İlgi Şemin - Academia.edu (original) (raw)

Papers by İlgi Şemin

Noropsikiyatri Arsivi-archives of Neuropsychiatry, Sep 15, 2011

Bebek kayb› ile oluflan komplike yas, hem anne hem de sonraki kuflaklar için olumsuz sonuçlar› ol... more Bebek kayb› ile oluflan komplike yas, hem anne hem de sonraki kuflaklar için olumsuz sonuçlar› olan, ruhsal hastal›klar aç›s›ndan incinebilirli¤i artt›ran bir durumdur Bu çal›flma, yavru kay›plar›n›n difli s›çanlara etkilerini ve bir sonraki jenerasyon için do¤urabilece¤i sonuçlar› araflt›rmay› amaçlayan bir hayvan modeli çal›flmas›d›r. Yöntemler: Primipar Sprague-Dawley s›çanlar› ayr›lma-birleflme grubu, tam ayr›l›k grubu ve ayr›l›k yaflamayan kontrol grubu olarak gruplanm›flt›r. Ayr›lmay›, birleflmeyi ve bir sonraki yavrular›n do¤umunu izleyen süreçlerde annelik davran›fllar› gözlenmifl, kan kortikosteron düzeyleri ölçülmüfltür. Gruplar›n ikinci kuflak yavrular›n ö¤renmeleri, aktivite düzeyleri, anksiyete durumlar› ve psikojenik stresöre maruziyetin ard›ndan kan kortikosteron düzeyleri incelenmifltir. Bulgular: Yavrular›ndan ayr›l›p, tekrar birleflen s›çanlar›n birleflmeyi takiben yuvada anlaml› olarak daha fazla zaman geçirdikleri ve ikinci kuflak yavrular›n› an-laml› düzeyde daha fazla yalad›klar› görülmüfltür. Bu grubun kontrol grubunda gözlenen ikinci kuflak yavrular› emzirme süresindeki anlaml› art›fl› göstermedi¤i saptanm›flt›r. Anne s›çanlar›n kan kortikosteron düzeyleri yavrulardan ayr›lma ve birleflme sonras› anlaml› olarak etkilenmifltir. Erken yavru kayb› yaflayan annelerin sonraki kuflak yavrular›nda kontrol grubuyla karfl›laflt›r›ld›¤›nda anlaml› düzeyde daha fazla biliflsel bozulma saptanm›flt›r. Sonuç: Hayvan modellerinde kay›p süreçlerinin çal›fl›lmaya devam edilmesinin yas sürecindeki anneler ve bebekleri için klinik de¤eri olabilir.(Nöropsikiyatri Arflivi 2011; 48: 44-52) Anahtar kelimeler: Komplike yas, yavru kayb›, annelik davran›fl›, kan kortikosteron düzeyi, ö¤renme ABSTRACT Objective: Loss of a baby accompanied by complicated grief increases vulnerability to mental disease with adverse consequences both for the mother and the long-term well-being of the subsequent generations. This study presents an animal model and aims to study the reactions of female rats to the loss of their litters and the consequences for the next litter. Methods: Primiparious Sprague-Dawley rats were recruited into three groups: of separation-reunion, complete separation and no-separation. Maternal behaviors following separation, reunion and the birth of the subsequent litter were observed. The blood corticosterone levels of the dams in response to separation and reunion were measured. Learning, activity, anxiety and blood corticosterone response to stress of the second litters were evaluated. Results: Dams in the separation group spent significantly more time at the nest following reunion, displayed increased pup licking in their second litters compared to their first litters and did not achieve the increased duration of nursing in their second generation litters as observed for the control group. Dams' blood corticosterone levels were significantly influenced by separation and reunion. Pups born to mothers that have experienced an early loss of their previous litters had significantly impaired cognitive abilities compared to controls. Conclusion: Further analysis of the process of loss in animal models may have clinical implications for bereaved mothers.

Türk biyokimya dergisi, Aug 1, 2022

Objectives: Virtual laboratory simulations (VLSs) are computer-based tools that offer unlimited a... more Objectives: Virtual laboratory simulations (VLSs) are computer-based tools that offer unlimited application options in scientific, medical, and engineering fields. The aim of this study was to evaluate whether VLSs are efficient learning tools and how these simulations can be integrated into laboratory practice in medical laboratory education. Methods: In this pre-test/post-test control group study, 32 volunteers were randomly assigned to either experimental or control groups. The experimental group performed laboratory simulations based on biochemistry and microbiology and then completed a self-report survey to evaluate their satisfaction and beliefs about simulations. Results: In the experimental group, post-test scores of each simulation were significantly elevated compared to pre-test scores; however, pre-and post-test scores of control group were statistically the same. The experimental group agreed that these simulations should be applied before theoretical lectures and laboratory practices. They also highlighted that translating from English to their native language creates difficulties in applying and understanding the simulation. Conclusions: We emphasized that VLSs are excellent learning tools that increase not only the knowledge but also the self-motivation and focus of the students. Based on feedbacks, native language options are necessary to enable the students to achieve equality of opportunity in education.

Tobacco Induced Diseases, Oct 3, 2018

The aim of this study was to identify probable intermediate biomarkers of disturbed pathways and ... more The aim of this study was to identify probable intermediate biomarkers of disturbed pathways and their link between smoking. Methods Un-stimulated whole saliva and serum samples were collected from a total of 30 systemically healthy participants with periodontally healthy smokers (S) (n=15) and nonsmokers (n=15). Periodontal indices (plaque index, gingival index, probing depth, bleeding on probing, clinical attachment level) were recorded to confirm periodontal health. Saliva was purified, and a total of 28 amino acids and metabolites were analyzed by liquid chromatographymass spectrometry (LC-MS/MS). Smoking status was validated measuring serum cotinine levels. Intergroup comparisons were assessed using the Mann Whitney U test. Results When 28 amino acids were evaluated, smokers had statistically significantly higher cystathionine levels than non-smokers (p <0.05). Conclusions Saliva cystathionine is associated with smoking in periodontally healthy individuals, and is possibly related to altered sulfuration pathway.

Physiological Research

Progressive compromise of antioxidant defenses and free radical-mediated lipid peroxidation, whic... more Progressive compromise of antioxidant defenses and free radical-mediated lipid peroxidation, which is one of the major mechanisms of secondary traumatic brain injury (TBI), has also been reported in pediatric head trauma. In the present study, we aimed to demonstrate the effect of melatonin, which is a potent free radical scavenger, on brain oxidative damage in 7-day-old rat pups subjected to contusion injury. Whereas TBI significantly increased thiobarbituric acid reactive substances (TBARS) levels, there was no compensatory increase in the antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPx) 24 hours after TBI in 7-day-old rats. Melatonin administered as a single dose of 5 mg/kg prevented the increase in TBARS levels in both non-traumatized and traumatized brain hemispheres. In conclusion, melatonin protects against oxidative damage induced by TBI in the immature brain.

Physiological Research

In a previous study we demonstrated that acute footshock stress increased glutathione peroxidase ... more In a previous study we demonstrated that acute footshock stress increased glutathione peroxidase activity in the prefrontal cortex and striatum of adult male rats. Adolescents may respond differently to stress as life stressors may be greater than at other ages. The present study examined the effects of the acute footshock stress on superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzyme activities and thiobarbituric acid reactive substances (TBARS) levels in adolescent male and female rat brains. We demonstrated that acute footshock stress increased SOD activity in the prefrontal cortex, and increased GPx activity in the hippocampus in female rats. In males, acute footshock stress increased GPx activity in the prefrontal cortex and hippocampus. Footshock stress did not change TBARS levels. These results indicate a strong role of gender in the response of adolescent subjects to various aspects of stress.

Physiological Research

Melatonin has recently been suggested as an antioxidant that may protect neurons from oxidative s... more Melatonin has recently been suggested as an antioxidant that may protect neurons from oxidative stress. Acute ethanol administration produces both lipid peroxidation as an indicator of oxidative stress in the brain and impairs water-maze performance in spatial learning and memory tasks. The present study investigated the effect of melatonin against ethanol-induced oxidative stress and spatial memory impairment. The Morris water maze was used to evaluate the cognitive functions of rats. Thiobarbituric acid reactive substances (TBARS), which are the indicators of lipid peroxidation, and the activities of antioxidative enzymes (glutathione peroxidase and superoxide dismutase) were measured in the rat hippocampus and prefrontal cortex which form interconnected neural circuits for spatial memory. Acute administration of ethanol significantly increased TBARS levels in the hippocampus. Combined melatonin-ethanol treatment caused a significant increase in glutathione peroxidase activities a...

Research Quarterly for Exercise and Sport, 2020

Purpose: There is no significant evidence of both biological and motivational effects between vir... more Purpose: There is no significant evidence of both biological and motivational effects between virtual reality exercises to traditional/conventional exercise. The aim of this study is to assess the biological and motivational effects of aerobic exercises with virtual reality and traditional exercise methods. Methods: 20 students participated as control and 60 students were divided randomly and equally into two groups, virtual reality exercise group (VRE) and traditional exercise group (TE). Two groups completed the exercise training. Tests were applied to the three groups at the beginning and in the end of the study. An activity monitor and pulse oximeter were used to measure energy expenditure during exercises. Results: After eight weeks, the data from pulse oximeter showed no statistical significance between the exercise groups. The active energy expenditure, PAL and step counts were statistically significant in TE group. There was a statistically significant increase in the sleep quality of the TE group (p = .000). There was no statistical significance among the anxiety scores of all groups. In the spring semester, there was a statistically significant increase in both VRE and TE groups compared to the fall semester (p < .05). Conclusion: The virtual reality exercises produce greater motivational effects, whereas traditional exercises bring greater physical improvements.

Amac: Herhangi bir sekilde ani olarak hastalanan veya kazaya ugrayan kimseye olay yerinde bilincl... more Amac: Herhangi bir sekilde ani olarak hastalanan veya kazaya ugrayan kimseye olay yerinde bilincli ilk yardimcilarin mudahale etmesi ve hayat kurtarma zincirinin ilk adimlarinin baslatilmasi cok onemlidir. Bu arastirma, bireylerin ilkyardim bilgilerini olcmek ve dogru uygulamalar icin egitim gereksinimlerini saptamak ve bu dogrultuda zamaninda ve dogru ilk yardim yaklasimlarini kolaylastiracak mobil aplikasyonlar gelistirmek amaciyla planlanmistir. Gerec ve Yontemler: Arastirmacilar tarafindan hazirlanan 27 soruluk anket formu, Izmir Ekonomi Universitesi Saglik Hizmetleri Meslek Yuksekokulu bunyesindeki programlarda, ilkyardim dersi alan ogrenciler tarafindan uygulanmistir. Orneklem tesadufi ornekleme yontemiyle belirlenmis ve arastirmaya Izmir ilinde yasayan, 18-100 yas arasinda 390 kisi dâhil edilmistir. Arastirmaya katilmayi kabul eden kisilere anketler yuz yuze uygulanmis ve uygulama sirasinda eksik ya da yanlis bilgiler ogrenciler tarafindan belirlenerek, gerekli bilgilendirme...

Egzersiz siresmde kas dokusunda kanlanma artarken, ince barsak ve bob rek dokulannda azalmakta ve... more Egzersiz siresmde kas dokusunda kanlanma artarken, ince barsak ve bob rek dokulannda azalmakta ve egzersizden sonra yeniden duzelmekieotr. Bu kanlanma degi$ikliginden yola 91karak uzun siueli egzersizden sonra kes, ince barsak ve bobrek dokulannda oksidan hasan erestumek emeciyle bu cehsm« plentenmssnr. Denekler 7 hafta sureyte giderek artan sekllde, en son haftada 5 gun, qimde 30 dakika, 5 derece egimde 20 m/dak tuzae kU9uk hap!p.n kosu ban dtnde antrene edilmisler, son antrenmandan 2 gun sonra eytn egim ve tiizde 60 dakika kosiutulmusterd«. 2. grupta bulunan farelerin hemen egzersizin bitimin de, 3. gruptakilerin egzersizden 3 saat sonra, 4. gruptakilerin ise 24 saat sonra ince barsak, kas ve b6brek dokulan ve kontrol grubunun (1. grup) dokulan alma rak, superokstt dismutaz, glutatyon peroksidaz, ksantin oksidaz ektiviieleti ve tt

Tıp Eğitimi Dünyası, 2021

Amaç: Bu çalışmada, 2019-20 eğitim yılı bahar yarıyılında İEÜTF tıp eğitiminde, COVID-19 pandemis... more Amaç: Bu çalışmada, 2019-20 eğitim yılı bahar yarıyılında İEÜTF tıp eğitiminde, COVID-19 pandemisinde uyarlanan yöntemleri/uygulamaları tanımlamak ve sonuçlarını tartışmak amaçlanmaktadır. Gereç ve Yöntem: Makalede İEÜTF tıp eğitimi tanıtılmış, pandemi nedeniyle eğitim programında yapılan değişiklikler, eğitimin nasıl yürütüldüğü ve değerlendirmesi konusundaki bilgiler paylaşılmıştır. Bulgular: İEÜTF pandemi öncesinde de eğitimde teknolojiyi yaygın kullanmakta olup, uzaktan eğitime neredeyse hiç ara vermeden başlayabilmiş, planlanan eğitsel etkinlikler gerçekleştirilmiştir. Bunda İEÜTF’de yalnızca ilk üç sınıfın eğitim görmesinin payı da büyüktür. Yüz yüze eğitimin zorunlu olduğu teknik ve klinik beceri uygulamaları ertelenmiştir. Sonuç: Halen yaşanan COVID-19 pandemi sürecinde tıp eğitiminde klinik eğitimlerin nasıl yürütüleceği konusunda stratejiler geliştirilmelidir. Yaşanan tüm bu sürecin, uzun vadede tıp eğitiminde değişikliğe neden olacağı düşünülmektedir.

Turkiye Klinikleri Journal of Health Sciences, 2016

In this study, we aimed to investigate whether "Health and Life" course improved the university s... more In this study, we aimed to investigate whether "Health and Life" course improved the university students' healthy lifestyle behavior or not and to determine the most preferred educational method used during the course. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : The research design was based on the principle of single group pretest-posttest pattern. The participants were 47 students who had attended "Health and Life" course in Izmir University of Economics at Fall semester of 2014-2015 educational year. Students completed a questionnaire, containing the Healthy Lifestyle Behavior-II Scale (HLSB-II) as well as additional questions about health behavior (11 items) and educational methods, in the first week of the course (pretest) and before the final exam (posttest). R Re es su ul lt ts s: : The internal consistency coefficient consulted for the analysis of the HLSB-II scale reliability was determined as Crohnbach α: 0.93. Mean pretest scale score was 136.79±17.80, and posttest was 148.34±20.89. The difference between pretest and posttest was statistically significant by paired samples t-test (p<0.05). The highest mean score for the subcategories of the scale that contribute to the development of healthy lifestyle, was interpersonal relations (28.23±3.95/28.98±4.13), whereas the lowest mean score was physical activity (18.81±4.88/21.63±4.77). The "collaborative learning method-small group discussion after presentation" was found more useful educational method (41.3%) than the other methods as interactive method-question-answer (26.1%), lecturing (21.7%) and flipped classroom (10.9%). C Co on nc cl lu us si io on n: : Education should be organized to improve the university students' understanding of three components of health and their lifestyle behavior, and small group discussions with the enhanced cooperative learning methods would be preferred.

Indian journal of physiology and pharmacology, 1999

Physiological Research, 2006

In the present study, we investigated whether erythropoietin (Epo) has a protective effect agains... more In the present study, we investigated whether erythropoietin (Epo) has a protective effect against cytotoxicity induced by interferon-gamma (IFN-gamma ) and lipopolysaccharide (LPS) in primary rat oligodendrocyte cultures. The possible modulatory effect of erythropoietin on inducible nitric oxide synthase (iNOS) mRNA expression and nitrite production were also analyzed. Erythropoietin exerted a significant protective effect against IFN-gamma and LPS-induced oligodendrocyte injury as determined by lactate dehydrogenase assay. Treatment with erythropoietin inhibited the expression of iNOS mRNA and nitrite production resulting from proinflammatory stimulation by IFN-gamma and LPS. These results suggest that erythropoietin has protective effects against inflammatory oligodendrocyte injury in vitro and may play a protective role in neurological disorders characterized by oligodendrocyte death, such as multiple sclerosis.

DergiPark (Istanbul University), Mar 14, 2023

Objectives: The morbidities and long-term multiple medication use among elderly. Methods: The stu... more Objectives: The morbidities and long-term multiple medication use among elderly. Methods: The study was conducted by the 2nd grade medical students from Izmir University of Economics under the supervision of instructors. In this descriptive cohort, the study sample included 45 individuals over 65 years of age among the identified 150 residents in Balcova. The response rate was 26.4% for men and 73.3% for women. A questionnaire was defined for a face-to-face interview, which included sociodemographic variables, medical history, lifestyle, systems inquiry, and a detailed list of all medications. Results: Mean age of the elderly was 78.5 ± 7.2 years. Women, widows, and primary school graduates constituted the majority. Hypertension, osteoarthritis, and osteoporosis were the leading morbidities by 71.1, 46.7 and 31.1% respectively. Stroke, kidney disease and migraine were the least morbidities by 3%. 66.7% were using five or more than five medications, 93.3% were using medications prescribed by the doctor, none complained of adverse effects, 4.4% were non-compliant to treatment and 28.9% were using vitamin supplements and herbal remedies. Conclusion: Increase in the prevalence of age-related chronic diseases is accompanied by an increase in polypharmacy,

Tıp eğitimi dünyası, Dec 30, 2020

Meslekler arası eğitim (IPE); tıp, sağlık ve sosyal hizmet alanları içerisinde iki veya daha fazl... more Meslekler arası eğitim (IPE); tıp, sağlık ve sosyal hizmet alanları içerisinde iki veya daha fazla meslekten öğrenenin, iş birliğini ve hizmet niteliğini arttırmak amacıyla, birbirleri hakkında ve birbirlerinden öğrenme sürecidir. IPE ile bütüncül bir bakım anlayışı, sağlık ve sosyal hizmet çalışmalarının birbirleriyle koordine ve çözüm odaklı çalışmaları, daha esnek çalışma standartlarının belirlenmesi hedeflenmektedir. IPE dünyada çeşitli sağlık meslekleri eğitimi müfredatında yer almaktadır. Ülkemizde Sağlık Hizmetleri Meslek Yüksekokullarında bu konuda eğitim programlarının geliştirilmesine ihtiyaç vardır. Bir eğitim programının başarılı olabilmesi için öğretim üyeleri, öğrenciler ve eğitim yöneticileri tarafından kabul edilmesi kritiktir. Bu nedenle meslekler arası eğitim konusunda program geliştirme aşamasında öğrencilerin hazırbulunuşluğu incelenmelidir. Bu çalışmanın amacı, Sağlık Hizmetleri Meslek Yüksekokulu öğrencilerinin meslekler arası eğitime hazır olup olmadıklarının belirlenmesidir. Gereç ve Yöntem: Çalışma kesitsel olarak tasarlanmış ve Türkiye'deki dört Sağlık Hizmetleri Meslek Yüksekokulu'nda yürütülmüştür. Uygun örnekleme yöntemi kullanılan araştırmada ölçme aracı olarak Parsell and Bligh (1999) tarafından geliştirilen Meslekler arası Eğitime Hazırbulunuşluk Ölçeği (RIPLS) kullanılmıştır. Veri analizinde tanımlayıcı istatistikler ve Student t-testi uygulanmıştır.

Turkish Journal of Biochemistry

Objectives Virtual laboratory simulations (VLSs) are computer-based tools that offer unlimited ap... more Objectives Virtual laboratory simulations (VLSs) are computer-based tools that offer unlimited application options in scientific, medical, and engineering fields. The aim of this study was to evaluate whether VLSs are efficient learning tools and how these simulations can be integrated into laboratory practice in medical laboratory education. Methods In this pre-test/post-test control group study, 32 volunteers were randomly assigned to either experimental or control groups. The experimental group performed laboratory simulations based on biochemistry and microbiology and then completed a self-report survey to evaluate their satisfaction and beliefs about simulations. Results In the experimental group, post-test scores of each simulation were significantly elevated compared to pre-test scores; however, pre- and post-test scores of control group were statistically the same. The experimental group agreed that these simulations should be applied before theoretical lectures and laborato...

TED EĞİTİM VE BİLİM, 2020

Bu araştırmanın amacı, erken çocukluk dönemindeki çocuklarla yürütülen yoga çalışmasının çocuklar... more Bu araştırmanın amacı, erken çocukluk dönemindeki çocuklarla yürütülen yoga çalışmasının çocukların bilişsel işlevlerine etkisini incelemektir. Bu araştırma, Ön Test-Son Test Kontrol Gruplu Deney Deseni (ÖSKD) ile yapılan yarı-deneysel bir çalışmadır. Araştırmanın örneklemi, İzmir ilindeki iki okul öncesi kurumunda öğrenim görmekte olan 4-5 yaş grubunda 10'u deney 18'i kontrol grubuna dâhil edilen 28 çocuktan oluşmaktadır. Araştırmada çocukların bilişsel işlevlerini belirlemek amacıyla "Bilişsel İşlevlerin Uygulanması Ölçeği (BİUÖ)" ve "Kişisel Bilgi Formu" kullanılmıştır. Araştırmada deney grubuna dahil edilen çocuklara 12 hafta boyunca haftanın 1 günü, 1 saat olmak üzere sertifikalı uzman yoga eğitmeni önderliğinde yoga eğitimi verilmiştir. Kontrol grubuna dâhil edilen çocuklara ise herhangi bir müdahalede bulunulmamıştır. Verilerin analizinde Mann Whitney-U testi ve Wilcoxon İşaretli Sıra testi kullanılmıştır. Araştırmadan elde edilen bulgulara göre; deney grubuna dâhil edilen çocukların BİUÖ toplam puanları ve Görevler Bölümü alt ölçeklerinden aldıkları son test puan ortalamaları ön test toplam puan ortalamalarından anlamlı düzeyde yüksek bulunmuştur. Kontrol grubuna dâhil edilen çocukların son test puan ortalamaları ile ön test puan ortalamaları arasında anlamlı bir fark bulunmamıştır. Deney ve kontrol gruplarının son test puan ortalamaları karşılaştırıldığında, kısa süreli işitsel bellek, bakış açısı alma ve sözel planlama alt ölçeklerinde istatistiksel olarak anlamlı bir farklılaşma olmadığı; sınıflandırma, kısa süreli işitsel bellek yeniden hatırlama, kısa süreli görsel bellek ve örüntü tamamlama alt ölçekleri ve BİUÖ son test toplam puanları arasında istatistik olarak anlamlı bir farklılaşma olduğu görülmektedir. Araştırmanın bulguları literatür doğrultusunda tartışılmıştır.

Turkish Journal of Biochemistry, 2018

Objectives: Integration of the basic medical sciences with clinical medicine motivates medical st... more Objectives: Integration of the basic medical sciences with clinical medicine motivates medical students by showing how the fundamental concepts they have learned will come into their future practice. In this context, we created clinical integration sessions (CIS) in our first-year medical curriculum. Methods: The instructors of different disciplines wrote the clinical scenarios together. The scenarios were discussed in five sessions with 39 first-year students. The first session's scenario consisted of four brief "anemia" cases. The next four sessions included a single case, according to the feedback of the students. Students formed groups of 7-8 participants. In the first 2 h, the scenarios were discussed in the groups and questions were answered by the students. In the third hour, the instructors answered the questions together with the students. After the first CIS, written feedback obtained from the students via a survey. Results: The survey provided positive feedback on the benefits of active learning within small group discussions, and most of the students thought that their background was sufficient to solve the cases, with some literature search. Conclusion: The scenarios, which provide multidisciplinary integration of basic medical sciences and clinical medicine, can be useful educational materials.

Turkiye Klinikleri Journal of Family Medicine Special Topics, 2010

Noropsikiyatri Arsivi-archives of Neuropsychiatry, Sep 15, 2011

Bebek kayb› ile oluflan komplike yas, hem anne hem de sonraki kuflaklar için olumsuz sonuçlar› ol... more Bebek kayb› ile oluflan komplike yas, hem anne hem de sonraki kuflaklar için olumsuz sonuçlar› olan, ruhsal hastal›klar aç›s›ndan incinebilirli¤i artt›ran bir durumdur Bu çal›flma, yavru kay›plar›n›n difli s›çanlara etkilerini ve bir sonraki jenerasyon için do¤urabilece¤i sonuçlar› araflt›rmay› amaçlayan bir hayvan modeli çal›flmas›d›r. Yöntemler: Primipar Sprague-Dawley s›çanlar› ayr›lma-birleflme grubu, tam ayr›l›k grubu ve ayr›l›k yaflamayan kontrol grubu olarak gruplanm›flt›r. Ayr›lmay›, birleflmeyi ve bir sonraki yavrular›n do¤umunu izleyen süreçlerde annelik davran›fllar› gözlenmifl, kan kortikosteron düzeyleri ölçülmüfltür. Gruplar›n ikinci kuflak yavrular›n ö¤renmeleri, aktivite düzeyleri, anksiyete durumlar› ve psikojenik stresöre maruziyetin ard›ndan kan kortikosteron düzeyleri incelenmifltir. Bulgular: Yavrular›ndan ayr›l›p, tekrar birleflen s›çanlar›n birleflmeyi takiben yuvada anlaml› olarak daha fazla zaman geçirdikleri ve ikinci kuflak yavrular›n› an-laml› düzeyde daha fazla yalad›klar› görülmüfltür. Bu grubun kontrol grubunda gözlenen ikinci kuflak yavrular› emzirme süresindeki anlaml› art›fl› göstermedi¤i saptanm›flt›r. Anne s›çanlar›n kan kortikosteron düzeyleri yavrulardan ayr›lma ve birleflme sonras› anlaml› olarak etkilenmifltir. Erken yavru kayb› yaflayan annelerin sonraki kuflak yavrular›nda kontrol grubuyla karfl›laflt›r›ld›¤›nda anlaml› düzeyde daha fazla biliflsel bozulma saptanm›flt›r. Sonuç: Hayvan modellerinde kay›p süreçlerinin çal›fl›lmaya devam edilmesinin yas sürecindeki anneler ve bebekleri için klinik de¤eri olabilir.(Nöropsikiyatri Arflivi 2011; 48: 44-52) Anahtar kelimeler: Komplike yas, yavru kayb›, annelik davran›fl›, kan kortikosteron düzeyi, ö¤renme ABSTRACT Objective: Loss of a baby accompanied by complicated grief increases vulnerability to mental disease with adverse consequences both for the mother and the long-term well-being of the subsequent generations. This study presents an animal model and aims to study the reactions of female rats to the loss of their litters and the consequences for the next litter. Methods: Primiparious Sprague-Dawley rats were recruited into three groups: of separation-reunion, complete separation and no-separation. Maternal behaviors following separation, reunion and the birth of the subsequent litter were observed. The blood corticosterone levels of the dams in response to separation and reunion were measured. Learning, activity, anxiety and blood corticosterone response to stress of the second litters were evaluated. Results: Dams in the separation group spent significantly more time at the nest following reunion, displayed increased pup licking in their second litters compared to their first litters and did not achieve the increased duration of nursing in their second generation litters as observed for the control group. Dams' blood corticosterone levels were significantly influenced by separation and reunion. Pups born to mothers that have experienced an early loss of their previous litters had significantly impaired cognitive abilities compared to controls. Conclusion: Further analysis of the process of loss in animal models may have clinical implications for bereaved mothers.

Türk biyokimya dergisi, Aug 1, 2022

Objectives: Virtual laboratory simulations (VLSs) are computer-based tools that offer unlimited a... more Objectives: Virtual laboratory simulations (VLSs) are computer-based tools that offer unlimited application options in scientific, medical, and engineering fields. The aim of this study was to evaluate whether VLSs are efficient learning tools and how these simulations can be integrated into laboratory practice in medical laboratory education. Methods: In this pre-test/post-test control group study, 32 volunteers were randomly assigned to either experimental or control groups. The experimental group performed laboratory simulations based on biochemistry and microbiology and then completed a self-report survey to evaluate their satisfaction and beliefs about simulations. Results: In the experimental group, post-test scores of each simulation were significantly elevated compared to pre-test scores; however, pre-and post-test scores of control group were statistically the same. The experimental group agreed that these simulations should be applied before theoretical lectures and laboratory practices. They also highlighted that translating from English to their native language creates difficulties in applying and understanding the simulation. Conclusions: We emphasized that VLSs are excellent learning tools that increase not only the knowledge but also the self-motivation and focus of the students. Based on feedbacks, native language options are necessary to enable the students to achieve equality of opportunity in education.

Tobacco Induced Diseases, Oct 3, 2018

The aim of this study was to identify probable intermediate biomarkers of disturbed pathways and ... more The aim of this study was to identify probable intermediate biomarkers of disturbed pathways and their link between smoking. Methods Un-stimulated whole saliva and serum samples were collected from a total of 30 systemically healthy participants with periodontally healthy smokers (S) (n=15) and nonsmokers (n=15). Periodontal indices (plaque index, gingival index, probing depth, bleeding on probing, clinical attachment level) were recorded to confirm periodontal health. Saliva was purified, and a total of 28 amino acids and metabolites were analyzed by liquid chromatographymass spectrometry (LC-MS/MS). Smoking status was validated measuring serum cotinine levels. Intergroup comparisons were assessed using the Mann Whitney U test. Results When 28 amino acids were evaluated, smokers had statistically significantly higher cystathionine levels than non-smokers (p <0.05). Conclusions Saliva cystathionine is associated with smoking in periodontally healthy individuals, and is possibly related to altered sulfuration pathway.

Physiological Research

Progressive compromise of antioxidant defenses and free radical-mediated lipid peroxidation, whic... more Progressive compromise of antioxidant defenses and free radical-mediated lipid peroxidation, which is one of the major mechanisms of secondary traumatic brain injury (TBI), has also been reported in pediatric head trauma. In the present study, we aimed to demonstrate the effect of melatonin, which is a potent free radical scavenger, on brain oxidative damage in 7-day-old rat pups subjected to contusion injury. Whereas TBI significantly increased thiobarbituric acid reactive substances (TBARS) levels, there was no compensatory increase in the antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPx) 24 hours after TBI in 7-day-old rats. Melatonin administered as a single dose of 5 mg/kg prevented the increase in TBARS levels in both non-traumatized and traumatized brain hemispheres. In conclusion, melatonin protects against oxidative damage induced by TBI in the immature brain.

Physiological Research

In a previous study we demonstrated that acute footshock stress increased glutathione peroxidase ... more In a previous study we demonstrated that acute footshock stress increased glutathione peroxidase activity in the prefrontal cortex and striatum of adult male rats. Adolescents may respond differently to stress as life stressors may be greater than at other ages. The present study examined the effects of the acute footshock stress on superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzyme activities and thiobarbituric acid reactive substances (TBARS) levels in adolescent male and female rat brains. We demonstrated that acute footshock stress increased SOD activity in the prefrontal cortex, and increased GPx activity in the hippocampus in female rats. In males, acute footshock stress increased GPx activity in the prefrontal cortex and hippocampus. Footshock stress did not change TBARS levels. These results indicate a strong role of gender in the response of adolescent subjects to various aspects of stress.

Physiological Research

Melatonin has recently been suggested as an antioxidant that may protect neurons from oxidative s... more Melatonin has recently been suggested as an antioxidant that may protect neurons from oxidative stress. Acute ethanol administration produces both lipid peroxidation as an indicator of oxidative stress in the brain and impairs water-maze performance in spatial learning and memory tasks. The present study investigated the effect of melatonin against ethanol-induced oxidative stress and spatial memory impairment. The Morris water maze was used to evaluate the cognitive functions of rats. Thiobarbituric acid reactive substances (TBARS), which are the indicators of lipid peroxidation, and the activities of antioxidative enzymes (glutathione peroxidase and superoxide dismutase) were measured in the rat hippocampus and prefrontal cortex which form interconnected neural circuits for spatial memory. Acute administration of ethanol significantly increased TBARS levels in the hippocampus. Combined melatonin-ethanol treatment caused a significant increase in glutathione peroxidase activities a...

Research Quarterly for Exercise and Sport, 2020

Purpose: There is no significant evidence of both biological and motivational effects between vir... more Purpose: There is no significant evidence of both biological and motivational effects between virtual reality exercises to traditional/conventional exercise. The aim of this study is to assess the biological and motivational effects of aerobic exercises with virtual reality and traditional exercise methods. Methods: 20 students participated as control and 60 students were divided randomly and equally into two groups, virtual reality exercise group (VRE) and traditional exercise group (TE). Two groups completed the exercise training. Tests were applied to the three groups at the beginning and in the end of the study. An activity monitor and pulse oximeter were used to measure energy expenditure during exercises. Results: After eight weeks, the data from pulse oximeter showed no statistical significance between the exercise groups. The active energy expenditure, PAL and step counts were statistically significant in TE group. There was a statistically significant increase in the sleep quality of the TE group (p = .000). There was no statistical significance among the anxiety scores of all groups. In the spring semester, there was a statistically significant increase in both VRE and TE groups compared to the fall semester (p < .05). Conclusion: The virtual reality exercises produce greater motivational effects, whereas traditional exercises bring greater physical improvements.

Amac: Herhangi bir sekilde ani olarak hastalanan veya kazaya ugrayan kimseye olay yerinde bilincl... more Amac: Herhangi bir sekilde ani olarak hastalanan veya kazaya ugrayan kimseye olay yerinde bilincli ilk yardimcilarin mudahale etmesi ve hayat kurtarma zincirinin ilk adimlarinin baslatilmasi cok onemlidir. Bu arastirma, bireylerin ilkyardim bilgilerini olcmek ve dogru uygulamalar icin egitim gereksinimlerini saptamak ve bu dogrultuda zamaninda ve dogru ilk yardim yaklasimlarini kolaylastiracak mobil aplikasyonlar gelistirmek amaciyla planlanmistir. Gerec ve Yontemler: Arastirmacilar tarafindan hazirlanan 27 soruluk anket formu, Izmir Ekonomi Universitesi Saglik Hizmetleri Meslek Yuksekokulu bunyesindeki programlarda, ilkyardim dersi alan ogrenciler tarafindan uygulanmistir. Orneklem tesadufi ornekleme yontemiyle belirlenmis ve arastirmaya Izmir ilinde yasayan, 18-100 yas arasinda 390 kisi dâhil edilmistir. Arastirmaya katilmayi kabul eden kisilere anketler yuz yuze uygulanmis ve uygulama sirasinda eksik ya da yanlis bilgiler ogrenciler tarafindan belirlenerek, gerekli bilgilendirme...

Egzersiz siresmde kas dokusunda kanlanma artarken, ince barsak ve bob rek dokulannda azalmakta ve... more Egzersiz siresmde kas dokusunda kanlanma artarken, ince barsak ve bob rek dokulannda azalmakta ve egzersizden sonra yeniden duzelmekieotr. Bu kanlanma degi$ikliginden yola 91karak uzun siueli egzersizden sonra kes, ince barsak ve bobrek dokulannda oksidan hasan erestumek emeciyle bu cehsm« plentenmssnr. Denekler 7 hafta sureyte giderek artan sekllde, en son haftada 5 gun, qimde 30 dakika, 5 derece egimde 20 m/dak tuzae kU9uk hap!p.n kosu ban dtnde antrene edilmisler, son antrenmandan 2 gun sonra eytn egim ve tiizde 60 dakika kosiutulmusterd«. 2. grupta bulunan farelerin hemen egzersizin bitimin de, 3. gruptakilerin egzersizden 3 saat sonra, 4. gruptakilerin ise 24 saat sonra ince barsak, kas ve b6brek dokulan ve kontrol grubunun (1. grup) dokulan alma rak, superokstt dismutaz, glutatyon peroksidaz, ksantin oksidaz ektiviieleti ve tt

Tıp Eğitimi Dünyası, 2021

Amaç: Bu çalışmada, 2019-20 eğitim yılı bahar yarıyılında İEÜTF tıp eğitiminde, COVID-19 pandemis... more Amaç: Bu çalışmada, 2019-20 eğitim yılı bahar yarıyılında İEÜTF tıp eğitiminde, COVID-19 pandemisinde uyarlanan yöntemleri/uygulamaları tanımlamak ve sonuçlarını tartışmak amaçlanmaktadır. Gereç ve Yöntem: Makalede İEÜTF tıp eğitimi tanıtılmış, pandemi nedeniyle eğitim programında yapılan değişiklikler, eğitimin nasıl yürütüldüğü ve değerlendirmesi konusundaki bilgiler paylaşılmıştır. Bulgular: İEÜTF pandemi öncesinde de eğitimde teknolojiyi yaygın kullanmakta olup, uzaktan eğitime neredeyse hiç ara vermeden başlayabilmiş, planlanan eğitsel etkinlikler gerçekleştirilmiştir. Bunda İEÜTF’de yalnızca ilk üç sınıfın eğitim görmesinin payı da büyüktür. Yüz yüze eğitimin zorunlu olduğu teknik ve klinik beceri uygulamaları ertelenmiştir. Sonuç: Halen yaşanan COVID-19 pandemi sürecinde tıp eğitiminde klinik eğitimlerin nasıl yürütüleceği konusunda stratejiler geliştirilmelidir. Yaşanan tüm bu sürecin, uzun vadede tıp eğitiminde değişikliğe neden olacağı düşünülmektedir.

Turkiye Klinikleri Journal of Health Sciences, 2016

In this study, we aimed to investigate whether "Health and Life" course improved the university s... more In this study, we aimed to investigate whether "Health and Life" course improved the university students' healthy lifestyle behavior or not and to determine the most preferred educational method used during the course. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : The research design was based on the principle of single group pretest-posttest pattern. The participants were 47 students who had attended "Health and Life" course in Izmir University of Economics at Fall semester of 2014-2015 educational year. Students completed a questionnaire, containing the Healthy Lifestyle Behavior-II Scale (HLSB-II) as well as additional questions about health behavior (11 items) and educational methods, in the first week of the course (pretest) and before the final exam (posttest). R Re es su ul lt ts s: : The internal consistency coefficient consulted for the analysis of the HLSB-II scale reliability was determined as Crohnbach α: 0.93. Mean pretest scale score was 136.79±17.80, and posttest was 148.34±20.89. The difference between pretest and posttest was statistically significant by paired samples t-test (p<0.05). The highest mean score for the subcategories of the scale that contribute to the development of healthy lifestyle, was interpersonal relations (28.23±3.95/28.98±4.13), whereas the lowest mean score was physical activity (18.81±4.88/21.63±4.77). The "collaborative learning method-small group discussion after presentation" was found more useful educational method (41.3%) than the other methods as interactive method-question-answer (26.1%), lecturing (21.7%) and flipped classroom (10.9%). C Co on nc cl lu us si io on n: : Education should be organized to improve the university students' understanding of three components of health and their lifestyle behavior, and small group discussions with the enhanced cooperative learning methods would be preferred.

Indian journal of physiology and pharmacology, 1999

Physiological Research, 2006

In the present study, we investigated whether erythropoietin (Epo) has a protective effect agains... more In the present study, we investigated whether erythropoietin (Epo) has a protective effect against cytotoxicity induced by interferon-gamma (IFN-gamma ) and lipopolysaccharide (LPS) in primary rat oligodendrocyte cultures. The possible modulatory effect of erythropoietin on inducible nitric oxide synthase (iNOS) mRNA expression and nitrite production were also analyzed. Erythropoietin exerted a significant protective effect against IFN-gamma and LPS-induced oligodendrocyte injury as determined by lactate dehydrogenase assay. Treatment with erythropoietin inhibited the expression of iNOS mRNA and nitrite production resulting from proinflammatory stimulation by IFN-gamma and LPS. These results suggest that erythropoietin has protective effects against inflammatory oligodendrocyte injury in vitro and may play a protective role in neurological disorders characterized by oligodendrocyte death, such as multiple sclerosis.

DergiPark (Istanbul University), Mar 14, 2023

Objectives: The morbidities and long-term multiple medication use among elderly. Methods: The stu... more Objectives: The morbidities and long-term multiple medication use among elderly. Methods: The study was conducted by the 2nd grade medical students from Izmir University of Economics under the supervision of instructors. In this descriptive cohort, the study sample included 45 individuals over 65 years of age among the identified 150 residents in Balcova. The response rate was 26.4% for men and 73.3% for women. A questionnaire was defined for a face-to-face interview, which included sociodemographic variables, medical history, lifestyle, systems inquiry, and a detailed list of all medications. Results: Mean age of the elderly was 78.5 ± 7.2 years. Women, widows, and primary school graduates constituted the majority. Hypertension, osteoarthritis, and osteoporosis were the leading morbidities by 71.1, 46.7 and 31.1% respectively. Stroke, kidney disease and migraine were the least morbidities by 3%. 66.7% were using five or more than five medications, 93.3% were using medications prescribed by the doctor, none complained of adverse effects, 4.4% were non-compliant to treatment and 28.9% were using vitamin supplements and herbal remedies. Conclusion: Increase in the prevalence of age-related chronic diseases is accompanied by an increase in polypharmacy,

Tıp eğitimi dünyası, Dec 30, 2020

Meslekler arası eğitim (IPE); tıp, sağlık ve sosyal hizmet alanları içerisinde iki veya daha fazl... more Meslekler arası eğitim (IPE); tıp, sağlık ve sosyal hizmet alanları içerisinde iki veya daha fazla meslekten öğrenenin, iş birliğini ve hizmet niteliğini arttırmak amacıyla, birbirleri hakkında ve birbirlerinden öğrenme sürecidir. IPE ile bütüncül bir bakım anlayışı, sağlık ve sosyal hizmet çalışmalarının birbirleriyle koordine ve çözüm odaklı çalışmaları, daha esnek çalışma standartlarının belirlenmesi hedeflenmektedir. IPE dünyada çeşitli sağlık meslekleri eğitimi müfredatında yer almaktadır. Ülkemizde Sağlık Hizmetleri Meslek Yüksekokullarında bu konuda eğitim programlarının geliştirilmesine ihtiyaç vardır. Bir eğitim programının başarılı olabilmesi için öğretim üyeleri, öğrenciler ve eğitim yöneticileri tarafından kabul edilmesi kritiktir. Bu nedenle meslekler arası eğitim konusunda program geliştirme aşamasında öğrencilerin hazırbulunuşluğu incelenmelidir. Bu çalışmanın amacı, Sağlık Hizmetleri Meslek Yüksekokulu öğrencilerinin meslekler arası eğitime hazır olup olmadıklarının belirlenmesidir. Gereç ve Yöntem: Çalışma kesitsel olarak tasarlanmış ve Türkiye'deki dört Sağlık Hizmetleri Meslek Yüksekokulu'nda yürütülmüştür. Uygun örnekleme yöntemi kullanılan araştırmada ölçme aracı olarak Parsell and Bligh (1999) tarafından geliştirilen Meslekler arası Eğitime Hazırbulunuşluk Ölçeği (RIPLS) kullanılmıştır. Veri analizinde tanımlayıcı istatistikler ve Student t-testi uygulanmıştır.

Turkish Journal of Biochemistry

Objectives Virtual laboratory simulations (VLSs) are computer-based tools that offer unlimited ap... more Objectives Virtual laboratory simulations (VLSs) are computer-based tools that offer unlimited application options in scientific, medical, and engineering fields. The aim of this study was to evaluate whether VLSs are efficient learning tools and how these simulations can be integrated into laboratory practice in medical laboratory education. Methods In this pre-test/post-test control group study, 32 volunteers were randomly assigned to either experimental or control groups. The experimental group performed laboratory simulations based on biochemistry and microbiology and then completed a self-report survey to evaluate their satisfaction and beliefs about simulations. Results In the experimental group, post-test scores of each simulation were significantly elevated compared to pre-test scores; however, pre- and post-test scores of control group were statistically the same. The experimental group agreed that these simulations should be applied before theoretical lectures and laborato...

TED EĞİTİM VE BİLİM, 2020

Bu araştırmanın amacı, erken çocukluk dönemindeki çocuklarla yürütülen yoga çalışmasının çocuklar... more Bu araştırmanın amacı, erken çocukluk dönemindeki çocuklarla yürütülen yoga çalışmasının çocukların bilişsel işlevlerine etkisini incelemektir. Bu araştırma, Ön Test-Son Test Kontrol Gruplu Deney Deseni (ÖSKD) ile yapılan yarı-deneysel bir çalışmadır. Araştırmanın örneklemi, İzmir ilindeki iki okul öncesi kurumunda öğrenim görmekte olan 4-5 yaş grubunda 10'u deney 18'i kontrol grubuna dâhil edilen 28 çocuktan oluşmaktadır. Araştırmada çocukların bilişsel işlevlerini belirlemek amacıyla "Bilişsel İşlevlerin Uygulanması Ölçeği (BİUÖ)" ve "Kişisel Bilgi Formu" kullanılmıştır. Araştırmada deney grubuna dahil edilen çocuklara 12 hafta boyunca haftanın 1 günü, 1 saat olmak üzere sertifikalı uzman yoga eğitmeni önderliğinde yoga eğitimi verilmiştir. Kontrol grubuna dâhil edilen çocuklara ise herhangi bir müdahalede bulunulmamıştır. Verilerin analizinde Mann Whitney-U testi ve Wilcoxon İşaretli Sıra testi kullanılmıştır. Araştırmadan elde edilen bulgulara göre; deney grubuna dâhil edilen çocukların BİUÖ toplam puanları ve Görevler Bölümü alt ölçeklerinden aldıkları son test puan ortalamaları ön test toplam puan ortalamalarından anlamlı düzeyde yüksek bulunmuştur. Kontrol grubuna dâhil edilen çocukların son test puan ortalamaları ile ön test puan ortalamaları arasında anlamlı bir fark bulunmamıştır. Deney ve kontrol gruplarının son test puan ortalamaları karşılaştırıldığında, kısa süreli işitsel bellek, bakış açısı alma ve sözel planlama alt ölçeklerinde istatistiksel olarak anlamlı bir farklılaşma olmadığı; sınıflandırma, kısa süreli işitsel bellek yeniden hatırlama, kısa süreli görsel bellek ve örüntü tamamlama alt ölçekleri ve BİUÖ son test toplam puanları arasında istatistik olarak anlamlı bir farklılaşma olduğu görülmektedir. Araştırmanın bulguları literatür doğrultusunda tartışılmıştır.

Turkish Journal of Biochemistry, 2018

Objectives: Integration of the basic medical sciences with clinical medicine motivates medical st... more Objectives: Integration of the basic medical sciences with clinical medicine motivates medical students by showing how the fundamental concepts they have learned will come into their future practice. In this context, we created clinical integration sessions (CIS) in our first-year medical curriculum. Methods: The instructors of different disciplines wrote the clinical scenarios together. The scenarios were discussed in five sessions with 39 first-year students. The first session's scenario consisted of four brief "anemia" cases. The next four sessions included a single case, according to the feedback of the students. Students formed groups of 7-8 participants. In the first 2 h, the scenarios were discussed in the groups and questions were answered by the students. In the third hour, the instructors answered the questions together with the students. After the first CIS, written feedback obtained from the students via a survey. Results: The survey provided positive feedback on the benefits of active learning within small group discussions, and most of the students thought that their background was sufficient to solve the cases, with some literature search. Conclusion: The scenarios, which provide multidisciplinary integration of basic medical sciences and clinical medicine, can be useful educational materials.

Turkiye Klinikleri Journal of Family Medicine Special Topics, 2010