özge zincir - Academia.edu (original) (raw)

Papers by özge zincir

Objective: The rapid palatal expansion (RPE) procedure is a frequently used treatment for maloccl... more Objective: The rapid palatal expansion (RPE) procedure is a frequently used treatment for malocclusion before pubertal growth. However, relapses often occur after the retention period of this procedure. In this study, we aimed to eliminate this deficiency, considering that there would be a deficiency in the new bone metabolism in the expanded area between the palatal sutures. Design: Twenty-four male Wistar rats, 7-8 weeks old, with an average weight of 200 g, were divided into 3 groups in equal numbers. 5 days of expansion was applied to all groups with 50 g of force, then a retention period of 12 days was expected. While no application was made to the control group (CG) during the retention period, mechanical vibration was applied to the vibration group (VF) at a frequency of 111 Hz and the active substance was applied to the thymoquinone group (TQ) at a dose of 10 mg/kg. Result: At the end of the retention period, all animals were sacrificed and sections were taken from the prema...

Turkiye Klinikleri Journal of Dental Sciences, 2021

Acta Odontologica Turcica, 2021

Bu çalışmanın amacı, diş hekimliğinde sıklıkla tercih edilen All-on-4 dental implant sistemi hakk... more Bu çalışmanın amacı, diş hekimliğinde sıklıkla tercih edilen All-on-4 dental implant sistemi hakkındaki bilgilerin yer aldığı YouTube™ videolarını inceleyerek bilgilerin yararlılığını ve içeriğini değerlendirmektir. GEREÇ VE YÖNTEM: 'All-on-4 dental implant' anahtar kelimeleriyle yapılan YouTube™ video taramasında ilk 150 video izlenerek değerlendirmeye alındı. Analiz kriterlerine uymayan 70 video değerlendirme dışı bırakılarak geriye kalan 80 videonun analizi yapıldı. Analizi yapılan tüm videoların bilgi içeriklerine göre 9 puan üzerinden yararlılık skorları belirlendi: 0-2 puan aralığındakiler yetersiz (kod 0), 3-5 puan aralığındakiler orta (kod 1) ve 6-9 puan aralığındakiler mükemmel (kod 2). Videoların süresi, izlenme sayısı, beğeni sayısı, beğenmeme sayısı ve yorum sayısı gibi demografik bilgileri kaydedildi. Tüm videolar yüklenme kaynağına (sağlık uzmanları, sağlık şirketi ve bilgilendirme web sitesi, bireysel kullanıcı) ve video tipine (hasta deneyimi, eğitsel) göre sınıflandırıldı. İstatistiksel analiz için Anova, Kruskal-Wallis testi, ki-kare testi ve Pearson-Spearman testi kullanılarak anlamlılık düzeyi p<0.05 olarak belirlendi. BULGULAR: Videoların yararlılık skorları ortalaması 0.45 bulundu. Videoların yararlılık skorları ile demografik bilgileri karşılaştırıldığında sadece video süresi ile aralarında anlamlı bir ilişki olduğu bulundu (p=0.002). Yararlılık skoruyla izlenme oranı arasında anlamlı bir ilişki yoktu (p=0.522). Video tipleri ile yararlılık skoru arasında anlamlı bir ilişki vardı ve bu anlamlılık eğitsel videolar lehineydi (p=0.022). Ayrıca etkileşim indeksi ile yükleme kaynağı arasında da anlamlı bir ilişki vardı ve bireysel kullanıcı lehineydi (p=0.008). SONUÇ: All-on-4 dental implant sistemi hakkındaki videoların yararlılığı kısıtlı bulunmuştur. Bu tür videoların konunun uzmanları tarafından denetlenmesi gerektiği düşünülmektedir.

Bu çalışmanın amacı saf hindistan cevizi yağının ve laurik asitin kandida suşları üzerindeki in v... more Bu çalışmanın amacı saf hindistan cevizi yağının ve laurik asitin kandida suşları üzerindeki in vitro antimikrobiyal etkinliğini araştırmak; bu ajanların aktivitelerini, flukonazol ve klorheksidin aktivitesiyle karşılaştırmaktır. Gereç ve yöntem: Çalışmamızda antimikrobiyal ajan olarak Klorheksidin, Flukonazol, Laurik asit, ve saf hindistan cevizi yağı kullanılarak kandida suşları üzerindeki MİK (Minimum İnhibisyon Konsantrasyonu) değerleri tespit edilmiştir. Kandida suşlarından; Candida albicans [American Type Culture Collection (ATCC)] 10231, C. tropicalis ATCC 750, C. krusei ATCC 6258 ve C. glabrata ATCC 2001 standart suşları kullanılmıştır. Kandida suşları, 0.5 McFarland türbidite standardına göre BHI içerisinde de seyreltilmiş ve her kuyucuğa 10 uL eklenmiştir. Her plaka gece boyunca 37 ° C'de inkübe edilmiştir. Her oyuktaki kandida büyümesi, üretici talimatlarına göre Epoch spektrofotometre (Biotek, Almanya) kullanılarak 600 nm optik yoğunlukta ölçülmüştür. Verilerin değerlendirilmesinde SPPS 25 (IBM Corp. Released 2017. IBM SPSS Statistics for Windows, Version 25.0. Armonk, NY: IBM Corp.) istatistik paket programı kullanılmıştır. Testlerin anlamlılık düzeyi için p<0,05 ve p<0,01 değeri kabul edilmiştir Bulgular: Klorheksidinin çalışmamızda kullanılan tüm kandida türleri arasındaki MİK. düzeyi 0,625' tir. Flukonazolun Candida glabrata üzerindeki MİK düzeyi 0,03125; Candida krusei üzerindeki MİK düzeyi 0,25; Candida albicans üzerindeki MİK düzeyi 0, 0078131; Candida tropicalis üzerindeki MİK düzeyi ise 0,003906'dır. Laurik asit ve saf hindistan cevizi yağının kandida suşları arasında istatistiksel olarak en yüksek oranda Candida Albicans 'a etkili olduğu tespit edilmekle birlikte MİK değeri tespit edilememiştir. Sonuç: Laurik asit ve Saf hindistan cevizi yağının kandida suşları üzerinde en yüksek oranda Candida albicansa etkili olduğu fakat bu etkinin tamamiyle inhibe edici düzeyde olmadığı, Klorheksidin ve Flukonazol düzeyine ulaşamadığı sonucuna ulaşılmıştır.

Eurasian Journal of Medical Investigation, 2017

O dontogenicmyxomas (OMs) are benign tumors that originate from the structures of a developing to... more O dontogenicmyxomas (OMs) are benign tumors that originate from the structures of a developing tooth, including the dental follicle, dental papilla, or periodontal ligament. [1] Histologically OMs are described as benign odontogenic tumors of embryonic mesenchymal tissue characterized by a rare composition of round and angularshaped cells in. OM is a slow growing tumor. Its stroma contains different amounts of mucoid and collagen substances. The local invasive character of OMs originates from the accumulation of these substances in the stroma, which promotes tumor growth. [2] It is a painless, slow-growing swelling in the maxillary or mandibular region. [3] CT and MRI imaging is superior to plain radiography. Radiographically OM presents a unilocular or multilocular radiolucency with well-defined borders and fine bony trabeculae within its structure; [4] dental displacement and root resorption on conventional radiographs and panoramic radiographs are relatively common findings. [5] A definite diagnosis is achieved by biopsy.

BMC Oral Health, 2021

Background The All-on-four dental implant method is an implantology method designed to provide a ... more Background The All-on-four dental implant method is an implantology method designed to provide a comfortable prosthetic treatment option by avoiding advanced surgical procedures. This research aims to compare and evaluate the stress and tension values in conventional angled multiunit abutment-implant connection systems and monoblock dental implants used in the all-on-four procedure with finite element analysis. Methods Two master models were created by placing four implants connected to multiunit abutments (group A) in the interforaminal region of a completely edentulous mandible and four monoblock implants (group B) in the same region of another completely edentulous mandible. Group A implants were classified according to their diameter as follows: 3.5 mm (M1A), 4.0 mm (M2A), and 4.5 mm (M3A). Similarly, group B implants were classified as M1B, M2B, and M3B. In the six models rehabilitated with acrylic fixed prostheses, a 100 N force was applied to the anterior implant region, and ...

Balkan Journal of Dental Medicine, 2019

Summary Background/Aim: A factor affecting the success rate of dental implants, which has been us... more Summary Background/Aim: A factor affecting the success rate of dental implants, which has been used successfully for many years, is the implant-abutment connection system. The purpose of this study was to evaluate the stress distribution of different implant-abutment connection systems under different forces. Material and Methods: This in vitro study included a finite element analysis. In the study, the cylindrical and screwed dental implants available in 3 different diameters from 4 different companies were categorized into 12 different models. Two different scenarios of force application were conducted on each model in this study. In the first scenario, 100 N force and 100 N moment were applied in a vertical direction onto a point considered as the center of each tooth. In the second scenario, a 100 N force and moment were applied at a 45° angle in an oblique direction. Results: As a result of the forces applied to dental implants of different diameters from different companies, o...

Summary Background/Aim: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) was first introdu... more Summary Background/Aim: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) was first introduced in 2003 and its scope was expanded by the name medication-related osteonecrosis of the jaw (MRONJ), since 2014. This study aimed to evaluate the effects of photodynamic therapy (FDT) on tissue samples by histopathological and histomorphometric examination and serum TRACP-5b (Tartrateresistant acid phosphatase-5b) measurement in rats. Material and Methods: 24 Sprague-Dawley male rats were divided into 3 groups comprising 8 animals. Zoledronic acid was administered to groups 1 and 2 and 0.9% sodium chloride was administered to group 3 intraperitoneally. After the injections were completed, dental extractions were performed. Photodynamic therapy was applied to group 2, three times a weekfor the two weeks after the extraction. In the 16th week, sacrification was performed. Rats were undergone histopathologic and histomorphometric evaluations. Results: Photodynamic therapy has led to a de...

White sponge nevus is a rare, autosomal-dominant disorder that affects the uncornified stratified... more White sponge nevus is a rare, autosomal-dominant disorder that affects the uncornified stratified squamous epithelia. Clinically, the presence of white, spongy plaques mostly in the buccal, labial, and gingival mucosa and the floor of the mouth characterize the lesions. The differential diagnosis of the lesion may be difficult and it is best diagnosed by biopsy. No standard treatment for the condition exists although numerous treatments have been tried. We report a case of white sponge nevus in the oral cavity of a 28-year-old man and review of the literature.

Odontology

In the original publication of the article, affiliation of the authors "Özge Ünlü, Mehmet Demirci... more In the original publication of the article, affiliation of the authors "Özge Ünlü, Mehmet Demirci and Ahmet Bülent Katiboğlu" was published incorrectly. The correct affiliation is provided below.

Odontology

The effectiveness of antifungal agents may be insufficient against resistant strains in some case... more The effectiveness of antifungal agents may be insufficient against resistant strains in some cases of oral candidiasis. The aim of this study was to evaluate the antifungal effect of thymoquinone against Candida albicans, Candida tropicalis, Candida glabrata and Candida krusei strains and the synergistic antifungal activity of these strains in combination with nystatin. To evaluate in vitro antifungal activity and interactions between thymoquinone and nystatin, substances were tested against Candida albicans ATCC 10,231, C. tropicalis ATCC 750, C.krusei ATCC 6258 and C. glabrata ATCC 2001 standard strains both individually and combinationally via microdilution method. MIC and ΣFIC index value were analysed. The Kruskal Wallis test and Bonferroni test were used for statistical evaluations. Statistical significance was set at p < 0.05. A statistically significant difference was observed between the mean ranks of all Candida species and doses of thymoquinone, nystatin, and the combination thymoquinone-nystatin (p < 0.05). MIC values for thymoquinone were determined as 15 μg/mL for C. albicans, C. tropicalis and C. krusei while it was 30 μg/mL for C. glabrata. Moreover, MIC for nystatin was found as 1.875 μg/mL for C. albicans, C. tropicalis and C. krusei, whereas it was 7.5 μg/mL in C. glabrata. Interaction assays and ΣFIC index value revealed that, TQ and nystatin have a synergistic effect against to all strains. Thymoquinone was found to have antifungal activity on Candida species and synergistic effect when combined with nystatin.

Journal of Istanbul University Faculty of Dentistry, 2014

Balkan Journal of Dental Medicine

Summary Background/Aim: This study aimed to evaluate the effect of local zeolite and tranexamic a... more Summary Background/Aim: This study aimed to evaluate the effect of local zeolite and tranexamic acid application on hemostasis duration and histopathological changes in the experimental bleeding model, created by puncturing femoral arteries in rats. Material and Methods: A total of 36 Sprague Dawley female rats weighing an average of 240 ± 20 g were used in the study. The three main study groups were the zeolite, zeolite+tranexamic acid, and control groups. Each group was sacrificed on the seventh and fourteenth days of the study, using subgroups for histopathological findings. After piercing the femoral artery of each rat, one gram of the material assigned to the group was applied to the bleeding site after which a 100-gram scale weight was placed on the site for 30 sec intervals, during which temperature was measured. The same sequence of procedures was repeated for the control group, using only standard compression. Statistical analysis was performed using IBM Statistical Package...

International Orthodontics

Journal of Craniofacial Surgery

Journal of Oral and Maxillofacial Surgery

Objective: The rapid palatal expansion (RPE) procedure is a frequently used treatment for maloccl... more Objective: The rapid palatal expansion (RPE) procedure is a frequently used treatment for malocclusion before pubertal growth. However, relapses often occur after the retention period of this procedure. In this study, we aimed to eliminate this deficiency, considering that there would be a deficiency in the new bone metabolism in the expanded area between the palatal sutures. Design: Twenty-four male Wistar rats, 7-8 weeks old, with an average weight of 200 g, were divided into 3 groups in equal numbers. 5 days of expansion was applied to all groups with 50 g of force, then a retention period of 12 days was expected. While no application was made to the control group (CG) during the retention period, mechanical vibration was applied to the vibration group (VF) at a frequency of 111 Hz and the active substance was applied to the thymoquinone group (TQ) at a dose of 10 mg/kg. Result: At the end of the retention period, all animals were sacrificed and sections were taken from the prema...

Turkiye Klinikleri Journal of Dental Sciences, 2021

Acta Odontologica Turcica, 2021

Bu çalışmanın amacı, diş hekimliğinde sıklıkla tercih edilen All-on-4 dental implant sistemi hakk... more Bu çalışmanın amacı, diş hekimliğinde sıklıkla tercih edilen All-on-4 dental implant sistemi hakkındaki bilgilerin yer aldığı YouTube™ videolarını inceleyerek bilgilerin yararlılığını ve içeriğini değerlendirmektir. GEREÇ VE YÖNTEM: 'All-on-4 dental implant' anahtar kelimeleriyle yapılan YouTube™ video taramasında ilk 150 video izlenerek değerlendirmeye alındı. Analiz kriterlerine uymayan 70 video değerlendirme dışı bırakılarak geriye kalan 80 videonun analizi yapıldı. Analizi yapılan tüm videoların bilgi içeriklerine göre 9 puan üzerinden yararlılık skorları belirlendi: 0-2 puan aralığındakiler yetersiz (kod 0), 3-5 puan aralığındakiler orta (kod 1) ve 6-9 puan aralığındakiler mükemmel (kod 2). Videoların süresi, izlenme sayısı, beğeni sayısı, beğenmeme sayısı ve yorum sayısı gibi demografik bilgileri kaydedildi. Tüm videolar yüklenme kaynağına (sağlık uzmanları, sağlık şirketi ve bilgilendirme web sitesi, bireysel kullanıcı) ve video tipine (hasta deneyimi, eğitsel) göre sınıflandırıldı. İstatistiksel analiz için Anova, Kruskal-Wallis testi, ki-kare testi ve Pearson-Spearman testi kullanılarak anlamlılık düzeyi p<0.05 olarak belirlendi. BULGULAR: Videoların yararlılık skorları ortalaması 0.45 bulundu. Videoların yararlılık skorları ile demografik bilgileri karşılaştırıldığında sadece video süresi ile aralarında anlamlı bir ilişki olduğu bulundu (p=0.002). Yararlılık skoruyla izlenme oranı arasında anlamlı bir ilişki yoktu (p=0.522). Video tipleri ile yararlılık skoru arasında anlamlı bir ilişki vardı ve bu anlamlılık eğitsel videolar lehineydi (p=0.022). Ayrıca etkileşim indeksi ile yükleme kaynağı arasında da anlamlı bir ilişki vardı ve bireysel kullanıcı lehineydi (p=0.008). SONUÇ: All-on-4 dental implant sistemi hakkındaki videoların yararlılığı kısıtlı bulunmuştur. Bu tür videoların konunun uzmanları tarafından denetlenmesi gerektiği düşünülmektedir.

Bu çalışmanın amacı saf hindistan cevizi yağının ve laurik asitin kandida suşları üzerindeki in v... more Bu çalışmanın amacı saf hindistan cevizi yağının ve laurik asitin kandida suşları üzerindeki in vitro antimikrobiyal etkinliğini araştırmak; bu ajanların aktivitelerini, flukonazol ve klorheksidin aktivitesiyle karşılaştırmaktır. Gereç ve yöntem: Çalışmamızda antimikrobiyal ajan olarak Klorheksidin, Flukonazol, Laurik asit, ve saf hindistan cevizi yağı kullanılarak kandida suşları üzerindeki MİK (Minimum İnhibisyon Konsantrasyonu) değerleri tespit edilmiştir. Kandida suşlarından; Candida albicans [American Type Culture Collection (ATCC)] 10231, C. tropicalis ATCC 750, C. krusei ATCC 6258 ve C. glabrata ATCC 2001 standart suşları kullanılmıştır. Kandida suşları, 0.5 McFarland türbidite standardına göre BHI içerisinde de seyreltilmiş ve her kuyucuğa 10 uL eklenmiştir. Her plaka gece boyunca 37 ° C'de inkübe edilmiştir. Her oyuktaki kandida büyümesi, üretici talimatlarına göre Epoch spektrofotometre (Biotek, Almanya) kullanılarak 600 nm optik yoğunlukta ölçülmüştür. Verilerin değerlendirilmesinde SPPS 25 (IBM Corp. Released 2017. IBM SPSS Statistics for Windows, Version 25.0. Armonk, NY: IBM Corp.) istatistik paket programı kullanılmıştır. Testlerin anlamlılık düzeyi için p<0,05 ve p<0,01 değeri kabul edilmiştir Bulgular: Klorheksidinin çalışmamızda kullanılan tüm kandida türleri arasındaki MİK. düzeyi 0,625' tir. Flukonazolun Candida glabrata üzerindeki MİK düzeyi 0,03125; Candida krusei üzerindeki MİK düzeyi 0,25; Candida albicans üzerindeki MİK düzeyi 0, 0078131; Candida tropicalis üzerindeki MİK düzeyi ise 0,003906'dır. Laurik asit ve saf hindistan cevizi yağının kandida suşları arasında istatistiksel olarak en yüksek oranda Candida Albicans 'a etkili olduğu tespit edilmekle birlikte MİK değeri tespit edilememiştir. Sonuç: Laurik asit ve Saf hindistan cevizi yağının kandida suşları üzerinde en yüksek oranda Candida albicansa etkili olduğu fakat bu etkinin tamamiyle inhibe edici düzeyde olmadığı, Klorheksidin ve Flukonazol düzeyine ulaşamadığı sonucuna ulaşılmıştır.

Eurasian Journal of Medical Investigation, 2017

O dontogenicmyxomas (OMs) are benign tumors that originate from the structures of a developing to... more O dontogenicmyxomas (OMs) are benign tumors that originate from the structures of a developing tooth, including the dental follicle, dental papilla, or periodontal ligament. [1] Histologically OMs are described as benign odontogenic tumors of embryonic mesenchymal tissue characterized by a rare composition of round and angularshaped cells in. OM is a slow growing tumor. Its stroma contains different amounts of mucoid and collagen substances. The local invasive character of OMs originates from the accumulation of these substances in the stroma, which promotes tumor growth. [2] It is a painless, slow-growing swelling in the maxillary or mandibular region. [3] CT and MRI imaging is superior to plain radiography. Radiographically OM presents a unilocular or multilocular radiolucency with well-defined borders and fine bony trabeculae within its structure; [4] dental displacement and root resorption on conventional radiographs and panoramic radiographs are relatively common findings. [5] A definite diagnosis is achieved by biopsy.

BMC Oral Health, 2021

Background The All-on-four dental implant method is an implantology method designed to provide a ... more Background The All-on-four dental implant method is an implantology method designed to provide a comfortable prosthetic treatment option by avoiding advanced surgical procedures. This research aims to compare and evaluate the stress and tension values in conventional angled multiunit abutment-implant connection systems and monoblock dental implants used in the all-on-four procedure with finite element analysis. Methods Two master models were created by placing four implants connected to multiunit abutments (group A) in the interforaminal region of a completely edentulous mandible and four monoblock implants (group B) in the same region of another completely edentulous mandible. Group A implants were classified according to their diameter as follows: 3.5 mm (M1A), 4.0 mm (M2A), and 4.5 mm (M3A). Similarly, group B implants were classified as M1B, M2B, and M3B. In the six models rehabilitated with acrylic fixed prostheses, a 100 N force was applied to the anterior implant region, and ...

Balkan Journal of Dental Medicine, 2019

Summary Background/Aim: A factor affecting the success rate of dental implants, which has been us... more Summary Background/Aim: A factor affecting the success rate of dental implants, which has been used successfully for many years, is the implant-abutment connection system. The purpose of this study was to evaluate the stress distribution of different implant-abutment connection systems under different forces. Material and Methods: This in vitro study included a finite element analysis. In the study, the cylindrical and screwed dental implants available in 3 different diameters from 4 different companies were categorized into 12 different models. Two different scenarios of force application were conducted on each model in this study. In the first scenario, 100 N force and 100 N moment were applied in a vertical direction onto a point considered as the center of each tooth. In the second scenario, a 100 N force and moment were applied at a 45° angle in an oblique direction. Results: As a result of the forces applied to dental implants of different diameters from different companies, o...

Summary Background/Aim: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) was first introdu... more Summary Background/Aim: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) was first introduced in 2003 and its scope was expanded by the name medication-related osteonecrosis of the jaw (MRONJ), since 2014. This study aimed to evaluate the effects of photodynamic therapy (FDT) on tissue samples by histopathological and histomorphometric examination and serum TRACP-5b (Tartrateresistant acid phosphatase-5b) measurement in rats. Material and Methods: 24 Sprague-Dawley male rats were divided into 3 groups comprising 8 animals. Zoledronic acid was administered to groups 1 and 2 and 0.9% sodium chloride was administered to group 3 intraperitoneally. After the injections were completed, dental extractions were performed. Photodynamic therapy was applied to group 2, three times a weekfor the two weeks after the extraction. In the 16th week, sacrification was performed. Rats were undergone histopathologic and histomorphometric evaluations. Results: Photodynamic therapy has led to a de...

White sponge nevus is a rare, autosomal-dominant disorder that affects the uncornified stratified... more White sponge nevus is a rare, autosomal-dominant disorder that affects the uncornified stratified squamous epithelia. Clinically, the presence of white, spongy plaques mostly in the buccal, labial, and gingival mucosa and the floor of the mouth characterize the lesions. The differential diagnosis of the lesion may be difficult and it is best diagnosed by biopsy. No standard treatment for the condition exists although numerous treatments have been tried. We report a case of white sponge nevus in the oral cavity of a 28-year-old man and review of the literature.

Odontology

In the original publication of the article, affiliation of the authors "Özge Ünlü, Mehmet Demirci... more In the original publication of the article, affiliation of the authors "Özge Ünlü, Mehmet Demirci and Ahmet Bülent Katiboğlu" was published incorrectly. The correct affiliation is provided below.

Odontology

The effectiveness of antifungal agents may be insufficient against resistant strains in some case... more The effectiveness of antifungal agents may be insufficient against resistant strains in some cases of oral candidiasis. The aim of this study was to evaluate the antifungal effect of thymoquinone against Candida albicans, Candida tropicalis, Candida glabrata and Candida krusei strains and the synergistic antifungal activity of these strains in combination with nystatin. To evaluate in vitro antifungal activity and interactions between thymoquinone and nystatin, substances were tested against Candida albicans ATCC 10,231, C. tropicalis ATCC 750, C.krusei ATCC 6258 and C. glabrata ATCC 2001 standard strains both individually and combinationally via microdilution method. MIC and ΣFIC index value were analysed. The Kruskal Wallis test and Bonferroni test were used for statistical evaluations. Statistical significance was set at p < 0.05. A statistically significant difference was observed between the mean ranks of all Candida species and doses of thymoquinone, nystatin, and the combination thymoquinone-nystatin (p < 0.05). MIC values for thymoquinone were determined as 15 μg/mL for C. albicans, C. tropicalis and C. krusei while it was 30 μg/mL for C. glabrata. Moreover, MIC for nystatin was found as 1.875 μg/mL for C. albicans, C. tropicalis and C. krusei, whereas it was 7.5 μg/mL in C. glabrata. Interaction assays and ΣFIC index value revealed that, TQ and nystatin have a synergistic effect against to all strains. Thymoquinone was found to have antifungal activity on Candida species and synergistic effect when combined with nystatin.

Journal of Istanbul University Faculty of Dentistry, 2014

Balkan Journal of Dental Medicine

Summary Background/Aim: This study aimed to evaluate the effect of local zeolite and tranexamic a... more Summary Background/Aim: This study aimed to evaluate the effect of local zeolite and tranexamic acid application on hemostasis duration and histopathological changes in the experimental bleeding model, created by puncturing femoral arteries in rats. Material and Methods: A total of 36 Sprague Dawley female rats weighing an average of 240 ± 20 g were used in the study. The three main study groups were the zeolite, zeolite+tranexamic acid, and control groups. Each group was sacrificed on the seventh and fourteenth days of the study, using subgroups for histopathological findings. After piercing the femoral artery of each rat, one gram of the material assigned to the group was applied to the bleeding site after which a 100-gram scale weight was placed on the site for 30 sec intervals, during which temperature was measured. The same sequence of procedures was repeated for the control group, using only standard compression. Statistical analysis was performed using IBM Statistical Package...

International Orthodontics

Journal of Craniofacial Surgery

Journal of Oral and Maxillofacial Surgery