özlem ediboğlu - Academia.edu (original) (raw)

Papers by özlem ediboğlu

Journal of İzmir Chest Hospital

Chronic Obstructive Pulmonary Disease - A Current Conspectus, 2021

Mechanical ventilation is a lifesaving therapy in patients who have acute respiratory failure due... more Mechanical ventilation is a lifesaving therapy in patients who have acute respiratory failure due to chronic obstructive pulmonary disease (COPD). Mechanical ventilaton either invasive or non-invasive has an important role in the management of acute exacerbation of COPD (AECOPD). AECOPD required hospitalizaton had increased mortality and poor prognosis. Ventilatory management success related to understanding physiopathology of the disease. Clinicians must be aware of deterioration of clinical signs of COPD patients. The most appropriate treatment should be performed at optimal time. Some COPD patients are at high risk for prolonged mechanical ventilation due to COPD is a progressive disease.

Erciyes Medical Journal, 2019

Introduction: Thrombolytic and anticoagulation therapy are the possible treatment modalities for ... more Introduction: Thrombolytic and anticoagulation therapy are the possible treatment modalities for submassive pulmonary embolism (PE). However, the indications are still the subject of debate. The aim of this study was to compare the efficacies of thrombolytic and standard anticoagulation treatment modalities on mortality, and also to determine the safety of thrombolytic treatment in subjects with submassive PE. Methods: Subjects with submassive PE were recruited from the intensive care unit (ICU). The demographic data, comorbidity, bedside echocardiography (ECHO) findings, treatment procedure, treatment-related side effects, total length of stay in hospital and ICU were collected. Control ECHO was performed 48 hours after the initiation of the treatment. Short-term and one year mortality were recorded. The correlation between the increased risk for major bleeding and thrombolytic treatment was assessed. Results: Fifty-four subjects with a median age of 66 (54-73) years were enrolled during the study period. 18 subjects (33.3%) underwent thrombolytic treatment and 36 subjects (66.7%) received standard anticoagulation therapy. Short-term and one year mortality were statistically lower in subjects who received thrombolytic therapy (p=.02 and p=.04, respectively). The reduction in the mean pulmonary arterial pressure was significantly higher in the thrombolytic treatment group (p<.001). Risk for major bleeding was similar between two groups. Conclusion: Thrombolytic therapy may reduce the mortality rates in subjects with submassive PE without an increase in the risk of major bleeding.

Turkish Journal of Medical and Surgical Intensive Care, 2017

2=62 years (range, 56-76 years)]. The APACHE II score was significantly higher in Group 1 patient... more 2=62 years (range, 56-76 years)]. The APACHE II score was significantly higher in Group 1 patients than in Group 2 patients (27 vs. 23, p=0.03). The pH was significantly lower in Group 1 (7.26 vs. 7.35, p=0.008). Weaning success was significantly lower and mortality was significantly higher in Group 1 patients than in Group 2 patients (1/12 vs. 8/12, p=0.003 and 11/12 vs. 1/12, p=0.0001, respectively). The number of patients with ventilator-associated pneumonia was higher in Group 1 than in Group 2 (7/12 vs 2/12, p=0.035). NIV was applied to all patients except one. Conclusion: Unplanned extubation is an undesirable condition in intensive care. Patients with advanced age and higher APACHE II scores may be at a high risk of reintubation and mortality.

Balkan Medical Journal, 2015

Background: The influence of meteorological conditions on cardiovascular morbidity and mortality ... more Background: The influence of meteorological conditions on cardiovascular morbidity and mortality has been known for a long time. However, few reports have been published on the influence of meteorological parameters on the occurrence of acute pulmonary embolism (PE). Aims: In this retrospective study, we compared the meteorological parameters between PE patients with risk factors and idiopathic PE patients. Study Design: Cross-sectional study. Methods: Medical documentation of 1180 patients with suspected acute pulmonary embolism diagnosed between January 2010 and December 2012 was retrospectively analyzed. A total of 530 patients with PE confirmed by computed tomography pulmonary angiography and/or ventilation/perfusion scan were included for further analysis. We divided the patients into two groups: PE with risk factors (provoked) and PE without risk factors (unprovoked). The meteorological data were collected from the relevant time period: temperature, humidity, pressure, and wind velocity. As the exact time of PE onset was unknown, the meteorological values attributed to each patient were the means of the values in the months or weeks at the time of diagnosis of PE. Results: The highest numbers of cases were seen in autumn (29.8%), followed by summer (28.9%), spring (22.1%), and winter (19.2%). In terms of months, the greatest number of cases occurred in June (57), followed by November (56) and October (54). Case distribution according to the months and seasons were statistically significant. The wind direction also affected the incidence of PE. There was a statistically significant positive correlation between case frequency and air temperature (r=0.300; p=0.031). No correlation was found between the unprovoked PE cases' monthly distribution and pressure, humidity, or temperature. However, there was a statistically significant positive correlation between the monthly distribution of the group with provoked PE cases and air temperature (r=0.586; p=0.045). Conclusion: A statistically significant inverse correlation between atmospheric pressure and temperature and the number of all PE cases was observed in our study, which is in accordance with other reports. However, in unprovoked PE cases, there was no correlation between meteorological parameters and case incidence.

Lung Cancer, 2005

The role of transbronchial needle aspiration (TBNA) in diagnosing endobronchial lung cancers has ... more The role of transbronchial needle aspiration (TBNA) in diagnosing endobronchial lung cancers has not been elucidated. The definitive combination of procedures that offers the best diagnostic yield following fiberoptic bronchoscopy remains controversial. This study was designed to investigate the diagnostic yield of transbronchial needle aspiration and other cytologic and histologic diagnostic procedures (i.e., forceps biopsy, brushing, and washing) and to assess the optimal combination for diagnosing endobronchial lung cancers. This prospective study included 95 patients presenting with visible tumors detected during bronchoscopic procedure as either an exophytic endobronchial lesion (EEL) or submucosal-peribronchial disease (SPD). Transbronchial needle aspiration, forceps biopsy, brushing, and washing were performed in all patients, and 91 patients were diagnosed. Rates of positive results were 75.8% for needle aspiration, 71.6% for forceps biopsy, 61.1% for brushing, and 32.6% for washing. Needle aspiration was used as the sole diagnostic method in 11, forceps biopsy was the sole diagnostic method in 5, and brushing was the sole diagnostic method in 4 patients. Washing was not used as the sole diagnostic method in any case. Forceps biopsy yielded the highest diagnostic rate for an EEL (86.4%); however, when compared with needle aspiration (77.9%), no significant difference was observed between these two procedures (P = 0.302). In patients with a diagnosis of SPD, needle aspiration was determined to be the sole diagnostic method in eight patients. In this group of patients, the highest rate of diagnosis was achieved with needle aspiration (72.2%), and when compared with forceps biopsy (47.2%), a significant difference between the two procedures (forceps biopsy versus needle aspiration) was observed (P = 0.049). By adding transbronchial needle aspiration to the conventional diagnostic methods (forceps biopsy, brushing, and washing), the rate of diagnosis increased from 82.1% to 95.8% (P = 0.001), and in patients with a diagnosis of SPD, this rate increased from 69.4% to 94.4% (P = 0.008). In patients with a diagnosis of an EEL, addition of needle aspiration led to an increase in diagnostic yield but this difference was not statistically significant (89.8% versus 96.6%, P = 0.250). In endobronchial lung cancers, transbronchial needle aspiration is a safe method that can be used together with conventional diagnostic procedures to increase the diagnostic yield and should be considered a valuable diagnostic tool, particularly in cases of SPD. The highest rate of diagnostic yield in this study was obtained using a combination of forceps biopsy, transbronchial needle aspiration, and brushing; washing did not contribute to this high rate.

igh.dergisi.org

Malign hastalıkların seyri sırasında yaklaşık olarak % 30 oranında pulmoner metastazlar gelişmekt... more Malign hastalıkların seyri sırasında yaklaşık olarak % 30 oranında pulmoner metastazlar gelişmektedir. Pulmoner metastatik lezyonlar daha çok parankimde görülmekte olup, endobronşiyal metastazlar nadir görülmektedir. 37 yaşında erkek olgunun akciğer radyogramında solda total atelektazi mevcuttu. Olgu 2 yıl önce sol asetabulumda osteosarkom nedeniyle opere edilmişti. Olgudan alınan bronkoskopik biyopsi materyalinin patolojisi osteosarkom metastazı olarak rapor edildi. Nadir görülmesi sebebiyle endobronşiyal metastaz yapan bir opere osteosarkom olgusu sunulmuştur.

European Respiratory Journal, 2012

Background and aim: There are some studies suggesting that adaptive support ventilation (ASV), a ... more Background and aim: There are some studies suggesting that adaptive support ventilation (ASV), a closed loop ventilation mode, shortens the weaning duration in some patient groups. We aimed to investigate the effect of ASV on total duration of mechanical ventilation (MV), weaning and intensive care unit (ICU) stay when compared to pressure controlled ventilation (PCV), a conventional mode. Materials and Methods: Patients who were mechanically ventilated longer than 24 hours were randomized into ASV and PCV. Demographic data and total duration of MV, weaning and ICU stay, total number of manuplations, need for sedation and complications (self-extubation, ventilator associated pneumonia) were compared. Results: Data are expressed as median (IQR). 96 patients (73 COPD) were enrolled between December 2011 and February 2012. Duration of weaning was 2 hours (2–7) in ASV and 4 hours (2–26) in PCV (p=0.013). Number of manuplations were 2 (1–3) in ASV and 3 (1–6) in PCV (p Conclusion: ASV se...

Balkan Medical Journal, 2018

Background: The prognostic value of amino terminal pro-brain natriuretic peptide levels in patien... more Background: The prognostic value of amino terminal pro-brain natriuretic peptide levels in patients with acute exacerbation of chronic obstructive pulmonary disease has not been fully established. Aims: To investigate the predictive value of amino terminal pro-brain natriuretic peptide levels in terms of mortality, need for noninvasive mechanical ventilation, invasive mechanical ventilation, and weaning success. Study Design: Cohort study. Methods: Patients who were admitted to intensive care unit between December 2015 and December 2016 due to acute exacerbation of chronic obstructive pulmonary disease were included in the study. Demographic data, noninvasive mechanical ventilation application, need for invasive mechanical ventilation, amino terminal pro-brain natriuretic peptide level, duration of mechanical ventilation, intensive care unit and hospital stay, weaning success, and mortality rates were recorded. Results: A total of 110 patients (75 males) were included in the study. ...

Tuberkuloz ve Toraks

Characteristics of influenza pneumonia patients admitted to the iCu due to hypoxemic respiratory ... more Characteristics of influenza pneumonia patients admitted to the iCu due to hypoxemic respiratory failure introduction: Hypoxemic respiratory failure due to influenza pneumonia during epidemic seasons sometimes may require mechanical ventilation support and intensive care unit (ICU) stay. We aimed to evaluate the characteristics and risk factors of influenza pneumonia patients admitted to our ICU due to hypoxemic respiratory failure. Materials and Methods: Patients admitted to our ICU between December 2015 and March 2016 who had hypoxemic respiratory failure due to clinically and radiologically suspected influenza pneumonia were enrolled. Results: Twenty two patients (11 male) met the enrollment criteria. Median age and APACHE II score was 45 (36-63) years and 19 (13-25) respectively. Maximum set PEEP levels during mechanical ventilation was significantly lower in patients who survived [10 (8-10) vs 13 (10-16), p= 0.025)]. Deceased patients spent more time under a PaO 2 /FiO 2 ratio below 100 [72 (24-90) vs. 0 (0-48) hours, p= 0.024]. Survival rate was 88% (7/8) in patients who had noninvasive ventilation (NIV) success while it was only 7% (1/14) in patients who had undergone invasive mechanical ventilation (p< 0.001). Overall mortality was 64%. Conclusion: Viral pneumonia may result in severe hypoxemic respiratory failure and ARDS especially during epidemic seasons. NIV success, time spent under a PaO 2 /FiO 2 ratio below 100 and low serum albumin levels at admission may be predictors of severity of the disease and mortality.

Tuberkuloz Ve …, 2008

Since 1939, it has been known that, silicosis and extrinsic allergic alveolitis can be seen among... more Since 1939, it has been known that, silicosis and extrinsic allergic alveolitis can be seen among dental technicians. The interstitial disease caused by the exposure to complex substances used by dental technicians is classified as a special group called dental technician&amp;amp;amp;amp;amp;#39;s pneumoconiosis. A 36-year-old man, who has no smoking history, presented with severe dyspnea. He had worked in different dental laboratories for 22 years, but he did not have respiratory symptoms until five years ago. After that date, he had hospitalized and had been examined for respiratory pathologies for many times. He had came to our clinic, because of the progression of his dyspnea. Diffuse pulmonary parenchymal infiltrates which can be related with pneumoconiosis and chronic type 1 respiratory deficiency had been diagnosed as the result of the examinations. While he has no history of smoking or any other risk factors or diseases in his medical history, the case was accepted as dental technician&amp;amp;amp;amp;amp;#39;s pneumoconiosis. The factors related with the pathogenesis of dental technician&amp;amp;amp;amp;amp;#39;s pneumoconiosis are; the complex compound of the substances (metal dusts, silica, plaster, wax and resins, chemical liquids, methyl methacrylate) used in this sector and their effects on the lung parenchyma. Extrinsic allergic alveolitis related with methyl methacrylate has been reported. The most important factor to acquire an occupational lung disease is a complex occupational exposure. The insufficient workplace airing and the lack of preventive measures added on this exposure, the risks become much more greater.

TURKISH JOURNAL OF MEDICAL SCIENCES

Background/aim: Cancer patients frequently need intensive care support due to respiratory failure... more Background/aim: Cancer patients frequently need intensive care support due to respiratory failure. We aimed to evaluate the predictors of mortality in cancer patients who were admitted to the intensive care unit (ICU). Materials and methods: This study was performed in the ICUs of two centers between 1 January 2008 and 31 December 2015. Demographic data, cancer type, causes of respiratory failure, comorbidities, APACHE II scores, treatments, and mortality rates were recorded. Results: A total number of 583 cancer patients (477 males) were enrolled from the two centers. Of those, 472 patients had lung cancer (81%), while 111 had extrapulmonary malignancies (19%), having similar mortality rates. Causes of respiratory failure were mostly invasion of the cancer itself in 84% of cases and due to infection in 12%. ICU mortality rate was 53% and the 1-year mortality rate was 80%. APACHE II scores were significantly higher in nonsurvivors (P < 0.001). One-year survival was found to be significantly shorter in females than males (9 days vs. 12 days) in patients with lung cancer. Conclusion: Mortality rates of cancer patients who need ICU support are higher than overall ICU mortality. High APACHE II scores and female sex seem to be related to mortality in these patients.

Turkish Journal of Intensive Care

İnsanlarda bulunan mikroorganizmaların tamamına "mikrobiyota", mikroorganizmaların genomuna ise "... more İnsanlarda bulunan mikroorganizmaların tamamına "mikrobiyota", mikroorganizmaların genomuna ise "mikrobiyom" adı verilmektedir. İnsan vücudunda trilyonlarca, neredeyse konak hücrelerin 10 katı kadar bakteri olduğu tahmin edilmektedir. İnsan, kabaca %10'u insan hücresi, %90'ı bu konağa yerleşmiş mikrobiyal hücrelerden oluşan bir süperorganizmadır (1). İnsan vücudunda birçok organ ve dokuda kolonize olmuş toplam 1014 mikroorganizma olduğu tahmin edilmektedir. Ayrıca bu mikroorganizmalar insan genomundan 150 kat fazla gen içermektedir (2-4). Normal şartlar altında sağlıklı bireylerde barsak florasının %90'ını gram-pozitif Firmicutes (Clostridium, Eubacterium, Ruminococcus, Butyrivibrio, Roseburia, Anaerostipes, Faecalibacterium), gram-negatif Bacteroidetes, Proteobacteria ve gram-pozitif Actinobacteria (Bifidobacterium cinsleri) tipi organizmalar oluşturmaktadır. Firmicutes oranı tüm floranın %60'ı, Bacteroidetes %10 ve Actinobacteria %10 kadarını oluşturmaktadır. Flora belirli bir ABSTRACT It is estimated that there are a total of 1014 microorganisms colonized in many organs and tissues in the human body. It is also estimated that there are trillions of bacteria in the human body, almost 10 times that of host cells. This new life association, which we define as microbiomes, has been shown to be essential for protection against enteric and systemic pathogens through many direct and indirect (immunologically mediated) mechanisms in preclinical studies. Dysbiosis or imbalance in the homeostasis of the intestinal microbiota has been associated with many different diseases such as diabetes, obesity, inflammatory bowel disease and rheumatoid arthritis. In general, intestinal microbiota in patients with sepsis following intensive care unit (ICU) follow-up is characterized by lower diversity and commensal species (such as Faecalibacterium, Blautia, Ruminococcus) and an increase in strains such as Escherichia, Shigella, Salmonella, Enterococcus, C. difficile or Staphylococcus. Current treatment methods are based on two principles, either to reduce the excess proliferation of potentially pathogenic microorganisms (decolonization strategies) or to re-supply the pool of beneficial organisms. As in all areas, research on microbiota-targeted treatment strategies in ICU continues.

Turkish thoracic journal, Jan 13, 2018

We aimed to obtain information about the characteristics of the ICUs in our country via a point p... more We aimed to obtain information about the characteristics of the ICUs in our country via a point prevalence study. This cross-sectional study was planned by the Respiratory Failure and Intensive Care Assembly of Turkish Thoracic Society. A questionnaire was prepared and invitations were sent from the association's communication channels to reach the whole country. Data were collected through all participating intensivists between the October 26, 2016 at 08:00 and October 27, 2016 at 08:00. Data were collected from the 67 centers. Overall, 76.1% of the ICUs were managed with a closed system. In total, 35.8% (n=24) of ICUs were levels of care (LOC) 2 and 64.2% (n=43) were LOC 3. The median total numbers of ICU beds, LOC 2, and LOC 3 beds were 12 (8-23), 14 (10-25), and 12 (8-20), respectively. The median number of ventilators was 12 (7-21) and that of ventilators with non-invasive ventilation mode was 11 (6-20). The median numbers of patients per physician during day and night were...

Turkish thoracic journal, Jan 13, 2018

Journal of İzmir Chest Hospital

Chronic Obstructive Pulmonary Disease - A Current Conspectus, 2021

Erciyes Medical Journal, 2019

Turkish Journal of Medical and Surgical Intensive Care, 2017

Balkan Medical Journal, 2015

Lung Cancer, 2005

igh.dergisi.org

European Respiratory Journal, 2012

Balkan Medical Journal, 2018

Tuberkuloz ve Toraks

Tuberkuloz Ve …, 2008

TURKISH JOURNAL OF MEDICAL SCIENCES

Turkish Journal of Intensive Care

Turkish thoracic journal, Jan 13, 2018