Łukasz Krakowczyk - Academia.edu (original) (raw)
Papers by Łukasz Krakowczyk
Polski Przegląd Otorynolaryngologiczny, 2019
The Polish otolaryngology, 2008
Background: Extended supraomohyoid neck nodes dissection (ESOHND) involves surgical resection of ... more Background: Extended supraomohyoid neck nodes dissection (ESOHND) involves surgical resection of nodal levels from I to IV. The incidence of occult metastases in level V is rare and mainly depends of the location and size of the primary tumour in oral cavity and oropharynx squamous cell cancer. Aim: The aim of this study was to present the results of treatment with extended supraomohyoid neck dissection. Methods: The records of 72 patients with cancer of the oral cavity undergoing extended supraomohyoid neck dissection (ESOHND) during the period 15.12.2003 - 13.06.2005 were reviewed. Results: Tumor and nodal stage were: T2-9(13%), T3-39(54%), T4-24(33%), N0-14(19%), N1-31(43%), N2-25(35%), N3-2(3%). 64 patients were treated with surgery and postoperative adjuvant radiotherapy. The follow-up period ranged from 11 to 27 months. The surgical failure rate was 8% (occurred in 6 of 72 patients). Conclusions: Preliminary analysis suggests extended supraomohyoid neck nodes dissection to be considered as a therapeutic and diagnostic procedure in patients with squamous cell cancer of oral cavity and oropharynx.
Hereditary Cancer in Clinical Practice, Nov 26, 2015
American Journal of Case Reports, Jan 14, 2010
Polish Journal of Surgery, 2010
The rectovaginal or rectovesical fistula is a rare complication after low anterior resection for ... more The rectovaginal or rectovesical fistula is a rare complication after low anterior resection for rectal cancer. Treatment is difficult and the result is often unsatisfactory. the aim of this paper was to present results of treatment with transverse rectus abdominis myocutaneous flaps of rectovaginal and rectovesical fistulas as complication of low anterior rectal resection due to adenocarcinoma. material and methods. We report six patients with rectovaginal or rectovesical fistulas as a postoperative complication after low anterior resection of rectal cancer in Department of Oncological and Reconstructive Surgery in 2006-2008. Transverse rectus abdominis myocutaneous flaps are used for rectovaginal and rectovesical fistulas treatment. Results. In the follow-up period from 4 to 30 months no rectovaginal or rectovesical fistula recurrences and any postoperative complications were noted in all cases. conclusions. Transverse (TRAM) rectus abdominis myocutaneous flaps are an effective, surgical method for rectovaginal or rectovesical fistulas treatement, especially in patients who recived pre or postoperative radiotherapy.
Polish Journal of Surgery, 2010
Cracow 2 Kierownik: prof. dr hab. J. Składzień Malignant tumors of head and neck regions usually ... more Cracow 2 Kierownik: prof. dr hab. J. Składzień Malignant tumors of head and neck regions usually need wide radical resections and may cause significant functional and aesthetic deficits. When a surgeon has to deal with extensive 3-D defect in lower or middle face region, double or multiple free flaps can be used. the aim of the study was to present own methods modifications and results of double free flaps techniques in patients with extensive defects of head and neck region. The authors present quality of life evaluation related to different flaps reconstructions. material and methods. Clinical material consists of 33 patients with locally advanced cancer of lower or middle face region, who underwent surgical treatment in Departmant of Surgical and Reconstructive Surgery, Cancer Center Maria Skłodowska-Curie Instytute, Gliwice, Poland. In all patients double free flaps were chosen. results. Whole group good functional and aesthetic results have been achieved. The QOL analysis show that the use of double flap in middle of lower face reconstruction gives generally very good results. conclusions. The use of double free flaps after extensive resections of head and neck tumors is an efficient solution. The above-mentioned technique enables to reconstruct several different anatomical structures, restore optimal functioning, and assure a satisfactory psychosocial effect.
Polish Journal of Surgery, Oct 5, 2020
Introduction: The perforation of gloves during surgical procedures is quite common. A cheap and q... more Introduction: The perforation of gloves during surgical procedures is quite common. A cheap and quite effective method of reducing the risk of blood-borne infections is wearing two pairs of gloves. Unfortunately, some surgeons are reluctant to it, and they report decreased dexterity and sensation. The aim of the study was to evaluate surgeons' double-gloving practices to determine the factors related to compliance. Material and methods: An anonymous, 21-question survey in Polish was sent by post to 41 surgical departments. The questions concerned: demographic data, type of surgical gloves used, allergy to latex, number of surgeries performed, frequency of using double gloves and negative impressions from using them and finally, the frequency of needlestick injuries during surgical procedures. Results: We received 179 questionnaires back. More than 62% of the surgeons believe that double gloves provide better protection than a single pair, 24% do not believe in this, and 14% have no opinion. Only 0.6% of respondents always use double gloves during surgery, 19% double glove in at least 25% of cases and 68% do it occasionally. 13% of the surgeons declared that they had never worn double gloves. During high-risk procedures, 86% of respondents wear double gloves. About half of respondents (50.3%) report discomfort while wearing double gloves; 45%-decreased dexterity; about 30% complain of numbness and tingling; and 64%-decreased sensation. Conclusion: Due to the high number of surgical glove perforations and relatively high prevalence of needlestick injuries, it is necessary to use methods that reduce the risk of transmission of pathogens. The habit of using a double pair of gloves should be implemented especially among young surgeons starting to train in their specialities. Consequently, the period of initial discomfort will be combined with the acquisition of surgical skills, which will allow for gradual acclimatization.
Contemporary Oncology/Współczesna Onkologia, Jul 23, 2009
W Ws st tę ęp p: : Mięsaki tkanek miękkich są rzadkimi nowotworami, stanowiącymi 1-2% wszystkich ... more W Ws st tę ęp p: : Mięsaki tkanek miękkich są rzadkimi nowotworami, stanowiącymi 1-2% wszystkich nowotworów złośliwych. Zaledwie 10% z nich to mięsaki rejonu głowy i szyi. Pomimo postępów w leczeniu wyniki wciąż pozostają niezadowalające. Leczeniem z wyboru pozostaje radykalne leczenie operacyjne w skojarzeniu z przedoperacyjną lub pooperacyjną radioterapią i/lub chemioterapią. M Ma at te er ri ia ał ł i i m me et to od dy y: : Badaną grupę stanowiło 34 kolejnych chorych na mięsaki regionu głowy i szyi, leczonych chirurgicznie w Centrum Onkologii, Instytucie Onkologii IMSC w Gliwicach w latach 1993-2004 (przedział wiekowy 29-72 lat, średnia wieku 49 lat). Mężczyźni stanowili 59% badanej grupy (20 chorych), a kobiety 41%. W Wy yn ni ik ki i: : U ponad 90% chorych stwierdzono stopień zaawansowania klinicznego T2. U większości chorych radykalne leczenie operacyjne wiązało się z koniecznością rekonstrukcji ubytku przy zastosowaniu płatów wolnych lub uszypułowanych. Pooperacyjną radioterapię zastosowano u 41% chorych. Pięcioletnie przeżycie całkowite w badanej grupie wyniosło 68%, a przeżycie bezobjawowe 52%. Nawrót miejscowy wystąpił u 35%, a przerzuty odległe u 11% chorych. Znaczenie prognostyczne miały następujące czynniki: zróżnicowanie histopatologiczne, zaawansowanie miejscowe, margines chirurgiczny oraz schemat postępowania terapeutycznego. W Wn ni io os sk ki i: : Rokowanie u chorych na mięsaki tkanek miękkich rejonu głowy i szyi zależy od wielkości guza pierwotnego oraz zróżnicowania histopatologicznego. Przeżycia są uzależnione również od radykalności makroskopowej i mikroskopowej. Leczenie chirurgiczne pozostaje nadal leczeniem z wyboru. S Sł ło ow wa a k kl lu uc cz zo ow we e: : mięsaki regionu głowy i szyi, czynniki prognostyczne, leczenie skojarzone.
Journal of Reconstructive Microsurgery, Jan 18, 2016
Pharmacological Reports, Jun 1, 2016
Thanks to detailed studies conducted in recent years, a new disease syndrome was identified in 20... more Thanks to detailed studies conducted in recent years, a new disease syndrome was identified in 2001. It is known as a IgG4-related disease and its differentiation is based on the analysis of IgG4 levels in the affected tissues. The IgG4-related disease is considered to be a generalized pathological process involving a wide spectrum of various disorders that may affect distant organs. Orbital IgG4-related disease is a recently reported issue that may prove important for the elucidation of the etiology of idiopathic, lymphoplasmacytic or fibrotic disorders of various organs, including the orbits. In this article, we are describing epidemiology and differential diagnostics of IgG4-related orbital disease with particular focus on pseudotumors, MALT lymphomas and lymphocyte/plasma cell infiltrations of the orbit. We are also discussing therapeutic possibilities currently available in the management of the disease.
Journal of Reconstructive Microsurgery, Aug 17, 2015
Polish Journal of Surgery, 2015
The use of microsurgery for oral reconstruction of cancer patients, has become standard treatment... more The use of microsurgery for oral reconstruction of cancer patients, has become standard treatment in restoring oral function. The free anterolateral thigh flap is one of the most preferred options in reconstruction after total, subtotal or hemiresection of the tonque due to squamous cell cancer. the aim of the study was to present the reconstructive method using anterolateral thigh free flap with evaluation of quality of live. material and methods. Clinical material includes 46 consecutive patients with tongue cancer, who underwent complex surgical treatment between 2009 and 2011. There were 36 males and 10 females and the M: F ratio was 3.6: 1. All of them were reconstructed using the anterolateral thigh free flap. The quality of life was evaluated 6 months after completing the treatment, based on postoperative functional and aesthetic status. Results. The overall flap survival rate was 96%. Surgical complications were observed in 8 patients (17%). Donor site was closed primarly in 42 cases and in remaining 4 skin graft was required. In all 46 cases understandable speech and return to unrestricted diet mastication and swallowing were achieved. The mean follow-up period after treatment was 32 months. Analysis of aesthetic effects evaluated in 23 cases and shows generally very good results. According to average transformed scores the QOL can be characterized as excellent for >90, very good for 76-90, good for 51-75, moderate for 25-50 and bad for <25 points. Conclusions. Anterolateral thigh flap, with its versatility in design, long pedicle with a suitable vessel diameter, low donor site morbidity, and very good aesthetic effects, could be the ideal flap for functional tongue reconstruction.
Annals of Surgery, Mar 1, 2016
Polski Przegląd Otorynolaryngologiczny, Sep 5, 2019
Cone-beam computed tomography (CBCT) is a relatively new diagnostic imaging method. It was first ... more Cone-beam computed tomography (CBCT) is a relatively new diagnostic imaging method. It was first used in 1982 at the Mayo Clinic Biodynamics Research Laboratory [1], and since 2001 is commercially used in dentistry. In differs from multidetector computed tomography in terms of implementation technique and some parameters. A low dose of radiation is its greatest advantage, thanks to which many specialists, including ENT doctors and reconstructive surgeons, are more willing to use it. In otorhinolaryngology, CBCT is applied in pre- and peri-operative diagnostics in both rhinology and otology. In reconstructive surgery, CBCT facilitates precise planning of the flap, and intraoperatively allows a perfect match of the reconstructed tissue elements. In the article, the authors present current information on CBCT in ENT obtained on the basis of a review of Polish and foreign literature and share their own experience in its application in reconstructive surgery within the craniofacial region.
Contemporary Oncology/Współczesna Onkologia, Sep 6, 2007
PubMed, 2011
Objective: Heat shock proteins (HSPs) play a very important role in eukaryotic and prokaryotic ce... more Objective: Heat shock proteins (HSPs) play a very important role in eukaryotic and prokaryotic cells. They are produced in cells constitutively or induced under stress conditions. During carcinogenesis, HSPs have been reported to show alteration of their expression levels. Aim of the study: The aim of the study was assessment of the concentration of HSP 27 in tumour and adjacent distal normal mucosa in colorectal adenocarcinomas. Material and methods: Samples of tumour tissues and adjacent distal normal colon tissues were obtained during resection operations from 47 patients aged between 26-82. Average distance of adjacent distal normal mucosa from the tumour was 4.49 cm. In tissues homogenate total protein level and concentration of HSP 27 were assayed. The patients were grouped according to clinical classification (Duke's staging), grade of differentiation, localization, and size of tumour, as well as age and sex. Relation between adjacent distal normal mucosa collected in different distances from the tumour and compared to concentration of HSP 27 was analyzed. Statistical analysis was performed. Results: The concentration of HSP 27 was significantly increased in adjacent distal normal tissues compared with tumour tissues. Moreover, the concentration of HSP 27 was increased in adjacent normal tissues in patients with CD Duke's staging compared to patients with AB Duke's staging. No differences in concentration of HSP 27 between tumour and normal tissues compared with grade of differentiation, localization, and size oftumour, as well as age and sex were observed. No relation between adjacent distal normal mucosa collected in different distances from the tumour and compared to concentration of HSP 27 was observed. Conclusions: The higher concentration of HSP 27 in adjacent distal normal mucosa can be a response to stress factors related with metabolic changes of cancer tissues or can be a protective function to stress factors of the tumour.
Otolaryngologia Polska, Jun 1, 2010
Introduction: About 25% of melanomas are localized in head and neck skin, and this particular loc... more Introduction: About 25% of melanomas are localized in head and neck skin, and this particular localization is most diffi cult to treat, and the prognosis is less favorable. The depth of melanoma infi ltration (Clark and Breslau grade) into the skin is the main factor of local advancement of the disease. Surgical treatment is an essential therapeutic modality in patients with melanoma. Aim: The aim of this study was to evaluate results of our surgical treatment of melanomas in head and neck localisation, treated from 1997 to 2007 in Department of Oncological and Reconstructive Surgery in Center of Oncology IMSC in Gliwice. Material: We analysed group of 47 patients (aged 26 to 75 years, mean 49), treated by surgical excision of malignant melanoma in the head and neck region. Most of the patiens required to use free fl aps or skin graft technique to close posexcisional defect, on basis of clinical considerations. Results: The 5-year total survival for all patients was 62% and were dependent on depht of melanoma infi ltration and regional lymph node metastasis. The signifi cant prognostic factors were: localization of primary focus, local progression of disease, free microscopical excision margins sex and age. Conclusions: Prognosis in the patients with melanoma of the head and neck is unreliable and dependent on local advancement of disease and localization of primary focus. Surgical treatment is an essential therapeutic modality in patients with melanoma. Adiuvant radiotherapy after surgical treatment of melanoma of the head and neck is intended for the patiens with high risk of local or regional recurence of disease.
BioMed Research International, Mar 30, 2021
Oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma (OPSCC) are subgrou... more Oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma (OPSCC) are subgroups of head and neck squamous cell carcinoma. E2F Transcription Factor 2 (E2F2) could contribute to cancer development, because it plays a critical role in many cellular processes, including the cell cycle, proliferation, differentiation, DNA damage response, and cell death. In the current study, we assessed the associations of five E2F2 polymorphisms (rs6667575, rs3218121, rs3218211, rs3218148, and rs3218203) with OSCC and OPSCC and influence on the TNM staging and grading. This is the first such survey to concern the European population. The study included 94 primary tumour samples following surgical resection from patients, whereas the control group consisted of 99 healthy individuals. We tried a matching of cases and controls for age and sample size. DNA samples were genotyped by employing the 5′ nuclease assay for allelic discrimination. Our results suggested that the most significant difference between the control group and the cancer group was the A/G heterozygote for rs3218121. Samples containing this genotype were mostly found in the control group. In our samples, rs6667575, rs3218121, rs3218211, and rs3218148 polymorphisms may affect the course of OSCC and OPSCC, while rs3218203 was not associated with OSCC and OPSCC. However, further studies are warranted to confirm our findings.
Advances in Clinical and Experimental Medicine, Jun 30, 2018
Journal of Craniofacial Surgery, Feb 16, 2022
ABSTRACT Ameloblastoma (AM) is the most common, locally aggressive odontogenic tumor. It comprise... more ABSTRACT Ameloblastoma (AM) is the most common, locally aggressive odontogenic tumor. It comprises about 1% of all head and neck neoplasms. It occurs mainly in young adults in their 3rd and 4th decade of life. It localizes in the mandible in about 80% of the cases. According to the 2017 WHO classification, 4 types of ameloblastoma can be distinguished: ameloblastoma (previously referred to as solid/multicystic-SMA; the "conventional type" AM), unicystic (AM-UA), extraosseous/peripheral (AM-PA), and malignant/metastatic (AM-MA). Solid, multicystic is the most common type. It is characteristic for its aggressiveness and high risk of recurrence. Radical resection with consecutive reconstruction is the treatment of choice of mandibular ameloblastomas.In this study, the authors present their experience in the surgical treatment of mandibular ameloblastomas with vascularized free flap reconstructions. They discuss new technological possibilities that could improve the precision of the reconstructive procedure and therefore result in the better aesthetic outcome.The retrospective study of a group of 21 patients suffering from mandibular ameloblastoma who underwent segmental mandibulectomy with simultaneous microvascular free flap reconstruction was conducted. A thorough clinical analysis with various aspects was performed. Tumors resected before 2017 were double checked patomorphologically and assigned to the corrected subtype group.Seven patients were admitted to the department due to recurrent ameloblastoma. The most common localization of the tumor was the mandibular body (n = 6) and body with ramus of the mandible (n = 6). A total amount of 10 iliac crest free flaps and 12 fibular free flaps were performed. Complications were reported in 4 patients. A purulent oro-cutaneus fistula occurred in 3patients. There was a flap failure in each reconstructive group. The virtual surgical planning with intraoperative cone-beam computed tomography was used in 3 patients. Dentition implantation was conducted in 4 patients (3 simultaneously, 1 postponed). The mean follow-up was 5 years and 8 months.Radical resection that covers radical segmental mandibulectomy with immediate microvascular free flap reconstruction is a first-line and only effective treatment of mandibular ameloblastomas, that eliminates the risk of recurrence. The extent of surgical margins seems not to influence the recurrence rate, yet further investigation with statistical analysis should be performed. The choice of the adequate free flap must be adapted to dimensions and localization of the tumor and to each patient individually.New technologies such as virtual surgical planning with 3D models and intraoperativecone-beam computed tomography can make the reconstruction more accurate, improving patient's quality of life.
Polski Przegląd Otorynolaryngologiczny, 2019
The Polish otolaryngology, 2008
Background: Extended supraomohyoid neck nodes dissection (ESOHND) involves surgical resection of ... more Background: Extended supraomohyoid neck nodes dissection (ESOHND) involves surgical resection of nodal levels from I to IV. The incidence of occult metastases in level V is rare and mainly depends of the location and size of the primary tumour in oral cavity and oropharynx squamous cell cancer. Aim: The aim of this study was to present the results of treatment with extended supraomohyoid neck dissection. Methods: The records of 72 patients with cancer of the oral cavity undergoing extended supraomohyoid neck dissection (ESOHND) during the period 15.12.2003 - 13.06.2005 were reviewed. Results: Tumor and nodal stage were: T2-9(13%), T3-39(54%), T4-24(33%), N0-14(19%), N1-31(43%), N2-25(35%), N3-2(3%). 64 patients were treated with surgery and postoperative adjuvant radiotherapy. The follow-up period ranged from 11 to 27 months. The surgical failure rate was 8% (occurred in 6 of 72 patients). Conclusions: Preliminary analysis suggests extended supraomohyoid neck nodes dissection to be considered as a therapeutic and diagnostic procedure in patients with squamous cell cancer of oral cavity and oropharynx.
Hereditary Cancer in Clinical Practice, Nov 26, 2015
American Journal of Case Reports, Jan 14, 2010
Polish Journal of Surgery, 2010
The rectovaginal or rectovesical fistula is a rare complication after low anterior resection for ... more The rectovaginal or rectovesical fistula is a rare complication after low anterior resection for rectal cancer. Treatment is difficult and the result is often unsatisfactory. the aim of this paper was to present results of treatment with transverse rectus abdominis myocutaneous flaps of rectovaginal and rectovesical fistulas as complication of low anterior rectal resection due to adenocarcinoma. material and methods. We report six patients with rectovaginal or rectovesical fistulas as a postoperative complication after low anterior resection of rectal cancer in Department of Oncological and Reconstructive Surgery in 2006-2008. Transverse rectus abdominis myocutaneous flaps are used for rectovaginal and rectovesical fistulas treatment. Results. In the follow-up period from 4 to 30 months no rectovaginal or rectovesical fistula recurrences and any postoperative complications were noted in all cases. conclusions. Transverse (TRAM) rectus abdominis myocutaneous flaps are an effective, surgical method for rectovaginal or rectovesical fistulas treatement, especially in patients who recived pre or postoperative radiotherapy.
Polish Journal of Surgery, 2010
Cracow 2 Kierownik: prof. dr hab. J. Składzień Malignant tumors of head and neck regions usually ... more Cracow 2 Kierownik: prof. dr hab. J. Składzień Malignant tumors of head and neck regions usually need wide radical resections and may cause significant functional and aesthetic deficits. When a surgeon has to deal with extensive 3-D defect in lower or middle face region, double or multiple free flaps can be used. the aim of the study was to present own methods modifications and results of double free flaps techniques in patients with extensive defects of head and neck region. The authors present quality of life evaluation related to different flaps reconstructions. material and methods. Clinical material consists of 33 patients with locally advanced cancer of lower or middle face region, who underwent surgical treatment in Departmant of Surgical and Reconstructive Surgery, Cancer Center Maria Skłodowska-Curie Instytute, Gliwice, Poland. In all patients double free flaps were chosen. results. Whole group good functional and aesthetic results have been achieved. The QOL analysis show that the use of double flap in middle of lower face reconstruction gives generally very good results. conclusions. The use of double free flaps after extensive resections of head and neck tumors is an efficient solution. The above-mentioned technique enables to reconstruct several different anatomical structures, restore optimal functioning, and assure a satisfactory psychosocial effect.
Polish Journal of Surgery, Oct 5, 2020
Introduction: The perforation of gloves during surgical procedures is quite common. A cheap and q... more Introduction: The perforation of gloves during surgical procedures is quite common. A cheap and quite effective method of reducing the risk of blood-borne infections is wearing two pairs of gloves. Unfortunately, some surgeons are reluctant to it, and they report decreased dexterity and sensation. The aim of the study was to evaluate surgeons' double-gloving practices to determine the factors related to compliance. Material and methods: An anonymous, 21-question survey in Polish was sent by post to 41 surgical departments. The questions concerned: demographic data, type of surgical gloves used, allergy to latex, number of surgeries performed, frequency of using double gloves and negative impressions from using them and finally, the frequency of needlestick injuries during surgical procedures. Results: We received 179 questionnaires back. More than 62% of the surgeons believe that double gloves provide better protection than a single pair, 24% do not believe in this, and 14% have no opinion. Only 0.6% of respondents always use double gloves during surgery, 19% double glove in at least 25% of cases and 68% do it occasionally. 13% of the surgeons declared that they had never worn double gloves. During high-risk procedures, 86% of respondents wear double gloves. About half of respondents (50.3%) report discomfort while wearing double gloves; 45%-decreased dexterity; about 30% complain of numbness and tingling; and 64%-decreased sensation. Conclusion: Due to the high number of surgical glove perforations and relatively high prevalence of needlestick injuries, it is necessary to use methods that reduce the risk of transmission of pathogens. The habit of using a double pair of gloves should be implemented especially among young surgeons starting to train in their specialities. Consequently, the period of initial discomfort will be combined with the acquisition of surgical skills, which will allow for gradual acclimatization.
Contemporary Oncology/Współczesna Onkologia, Jul 23, 2009
W Ws st tę ęp p: : Mięsaki tkanek miękkich są rzadkimi nowotworami, stanowiącymi 1-2% wszystkich ... more W Ws st tę ęp p: : Mięsaki tkanek miękkich są rzadkimi nowotworami, stanowiącymi 1-2% wszystkich nowotworów złośliwych. Zaledwie 10% z nich to mięsaki rejonu głowy i szyi. Pomimo postępów w leczeniu wyniki wciąż pozostają niezadowalające. Leczeniem z wyboru pozostaje radykalne leczenie operacyjne w skojarzeniu z przedoperacyjną lub pooperacyjną radioterapią i/lub chemioterapią. M Ma at te er ri ia ał ł i i m me et to od dy y: : Badaną grupę stanowiło 34 kolejnych chorych na mięsaki regionu głowy i szyi, leczonych chirurgicznie w Centrum Onkologii, Instytucie Onkologii IMSC w Gliwicach w latach 1993-2004 (przedział wiekowy 29-72 lat, średnia wieku 49 lat). Mężczyźni stanowili 59% badanej grupy (20 chorych), a kobiety 41%. W Wy yn ni ik ki i: : U ponad 90% chorych stwierdzono stopień zaawansowania klinicznego T2. U większości chorych radykalne leczenie operacyjne wiązało się z koniecznością rekonstrukcji ubytku przy zastosowaniu płatów wolnych lub uszypułowanych. Pooperacyjną radioterapię zastosowano u 41% chorych. Pięcioletnie przeżycie całkowite w badanej grupie wyniosło 68%, a przeżycie bezobjawowe 52%. Nawrót miejscowy wystąpił u 35%, a przerzuty odległe u 11% chorych. Znaczenie prognostyczne miały następujące czynniki: zróżnicowanie histopatologiczne, zaawansowanie miejscowe, margines chirurgiczny oraz schemat postępowania terapeutycznego. W Wn ni io os sk ki i: : Rokowanie u chorych na mięsaki tkanek miękkich rejonu głowy i szyi zależy od wielkości guza pierwotnego oraz zróżnicowania histopatologicznego. Przeżycia są uzależnione również od radykalności makroskopowej i mikroskopowej. Leczenie chirurgiczne pozostaje nadal leczeniem z wyboru. S Sł ło ow wa a k kl lu uc cz zo ow we e: : mięsaki regionu głowy i szyi, czynniki prognostyczne, leczenie skojarzone.
Journal of Reconstructive Microsurgery, Jan 18, 2016
Pharmacological Reports, Jun 1, 2016
Thanks to detailed studies conducted in recent years, a new disease syndrome was identified in 20... more Thanks to detailed studies conducted in recent years, a new disease syndrome was identified in 2001. It is known as a IgG4-related disease and its differentiation is based on the analysis of IgG4 levels in the affected tissues. The IgG4-related disease is considered to be a generalized pathological process involving a wide spectrum of various disorders that may affect distant organs. Orbital IgG4-related disease is a recently reported issue that may prove important for the elucidation of the etiology of idiopathic, lymphoplasmacytic or fibrotic disorders of various organs, including the orbits. In this article, we are describing epidemiology and differential diagnostics of IgG4-related orbital disease with particular focus on pseudotumors, MALT lymphomas and lymphocyte/plasma cell infiltrations of the orbit. We are also discussing therapeutic possibilities currently available in the management of the disease.
Journal of Reconstructive Microsurgery, Aug 17, 2015
Polish Journal of Surgery, 2015
The use of microsurgery for oral reconstruction of cancer patients, has become standard treatment... more The use of microsurgery for oral reconstruction of cancer patients, has become standard treatment in restoring oral function. The free anterolateral thigh flap is one of the most preferred options in reconstruction after total, subtotal or hemiresection of the tonque due to squamous cell cancer. the aim of the study was to present the reconstructive method using anterolateral thigh free flap with evaluation of quality of live. material and methods. Clinical material includes 46 consecutive patients with tongue cancer, who underwent complex surgical treatment between 2009 and 2011. There were 36 males and 10 females and the M: F ratio was 3.6: 1. All of them were reconstructed using the anterolateral thigh free flap. The quality of life was evaluated 6 months after completing the treatment, based on postoperative functional and aesthetic status. Results. The overall flap survival rate was 96%. Surgical complications were observed in 8 patients (17%). Donor site was closed primarly in 42 cases and in remaining 4 skin graft was required. In all 46 cases understandable speech and return to unrestricted diet mastication and swallowing were achieved. The mean follow-up period after treatment was 32 months. Analysis of aesthetic effects evaluated in 23 cases and shows generally very good results. According to average transformed scores the QOL can be characterized as excellent for >90, very good for 76-90, good for 51-75, moderate for 25-50 and bad for <25 points. Conclusions. Anterolateral thigh flap, with its versatility in design, long pedicle with a suitable vessel diameter, low donor site morbidity, and very good aesthetic effects, could be the ideal flap for functional tongue reconstruction.
Annals of Surgery, Mar 1, 2016
Polski Przegląd Otorynolaryngologiczny, Sep 5, 2019
Cone-beam computed tomography (CBCT) is a relatively new diagnostic imaging method. It was first ... more Cone-beam computed tomography (CBCT) is a relatively new diagnostic imaging method. It was first used in 1982 at the Mayo Clinic Biodynamics Research Laboratory [1], and since 2001 is commercially used in dentistry. In differs from multidetector computed tomography in terms of implementation technique and some parameters. A low dose of radiation is its greatest advantage, thanks to which many specialists, including ENT doctors and reconstructive surgeons, are more willing to use it. In otorhinolaryngology, CBCT is applied in pre- and peri-operative diagnostics in both rhinology and otology. In reconstructive surgery, CBCT facilitates precise planning of the flap, and intraoperatively allows a perfect match of the reconstructed tissue elements. In the article, the authors present current information on CBCT in ENT obtained on the basis of a review of Polish and foreign literature and share their own experience in its application in reconstructive surgery within the craniofacial region.
Contemporary Oncology/Współczesna Onkologia, Sep 6, 2007
PubMed, 2011
Objective: Heat shock proteins (HSPs) play a very important role in eukaryotic and prokaryotic ce... more Objective: Heat shock proteins (HSPs) play a very important role in eukaryotic and prokaryotic cells. They are produced in cells constitutively or induced under stress conditions. During carcinogenesis, HSPs have been reported to show alteration of their expression levels. Aim of the study: The aim of the study was assessment of the concentration of HSP 27 in tumour and adjacent distal normal mucosa in colorectal adenocarcinomas. Material and methods: Samples of tumour tissues and adjacent distal normal colon tissues were obtained during resection operations from 47 patients aged between 26-82. Average distance of adjacent distal normal mucosa from the tumour was 4.49 cm. In tissues homogenate total protein level and concentration of HSP 27 were assayed. The patients were grouped according to clinical classification (Duke's staging), grade of differentiation, localization, and size of tumour, as well as age and sex. Relation between adjacent distal normal mucosa collected in different distances from the tumour and compared to concentration of HSP 27 was analyzed. Statistical analysis was performed. Results: The concentration of HSP 27 was significantly increased in adjacent distal normal tissues compared with tumour tissues. Moreover, the concentration of HSP 27 was increased in adjacent normal tissues in patients with CD Duke's staging compared to patients with AB Duke's staging. No differences in concentration of HSP 27 between tumour and normal tissues compared with grade of differentiation, localization, and size oftumour, as well as age and sex were observed. No relation between adjacent distal normal mucosa collected in different distances from the tumour and compared to concentration of HSP 27 was observed. Conclusions: The higher concentration of HSP 27 in adjacent distal normal mucosa can be a response to stress factors related with metabolic changes of cancer tissues or can be a protective function to stress factors of the tumour.
Otolaryngologia Polska, Jun 1, 2010
Introduction: About 25% of melanomas are localized in head and neck skin, and this particular loc... more Introduction: About 25% of melanomas are localized in head and neck skin, and this particular localization is most diffi cult to treat, and the prognosis is less favorable. The depth of melanoma infi ltration (Clark and Breslau grade) into the skin is the main factor of local advancement of the disease. Surgical treatment is an essential therapeutic modality in patients with melanoma. Aim: The aim of this study was to evaluate results of our surgical treatment of melanomas in head and neck localisation, treated from 1997 to 2007 in Department of Oncological and Reconstructive Surgery in Center of Oncology IMSC in Gliwice. Material: We analysed group of 47 patients (aged 26 to 75 years, mean 49), treated by surgical excision of malignant melanoma in the head and neck region. Most of the patiens required to use free fl aps or skin graft technique to close posexcisional defect, on basis of clinical considerations. Results: The 5-year total survival for all patients was 62% and were dependent on depht of melanoma infi ltration and regional lymph node metastasis. The signifi cant prognostic factors were: localization of primary focus, local progression of disease, free microscopical excision margins sex and age. Conclusions: Prognosis in the patients with melanoma of the head and neck is unreliable and dependent on local advancement of disease and localization of primary focus. Surgical treatment is an essential therapeutic modality in patients with melanoma. Adiuvant radiotherapy after surgical treatment of melanoma of the head and neck is intended for the patiens with high risk of local or regional recurence of disease.
BioMed Research International, Mar 30, 2021
Oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma (OPSCC) are subgrou... more Oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma (OPSCC) are subgroups of head and neck squamous cell carcinoma. E2F Transcription Factor 2 (E2F2) could contribute to cancer development, because it plays a critical role in many cellular processes, including the cell cycle, proliferation, differentiation, DNA damage response, and cell death. In the current study, we assessed the associations of five E2F2 polymorphisms (rs6667575, rs3218121, rs3218211, rs3218148, and rs3218203) with OSCC and OPSCC and influence on the TNM staging and grading. This is the first such survey to concern the European population. The study included 94 primary tumour samples following surgical resection from patients, whereas the control group consisted of 99 healthy individuals. We tried a matching of cases and controls for age and sample size. DNA samples were genotyped by employing the 5′ nuclease assay for allelic discrimination. Our results suggested that the most significant difference between the control group and the cancer group was the A/G heterozygote for rs3218121. Samples containing this genotype were mostly found in the control group. In our samples, rs6667575, rs3218121, rs3218211, and rs3218148 polymorphisms may affect the course of OSCC and OPSCC, while rs3218203 was not associated with OSCC and OPSCC. However, further studies are warranted to confirm our findings.
Advances in Clinical and Experimental Medicine, Jun 30, 2018
Journal of Craniofacial Surgery, Feb 16, 2022
ABSTRACT Ameloblastoma (AM) is the most common, locally aggressive odontogenic tumor. It comprise... more ABSTRACT Ameloblastoma (AM) is the most common, locally aggressive odontogenic tumor. It comprises about 1% of all head and neck neoplasms. It occurs mainly in young adults in their 3rd and 4th decade of life. It localizes in the mandible in about 80% of the cases. According to the 2017 WHO classification, 4 types of ameloblastoma can be distinguished: ameloblastoma (previously referred to as solid/multicystic-SMA; the "conventional type" AM), unicystic (AM-UA), extraosseous/peripheral (AM-PA), and malignant/metastatic (AM-MA). Solid, multicystic is the most common type. It is characteristic for its aggressiveness and high risk of recurrence. Radical resection with consecutive reconstruction is the treatment of choice of mandibular ameloblastomas.In this study, the authors present their experience in the surgical treatment of mandibular ameloblastomas with vascularized free flap reconstructions. They discuss new technological possibilities that could improve the precision of the reconstructive procedure and therefore result in the better aesthetic outcome.The retrospective study of a group of 21 patients suffering from mandibular ameloblastoma who underwent segmental mandibulectomy with simultaneous microvascular free flap reconstruction was conducted. A thorough clinical analysis with various aspects was performed. Tumors resected before 2017 were double checked patomorphologically and assigned to the corrected subtype group.Seven patients were admitted to the department due to recurrent ameloblastoma. The most common localization of the tumor was the mandibular body (n = 6) and body with ramus of the mandible (n = 6). A total amount of 10 iliac crest free flaps and 12 fibular free flaps were performed. Complications were reported in 4 patients. A purulent oro-cutaneus fistula occurred in 3patients. There was a flap failure in each reconstructive group. The virtual surgical planning with intraoperative cone-beam computed tomography was used in 3 patients. Dentition implantation was conducted in 4 patients (3 simultaneously, 1 postponed). The mean follow-up was 5 years and 8 months.Radical resection that covers radical segmental mandibulectomy with immediate microvascular free flap reconstruction is a first-line and only effective treatment of mandibular ameloblastomas, that eliminates the risk of recurrence. The extent of surgical margins seems not to influence the recurrence rate, yet further investigation with statistical analysis should be performed. The choice of the adequate free flap must be adapted to dimensions and localization of the tumor and to each patient individually.New technologies such as virtual surgical planning with 3D models and intraoperativecone-beam computed tomography can make the reconstruction more accurate, improving patient's quality of life.