Álvaro Sebastián - Academia.edu (original) (raw)
Papers by Álvaro Sebastián
Educación, Formación e Investigación., Dec 31, 2020
Chapter 6 of the book "Bioinformática con Ñ" a project aiming to provide specialized ed... more Chapter 6 of the book "Bioinformática con Ñ" a project aiming to provide specialized educational bibliography on Bioinformatics for Spanish speakers. The result consists on more than 500 pages where the following matters are covered: biomedical databases, sequence analysis, phylogeny and evolution, structural biology, including diverse topics such as docking, virtual screening or molecular dynamics, statistics and R, systems biology, programming skills, data mining, parallel computation, bibliography management and science article writing.
Second Chapter of the book "Bioinformática con Ñ" a project aiming to provide specializ... more Second Chapter of the book "Bioinformática con Ñ" a project aiming to provide specialized educational bibliography on Bioinformatics for Spanish speakers. The result consists on more than 500 pages where the following matters are covered: biomedical databases, sequence analysis, phylogeny and evolution, structural biology, including diverse topics such as docking, virtual screening or molecular dynamics, statistics and R, systems biology, programming skills, data mining, parallel computation, bibliography management and science article writing.
Index for the book "Bioinformática con Ñ" a project aiming to provide specialized educa... more Index for the book "Bioinformática con Ñ" a project aiming to provide specialized educational bibliography on Bioinformatics for Spanish speakers. The result consists on more than 500 pages where the following matters are covered: biomedical databases, sequence analysis, phylogeny and evolution, structural biology, including diverse topics such as docking, virtual screening or molecular dynamics, statistics and R, systems biology, programming skills, data mining, parallel computation, bibliography management and science article writing.
Según Bowles y Gintis la mayoría de los alumnos aprende a mirar cuando se les dice y a refrenar s... more Según Bowles y Gintis la mayoría de los alumnos aprende a mirar cuando se les dice y a refrenar sus fantasías durante la lección. Además esta destreza en el sometimiento a la
El complejo arqueologico de Ingapirca se ubica en la parroquia del mismo nombre, en el canton Can... more El complejo arqueologico de Ingapirca se ubica en la parroquia del mismo nombre, en el canton Canar, en el ano 2000 fue declarada capital arqueologica y cultural del Ecuador, por lo cual es necesario que cuente con un Documental y una Guia Informativa; con la finalidad de promocionar este complejo, principalmente entre los jovenes de 12 a 18 anos de edad de la localidad, para concienciarlos sobre la importancia y trascendencia historica. El programa Adobe Premiere, Adobe Audition con sus distintas opciones, permitio realizar el Documental y editar las distintas tomas del complejo, consiguiendo un resultado positivo y eficaz. Con la ayuda del programa Adobe illustardor y Photoshop se logro realizar la maquetacion y edicion de fotografias tomadas del complejo arqueologico Ingapirca y obtener como consecuencia, un Documental y una Guia Informativa. El Proyecto realizado cuenta con videos, imagenes, informacion y audio en el que se puede observar facilmente tomando decisiones propias. L...
Se realizo la implementacion de un modulo de servo posicionamiento con controladores de motores, ... more Se realizo la implementacion de un modulo de servo posicionamiento con controladores de motores, PLC y HMI, se empezo por la seleccion de los diferentes equipos y materiales, el diseno de la estructura del modulo y finalmente el montaje y conexion de los diferentes equipos, para verificar el funcionamiento de los dispositivos, se realizaron varios instrumentos virtuales que conFiguran y utilizan las caracteristicas de la tarjeta MyRIO mediante el envio y recepcion de senales digitales y senales PWM para controlar ya sea angulo de giro o velocidad de avance en los diferentes motores, ademas se utilizo un encoder para la retroalimentacion del valor de velocidad del motor brushless, el control de posicion del servomotor y del motor de pasos, asi como el control de velocidad del motor brushless se integraron con elementos de control en un Touch panel, que se enlazan a un PLC y al computador utilizando OPC de National Instruments, y funcionan conjuntamente con la tarjeta de procesamiento...
Tabla 16: Volumen Fase Metanogénica (segunda aproximación). FASE METANOGÉNICA Producción Anual po... more Tabla 16: Volumen Fase Metanogénica (segunda aproximación). FASE METANOGÉNICA Producción Anual por Ha 45 ton/ha/año Producción de CH4 384 m 3 /ton Cantidad Ha 200 Ha Producción Diaria 24.657.534 gr/día Producción Diaria CH4 9.468 m 3 /día Producción Biogás 18.937 m 3 /día Producción kcal 84.540.117 kcal/día Producción kWh 98.257 kWh/día Fuente: Elaboración Propia. Volumen Total: 986 m 3 Finalmente, considerando factores de diseño y construcción (como por ejemplo largos comerciales de ciertos materiales como barras de acero, etc.), los volúmenes finales a considerar para el diseño son:
Meta Gene, 2021
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Lecture Notes in Computer Science, 2012
The recently published 3D-footprint database contains an up-to-date repository of protein-DNA com... more The recently published 3D-footprint database contains an up-to-date repository of protein-DNA complexes of known structure that belong to different superfamilies and bind to DNA with distinct specificities. This repository can be scanned by means of sequence alignments in order to look for similar DNA-binding proteins, which might in turn recognize similar DNA motifs. Here we take the complete set of Homeobox proteins from Drosophila melanogaster and their preferred DNA motifs, which would fall in the largest 3D-footprint superfamily and were recently characterized by Noyes and collaborators, and annotate their interface residues. We then analyze the observed amino acid substitutions at equivalent interface positions and their effect on recognition. Finally we estimate to what extent interface similarity, computed over the set of residues which mediate DNA recognition, outperforms BLAST expectation values when deciding whether two aligned Homeobox proteins might bind to the same DNA motif.
Revue internationale des sciences sociales, 2007
Distribution électronique Cairn.info pour Érès. © Érès. Tous droits réservés pour tous pays. La r... more Distribution électronique Cairn.info pour Érès. © Érès. Tous droits réservés pour tous pays. La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que dans les limites des conditions générales d'utilisation du site ou, le cas échéant, des conditions générales de la licence souscrite par votre établissement. Toute autre reproduction ou représentation, en tout ou partie, sous quelque forme et de quelque manière que ce soit, est interdite sauf accord préalable et écrit de l'éditeur, en dehors des cas prévus par la législation en vigueur en France. Il est précisé que son stockage dans une base de données est également interdit.
International Social Science Journal, 2008
The reflections in this text summarise 7 years (1997-2004) of participatory research focused on u... more The reflections in this text summarise 7 years (1997-2004) of participatory research focused on urban and environmental transformation and gender relationships, carried out in the Dominican Republic, Argentina and Cuba. The reflections we provide here are part of a long drawn-out and continuous process of research and social action orientated to explore alternatives for confronting poverty and its disastrous consequences on the daily lives of men and women living in deprived neighbourhoods and on the city outskirts, and its interrelationship with public and private life. Our focus was always on knowing and reflecting on the possibilities of modifying, in the process of transforming livelihoods, discriminatory attitudes towards women, focusing in particular on their empowerment processes, if any. Our studies were in tune with the controversial, changing and dynamic Latin American reality, to which we try to respond in a similar way. They were part of an international research network sponsored by the MOST programme of UNESCO and dedicated to promoting interdisciplinary studies of transformations of urban environments and the social relationships between men and women, highlighting the empowerment experiences of women in peripheral countries. Besides our research teams, collectives in Africa, eastern Europe and Brazil also took part in the research network.
Bioinformatics, 2013
Motivation: Traditional and high-throughput techniques for determining transcription factor (TF) ... more Motivation: Traditional and high-throughput techniques for determining transcription factor (TF) binding specificities are generating large volumes of data of uneven quality, which are scattered across individual databases. Results: FootprintDB integrates some of the most comprehensive freely available libraries of curated DNA binding sites and systematically annotates the binding interfaces of the corresponding TFs. The first release contains 2422 unique TF sequences, 10 112 DNA binding sites and 3662 DNA motifs. A survey of the included data sources, organisms and TF families was performed together with proprietary database TRANSFAC, finding that footprintDB has a similar coverage of multicellular organisms, while also containing bacterial regulatory data. A search engine has been designed that drives the prediction of DNA motifs for input TFs, or conversely of TF sequences that might recognize input regulatory sequences, by comparison with database entries. Such predictions can also be extended to a single proteome chosen by the user, and results are ranked in terms of interface similarity. Benchmark experiments with bacterial, plant and human data were performed to measure the predictive power of footprintDB searches, which were able to correctly recover 10, 55 and 90% of the tested sequences, respectively. Correctly predicted TFs had a higher interface similarity than the average, confirming its diagnostic value.
Educación, Formación e Investigación., Dec 31, 2020
Chapter 6 of the book "Bioinformática con Ñ" a project aiming to provide specialized ed... more Chapter 6 of the book "Bioinformática con Ñ" a project aiming to provide specialized educational bibliography on Bioinformatics for Spanish speakers. The result consists on more than 500 pages where the following matters are covered: biomedical databases, sequence analysis, phylogeny and evolution, structural biology, including diverse topics such as docking, virtual screening or molecular dynamics, statistics and R, systems biology, programming skills, data mining, parallel computation, bibliography management and science article writing.
Second Chapter of the book "Bioinformática con Ñ" a project aiming to provide specializ... more Second Chapter of the book "Bioinformática con Ñ" a project aiming to provide specialized educational bibliography on Bioinformatics for Spanish speakers. The result consists on more than 500 pages where the following matters are covered: biomedical databases, sequence analysis, phylogeny and evolution, structural biology, including diverse topics such as docking, virtual screening or molecular dynamics, statistics and R, systems biology, programming skills, data mining, parallel computation, bibliography management and science article writing.
Index for the book "Bioinformática con Ñ" a project aiming to provide specialized educa... more Index for the book "Bioinformática con Ñ" a project aiming to provide specialized educational bibliography on Bioinformatics for Spanish speakers. The result consists on more than 500 pages where the following matters are covered: biomedical databases, sequence analysis, phylogeny and evolution, structural biology, including diverse topics such as docking, virtual screening or molecular dynamics, statistics and R, systems biology, programming skills, data mining, parallel computation, bibliography management and science article writing.
Según Bowles y Gintis la mayoría de los alumnos aprende a mirar cuando se les dice y a refrenar s... more Según Bowles y Gintis la mayoría de los alumnos aprende a mirar cuando se les dice y a refrenar sus fantasías durante la lección. Además esta destreza en el sometimiento a la
El complejo arqueologico de Ingapirca se ubica en la parroquia del mismo nombre, en el canton Can... more El complejo arqueologico de Ingapirca se ubica en la parroquia del mismo nombre, en el canton Canar, en el ano 2000 fue declarada capital arqueologica y cultural del Ecuador, por lo cual es necesario que cuente con un Documental y una Guia Informativa; con la finalidad de promocionar este complejo, principalmente entre los jovenes de 12 a 18 anos de edad de la localidad, para concienciarlos sobre la importancia y trascendencia historica. El programa Adobe Premiere, Adobe Audition con sus distintas opciones, permitio realizar el Documental y editar las distintas tomas del complejo, consiguiendo un resultado positivo y eficaz. Con la ayuda del programa Adobe illustardor y Photoshop se logro realizar la maquetacion y edicion de fotografias tomadas del complejo arqueologico Ingapirca y obtener como consecuencia, un Documental y una Guia Informativa. El Proyecto realizado cuenta con videos, imagenes, informacion y audio en el que se puede observar facilmente tomando decisiones propias. L...
Se realizo la implementacion de un modulo de servo posicionamiento con controladores de motores, ... more Se realizo la implementacion de un modulo de servo posicionamiento con controladores de motores, PLC y HMI, se empezo por la seleccion de los diferentes equipos y materiales, el diseno de la estructura del modulo y finalmente el montaje y conexion de los diferentes equipos, para verificar el funcionamiento de los dispositivos, se realizaron varios instrumentos virtuales que conFiguran y utilizan las caracteristicas de la tarjeta MyRIO mediante el envio y recepcion de senales digitales y senales PWM para controlar ya sea angulo de giro o velocidad de avance en los diferentes motores, ademas se utilizo un encoder para la retroalimentacion del valor de velocidad del motor brushless, el control de posicion del servomotor y del motor de pasos, asi como el control de velocidad del motor brushless se integraron con elementos de control en un Touch panel, que se enlazan a un PLC y al computador utilizando OPC de National Instruments, y funcionan conjuntamente con la tarjeta de procesamiento...
Tabla 16: Volumen Fase Metanogénica (segunda aproximación). FASE METANOGÉNICA Producción Anual po... more Tabla 16: Volumen Fase Metanogénica (segunda aproximación). FASE METANOGÉNICA Producción Anual por Ha 45 ton/ha/año Producción de CH4 384 m 3 /ton Cantidad Ha 200 Ha Producción Diaria 24.657.534 gr/día Producción Diaria CH4 9.468 m 3 /día Producción Biogás 18.937 m 3 /día Producción kcal 84.540.117 kcal/día Producción kWh 98.257 kWh/día Fuente: Elaboración Propia. Volumen Total: 986 m 3 Finalmente, considerando factores de diseño y construcción (como por ejemplo largos comerciales de ciertos materiales como barras de acero, etc.), los volúmenes finales a considerar para el diseño son:
Meta Gene, 2021
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Lecture Notes in Computer Science, 2012
The recently published 3D-footprint database contains an up-to-date repository of protein-DNA com... more The recently published 3D-footprint database contains an up-to-date repository of protein-DNA complexes of known structure that belong to different superfamilies and bind to DNA with distinct specificities. This repository can be scanned by means of sequence alignments in order to look for similar DNA-binding proteins, which might in turn recognize similar DNA motifs. Here we take the complete set of Homeobox proteins from Drosophila melanogaster and their preferred DNA motifs, which would fall in the largest 3D-footprint superfamily and were recently characterized by Noyes and collaborators, and annotate their interface residues. We then analyze the observed amino acid substitutions at equivalent interface positions and their effect on recognition. Finally we estimate to what extent interface similarity, computed over the set of residues which mediate DNA recognition, outperforms BLAST expectation values when deciding whether two aligned Homeobox proteins might bind to the same DNA motif.
Revue internationale des sciences sociales, 2007
Distribution électronique Cairn.info pour Érès. © Érès. Tous droits réservés pour tous pays. La r... more Distribution électronique Cairn.info pour Érès. © Érès. Tous droits réservés pour tous pays. La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que dans les limites des conditions générales d'utilisation du site ou, le cas échéant, des conditions générales de la licence souscrite par votre établissement. Toute autre reproduction ou représentation, en tout ou partie, sous quelque forme et de quelque manière que ce soit, est interdite sauf accord préalable et écrit de l'éditeur, en dehors des cas prévus par la législation en vigueur en France. Il est précisé que son stockage dans une base de données est également interdit.
International Social Science Journal, 2008
The reflections in this text summarise 7 years (1997-2004) of participatory research focused on u... more The reflections in this text summarise 7 years (1997-2004) of participatory research focused on urban and environmental transformation and gender relationships, carried out in the Dominican Republic, Argentina and Cuba. The reflections we provide here are part of a long drawn-out and continuous process of research and social action orientated to explore alternatives for confronting poverty and its disastrous consequences on the daily lives of men and women living in deprived neighbourhoods and on the city outskirts, and its interrelationship with public and private life. Our focus was always on knowing and reflecting on the possibilities of modifying, in the process of transforming livelihoods, discriminatory attitudes towards women, focusing in particular on their empowerment processes, if any. Our studies were in tune with the controversial, changing and dynamic Latin American reality, to which we try to respond in a similar way. They were part of an international research network sponsored by the MOST programme of UNESCO and dedicated to promoting interdisciplinary studies of transformations of urban environments and the social relationships between men and women, highlighting the empowerment experiences of women in peripheral countries. Besides our research teams, collectives in Africa, eastern Europe and Brazil also took part in the research network.
Bioinformatics, 2013
Motivation: Traditional and high-throughput techniques for determining transcription factor (TF) ... more Motivation: Traditional and high-throughput techniques for determining transcription factor (TF) binding specificities are generating large volumes of data of uneven quality, which are scattered across individual databases. Results: FootprintDB integrates some of the most comprehensive freely available libraries of curated DNA binding sites and systematically annotates the binding interfaces of the corresponding TFs. The first release contains 2422 unique TF sequences, 10 112 DNA binding sites and 3662 DNA motifs. A survey of the included data sources, organisms and TF families was performed together with proprietary database TRANSFAC, finding that footprintDB has a similar coverage of multicellular organisms, while also containing bacterial regulatory data. A search engine has been designed that drives the prediction of DNA motifs for input TFs, or conversely of TF sequences that might recognize input regulatory sequences, by comparison with database entries. Such predictions can also be extended to a single proteome chosen by the user, and results are ranked in terms of interface similarity. Benchmark experiments with bacterial, plant and human data were performed to measure the predictive power of footprintDB searches, which were able to correctly recover 10, 55 and 90% of the tested sequences, respectively. Correctly predicted TFs had a higher interface similarity than the average, confirming its diagnostic value.