Jia Li | Imperial College London (original) (raw)
Papers by Jia Li
Nature Communications, 2015
PLOS Neglected Tropical Diseases, 2008
BackgroundMetabolic profiling holds promise with regard to deepening our understanding of infecti... more BackgroundMetabolic profiling holds promise with regard to deepening our understanding of infection biology and disease states. The objectives of our study were to assess the global metabolic responses to an Echinostoma caproni infection in the mouse, and to compare the biomarkers extracted from different biofluids (plasma, stool, and urine) in terms of characterizing acute and chronic stages of this intestinal
The Biology of Echinostomes, 2008
... E. Holmes Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Bi... more ... E. Holmes Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK J. Utzinger Department of ...
Frontiers in microbiology, 2011
Bariatric surgery, also known as metabolic surgery, is an effective treatment for morbid obesity,... more Bariatric surgery, also known as metabolic surgery, is an effective treatment for morbid obesity, which also offers pronounced metabolic effects including the resolution of type 2 diabetes and a decrease in cardiovascular disease and long-term cancer risk. However, the mechanisms of surgical weight loss and the long-term consequences of bariatric surgery remain unclear. Bariatric surgery has been demonstrated to alter the composition of both the microbiome and the metabolic phenotype. We observed a marked shift toward Gammaproteobacteria, particularly Enterobacter hormaechei, following Roux-en-Y gastric bypass (RYGB) surgery in a rat model compared with sham-operated controls. Fecal water from RYGB surgery rats was highly cytotoxic to rodent cells (mouse lymphoma cell line). In contrast, fecal water from sham-operated animals showed no/very low cytotoxicity. This shift in the gross structure of the microbiome correlated with greatly increased cytotoxicity. Urinary phenylacetylglycin...
Advances in parasitology, 2010
Metabonomics, which is the combination of metabolic profiling of biological samples using spectro... more Metabonomics, which is the combination of metabolic profiling of biological samples using spectroscopic methods, together with multivariate data analysis, is a powerful approach for biomarker recovery. Moreover, metabonomics holds promise to enhance our understanding of host-parasite interactions at the metabolic level, and therefore provides a framework for discovery of novel targets for diagnostics, drugs and vaccines. In this review, we summarise progress made to date with metabolic profiling strategies applied to different host-parasite models in the laboratory. First, we emphasise the application of two parasitic worm infections that are particularly relevant for Southeast Asia and the People's Republic of China, namely the trematode Schistosoma japonicum causing schistosomiasis, and the nematode Necator americanus causing hookworm disease. Next, we review metabolic profiling studies on the liver fluke Fasciola hepatica in the rat model, the intestinal fluke Echinostoma cap...
Proceedings of the National Academy of Sciences, 2008
PLoS Neglected Tropical Diseases, 2008
Parasites & Vectors, 2011
Molecular Systems Biology, 2010
Molecular Systems Biology, 2011
Journal of Proteome Research, 2008
Journal of Proteome Research, 2010
Journal of Proteome Research, 2009
Journal of Proteome Research, 2008
Journal of Chromatography B, 2014
The objectives of this pilot study were to predict early postoperative recurrence in hepatocellul... more The objectives of this pilot study were to predict early postoperative recurrence in hepatocellular carcinoma (HCC) patients based on metabolic features and to explore the related metabolic disturbances. Liquid chromatography-mass spectrometry-based metabolic profiling was performed on the plasma of 18 late recurrent and 22 early recurrent HCC patients. Metabolic differences were found to be related to amino acid, bile acid, cholesterol, fatty acid, phospholipid and carbohydrate metabolism. Bile acids, steroids and fatty acids showed significant variation in the early recurrent HCC group compared to the late recurrence group. Decreased levels of polyunsaturated eicosapentaenoic acid, docosahexaenoic acid and linolenic acid were found to be specific metabolic features for early recurrence. With the combination of methionine, GCDCA and cholesterol sulfate, 85% of the early recurrent HCCs can be predicted correctly with the corresponding area under the curve (AUC) equal to 0.95 in the training set, and 80% of the early recurrent HCCs can be predicted correctly with the corresponding AUC equal to 0.91 in the test set.
International Journal for Parasitology, 2009
Nature Communications, 2015
PLOS Neglected Tropical Diseases, 2008
BackgroundMetabolic profiling holds promise with regard to deepening our understanding of infecti... more BackgroundMetabolic profiling holds promise with regard to deepening our understanding of infection biology and disease states. The objectives of our study were to assess the global metabolic responses to an Echinostoma caproni infection in the mouse, and to compare the biomarkers extracted from different biofluids (plasma, stool, and urine) in terms of characterizing acute and chronic stages of this intestinal
The Biology of Echinostomes, 2008
... E. Holmes Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Bi... more ... E. Holmes Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK J. Utzinger Department of ...
Frontiers in microbiology, 2011
Bariatric surgery, also known as metabolic surgery, is an effective treatment for morbid obesity,... more Bariatric surgery, also known as metabolic surgery, is an effective treatment for morbid obesity, which also offers pronounced metabolic effects including the resolution of type 2 diabetes and a decrease in cardiovascular disease and long-term cancer risk. However, the mechanisms of surgical weight loss and the long-term consequences of bariatric surgery remain unclear. Bariatric surgery has been demonstrated to alter the composition of both the microbiome and the metabolic phenotype. We observed a marked shift toward Gammaproteobacteria, particularly Enterobacter hormaechei, following Roux-en-Y gastric bypass (RYGB) surgery in a rat model compared with sham-operated controls. Fecal water from RYGB surgery rats was highly cytotoxic to rodent cells (mouse lymphoma cell line). In contrast, fecal water from sham-operated animals showed no/very low cytotoxicity. This shift in the gross structure of the microbiome correlated with greatly increased cytotoxicity. Urinary phenylacetylglycin...
Advances in parasitology, 2010
Metabonomics, which is the combination of metabolic profiling of biological samples using spectro... more Metabonomics, which is the combination of metabolic profiling of biological samples using spectroscopic methods, together with multivariate data analysis, is a powerful approach for biomarker recovery. Moreover, metabonomics holds promise to enhance our understanding of host-parasite interactions at the metabolic level, and therefore provides a framework for discovery of novel targets for diagnostics, drugs and vaccines. In this review, we summarise progress made to date with metabolic profiling strategies applied to different host-parasite models in the laboratory. First, we emphasise the application of two parasitic worm infections that are particularly relevant for Southeast Asia and the People's Republic of China, namely the trematode Schistosoma japonicum causing schistosomiasis, and the nematode Necator americanus causing hookworm disease. Next, we review metabolic profiling studies on the liver fluke Fasciola hepatica in the rat model, the intestinal fluke Echinostoma cap...
Proceedings of the National Academy of Sciences, 2008
PLoS Neglected Tropical Diseases, 2008
Parasites & Vectors, 2011
Molecular Systems Biology, 2010
Molecular Systems Biology, 2011
Journal of Proteome Research, 2008
Journal of Proteome Research, 2010
Journal of Proteome Research, 2009
Journal of Proteome Research, 2008
Journal of Chromatography B, 2014
The objectives of this pilot study were to predict early postoperative recurrence in hepatocellul... more The objectives of this pilot study were to predict early postoperative recurrence in hepatocellular carcinoma (HCC) patients based on metabolic features and to explore the related metabolic disturbances. Liquid chromatography-mass spectrometry-based metabolic profiling was performed on the plasma of 18 late recurrent and 22 early recurrent HCC patients. Metabolic differences were found to be related to amino acid, bile acid, cholesterol, fatty acid, phospholipid and carbohydrate metabolism. Bile acids, steroids and fatty acids showed significant variation in the early recurrent HCC group compared to the late recurrence group. Decreased levels of polyunsaturated eicosapentaenoic acid, docosahexaenoic acid and linolenic acid were found to be specific metabolic features for early recurrence. With the combination of methionine, GCDCA and cholesterol sulfate, 85% of the early recurrent HCCs can be predicted correctly with the corresponding area under the curve (AUC) equal to 0.95 in the training set, and 80% of the early recurrent HCCs can be predicted correctly with the corresponding AUC equal to 0.91 in the test set.
International Journal for Parasitology, 2009