Ł. Drobiec - Academia.edu (original) (raw)
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Papers by Ł. Drobiec
Brick and Block Masonry, 2016
The American Journal of Clinical Nutrition, 1989
MATERIAŁY BUDOWLANE, 2016
The paper shows a investigation of masonry components in a complex state of streses. In the morta... more The paper shows a investigation of masonry components in a complex state of streses. In the mortar and brick material model the Willam-Warnke failure criteria are used. All parameters of failure criteria are obtained from mortar and brick samples investigations. To estimate the position of the meradians of the failure surface, the triaxial and uniaxial tests of mortar and brick were made.
BACKGROUND/OBJECTIVES: In this study, potential anti-inflammatory effect of enzymatic hydrolysate... more BACKGROUND/OBJECTIVES: In this study, potential anti-inflammatory effect of enzymatic hydrolysates from Styela clava flesh tissue was assessed via nitric oxide (NO) production in lipopolysaccahride (LPS) induced RAW 264.7 macrophages and in vivo zebrafish model. MATERIALS/METHODS: We investigated the ability of enzymatic hydrolysates from Styela clava flesh tissue to inhibit LPS-induced expression of pro-inflammatory mediators in RAW 264.7 macrophages, and the molecular mechanism through which this inhibition occurred. In addition, we evaluated anti-inflammatory effect of enzymatic hydrolysates against a LPS-exposed in in vivo zebrafish model. RESULTS: Among the enzymatic hydrolysates, Protamex-proteolytic hydrolysate exhibited the highest NO inhibitory effect and was fractionated into three ranges of molecular weight by using ultrafiltration (UF) membranes (MWCO 5 kDa and 10 kDa). The above 10 kDa fraction down-regulated LPS-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), thereby reducing production of NO and prostaglandin E2 (PGE2) in LPS-activated RAW 264.7 macrophages. The above 10 kDa fraction suppressed LPS-induced production of pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α. In addition, the above 10 kDa fraction inhibited LPS-induced phosphorylation of extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinase (JNK), and p38. Furthermore, NO production in live zebrafish induced by LPS was reduced by addition of the above 10 kDa fraction from S. clava enzymatic hydrolysate. CONCLUSION: The results of this study suggested that hydrolysates derived from S. clava flesh tissue would be new anti-inflammation materials in functional resources.
Materialy Budowlane, 2010
Brick and Block Masonry, 2016
The American Journal of Clinical Nutrition, 1989
MATERIAŁY BUDOWLANE, 2016
The paper shows a investigation of masonry components in a complex state of streses. In the morta... more The paper shows a investigation of masonry components in a complex state of streses. In the mortar and brick material model the Willam-Warnke failure criteria are used. All parameters of failure criteria are obtained from mortar and brick samples investigations. To estimate the position of the meradians of the failure surface, the triaxial and uniaxial tests of mortar and brick were made.
BACKGROUND/OBJECTIVES: In this study, potential anti-inflammatory effect of enzymatic hydrolysate... more BACKGROUND/OBJECTIVES: In this study, potential anti-inflammatory effect of enzymatic hydrolysates from Styela clava flesh tissue was assessed via nitric oxide (NO) production in lipopolysaccahride (LPS) induced RAW 264.7 macrophages and in vivo zebrafish model. MATERIALS/METHODS: We investigated the ability of enzymatic hydrolysates from Styela clava flesh tissue to inhibit LPS-induced expression of pro-inflammatory mediators in RAW 264.7 macrophages, and the molecular mechanism through which this inhibition occurred. In addition, we evaluated anti-inflammatory effect of enzymatic hydrolysates against a LPS-exposed in in vivo zebrafish model. RESULTS: Among the enzymatic hydrolysates, Protamex-proteolytic hydrolysate exhibited the highest NO inhibitory effect and was fractionated into three ranges of molecular weight by using ultrafiltration (UF) membranes (MWCO 5 kDa and 10 kDa). The above 10 kDa fraction down-regulated LPS-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), thereby reducing production of NO and prostaglandin E2 (PGE2) in LPS-activated RAW 264.7 macrophages. The above 10 kDa fraction suppressed LPS-induced production of pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α. In addition, the above 10 kDa fraction inhibited LPS-induced phosphorylation of extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinase (JNK), and p38. Furthermore, NO production in live zebrafish induced by LPS was reduced by addition of the above 10 kDa fraction from S. clava enzymatic hydrolysate. CONCLUSION: The results of this study suggested that hydrolysates derived from S. clava flesh tissue would be new anti-inflammation materials in functional resources.
Materialy Budowlane, 2010
W nowym wydaniu książki przedstawiono szczegółowe rozwiązania podstawowych elementów budownictwa ... more W nowym wydaniu książki przedstawiono szczegółowe rozwiązania podstawowych elementów budownictwa żelbetowego w postaci rysunków konstrukcyjnych opracowanych w sposób zgodny z wymaganiami dotyczącymi projektów budowlano-wykonawczych. Do każdego rysunku dołączono zwięzły opis techniczny wraz z komentarzem wyjaśniającym zasady postępowania przy projektowaniu danego elementu. Rozwiązania obejmują stropy płytowo-belkowe, stropy gęstożebrowe, słupy, ściany, stropy wielokierunkowo zbrojone, stropy płaskie, tarcze, schody, fundamenty i ściany oporowe. Rysunki wykonano zgodnie z wymaganiami normy PN-EN 1992-1-1:2008 Eurocod 2 za pomocą programu komputerowego BeStCAD będącego nakładkę programu AutoCAD.
W książce przedstawiono szczegółowe rozwiązania podstawowych elementów budownictwa żelbetowego w ... more W książce przedstawiono szczegółowe rozwiązania podstawowych elementów budownictwa żelbetowego w postaci rysunków konstrukcyjnych opracowanych w sposób zgodny z wymaganiami dotyczącymi projektów budowlano-wykonawczych. Do każdego rysunku dołączono zwięzły opis techniczny wraz z komentarzem wyjaśniającym zasady postępowania przy projektowaniu danego elementu. Rozwiązania obejmują stropy płytowo-belkowe, stropy gęstożebrowe, słupy, ściany, stropy wielokierunkowo zbrojone, stropy płaskie, tarcze, schody, fundamenty i ściany oporowe.
Rysunki wykonano zgodnie z wymaganiami normy PN-B-03264:2002 i innych norm europejskich za pomocą programu komputerowego BeStCAD będącego nakładkę programu AutoCAD.