Özgül Altıntaş - Academia.edu (original) (raw)

Papers by Özgül Altıntaş

European Journal of Ophthalmology, 2005

PurposeTo determine a way to prevent the formation of adhesions and delay the time of suture adju... more PurposeTo determine a way to prevent the formation of adhesions and delay the time of suture adjustment in the course of adjustable strabismus surgery, an animal study was performed to assess and compare the effects of mitomycin C (Mit-C) and viscoelastic material Viscoat (sodium hyaluronate 3% and chondroitin sulphate 4%, Alcon, Fort Worth, TX).MethodsRight eyes of 47 rabbits were divided into three groups. After recession of the superior rectus muscle (SRM), Mit-C was administered beneath and over the SRM in Group M (16 eyes), Viscoat was administered beneath and over SRM in Group V (16 eyes), and ringer lactate was administered in Group C (15 eyes). SRM then recessed 5 mm with adjustable strabismus surgery technique. Animals in each group were subdivided into 1 and 2, where 1 = adjustment 1 week postoperatively and 2 = adjustment 3 weeks postoperatively. Delayed adjustment was performed in M1group (6 eyes), V1group (6 eyes), and C1group (7 eyes) after 1 week; in M2group (6 eyes),...

European Journal of Ophthalmology, 2006

Turkiye Klinikleri Journal of Dermatology, 2000

Türk Oftalmoloji Dergisi, 2015

This paper was introduced on the eleventh meeting of International Strabismological Association a... more This paper was introduced on the eleventh meeting of International Strabismological Association as a poster. In recent years, functional endoscopic sinus surgery (FESS) has improved the treatment of sinus disorders. However, various orbital complications have been reported, including optic nerve damage, orbital hemorrhage, infection, lacrimal drainage system injury, and strabismus. Complications are rare but may cause severe morbidity. We describe two patients who underwent endoscopic sinus surgery showed spontaneous resolution in a month. The other patient had an orbital medial wall defect with medial rectus injury and he underwent orbitotomy. Medial rectus innervation returned at postoperative 8 months. Several extraocular muscles may be traumatized during FESS. Timing and method of treatment are based on the severity and type of injury and the number of muscles involved. Treatment strategies are dependent on accurate interpretation of magnetic resonance imaging scans.

Turkish Journal of Trauma and Emergency Surgery, 2011

Open globe injury in northwest Turkey varied with age and gender. Education and safety precaution... more Open globe injury in northwest Turkey varied with age and gender. Education and safety precautions are essential to prevent open eye injuries.

Journal of Pediatric Ophthalmology & Strabismus, 2013

To detect the abnormalities of the anterior visual pathways in children with amblyopia with diffu... more To detect the abnormalities of the anterior visual pathways in children with amblyopia with diffusion tensor imaging. Ten children with unilateral amblyopia, 5 children with bilateral amblyopia, and 10 control children were treated using diffusion tensor imaging scanning in this institutional practice. Fractional anisotropy and mean diffusivity values were analyzed using diffusion tensor imaging in the prechiasmatic and chiasmatic regions. Fractional anisotropy and mean diffusivity values of the amblyopic groups were compared with the values of the control group using the Kruskal–Wallis test. The Mann–Whitney U test was used to evaluate pairwise differences between groups. When compared with the control group, prechiasmatic fractional anisotropy values were significantly decreased in both affected and sound fellow eyes in the unilateral amblyopic group (P = .019 and .013), but not in the bilateral amblyopic group (P = .221). Mean diffusivity values were significantly greater in the sound fellow eye in the unilateral amblyopic group in the prechiasmatic region (P = .001 and .049). Diffusion tensor imaging showed a significant decrease in fractional anisotropy and an increase in mean diffusivity values in the unilateral amblyopic group in both affected and sound fellow eyes. These findings may reflect axonal underdevelopment in anterior pathways, particularly in the unilateral amblyopic group.

Graefe's Archive for Clinical and Experimental Ophthalmology, 2005

Canadian Journal of Ophthalmology, 2013

To compare the effect of subconjunctivally injected bevacizumab, etanercept and the combination o... more To compare the effect of subconjunctivally injected bevacizumab, etanercept and the combination of both drugs on experimental corneal neovascularization in rats. Experimental study. 28 male Wistar-Albino rats. Right corneas of rats were cauterized by silver nitrate sticks. Rats were divided randomly and equally into 4 groups so that each group contained 7 subjects. Immediately after the cauterization, 0.05 ml normal saline was injected subconjunctivally in group 1 (control group); 0.05 ml (1.25 mg) bevacizumab was injected subconjunctivally in group 2; 0.05 ml (1.25 mg) etanercept was injected subconjunctivally in group 3; 0.05 ml (1.25 mg) bevacizumab and 0.05 ml (1.25 mg) etanercept was injected subconjunctivally in group 4. The rats were euthanized on the 8th day, and digital photographs were obtained before the eyes were enucleated. The area of corneal neovascularization was calculated from digital photographs. Corneal sections were analyzed by histopathologically. The burn stimulus score was +1 or higher in all eyes. The difference of the neovascularization score between groups was found to be statistically significant (p = 0.001). The area of corneal neovascularization was 79.8% in group 1, 43.2% in group 2, 54.5% in group 3, and 34.8% in group 4. In group 4, corneal neovascularization was inhibited more than in the other groups. Histologic examination showed that the treatment groups had less neovascularization, inflammation, and fibroblast activity than the control group (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). Our study has shown that etanercept does have some antiangiogenic and anti-inflammatory effects in treatment of corneal neovascularization. The combination of bevacizumab and etanercept may be a promising approach in the treatment of corneal neovascularization.

Canadian Journal of Ophthalmology, 2009

To investigate and compare the effect of cefuroxime and moxifloxacin on adhesion of Staphylococcu... more To investigate and compare the effect of cefuroxime and moxifloxacin on adhesion of Staphylococcus epidermidis to intraocular lenses (IOLs). Design: Experimental study The 3-pieced hydrophobic acrylic lenses were contaminated with S. epidermidis (American Type Culture Collection 35983) solutions containing 10 8 colony-forming units. IOLs were inoculated into test tubes containing tryptic soy broth after being held in antibiotic solutions for 15 minutes. Sonication and vortex procedures were performed in order to remove all the remaining bacteria. From each tube 10 μL and 100 μL was taken and inoculated into sheep blood agar. The colonies were counted overnight. The statistical analyses were made using oneway ANOVA, Tukey Honestly Significant Differences test (HSD) and independent t tests, and a p value less than 0.05 was considered statistically significant. Results: Overall, the mean numbers of colony-forming units on the lenses that were held in control, cefuroxime, moxifloxacin 0.5 mg/0.1 mL and moxifloxacin 0.1 mg/0.1 mL solutions were 1398 (SE 10.01 ×10 3), 29.9 (SE 1.16 ×10 3), 0.23 (SD 0.04 × 10 3), and 0.41 (SD 0.05 × 10 3), respectively. The evaluation using one-way ANOVA and Tukey HSD tests revealed significant statistical differences among the groups (p = 0.000). The evaluation using independent t tests revealed significant statistical differences between the 2 moxifloxacin groups (p < 0.05). Our results suggest that moxifloxacin and cefuroxime significantly inhibit bacterial adherence to IOLs. The effect of moxifloxacin on inhibition of bacterial adherence was significantly greater than that of cefuroxime. For this reason moxifloxacin might be considered as a better prophylactic agent. Objet : Investigation et comparaison de l'effet du céfuroxime et de la moxifloxacine sur l'adhésion du staphylococcus epidermidis sur les lentilles intraoculaires (LIO). Nature : Étude expérimentale. Des lentilles acryliques hydrophobes 3 pièces ont été contaminées par des solutions de staphylococcus epidermidis (Collection de culture de type américain 35983) contenant 10 8 unités formant des colonies. Les LIO ont été inoculées dans des éprouvettes contenant du bouillon trypticase soja après avoir trempé dans des solutions antibiotiques pendant 15 minutes. On a pratiqué les procédures de sonification et de vortex pour retirer toutes les bactéries restantes. De chaque éprouvette, on a prélevé 10 μL et 100 μL qu'on a inoculé dans la gélose au sang de mouton. On a compté les colonies le lendemain. Les analyses statistiques ont été faites avec l'analyse de variance « one-way ANOVA », les tests Tukey Honestly Significant Differences (HSD) et les tests indépendants t, et on a considéré statistiquement significative une valeur p inférieure à 0,05. En tout, les quantités moyennes d'unités formant des colonies sur les lentilles maîtrisées dans les solutions de contrôle, de céfuroxime, moxifloxacine 0,5 mg / 0,1 mL et de moxifloxacine 0,1 mg / 0,1 mL étaient de 1398 (ÉT 10,01 ×10 3), 29,9 (ÉT 1,16 ×10 3), 0,23 (ET 0,04 × 10 3) et 0,41 (ÉT 0,05 × 10 3), respectivement. L'évaluation à l'aide de one-way ANOVA et des tests HSD de Tukey ont révélé des différences statistiquement significatives entre les groupes (p = 0,000). L'évaluation selon les tests indépendants t a révélé des écarts statistiquement significatifs entre les 2 groupes de moxifloxacine (p < 0,05). Nos résultats suggèrent que le céfuroxime et la moxifloxacine inhibent l'adhérence des bactéries aux LIO. L'effet de la moxifloxacine sur l'inhibition de l'adhérence bactérienne était significativement supérieur à celui du céfuroxime. On peut donc considérer que la moxifloxacine est un meilleur agent prophylactique.

Journal of Pediatric Ophthalmology & Strabismus, 2015

Acquired progressive esotropia in patients with high myopia 1 is caused by conversion of lateral ... more Acquired progressive esotropia in patients with high myopia 1 is caused by conversion of lateral rectus muscle function from abduction to infraduction, leading to impaired abduction and supraduction. 2 Imaging techniques have revealed abnormal extraocular muscle position in these patients; the lateral rectus muscle is displaced inferiorly and the superior rectus muscle is shifted nasally, which is due to superior, posterior, and lateral protrusion of the myopic cone. 3 We report our first limited experience of the Yokoyama procedure, described as looping the superior rectus and lateral rectus muscles together using a 5-0 non-absorbable polyester suture, 4 in two pediatric cases of acquired esotropia with severe myopia, one of which had an accompanying motility dysfunction. The first case was a 5-year-old boy with a 2-year history of esotropia. Visual acuity was 20/50 in both eyes with a refraction of-7.50-1.00 × 90 in both eyes. He had 65 prism diopters (PD) esotropia at near and distance with glasses. Magnetic resonance imaging demonstrated a nasally deviated superior rectus muscle and an inferiorly deviated lateral rectus muscle in both eyes. The Yokoyama procedure was performed on both eyes, followed by bilateral 5.75-mm medial rectus recessions with hang-back sutures. Postoperatively, deviation was 8 PD at near and 10 PD at distance and reached up to 16 PD at near and distance with-1.25 diopters myopia progression in both eyes at 36 months. The second case was a 15-year-old boy presenting with a 8-year history of esotropia. Visual acuity was 20/20 in both eyes with-14.00 diopters myopia in both eyes. He had 85 PD esotropia at near and distance with his glasses. Abduction was moderately limited (-2) in both eyes. Magnetic resonance imaging demonstrated a nasally deviated superior rectus muscle and

Neuro-Ophthalmology, 2010

... 3 , Rebiay Kiran 3 ... Arch Ophthalmol 2009 Jun;127(6):737–741. Iseri PK, Altinaş O, Tokay T,... more ... 3 , Rebiay Kiran 3 ... Arch Ophthalmol 2009 Jun;127(6):737–741. Iseri PK, Altinaş O, Tokay T, Yüksel N. Relationship between cognitive impairment and retinal morphological and visual functional abnormalities in Alzheimer disease. J Neuroophthalmol 2006;26:18–24. ...

$Research paper thumbnail of Evaluation of Intranasal Midazolam in Refraction and Fundus Examination of Young Children With Strabismus$

Journal of Pediatric Ophthalmology & Strabismus, 2005

To determine the clinical sedative effect and dosage of intranasal midazolam in refraction and fu... more To determine the clinical sedative effect and dosage of intranasal midazolam in refraction and fundus examination of children with strabismus. Refraction and fundus examination with (n = 28) and without (n = 24) sedation were performed in 52 children with strabismus whose ages ranged from 7 to 26 months. We delivered a 5-mg/mL solution of midazolam via a syringe for 60 seconds to provide a dose of 0.2 mg/kg. We repeated the dose to a maximum of 0.3 mg/kg if there was no clinical sedative response after 10 to 15 minutes. The ease of examination and sedation for each patient was scored by a blinded observer. The groups were evaluated for ease of examination and the time needed to complete it. We obtained clinically adequate sedation at a mean (+/- standard deviation) of 15 minutes (+/- 2.69 minutes). Sedation was achieved with a mean dose of 2.64 mg/kg (+/- 0.66 mg/kg). Children receiving midazolam had significantly calmer examination scores. The time needed to complete the examination was statistically significantly shorter for these children than for children not receiving sedation (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .05). Intranasal midazolam is a beneficial drug and method of delivery for the sedation of anxious children with strabismus undergoing refraction and fundus examination. Sedation prior to examination is effective in reducing the anxiety and time associated with ophthalmologic examination of children with strabismus.

Balkan Medical Journal, 2019

Background: Partial posterior hyaloidectomy is suggested to minimize the traction on the vitreous... more Background: Partial posterior hyaloidectomy is suggested to minimize the traction on the vitreous base and therefore reduce the risk of iatrogenic breaks in patients with macular hole and epiretinal membrane. Aims: To evaluate the safety and effectivity of limited vitrectomy in patients with macular hole. Study Design: Retrospective cohort study. Methods: Fifty-two consecutive patients who underwent macular hole surgery without performing complete peripheral vitreous removal were included in the study. The improvement in visual acuity, the incidence of retinal breaks and detachment, anatomical results and intraoperative and postoperative complications of this technique were evaluated. Results: The median visual acuity was 0.2 (0.1-0.4) before surgery, ant it was 0.5 (0.3-0.6) after surgery (p<0.001). Retinal breaks and detachments did not occur in any of our patients. SF6 was used in 24 patients (46.2%), and C3F8 was used in 28 patients (53.8%) Three patients (5.76%) had revision surgery because of the recurrence of macular hole. We did not observe proliferative vitreoretinopathy or surgery related major complications in any patient during the follow up period. Conclusion: Limited vitrectomy without removing peripheral vitreous is safe and effective in macular hole surgery. It reduces the risk of peripheral retinal breaks and retinal detachment.

European Journal of Ophthalmology, 2004

PURPOSE. To describe and compare the diurnal intraocular pressure (IOP) variation in patients wit... more PURPOSE. To describe and compare the diurnal intraocular pressure (IOP) variation in patients with pseudoexfoliation syndrome (PXS) and normal subjects. METHODS. The authors prospectively investigated 19 PXS patients (10 bilateral and 9 unilateral) and 25 age-and sex-matched normal subjects. One eye of each control subject and bilateral PXS patient was selected randomly, and pseudoexfoliative eyes of unilateral cases were enrolled in this study. All patients were admitted to the authors' ophthalmology department and underwent diurnal IOP testing (six measurements over 24 hours). RESULTS. The mean IOP of PXS patients at all time intervals was significantly higher than the control group (p<0.05). Likewise, a significant difference in the maximum IOP, range of IOP, and minimum IOP, as well as the standard deviation of the pressure at each time point, existed between groups (p<0.05). Normal individuals did not show diurnal variation greater than 5 mmHg. Of patients with PXS, 55.6% showed diurnal variation greater than 5 mm Hg. In addition, in 10% of patients with PXS, the diurnal variations were equal to or higher than 10 mmHg. CONCLUSIONS. Variations in IOP during the daily 24-hour cycle in patients with PXS were higher than control groups. Significant fluctuations in the diurnal curve of IOP in PXS may be an important factor in predicting eyes that may develop pseudoexfoliative glaucoma. IOP fluctuation could influence the diagnostic and prognostic evaluation of PXS.

European Journal of Ophthalmology, 2009

International Ophthalmology, 2017

Purpose To elucidate the metabolic processes playing roles in the formation of keratoconus (KC). ... more Purpose To elucidate the metabolic processes playing roles in the formation of keratoconus (KC). Methods Tears samples were collected using capillary glass tubes without stimulation and without prior anesthesia from 17 patients and 16 controls. Proteomic analysis by fluorescent 2D gel electrophoresis (DIGE) coupled with MALDI-TOF/TOF was performed. The identified proteins that were differentially regulated were subjected to Ingenuity Pathway Analysis (IPA). Corneal topography analyses with Sirius topography system (Costruzioni Strumenti Oftalmici, Florence, Italy) were performed on all participants. The steepest keratometry index was lower than 50 diopters in all keratoconus patients. Results DIGE analysis showed changes in abundance of nine proteins. Six of these proteins, namely serum albumin, Keratin Type II Cytoskeletal 1, IgG gamma chain-1, GAPDH, alpha-1 antitrypsin and ApoA-I, were down-regulated in the KC samples in comparison with the controls. In addition, we detected up-regulation of lysozyme C, keratin type I cytoskeletal 10 and lipocalin. The subsequent IPA predicted that NADH repair pathway is activated in the KC patients. This pathway involves generation of NADHX as a by-product via catalysis by GAPDH. NADHX is an inhibitor of several dehydrogenases and must be removed. Conclusion The involvement of NADHX repair pathway in KC should be investigated, since preliminary clues obtained in this study point to that direction. In particular, showing the presence of ATP-dependent NAD(P)H-hydrate dehydratase that eliminates NADHX would strengthen our findings and would be a major step toward understanding KC.

International Ophthalmology, 2016

The aim of this study was to investigate whether a correlation exists between optical coherence t... more The aim of this study was to investigate whether a correlation exists between optical coherence tomography (OCT) of retina and diffusion tensor imaging (DTI) of the optic pathway measurements. All subjects underwent OCT measurements of optic nerve head, retinal nerve fiber layer, and macula. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of optic pathways were analyzed using DTI. Prechiasmatic FA values were significantly decreased in unilateral amblyopic group in both affected and sound fellow eyes (p = 0.019 and 0.013), but not in bilateral amblyopic group (p = 0.221) when compared with the control group. ADC values were significantly greater in sound eye in unilateral amblyopic group in prechiasmatic and postchiasmatic regions (p = 0.001 and 0.049). ADC values were also significantly greater in bilateral amblyopic group in postchiasmatic region (p = 0.037). There were no significant differences between the affected eye and sound eye side DTI measurements. There was no significant correlation between prechiasmatic DTI and OCT measurements in affected and sound eyes of unilateral amblyopia group. DTI results demonstrated that there is a functional underdevelopment of the anterior and posterior visual pathways in both affected and sound eye of unilateral amblyopic patients. Significantly reduced FA values in prechiasmatic region where OCT values of retina were normal can be explained by possible micro-structural changes.

$Research paper thumbnail of Effects of Refractive Errors on Visual Functional Magnetic Resonance Imaging$

Acta Medica Anatolia, 2016

Images were obtained using a 3-Tesla MRI scanner (Philips Achievea Intera Release, Einthoven, Net... more Images were obtained using a 3-Tesla MRI scanner (Philips Achievea Intera Release, Einthoven, Netherlands) with 16 channel head coil system. In all patients, sponge backing was placed bilaterally in the coil to prevent motion artifacts. Inversion recovery

Journal of Ophthalmology, 2015

Purpose. To determine whether subconjunctival lidocaine injection maintains additional anesthetic... more Purpose. To determine whether subconjunctival lidocaine injection maintains additional anesthetic effect during intravitreal Ozurdex injection.Methods. 63 patients who were diagnosed as central or branch retinal vein occlusion and planned to receive Ozurdex injection for macular edema were prospectively included in the study. The patients were randomized into one of the two anesthetic groups. The first group received topical proparacaine drop and lidocaine applied pledget. The second group received subconjunctival lidocaine injection in addition to the anesthetics in group 1.Results. Mean pain score was1.90±2.39in group 1 and 1.71 ± 2.09 in group 2 (p=0.746). Mean subconjunctival hemorrhage grade was1.67±0.17in group 1 and0.90±0.14in group 2 (p=0.001). There was no relationship between the amount of subconjunctival hemorrhage and pain score of the patients.Conclusions. There was no difference in pain scores between the two anesthetic methods. The addition of subconjunctival lidocain...