Mehmet Özçelik - Profile on Academia.edu (original) (raw)

Papers by Mehmet Özçelik

Atlas Universitesi Tip ve Saglik Bilimleri Dergisi, Oct 15, 2022

Jejunal divertikülozis tanısı zor konabilen, yüksek morbidite ve mortaliteye neden olabilen nadir... more Jejunal divertikülozis tanısı zor konabilen, yüksek morbidite ve mortaliteye neden olabilen nadir lezyonlardır. Genellikle asemptomatiktir, ancak bazen ishal, kronik karın ağrısı, şişkinlik, akut divertikülit, kanama, bağırsak tıkanıklığı ve delinme ile kendini gösterir. Bu yazıda jejunumda divertikül perforasyonu sonucu akut karın gelişen ve opere edilen bir hasta sunuldu. Acil servise ani başlayan karın ağrısı, ateş ve çarpıntı şikayetleri ile başvuran 67 yaşında kadın hastanın fizik muayenesinde yaygın karın hassasiyeti, defans ve rebound mevcuttu. Kan testlerinde WBC 15.480/ml, CRP 36 mg/l idi. Batın BT' de karında barsak ansları arasında serbest hava kesecikleri, jejunumda divertikül, diffüz kolon divertikülü, peritoneal kontaminasyon izlendi. İki ameliyat yaptık.Önce diagnostik laparaoskopi ile teşhis konarak konservatif tedavi yapıldı. Fakat iki hafta sonra karın içi apse oluştu.Tanısal laparatomi yaptık ve divertikülozisli jejunal ansı rezeke ettik. Hasta postoperatif 7. gün taburcu edildi.

Journal of Personalized Medicine

ERAS is a protocol consisting of multidisciplinary approaches, including patient education, fluid... more ERAS is a protocol consisting of multidisciplinary approaches, including patient education, fluid resuscitation, keeping patients’ innormothermic state, early feeding, and mobilization. We aimed to present and compare the postoperative results of patients operated on due to locally advanced gastric cancer who received neoadjuvant therapy in two high-volume tertiary centers, and aimed to present that ERAS protocols can be applied with success without increasing the complication rate. This retrospective study consisted of two groups: a non-ERAS group and an ERAS group. The ERAS group consisted of 106 patients and the non-ERAS group consisted of 104 patients. The time to first flatus was shorter in the ERAS group compared with the non-ERAS group: 2.8 (1–5) and 3.5 (1–5, p = 0.008), respectively. The average stay at the hospital was 9 (7–22) days in thenon-ERAS group and 6.5 (5–14) days in the ERAS group. Readmission to the hospital within first 15 days after discharge was observed in o...

The role of lactulose in the prevention of bacterial translocation in surgical trauma

Acta chirurgica Belgica, 1996

Surgical trauma (ST) is one of the causative factor of bacterial translocation. In this study we ... more Surgical trauma (ST) is one of the causative factor of bacterial translocation. In this study we investigated the prevention of bacterial translocation with lactulose in a surgical trauma model. The study was designed in 3 experimental groups consisting of 15 rats in each. Group 1 was sham operated controls, group 2 was ST + physiologic saline treated and group 3 was ST + lactulose treated animals. Lactulose and physiologic saline were given by oro-gastric intubation in a dose of 2 ml of 33.5% solution/d and 2 ml/d respectively starting 3 days prior to surgery. Bacterial translocation was investigated 48 hours after the operations. In sham operated controls only 1 bacterial translocation to the mesenteric lymph nodes (MLN) was observed. In the ST + physiologic saline treated group bacterial translocation to the MLN and portal venous blood (PVB) were significantly increased compared with both sham operated controls and the ST + lactulose treated group (p < 0.001). In rats with lac...

Clinicopathological features and management of colonic lipomas

Medicine, Mar 11, 2022

Abstract Introduction: Colonic lipomas are benign tumors of adipose tissue that are often asympto... more Abstract Introduction: Colonic lipomas are benign tumors of adipose tissue that are often asymptomatic, but they may present with rectal bleeding or obstructive symptoms. These tumors are unique in that they are rarely encountered within the gastrointestinal system and can mimic malignant tumors in appearance. Surgical resection and endoscopic removal of tumors have been shown to be successful in their management. Patient concerns: In this report, we present 3 cases of colonic lipomas, 2 of which are located in the cecum and the other within the sigmoid colon. The presenting symptoms of the patients included abdominal pain, constipation, and dyspepsia. Diagnosis: Patients typically presented with anemia and an elevated C-reactive protein count. Colonoscopic and computerized tomography findings were used for diagnosis. Interventions: Hemicolectomy was performed, depending on the localization, and the pathologic specimens were consistent with lipoma. Outcomes: Surgical resection was curative in all patients. The postoperative period was uneventful in all patients and all patients are symptom-free and alive at 3 years follow-up. Conclusion: Colonic lipomas are benign mesenchymal tumors of the gastrointestinal system with a male predominance and are observed within the fourth to sixth decades of life. Various genetic abnormalities have been reported and they have been linked to the formation of intussusception. The squeeze sign on radiological imaging, cushion sign and tenting sign in colonoscopy, and naked fat sign during pathologic examination is helpful towards reaching a diagnosis. Surgical resection is the treatment of choice but minimally invasive endoscopic approaches have also been shown to be successful.

Systemic Inflammatory Biomarkers as Surrogate Markers for Stage in Colon Cancer

American Surgeon, Feb 17, 2021

Background This study aimed to investigate whether the systemic inflammatory parameters currently... more Background This study aimed to investigate whether the systemic inflammatory parameters currently in use in staging the disease can be used as biomarker tests operated colon cancer patients. Neutrophil, lymphocyte, monocyte, platelet, neutrophil/lymphocyte ratio (NLR), lymphocyte/monocyte ratio (LMR), platelet/lymphocyte ratio (PLR), neutrophil/monocyte ratio (NMR), CRP, albumin, lymphocyte/CRP ratio, CRP/albumin ratio, and neutrophil/albumin ratio as systemic inflammatory biomarkers and prognostic nutritional index (PNI) were evaluated. Methods This retrospective study included 592 patients. Patients with colon cancer in the cohort were divided into 2 subgroups: Tumor, nodes, metastases (TNM) stage 0, TNM stage 1, and TNM stage 2; early stage (n: 332) and TNM stage 3 and TNM stage 4; late stage (n: 260) colon cancer patients. Results LDH ( P < .001), NLR ( P < .001), PLR ( P < .05), CRP/albumin ( P < .01), and neutrophil/albumin ( P < .01) were significantly higher, while monocyte count ( P < .05) and PNI ( P < .01) were found to be significantly lower in late stage colon cancer patients than in early stage colon cancer patients. Moderate negative correlation was found between the PNI and the neutrophil/albumin ratio in late stage colon cancer patients (r: −.568, P < .001). Conclusions Our data suggest that high serum LDH, NLR, PLR, CRP/albumin, and neutrophil/albumin may be useful predictive markers for advanced stage in colon cancer. According to the receiver operating characteristic analysis results, CRP/albumin ratio can be used to discriminate early from late stage. Preoperative low monocyte count and PNI are associated with postoperative staging patients with colon cancer.

Evaluating Portal Vein and Right Colon Venous Vascular Anatomy and Its Variations via Multidetector CT in Healthy Individuals

Indian Journal of Surgery

European review for medical and pharmacological sciences, 2013

BACKGROUND Preoperative radiotherapy in colorectal cancers is being used as an adjuvant therapy w... more BACKGROUND Preoperative radiotherapy in colorectal cancers is being used as an adjuvant therapy with increasing frequency. Postoperative complications in early and late periods in various ratios are reported. It has also been shown that radiation has a delaying effect on wound healing and this effect is dose-dependent. AIM This study investigated the effects of the Amifostine on healing of the irradiated colonic anastomosis. MATERIALS AND METHODS 30 female Wistar rats were divided randomly into three groups equally (n=10). Colonic anastomosis were performed to all rats. Group I served as a control. 800 rad abdominopelvic irradiation on the 5th day of preoperation was given to group II and III. Rats in the group III, prior to radiation, were given Amifostine at a dose of 200 mg/kg. On the 5th postoperative day all the rats were sacrificed and the healing of anastomosis was measured with bursting pressure, hydroxyproline levels and histopathological evaluations. Statistical analyses w...

Analysis of Outcomes of Laparoscopic Techniques for Inguinal Hernia Repair: A Cerrahpasa Experience

PubMed, May 1, 2013

Background: Preoperative radiotherapy in colorectal cancers is being used as an adjuvant therapy ... more Background: Preoperative radiotherapy in colorectal cancers is being used as an adjuvant therapy with increasing frequency. Postoperative complications in early and late periods in various ratios are reported. It has also been shown that radiation has a delaying effect on wound healing and this effect is dose-dependent. Aim: This study investigated the effects of the Amifostine on healing of the irradiated colonic anastomosis. Materials and methods: 30 female Wistar rats were divided randomly into three groups equally (n=10). Colonic anastomosis were performed to all rats. Group I served as a control. 800 rad abdominopelvic irradiation on the 5th day of preoperation was given to group II and III. Rats in the group III, prior to radiation, were given Amifostine at a dose of 200 mg/kg. On the 5th postoperative day all the rats were sacrificed and the healing of anastomosis was measured with bursting pressure, hydroxyproline levels and histopathological evaluations. Statistical analyses were expressed by analysis of variance (ANOVA) test and p < 0.05 was regarded as significant. Results: In group II, all parameters were found lower compared with control group and Amifostine+Radiation group. As compared with hydroxyproline values and the anastomotic wound healing scores, except group II, no significantly difference were determined between the two other groups. In bursting pressure levels, Group I and III were higher than group II, but not statistically significant (p > 0.05). In group III (Amifostine+Radiation group), the hydroxyproline levels and anastomotic wound healing scores were found significantly higher than group II (p < 0.05), and no significant difference were found between the control group. Conclusions: It is determined that radiation given on the 5th preoperative day has a negative effect on anastomotic wound healing and administered Amifostine prevent this negative effect. In the light of these data, the Amifostine may have a positive effect on preoperative irradiated colonic anastomosis and may play an important role in future on the supporting of the colonic anastomosis.

Turkish Journal of Trauma and Emergency Surgery, 2020

BACKGROUND: Inadequate intestinal perfusion resulting from hemorrhagic shock negatively affects w... more BACKGROUND: Inadequate intestinal perfusion resulting from hemorrhagic shock negatively affects wound healing. In this experimental study, we aimed to evaluate the effects of resuscitation with hypertonic saline on colonic anastomosis in rats with controlled hemorrhagic shock. A total of 24 male Wistar albino rats weighing between 200 and 250 g were used in this study. The rats were divided into four groups as: Control, hypotonic, isotonic, and hypertonic. Median laparotomy, colon resection, and colocolonic anastomosis were performed to the rats in the control group. After creating controlled hemorrhagic shock to rats in other three groups, resuscitation was achieved with hypotonic, isotonic, and hypertonic saline. After resuscitation, median laparotomy, colon resection, and colocolonic anastomosis were performed on rats in these three groups. On the 5 th post-operative day, a median laparotomy was applied to the rats in all groups and anastomosis lines were evaluated. Anastomotic bursting pressure, tissue hydroxyproline level, and tissue fibrosis degree were compared between the groups. There was no statistically significant difference between the groups in terms of anastomotic bursting pressure, tissue hydroxyproline level, and tissue fibrosis degree (respectively; p=0.320, p=0.537, p>0.05). In rats with controlled hemorrhagic shock, resuscitation with hypertonic saline does not differ significantly from isotonic or hypotonic saline in terms of healing of colonic anastomosis.

Transhiatal esophagectomy for esophageal carcinoma in turkey: With special reference to respiratory function

Surgery Today, 1993

Esophagectomy without opening the thoracic cavity--transhiatal esophagectomy--(THE) were performe... more Esophagectomy without opening the thoracic cavity--transhiatal esophagectomy--(THE) were performed in 47 patients with malignant tumors localized at various levels of the esophagus. Pulmonary function studies were performed in all patients and they are categorized as low, moderate, or high risk for probable postoperative pulmonary complications according to the risk category system. Nine of these patients were classified as high risk, seven as moderate risk, and the rest as low risk. In all patients but four, reconstruction was accomplished by using their stomachs as a substitute. In the remaining patient, intestinal continuity was established by a left and right colonic interposition. Three patients were lost in the early postoperative period. Two patients categorized as low risk died from pulmonary thromboembolism and cardiac failure, respectively. One patient categorized in the high risk group died of coronary thrombosis. Postoperative complications included transient hoarseness due to recurrent laryngeal nerve paresis in one patient, right pleural effusion in one patient, pneumothorax in two patients, and thrombophlebitis in one patient. In the high risk patient group, there were no pulmonary complications. This clinical study demonstrated the protective effect of THE in patients with serious pulmonary problems.

American Journal of Surgery, Feb 1, 2004

Background: To assess the effects of halofuginone, a specific inhibitor of synthesis of collagen ... more Background: To assess the effects of halofuginone, a specific inhibitor of synthesis of collagen type 1, which is the major constituent of fibrosis, on esophageal stricture formation due to caustic ingestion. Methods: Sixty rats were divided into four equal groups: control group; sham laparotomy group; caustic injury without treatment group; caustic injury with halofuginone treatment group. Caustic injuries were done by 50% sodium hydroxide. Halofuginone was administered by the first postoperative day. All animals were sacrificed on day 21; and the results were evaluated by hydroxyproline levels, stenosis index, lumen diameter, histopathological evaluation, wall thickness, and animal weights. Results: Mortality differences were significant comparing group 3 with group 1 and 2 (P ϭ 0.006) and group 4 (P ϭ 0.03). According to hydroxyproline levels, the differences are significantly higher (P Ͻ0.001) comparing group 3 with group 1, 2, and 4. The P value was considered significant in all other parameters (P Ͻ0.001) for all the groups but group 1 versus group 2 (P Ͼ0.05). Conclusions: Halofuginone, a specific inhibitor of collagen type 1 synthesis, significantly reduced esophageal stricture occurrence.

Turkish Journal of Trauma and Emergency Surgery

To evaluate AP severity, many different methods developed such as Ranson criteria, Acute Physiolo... more To evaluate AP severity, many different methods developed such as Ranson criteria, Acute Physiology and Chronic Health Evaluation 2 (APACHE 2) classification system, and various scoring systems such as the Balthazar score system were developed. At the time of patient admission, the effects of many

Turkish Journal of Colorectal Disease

Aim: Coronavirus disease-2019 (COVID-19) appeared in Wuhan, China in December 2019 and the World ... more Aim: Coronavirus disease-2019 (COVID-19) appeared in Wuhan, China in December 2019 and the World Health Organization declared it a pandemic the following March. Colorectal cancer (CRC) is the third most common cause of cancer-related deaths worldwide, but the impact of the global pandemic on health services has severely affected the delivery of health care, including the diagnosis and treatment of CRC. The aim of this study was to investigate the effect of the COVID-19 pandemic on the clinical and pathological stages of CRC patients at the time of operation. Method: Our study evaluated CRC patients who underwent surgery in a 6-month (May-October 2020) period during the COVID-19 pandemic and patients operated due to CRC in the same period of 2019, before the pandemic. Data collected included time of admission, complaints at admission, cancer stage and clinical characteristics, length of hospital stay, and complication and mortality rates. Results: The study included 47 patients operated during the pandemic and 83 patients operated in the corresponding period, one year earlier. The number of cancerous lymph nodes, rates of lymphovascular and perineural invasion, and complication and mortality rates were significantly higher in patients operated during the pandemic, while the pathological stage and the rate of receiving adjuvant treatment were higher. Conclusion: During the COVID-19 pandemic CRC patients presented with delayed diagnosis or more advanced cancer, leading to a significant increase in morbidity and mortality. Adjustment of health care provision during crises, such as the COVID-19 pandemic, should be planned to minimize the impact on emergency, cancer and infectious disease services.

Transhiyatal özofajektomi sırasında trakeal rüptür (olgu sunumu)

Dehydrated Human Dura Mater Patch Repair for Closure of Duodenal Defects

Turkish Journal of Medical Sciences, 1996

Konuralp Tıp Dergisi, 2021

Objective: To investigate the emergency department admissions, the general surgery consultation r... more Objective: To investigate the emergency department admissions, the general surgery consultation request, and the necessity of immediate treatment of patients despite the fact that the society did not leave the house unless necessary during the pandemic period. Methods: The files of patients who admitted to the emergency department and whose general surgery consultation was requested due to urgent surgical treatment were retrospectively scanned between March-May 2020, which is the Covid 19 pandemic period and March-May 2019, as a time period in which normal social life continues. Age, gender, complaints, comorbid diseases, the necessity of truly emergency surgical treatment as well as the socioeconomic level scale for each individual were recorded and analyzed. Results: The rate of request for consultation was 2.7% (n = 170) in the pandemic period, and 3.1% (n = 316) in the non-pandemic period. In both periods, no statistically significant difference was found in the distribution of ...

Namık Kemal Tıp Dergisi, 2021

Aim: Esophageal cancer is a fatal disease where the majority of patients are diagnosed at an adva... more Aim: Esophageal cancer is a fatal disease where the majority of patients are diagnosed at an advanced stage. In this study, we aimed to present the demographic and clinicopathological characteristics of patients who were operated for esophageal cancer. Materials and Methods: A total of 847 patients who underwent surgery, chemoradiotherapy, or palliative procedures for esophageal pathology between the years of 1985 and 2018 were retrospectively analyzed. Age, gender, tumor location, histopathology, surgical technique, and chemoradiotherapy history of patients were analyzed. Results: In the study, 488 patients were male (60.5%) and 319 were female (39.5%). The ratio of males and females was 1.52. The average age was 58.6 years, and 80.1% were older than 50 years. The most common pathological material obtained was squamous cell carcinoma (67.5%), followed by adenocarcinoma (27.7%). Total esophagectomy was performed in 435 patients; distal esophagectomy was performed in 38 patients. Tra...

Modern surgical procedure for familial polyposis and colitis ulcerosa patients total colectomy rectal mucosectomy and ileal pouch anal anastomosis

Annals of Medical Research, 2021

Jejunal diverticulosis is rare condition that commonly seen in elderly patient. The majority of c... more Jejunal diverticulosis is rare condition that commonly seen in elderly patient. The majority of cases are asymptomatic; however nonspecific abdominal symptoms like abdominal pain, nausea and diarrhea can be seen. Diverticulum perforation leads to generalized or localized peritonitis which may lead to emergency surgical intervention. Diagnosis of Jejunal diverticulosis is often difficult and it is commonly diagnosed incidentally by screening for other purposes. Jejunal diverticulosis is false diverticulum and is believed that Jejunal diverticulosis arises from herniation of the intestinal mucosa and submucosa without a muscle layer. In this report an 88-year-old male patient was admitted to the emergency department with abdominal pain. In abdominal computed tomography (CT) free gas and fluid were observed in the perihepatic area and between the jejunal loops. The patient was taken to emergency operation. During exploration, multiple diverticules were noted in the jejunum. Microperforation area was seen in one of the diverticula. Approximately 50 cm of jejunal segment with diverticulum was resected. The patient was discharged on the sixth day without any remarkable complications.