket, score :3= plenty of soft matter within the gingival pocket±on the tooth and gingival border. Scores ≤1, 2 and 3 equal to good, moderate, and poor oral hygiene, respectively. During upper GI endoscopy a total of six biopsy samples were taken from fundus, body, and antrum. A pathologist reported these samples according to Sidney's classification into superficial gastritis, atrophic gastritis, intestinal metaplasia, and dysplasia. RESULTS According to Sidney's classification 77 (89.5%) patients had superficial gastritis, 3 (3.5%) had atrophic gastritis, and 6 (7%) had intestinal metaplasia. HP was found in 80.2% of the gastric mucosal biopsy samples. There were not statistically significant relationship between Sidney's classification, presence of HP in gastric mucosal biopsies, and hygiene indicators (p>0.05). No relation was found between the DMFT index and superficial gastritis, atrophic gastritis, and intestinal metaplasia (p>0.05). Gastric infection with HP was found in 70%, 75%, and 100% of patients with mild, moderate, and sever DMFT index, respectively. CONCLUSION Our study showed that there might be a relation between poor oral hygiene and gastric precancerous lesions. In addition, HP infection in gastric histopathology might be associated with periodontal disease.

Archives of Iranian medicine, 2007

Los Angeles classification is widely adopted for reporting endoscopic gastroesophageal reflux dis... more Los Angeles classification is widely adopted for reporting endoscopic gastroesophageal reflux disease. We assessed the inter- and intra-observer variability of the Los Angeles classification. Still images (n = 254) of the lower esophagus were presented to 9 gastroenterologists (6 experts and 3 trainees) and they were asked to report the images according to the Los Angeles classification. After 2 weeks the images were reordered and they were asked to report them again. Kappa statistic was calculated for intra- and inter-observer variability. The kappa for intra-observer agreement was 0.54 (attendings: 0.54; trainees; 0.55; P = not significant) and the inter-observer agreement was 0.22 (attendings: 0.20; trainees: 0.31; P = 0.027). The inter- and intra-observer kappa values in differentiating nonerosive from erosive cases were 0.22 (attendings: 0.21; trainees: 0.31, P = not significant) and 0.57 (attendings: 0.58; trainees: 0.55, P = not significant), respectively. According to our da...

International Journal of Green Pharmacy, 2011

Helicobacter pylori infection is virtually always associated with duodenal, peptic and gastric ul... more Helicobacter pylori infection is virtually always associated with duodenal, peptic and gastric ulcers and promotion of gastrointestinal cancer. Some of medicinal plants traditionally have been used for gastrointestinal problems. In the present work, the inhibitory effect of the essential oils of some medicinal plants was evaluated against clinical isolate of H. pylori. H. pylori was isolated from gastric biopsy of patients with gastric complications. Agar diffusion and agar dilution methods were used for evaluating the anti-H. pylori effect and minimum inhibitory concentration (MIC) determination of tested plants. The results were reported as mean±SD and differences considered significant at a P value <0.05. The essential oils of Cinnamomum zeylanicum and Zataria multiflora demonstrated potent anti-H. pylori effect with inhibition zone diameter of 24.8 mm and 23.6 mm, respectively. The MIC of both two essential oils was estimated to be 0.3 µl/ml. The essential oils of Heracleum persicum, Syzygium aromaticum and Citrus aurantium exhibited more than 88% inhibition in concentration of 0.3 µl/ml. The essential oils of C. zeylanicum and Z. multiflora might be good candidate for treatment of gastrointestinal disorders caused by H. pylori and it is needed to do further study about these essential oils.

ABSTRACT Background &amp; Objective: Evaluating research indicators amongst clinical and ... more ABSTRACT Background &amp; Objective: Evaluating research indicators amongst clinical and basic science faculty members reveals that such indicators are lower in clinical faculty members. Hence, we decided to assess the effect of providing education-research services, by founding a clinical research development center, on the research performance of clinical faculty members of Kerman University of Medical Sciences. Methods: In this intervention field study, 66 faculty members of Afzalipour teaching hospital and 45 ones in Shafa teaching hospital were recruited as cases and controls respectively. After founding the research center in cases’ work place, education-research services were provided for two years. The research activities of cases and controls were compared two years before and two years after founding the center. Results: 39 and 33 percent increase were observed in the cases’ total and per capita number of published articles respectively; similar indicators showed 21% and 21.6% decrease in the controls accordingly. The differences between two groups regarding both indicators were significant (P&lt;0.01). Indicator of tutoring in dissertations and the total number and per capita number of presenting abstracts in the congresses showed a higher increase among cases. An increase in the total number and per capita number of accepted research proposals was 76% and 68% in cases and 120% and 122% in controls, respectively. Conclusion: Founding a clinical research center and providing education-research services in clinical faculty members’ workplace has positively influenced their performance and promoted their research indicators. Hence, establishing similar centers in other teaching hospitals is recommended.

American Journal of Applied Sciences, 2009

Problem statement: Helicobacter pylori (H. pylori) is a microaerophilic, gram negative bacillus, ... more Problem statement: Helicobacter pylori (H. pylori) is a microaerophilic, gram negative bacillus, which can cause peptic ulcer and gastric cancer. Recurrent infection with this agent is considered as one of the reasons for failure of peptic ulcer treatment. Some studies have reported colonization of H. pylori in dental plaques, tonsils and adenoid tissues. Therefore oral cavity could be the source of H. pylori and it might be the reason for unsuccessful eradication. Approach: In this cross sectional study, 95 patients with the average age of 12.1±7.5 years undergoing adenotonsillectomy were chosen consecutively. Intra-operatively a 2 mm section of the tonsils were removed and investigated for H. pylori by Rapid Urease Test (RUT). Post-operatively the removed tonsils were stained by hematoxylin-eosin (H and E) and Gimsa for direct investigation of H. pylori bacterium. Serum samples of the patients were also tested for the presence of H. pylori IgG antibody. Results: Overall 70 patients (73.7%) had positive anti-H. pylori IgG antibody in their sera. The results of RUT on adeno-tonsils showed that 42.1% of the specimens were positive for H. pylori. In histology examination, 9 patients (9.5%) were positive for the presence of bacterium. Conclusion: Based on our findings it seems that tonsils and adenoid tissues are the candidate places for the growth of H. pylori. Further studies about the role of tonsillar colonization of H. pylori in re-infection after treatment are recommended.

ACTA MEDICA IRANICA, 2020

Regarding the importance of non-alcoholic fatty liver disease (NAFLD) and the high prevalence of ... more Regarding the importance of non-alcoholic fatty liver disease (NAFLD) and the high prevalence of vitamin D3 deficiency in different societies. This study aimed to evaluate the distribution of Vit D3 deficiency in individuals with non-alcoholic fatty liver disease. In this cross-sectional study, 122 individuals with nonalcoholic fatty liver disease were selected by a simple sampling method. After collecting demographic data, serum Vit 25(OH) D3 level was measured by the ELFA method. Blood lipids level (TG, cholesterol, HDL, LDL), FBS, AST, ALT, alkaline phosphatase, total and direct bilirubin, albumin, and PT were measured by the enzymatic method. To analyze the data, descriptive and analytical methods and SPSS software version 16 were used. The study cases are comprised of 122 individuals (57.4% male). The average age of cases was 42.4±11.7 years, and the mean of serum Vit D3 level was 19.8±22 ng/dl (3-220 ng/dl). Regarding the serum 25(OH) D3 levels data showed 66.4% of cases were ...

Govaresh, May 19, 2014

Background: Chronic constipation is a common problem worldwide that negatively impacts quality of... more Background: Chronic constipation is a common problem worldwide that negatively impacts quality of life. Because of the effects of psychological and cultural factors on the function of the bowel tract and the vast variety of ethnicities and diet among the Iranian people, the present study describes the occurrence of constipation and its associated factors in Kerman, the largest city in Southeast Iran. Materials and Methods: This was a cross-sectional study conducted in Kerman, Iran from 2011 to 2012 that included 2191 adults who were randomly selected and interviewed face to face using a validated questionnaire based on Rome III criteria. Demographics, cigarette smoking, opium dependence, amount of fiber consumption, physical activity and psychological factors were assessed. Inclusion criteria was ages 15 to 85 years old. Exclusion criteria was the presence of any metabolic and/ or neuro-muscular disease that caused constipation. All data were analyzed with Stata11 software, with a confidence interval of 95%. A p-value of ≤0.05 was chosen for statistical significance. Results: Particiants had a mean age of 44.9 ± 16.2 years. There were 57.42% female participants. The prevalance of chronic constipation was estimated at 9.4% (7.7%-10.6%). Constipation was more prevalent in females, older individuals, those with decreased physical activity, people who were anxious and depressed, and opium addicted individuals (p<0.05). There was no significant difference in terms of cigarette smoking and amount of dietary fiber between constipated and non-constipated individuals (p>0.2). Conclusion: Although the prevalance of constipation in Iran is estimated to be lower than Western countries, new changes in life style can cause an increase in the burden of constipation in the future.

Middle East Journal of Digestive Diseases, Jan 12, 2014

Middle East Journal of Digestive Diseases, Oct 1, 2013

Blue Rubber Bleb Nevus Syndrome is a rare disorder that is characterized by multiple recurrent va... more Blue Rubber Bleb Nevus Syndrome is a rare disorder that is characterized by multiple recurrent vascular malformations of skin and gastrointestinal tract. The affected patients may present with diverse manifestations including iron deficiency anemia.

Iranian Journal of Medical Sciences

Background: Clarithromycin resistance in Helicbacter pylori has been found to be associated with ... more Background: Clarithromycin resistance in Helicbacter pylori has been found to be associated with point mutations in 23s rRNA gene leads to reduced affinity of the antibiotic to its ribosomal target or changing the site of methylation. The aim of this study was to determine the most important point mutations in 23s rRNA gene in H. pylori that are closely related to clarithromycin resistance among such isolates. Methods: Sixty three H. pylori isolates, obtained from gastric biopsy speciemens in Kerman, Iran, were used to evaluate their susceptibility to clarithromycin by disk diffusion test, and to detect the most common point mutations in 23s rRNA gene associated with clarithromycin resistance by Polymerase chain reaction-amplification and restriction fragment length polymorphism (PCR-RFLP) and 3'-mismatch PCR. Results: 31.7% of the H. pylori isolates were resistant to clarithromycin, and each of the resistant isolate had at least one of the most common point mutations in 23s rRN...

Middle East journal of digestive diseases, 2014

BACKGROUND The incidence of inflammatory bowel disease (IBD) varies among different societies. Th... more BACKGROUND The incidence of inflammatory bowel disease (IBD) varies among different societies. The aim of this study is to determine the incidence rate of IBD in Kerman, a city in Southeast Iran. METHODS All medical records that indicated a new diagnosis of ulcerative colitis (UC) or Crohn's disease (CD) were retrieved from the gastrointestinal endoscopy and pathology departments of 12 centers from October 2011 to September 2012. RESULTS The incidence rate of UC in Kerman was estimated at 4.98/100,000 (95% CI: 2.44-6.94). The mean age of patients was 39.4 years and male to female ratio was 0.89:1.0. UC patients had the following prevalence: cigarette smoking (30%), appendectomy (36%) and oral contraceptive (OCP) use (78.9%). The incidence rate of CD was 0.8/100,000 (95% CI: 0.6 4-1.14). The mean age at diagnosis was 33.3 years and male to female ratio was 0.5:1.0. Cigarette smoking was reported in 33.3%, appendectomy in 66.6% and OCP useing in 75% of CD patients. Rectal and dist...

Middle East journal of digestive diseases, 2013

Blue Rubber Bleb Nevus Syndrome is a rare disorder that is characterizedby multiple recurrent vas... more Blue Rubber Bleb Nevus Syndrome is a rare disorder that is characterizedby multiple recurrent vascular malformations of skin and gastrointestinal tract.The affected patients may present with diverse manifestations including irondeficiency anemia. We report this syndrome in a 22-year-old man that was referred to our hospitalfor iron deficiency anemia with unknown cause and vascular malformationsin the skin and gastrointestinal tract. Because of stable hemoglobin level,we decided to treatment him by iron supplementation and close follow up. Wereport this case along with a review of literature.

Iranian journal of medical sciences, 2011

Clarithromycin resistance in Helicbacter pylori has been found to be associated with point mutati... more Clarithromycin resistance in Helicbacter pylori has been found to be associated with point mutations in 23s rRNA gene leads to reduced affinity of the antibiotic to its ribosomal target or changing the site of methylation. The aim of this study was to determine the most important point mutations in 23s rRNA gene in H. pylori that are closely related to clarithromycin resistance among such isolates. Sixty three H. pylori isolates, obtained from gastric biopsy speciemens in Kerman, Iran, were used to evaluate their susceptibility to clarithromycin by disk diffusion test, and to detect the most common point mutations in 23s rRNA gene associated with clarithromycin resistance by Polymerase chain reaction-amplification and restriction fragment length polymorphism (PCR-RFLP) and 3'-mismatch PCR. 31.7% of the H. pylori isolates were resistant to clarithromycin, and each of the resistant isolate had at least one of the most common point mutations in 23s rRNA gene associated with calrith...

Middle East journal of digestive diseases, 2015

BACKGROUND Small intestinal bacterial overgrowth (SIBO) may have a role in the pathophysiology of... more BACKGROUND Small intestinal bacterial overgrowth (SIBO) may have a role in the pathophysiology of irritable bowel syndrome (IBS). So, the aim of this study was to assess the association between SIBO and IBS by using glucose breath test (GBT) in Kerman city as the first study in Iranian population. METHODS 107 patients with IBS and 107 healthy individuals were enrolled in our study. All the participants underwent GBT. A peak of H2 values >20 p.p.m above the basal value after glucose ingestion was considered suggestive of SIBO. SPSS software version 17 was used for data analysis. P value < 0.05 was considered as statistically significant. RESULTS Of the 107 patients with IBS, 40 had positive GBT (37.4%) compared with 14 (12.1%) out of the 107 control participants(p< 0.001). Dominant symptoms in patients with IBS were diarrhea in 36(33.6%), constipation in 12(11.2%), abdominal pain in 22(20.6%), bloating in 28(26.2%), and change in bowel habit in 9(8.4%) patients. There was no...