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Papers by Şükran KÜltÜr

International Journal of Life Sciences and Biotechnology

Asteraceae familyası 485’i endemik olmak üzere içerdiği 1311 tür ile ülkemiz florasında bulunan t... more Asteraceae familyası 485’i endemik olmak üzere içerdiği 1311 tür ile ülkemiz florasında bulunan tür sayısı bakımından en zengin familyadır. Familyanın Senecioneae tribusunda yer alan Doronicum L. cinsi son verilere göre ülkemizde 9 tür ve 1 alt tür ile temsil edilmekte olup endemizm oranı %40’tır. Ülkemizde bulunan türlerin genellikle yayılış alanları dar olup çoğunlukla Kuzey ve Doğu Anadolu dağlarının nemli bölgelerinde yetişmektedirler. Cins üzerinde en son kapsamlı çalışmalar 2000’li yılların başında gerçekleştirilmiş olup türler üzerinde yapılan bazı morfolojik ve moleküler çalışmalarla cinsin sistematiği aydınlatılmaya çalışılmıştır. Elde edilen veriler sonucunda Türkiyede’de yer alan bazı türler sinonim seviyesine düşürülmüştür. Avrupa’da Doronicum türlerinden halk arasında kalp hastalıkların, epilepsi, malarya, sindirim sistemi hastalıkları ve akrep-yılan zehirlenmeleri gibi çeşitli hastalıkların tedavisinde yararlanılmaktadır. Ülkemizde D. orientale (Acımık, Baylıkotu, Kapl...

Fresenius Environmental Bulletin, 2016

Abstract: This checklist contains a total of 168 taxa published as additions to the Flora of Turk... more Abstract: This checklist contains a total of 168 taxa published as additions to the Flora of Turkey. It includes details of taxa neither recorded by P.H.Davis ’ “Flora of Turkey and the East Aegean Islands ” or its Supplement, nor in the first of this series of checklists. The records in this list are based on data given in nearly 100 publications published up to the end of 1998.

Journal of Faculty Pharmacy of Istanbul University, 2014

Anatomical characters are very important to distinguish between closely related species and gener... more Anatomical characters are very important to distinguish between closely related species and genera, especially in the family Apiaceae. Anatomy of Apiaceae fruits varies strongly, even among closely related species in the same genus. An ethnobotanical study was conducted between 2004 and 2005 in order to determine wild used plants in West part of Nigde-Aladaglar. According the data of this study’s, 3 plant species belong to Apiaceae family sold to different tea companies by local people. Anatomical characteristics of fruits of the Ferulago pachyloba, Prangos ferulacea, Prangos meliocarpoides have been studied. Ferulago pachyloba has winged dorsal ribs, equal to or shorter than seeds. Prangos ferulacea has five blocks of mesocarp, they are not separated by the exocarp and the vascular bundles usually surround each block. Prangos meliocarpoides has continuous mesocarp and not separated into blocks. Druse crystals do not exist in the endosperm of F. pachyloba, P. ferulacea, and P. melio...

İstanbul Journal of Pharmacy, 2021

Background and Aims: This study reveals the anatomical features of Hypericum kotschyanum Boiss. s... more Background and Aims: This study reveals the anatomical features of Hypericum kotschyanum Boiss. species and compares them with previous studies. The anatomical characteristics of stem, leaf, and root were studied using a light microscope. In addition, anatomical structures were measured. Methods: The studied material was collected from Arslankoy, Mersin. The collected specimens were identified. Dried specimens were kept in Istanbul University Faculty of Pharmacy Herbarium (ISTE) and filed using the ISTE number system (ISTE 98173). Also, some plant materials were kept in 70% ethanol for anatomical examination. All sections from plants were cut by hand using a blade. Samples were examined in SARTUR reagent. Photographs were taken using a light microscope. Results: When we examined the cells around the stomata in the light of the neighboring cells, we observed that the stomata is an anomocytic type in leaf superficial section. The number of cells that radially surround the bottom of t...

Phytotaxa, 2016

Euphorbia akmanii, a new species of Euphorbiaceae (sect. Patellares) from Turkey (Osmaniye) is de... more Euphorbia akmanii, a new species of Euphorbiaceae (sect. Patellares) from Turkey (Osmaniye) is described on the basis of morphological characters. The species was found in the north-west part of the Amanus Mountains growing in open deciduous forests. It can be distinguished from E. erubescens by its longer stems, pubescent leaves and fruits, unicellular hairs, petiolate-subsessile second year cauline leaves and laciniate cyathial gland appendages. Diagnostic characters, a full description, and detailed illustrations are presented. These diagnostic characters and other observations concerning the new species are presented and compared with those from species of the sect. Patellares occurring in Turkey. The new species is the only one in sect. Patellares having laciniate gland appendages and unicellular hairs. Micromorphological structures of fruit and seed surfaces of E. akmanii and E. erubescens were examined by SEM. The geographical distribution of species of sect. Patellares in Tu...

Phytotaxa, 2016

Centaurea malatyensis Ş. Kültür & M. Bona sp. nova (Asteraceae) is described as new to science fr... more Centaurea malatyensis Ş. Kültür & M. Bona sp. nova (Asteraceae) is described as new to science from East Anatolia (B6: Malatya: Turkey). It is morphologically similar to C. leptophylla but differs mainly in its stem, basal and cauline leaf shape and size, achene, pappus and phyllary appendages. The geographical distribution of the new species and its relatives is mapped. The ecology and conservation status of the new species is also presented. Micromorphological structures of achenes of C. malatyensis and C. leptophylla are examined by SEM.

Journal of Faculty Pharmacy of Istanbul University, 2007

Turkish Journal of Pharmaceutical Sciences

Journal of Ethnopharmacology, 2021

ETHNOPHARMACOLOGICAL RELEVANCE The preparations of Phlomis aerial parts are used traditionally in... more ETHNOPHARMACOLOGICAL RELEVANCE The preparations of Phlomis aerial parts are used traditionally in Anatolia for wound healing and in inflammatory disorders. METHODS For the identification of the active fraction, the air dried aerial parts of Phlomis rigida Labill. were extracted by methanol and fractionated successively by n-hexane, dichloromethane and ethyl acetate, respectively. The phenolic constituents were characterized by the Folin-Ciocaltheu method; the antioxidant activity was performed by ABTS and DPPH radical scavenging assays. In vitro anti-inflammatory activity was evaluated by LOX enzyme inhibition, spectrophotometrically as well as cell cultures. The wound healing properties of P. rigida extract gels were studied via in vitro cell culture methods and in vivo by excisional wound model using Balb-c mice. The P. rigida extract was analyzed and characterized by GC-FID, GC-MS, and LC-MS. RESULTS The P. rigida methanol extract showed moderate LOX inhibitory at IC50=19.5 ± 2.8 μg/mL whereas the antioxidant activity was by DPPH• IC50=0.89 mg/mL, and by ABTS• IC50=0.99 mg/mL, respectively. In addition, a remarkable P. rigida extracts anti-inflammatory activity was observed in the cell culture assay, which was then confirmed by the in vitro wound healing activity applied at 0.125-0.5 mg/mL concentrations, resulting in a dose-dependent increase in wound closure at the final stage. The P. rigida gel formulation was prepared to evaluate the extract in vivo, whereas the experimental results of the new gel formulation supported the findings of the in vitro wound healing activity. CONCLUSION The findings of this in vitro and in vivo study suggest that the wound healing and anti-inflammatory properties provide a scientific evidence of the ethnopharmacological application of Phlomis species.

TURKISH JOURNAL OF BOTANY, 2021

Introduction Kidney diseases are a significant public health problem which can lead to end-stage ... more Introduction Kidney diseases are a significant public health problem which can lead to end-stage kidney failure and serious complications. The increasing prevalence of chronic kidney disease that causes high morbidity and mortality has reached to alarming levels all over the world. It is estimated that nowadays more than 1.4 million patients undergoing renal replacement therapy worldwide (Kazancıoğlu, 2013; Bikbov et al., 2020). According to the latest reports chronic kidney disease affects approximately 15.7% of population in Turkey (Ateş, 2020). Since there are some preventable risk factors leading to kidney diseases, identification of them is essential to maintain individual health and inhibition of progression of the disease. Kidney diseases associated with smoking, obesity, hypertension, and diabetes mellitus have been well documented. Moreover, factors such as race, gender, age, and family history have also been considered (Kazancıoğlu, 2013; Ateş, 2020). Despite the advancement in medical science, there are few treatment methods to cure kidney diseases. Patients have looked for more affordable, accessible and reliable options, therefore, the use of herbal remedies or natural products has gained much attention (Touwaide et al., 2005; Karimi et al., 2017). Medicinal plants have been serving mankind in treating diseases and improving health since ancient times. In recent years, scientific researches have proven that bioactive compounds from medicinal plants offer a good and safer alternative to modern synthetic drugs (Cotton, 1996; Baytop, 1999; Kendir and Güvenç, 2010; Yeşilada, 2013). The uses of traditional herbal remedies for the treatment of kidney diseases are common in many countries. Several medicinal plants such as Vaccinium macrocarpon Aiton, Harpagophytum procumbens DC. ex Meissner, Schisandra chinensis (Turcz.) Baill., Filipendula ulmaria (L.) Maxim, Tinospora cordifolia (Willd.) Miers, Astragalus sp. and Rheum sp. have been used by local people for various kidney problems, especially in Europe and Asia (Heinrich et al., 2012; Singh and Sharma, 2013; Zhong et al., 2013). In many countries, benefit from natural resources for medicinal use and other purposes are closely linked with the floristic richness and the accumulation of Abstract:Ethnobotanical and ethnomedicinal studies have become increasingly recognised as a valuable source of information on the use and possible pharmacological activity of many plant species. There is no study presenting traditional herbal remedies used for kidney diseases in Turkey. The purpose of the paper is to compile herbal remedies used in kidney diseases in Turkey with detailed usage information and chemical constituents. The botanical names, families, and local names; used parts; preparation methods; administration/ dosage; kidney problems and chemical constituents were presented by screening ethnobotanical, ethnomedicinaland phytochemical studies. The most cited plant families, the most cited genera, and the most frequently used plant parts were determined and presented in graphics. In total, 300 taxa belonging to 70 families were determined as being traditional herbal remedies used in kidney diseases. Asteraceae (57), Lamiaceae (33), Rosaceae (30), Fabaceae (16), Malvaceae (15), Apiaceae (13) and Poaceae (10) were found as the most cited plant families. The most cited genera were Helichrysum (44), Equisetum (27), Tribulus (23), Urtica (23), Rosa (17), Alcea (14), Hypericum (14) and Paliurus (14), respectively. It was found that the aerial parts were the most frequently used part of theplant, accounting for 28%. Following in this category are leaves (19%), flowers (14%), fruits (14%), underground parts (13%), seeds (5%), stem (3%), and other parts (4%). The pharmacological studies of the most cited genera were also reviewed to confirm the efficacy of these plants inthe treatment of kidney diseases. It is concluded that a number of pharmacological and phytochemical research support the traditional usage of plants, but further studies are needed. Our findings are expected to be the basis for candidate pharmaceutical products.

The diversity of vascular plants of Turkey was documented in the Flora of Turkey and the Eastern ... more The diversity of vascular plants of Turkey was documented in the Flora of Turkey and the Eastern Aegean Islands edited by Prof. Peter H. Davis and published in nine volumes between 1965 and 1985. The identification of additional taxa has necessitated the publication of the supplementary volumes to the Flora of Turkey volume 10 in 1988, and the second supplemental volume, vol. 11 edited by Turkish scientists published in 2000. Lamiaceae is cited in Flora of Turkey vol. 7 as 523 species, with 2 monotypic genera: Dorystaechas hastata Boiss. & Heldr. ex Benth. and Pentapleura subulifera Hand.-Mazz. and endemism percentage is 43.60. In the supplementary volumes: 20 species are added to vol. 10 (1988) and 31 more species are added to the vol. 11 (2000). In this present study, after publication of vol.11 additional taxa to the Flora of Turkey are given in a systematic order since the year 2000. In eighteen years the number of additional taxa is 78 of which 53 are new taxa for science and 2...

Cagla Bozkurt-Guzel*, Tuba Serbetci & Sukran Kultur 1Department of Pharmaceutical Microbiology, F... more Cagla Bozkurt-Guzel*, Tuba Serbetci & Sukran Kultur 1Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, Beyazit, Istanbul, 34116, Turkey; 2Herbasphere Biotechnology R&D Company, Inc., Istanbul University Technocity, Avcılar, Istanbul, 34310, Turkey; 3Department of Pharmaceutical Botany, Faculty of Pharmacy, Istanbul University, Beyazit, Istanbul, 34116, Turkey E-mail: caglabozkurt@hotmail.com

Natural dyes are recently becoming object of consumer interests because of the harmful effects o... more Natural dyes are recently becoming object of consumer interests because of the harmful effects of the synthetic dyes. The dyeing with natural colourants was one of the oldest techniques practiced by the ancient civilization people. An ethnobotanical study was conducted between 2012 and 2015 in order to determine wild plants used in Savastepe. Savastepe is a town and district of Balikesir Province in the Marmara region of Turkey. With this study, we aimed to document traditional uses of dye plants in Savastepe (Balikesir). According to the results of the identification, 15 species belonging to 12 families were used as dye source. Used parts of plants were flowers, fruits, leaves, roots, seeds and galls.

Journal of Research in Pharmacy, 2021

Karyotypes of 12 Euphorbia species were studied and described for the first time; Euphorbia cheir... more Karyotypes of 12 Euphorbia species were studied and described for the first time; Euphorbia cheiradenia, E. pannonica, E. pestalozzae, E. petrophila, E. pisidica, E. thessala and E. yildirimli. Karyological analyses indicate relationships among the species with respect to their asymmetry indices. Most of the investigated taxa are diploids with 2n = 2x = 18. E. macroclada and E. smirnovii showed tetraploid cytotypes 2n = 4x = 36. All karyotypes are symmetrical, consisting of metacentric and submetacentric chromosomes. The chromosomes range in size from 0.79 µm to 2.20 µm. The total haploid chromosome length (THL) ranges from 8.75 μm (E. terracina) to 16.78 μm (E. petrophila). Principal Coordinate Analysis with five uncorrelated parameters was performed to determine the karyological relationships among the taxa.

Journal of Faculty Pharmacy of Istanbul University, 2014

In this study, have been reported different medicinal plant recipes in the Kirklareli region. 15 ... more In this study, have been reported different medicinal plant recipes in the Kirklareli region. 15 medicinal plant recipes belonging to 20 families (20 wild plant species, 7 cultivated plant species) which were used for different medicinal purposes by local people have been recorded totally 27 plant species in the area. Traditional medicinal plant recipes have been mostly used for the traetment of cough, cold and influenza

Journal of Research in Pharmacy, 2021

The Coronavirus disease 2019 (Covid-19), caused by the severe acute respiratory syndrome coronavi... more The Coronavirus disease 2019 (Covid-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has led to unprecedented challenges for human life. During this pandemic, Turkish people have used various herbal remedies for both the prevention of Covid-19 and the alleviate of its symptoms. The present study aimed to investigate the herbal remedies used to prevent Covid-19 in Turkey and to determine whether the usage of herbal remedies was associated with sociodemographic properties. A cross-sectional study using an online questionnaire was conducted between November and December 2020. A total of 871 individuals (15 years of age or older) who lived in various provinces of Turkey participated in this study. Analysis was made in SPSS version 26.0 software using the descriptive statistics and appropriate tests of statistical significance for the comparisons. About 54.4% (n = 474) of the participants reported that they have used herbal remedies during the pandemic period. We identified a total of 45 plant species, the most frequently cited were ginger (Zingiber officinale Roscoe), linden (Tilia spp.), elderberry (Sambucus nigra L.), sage (Salvia spp.), and rosehip (Rosa canina L.), respectively. It has been found that the usage of herbal remedies was associated with several demographic variables. A considerable proportion of the participants reported the use of herbal remedies in order to prevent disease. This paper demonstrated the potential herbal remedies that can be used against Covid-19. Further research should be carried out to evaluate the efficacy of these medicinal plants and should control the flow of misleading information.

İstanbul Journal of Pharmacy, 2021

Background and Aims: In Turkey, there is a growing interest in ethnobotany due to the wealth of b... more Background and Aims: In Turkey, there is a growing interest in ethnobotany due to the wealth of biological and cultural diversity. The main purpose of this study is to record and highlight the medicinal plants used therapeutically in the Develi district. Methods: The data were obtained during different seasons of 2010-2011 through face-to-face interviews. Medicinal plants were collected with the guidance of the informants, and traditional uses was recorded. Botanical identification of all the species was made, and voucher specimens were deposited at Istanbul University, Herbarium of the Faculty of Pharmacy (ISTE). Results: The informants reported data on 14 medicinal plants belonging to 8 botanical families. These medicinal plants are used for about 26 different purposes. The most dominant family is Lamiaceae (6 species) followed by Asteraceae (2 species). Various plant parts such as leaf, fruit, flower, root, wood and fruity branch are used; the aerial part is consumed more frequen...

Phytotaxa, 2018

A comprehensive study based on seed morphology of perennial Euphorbia (Euphorbiaceae) sect. Pithy... more A comprehensive study based on seed morphology of perennial Euphorbia (Euphorbiaceae) sect. Pithyusa species occurring in Turkey is presented. A total of 14 species were studied. Seed characteristics were examined using scanning electron microscopy (SEM) as well as dissecting light microscopy. Significant features are: seed size, seed shape, shape of caruncle and seed surface ornamentation. Three different seed surface types (smooth, pitted, and wrinkled) were observed. Four main seed shapes (ovoid, oblong, quadrangular, and globose), as well as seven types of seed coat ornamentation (reticulate-areolate, areolate, alveolate, falsifoveate, pusticulate, colliculate and smooth) were found. The number of testa cells per 100 µm2 and also its range, from 8–12 to 57–63, are given.

International Journal of Life Sciences and Biotechnology

Asteraceae familyası 485’i endemik olmak üzere içerdiği 1311 tür ile ülkemiz florasında bulunan t... more Asteraceae familyası 485’i endemik olmak üzere içerdiği 1311 tür ile ülkemiz florasında bulunan tür sayısı bakımından en zengin familyadır. Familyanın Senecioneae tribusunda yer alan Doronicum L. cinsi son verilere göre ülkemizde 9 tür ve 1 alt tür ile temsil edilmekte olup endemizm oranı %40’tır. Ülkemizde bulunan türlerin genellikle yayılış alanları dar olup çoğunlukla Kuzey ve Doğu Anadolu dağlarının nemli bölgelerinde yetişmektedirler. Cins üzerinde en son kapsamlı çalışmalar 2000’li yılların başında gerçekleştirilmiş olup türler üzerinde yapılan bazı morfolojik ve moleküler çalışmalarla cinsin sistematiği aydınlatılmaya çalışılmıştır. Elde edilen veriler sonucunda Türkiyede’de yer alan bazı türler sinonim seviyesine düşürülmüştür. Avrupa’da Doronicum türlerinden halk arasında kalp hastalıkların, epilepsi, malarya, sindirim sistemi hastalıkları ve akrep-yılan zehirlenmeleri gibi çeşitli hastalıkların tedavisinde yararlanılmaktadır. Ülkemizde D. orientale (Acımık, Baylıkotu, Kapl...

Fresenius Environmental Bulletin, 2016

Abstract: This checklist contains a total of 168 taxa published as additions to the Flora of Turk... more Abstract: This checklist contains a total of 168 taxa published as additions to the Flora of Turkey. It includes details of taxa neither recorded by P.H.Davis ’ “Flora of Turkey and the East Aegean Islands ” or its Supplement, nor in the first of this series of checklists. The records in this list are based on data given in nearly 100 publications published up to the end of 1998.

Journal of Faculty Pharmacy of Istanbul University, 2014

Anatomical characters are very important to distinguish between closely related species and gener... more Anatomical characters are very important to distinguish between closely related species and genera, especially in the family Apiaceae. Anatomy of Apiaceae fruits varies strongly, even among closely related species in the same genus. An ethnobotanical study was conducted between 2004 and 2005 in order to determine wild used plants in West part of Nigde-Aladaglar. According the data of this study’s, 3 plant species belong to Apiaceae family sold to different tea companies by local people. Anatomical characteristics of fruits of the Ferulago pachyloba, Prangos ferulacea, Prangos meliocarpoides have been studied. Ferulago pachyloba has winged dorsal ribs, equal to or shorter than seeds. Prangos ferulacea has five blocks of mesocarp, they are not separated by the exocarp and the vascular bundles usually surround each block. Prangos meliocarpoides has continuous mesocarp and not separated into blocks. Druse crystals do not exist in the endosperm of F. pachyloba, P. ferulacea, and P. melio...

İstanbul Journal of Pharmacy, 2021

Background and Aims: This study reveals the anatomical features of Hypericum kotschyanum Boiss. s... more Background and Aims: This study reveals the anatomical features of Hypericum kotschyanum Boiss. species and compares them with previous studies. The anatomical characteristics of stem, leaf, and root were studied using a light microscope. In addition, anatomical structures were measured. Methods: The studied material was collected from Arslankoy, Mersin. The collected specimens were identified. Dried specimens were kept in Istanbul University Faculty of Pharmacy Herbarium (ISTE) and filed using the ISTE number system (ISTE 98173). Also, some plant materials were kept in 70% ethanol for anatomical examination. All sections from plants were cut by hand using a blade. Samples were examined in SARTUR reagent. Photographs were taken using a light microscope. Results: When we examined the cells around the stomata in the light of the neighboring cells, we observed that the stomata is an anomocytic type in leaf superficial section. The number of cells that radially surround the bottom of t...

Phytotaxa, 2016

Euphorbia akmanii, a new species of Euphorbiaceae (sect. Patellares) from Turkey (Osmaniye) is de... more Euphorbia akmanii, a new species of Euphorbiaceae (sect. Patellares) from Turkey (Osmaniye) is described on the basis of morphological characters. The species was found in the north-west part of the Amanus Mountains growing in open deciduous forests. It can be distinguished from E. erubescens by its longer stems, pubescent leaves and fruits, unicellular hairs, petiolate-subsessile second year cauline leaves and laciniate cyathial gland appendages. Diagnostic characters, a full description, and detailed illustrations are presented. These diagnostic characters and other observations concerning the new species are presented and compared with those from species of the sect. Patellares occurring in Turkey. The new species is the only one in sect. Patellares having laciniate gland appendages and unicellular hairs. Micromorphological structures of fruit and seed surfaces of E. akmanii and E. erubescens were examined by SEM. The geographical distribution of species of sect. Patellares in Tu...

Phytotaxa, 2016

Centaurea malatyensis Ş. Kültür & M. Bona sp. nova (Asteraceae) is described as new to science fr... more Centaurea malatyensis Ş. Kültür & M. Bona sp. nova (Asteraceae) is described as new to science from East Anatolia (B6: Malatya: Turkey). It is morphologically similar to C. leptophylla but differs mainly in its stem, basal and cauline leaf shape and size, achene, pappus and phyllary appendages. The geographical distribution of the new species and its relatives is mapped. The ecology and conservation status of the new species is also presented. Micromorphological structures of achenes of C. malatyensis and C. leptophylla are examined by SEM.

Journal of Faculty Pharmacy of Istanbul University, 2007

Turkish Journal of Pharmaceutical Sciences

Journal of Ethnopharmacology, 2021

ETHNOPHARMACOLOGICAL RELEVANCE The preparations of Phlomis aerial parts are used traditionally in... more ETHNOPHARMACOLOGICAL RELEVANCE The preparations of Phlomis aerial parts are used traditionally in Anatolia for wound healing and in inflammatory disorders. METHODS For the identification of the active fraction, the air dried aerial parts of Phlomis rigida Labill. were extracted by methanol and fractionated successively by n-hexane, dichloromethane and ethyl acetate, respectively. The phenolic constituents were characterized by the Folin-Ciocaltheu method; the antioxidant activity was performed by ABTS and DPPH radical scavenging assays. In vitro anti-inflammatory activity was evaluated by LOX enzyme inhibition, spectrophotometrically as well as cell cultures. The wound healing properties of P. rigida extract gels were studied via in vitro cell culture methods and in vivo by excisional wound model using Balb-c mice. The P. rigida extract was analyzed and characterized by GC-FID, GC-MS, and LC-MS. RESULTS The P. rigida methanol extract showed moderate LOX inhibitory at IC50=19.5 ± 2.8 μg/mL whereas the antioxidant activity was by DPPH• IC50=0.89 mg/mL, and by ABTS• IC50=0.99 mg/mL, respectively. In addition, a remarkable P. rigida extracts anti-inflammatory activity was observed in the cell culture assay, which was then confirmed by the in vitro wound healing activity applied at 0.125-0.5 mg/mL concentrations, resulting in a dose-dependent increase in wound closure at the final stage. The P. rigida gel formulation was prepared to evaluate the extract in vivo, whereas the experimental results of the new gel formulation supported the findings of the in vitro wound healing activity. CONCLUSION The findings of this in vitro and in vivo study suggest that the wound healing and anti-inflammatory properties provide a scientific evidence of the ethnopharmacological application of Phlomis species.

TURKISH JOURNAL OF BOTANY, 2021

Introduction Kidney diseases are a significant public health problem which can lead to end-stage ... more Introduction Kidney diseases are a significant public health problem which can lead to end-stage kidney failure and serious complications. The increasing prevalence of chronic kidney disease that causes high morbidity and mortality has reached to alarming levels all over the world. It is estimated that nowadays more than 1.4 million patients undergoing renal replacement therapy worldwide (Kazancıoğlu, 2013; Bikbov et al., 2020). According to the latest reports chronic kidney disease affects approximately 15.7% of population in Turkey (Ateş, 2020). Since there are some preventable risk factors leading to kidney diseases, identification of them is essential to maintain individual health and inhibition of progression of the disease. Kidney diseases associated with smoking, obesity, hypertension, and diabetes mellitus have been well documented. Moreover, factors such as race, gender, age, and family history have also been considered (Kazancıoğlu, 2013; Ateş, 2020). Despite the advancement in medical science, there are few treatment methods to cure kidney diseases. Patients have looked for more affordable, accessible and reliable options, therefore, the use of herbal remedies or natural products has gained much attention (Touwaide et al., 2005; Karimi et al., 2017). Medicinal plants have been serving mankind in treating diseases and improving health since ancient times. In recent years, scientific researches have proven that bioactive compounds from medicinal plants offer a good and safer alternative to modern synthetic drugs (Cotton, 1996; Baytop, 1999; Kendir and Güvenç, 2010; Yeşilada, 2013). The uses of traditional herbal remedies for the treatment of kidney diseases are common in many countries. Several medicinal plants such as Vaccinium macrocarpon Aiton, Harpagophytum procumbens DC. ex Meissner, Schisandra chinensis (Turcz.) Baill., Filipendula ulmaria (L.) Maxim, Tinospora cordifolia (Willd.) Miers, Astragalus sp. and Rheum sp. have been used by local people for various kidney problems, especially in Europe and Asia (Heinrich et al., 2012; Singh and Sharma, 2013; Zhong et al., 2013). In many countries, benefit from natural resources for medicinal use and other purposes are closely linked with the floristic richness and the accumulation of Abstract:Ethnobotanical and ethnomedicinal studies have become increasingly recognised as a valuable source of information on the use and possible pharmacological activity of many plant species. There is no study presenting traditional herbal remedies used for kidney diseases in Turkey. The purpose of the paper is to compile herbal remedies used in kidney diseases in Turkey with detailed usage information and chemical constituents. The botanical names, families, and local names; used parts; preparation methods; administration/ dosage; kidney problems and chemical constituents were presented by screening ethnobotanical, ethnomedicinaland phytochemical studies. The most cited plant families, the most cited genera, and the most frequently used plant parts were determined and presented in graphics. In total, 300 taxa belonging to 70 families were determined as being traditional herbal remedies used in kidney diseases. Asteraceae (57), Lamiaceae (33), Rosaceae (30), Fabaceae (16), Malvaceae (15), Apiaceae (13) and Poaceae (10) were found as the most cited plant families. The most cited genera were Helichrysum (44), Equisetum (27), Tribulus (23), Urtica (23), Rosa (17), Alcea (14), Hypericum (14) and Paliurus (14), respectively. It was found that the aerial parts were the most frequently used part of theplant, accounting for 28%. Following in this category are leaves (19%), flowers (14%), fruits (14%), underground parts (13%), seeds (5%), stem (3%), and other parts (4%). The pharmacological studies of the most cited genera were also reviewed to confirm the efficacy of these plants inthe treatment of kidney diseases. It is concluded that a number of pharmacological and phytochemical research support the traditional usage of plants, but further studies are needed. Our findings are expected to be the basis for candidate pharmaceutical products.

The diversity of vascular plants of Turkey was documented in the Flora of Turkey and the Eastern ... more The diversity of vascular plants of Turkey was documented in the Flora of Turkey and the Eastern Aegean Islands edited by Prof. Peter H. Davis and published in nine volumes between 1965 and 1985. The identification of additional taxa has necessitated the publication of the supplementary volumes to the Flora of Turkey volume 10 in 1988, and the second supplemental volume, vol. 11 edited by Turkish scientists published in 2000. Lamiaceae is cited in Flora of Turkey vol. 7 as 523 species, with 2 monotypic genera: Dorystaechas hastata Boiss. & Heldr. ex Benth. and Pentapleura subulifera Hand.-Mazz. and endemism percentage is 43.60. In the supplementary volumes: 20 species are added to vol. 10 (1988) and 31 more species are added to the vol. 11 (2000). In this present study, after publication of vol.11 additional taxa to the Flora of Turkey are given in a systematic order since the year 2000. In eighteen years the number of additional taxa is 78 of which 53 are new taxa for science and 2...

Cagla Bozkurt-Guzel*, Tuba Serbetci & Sukran Kultur 1Department of Pharmaceutical Microbiology, F... more Cagla Bozkurt-Guzel*, Tuba Serbetci & Sukran Kultur 1Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, Beyazit, Istanbul, 34116, Turkey; 2Herbasphere Biotechnology R&D Company, Inc., Istanbul University Technocity, Avcılar, Istanbul, 34310, Turkey; 3Department of Pharmaceutical Botany, Faculty of Pharmacy, Istanbul University, Beyazit, Istanbul, 34116, Turkey E-mail: caglabozkurt@hotmail.com

Natural dyes are recently becoming object of consumer interests because of the harmful effects o... more Natural dyes are recently becoming object of consumer interests because of the harmful effects of the synthetic dyes. The dyeing with natural colourants was one of the oldest techniques practiced by the ancient civilization people. An ethnobotanical study was conducted between 2012 and 2015 in order to determine wild plants used in Savastepe. Savastepe is a town and district of Balikesir Province in the Marmara region of Turkey. With this study, we aimed to document traditional uses of dye plants in Savastepe (Balikesir). According to the results of the identification, 15 species belonging to 12 families were used as dye source. Used parts of plants were flowers, fruits, leaves, roots, seeds and galls.

Journal of Research in Pharmacy, 2021

Karyotypes of 12 Euphorbia species were studied and described for the first time; Euphorbia cheir... more Karyotypes of 12 Euphorbia species were studied and described for the first time; Euphorbia cheiradenia, E. pannonica, E. pestalozzae, E. petrophila, E. pisidica, E. thessala and E. yildirimli. Karyological analyses indicate relationships among the species with respect to their asymmetry indices. Most of the investigated taxa are diploids with 2n = 2x = 18. E. macroclada and E. smirnovii showed tetraploid cytotypes 2n = 4x = 36. All karyotypes are symmetrical, consisting of metacentric and submetacentric chromosomes. The chromosomes range in size from 0.79 µm to 2.20 µm. The total haploid chromosome length (THL) ranges from 8.75 μm (E. terracina) to 16.78 μm (E. petrophila). Principal Coordinate Analysis with five uncorrelated parameters was performed to determine the karyological relationships among the taxa.

Journal of Faculty Pharmacy of Istanbul University, 2014

In this study, have been reported different medicinal plant recipes in the Kirklareli region. 15 ... more In this study, have been reported different medicinal plant recipes in the Kirklareli region. 15 medicinal plant recipes belonging to 20 families (20 wild plant species, 7 cultivated plant species) which were used for different medicinal purposes by local people have been recorded totally 27 plant species in the area. Traditional medicinal plant recipes have been mostly used for the traetment of cough, cold and influenza

Journal of Research in Pharmacy, 2021

The Coronavirus disease 2019 (Covid-19), caused by the severe acute respiratory syndrome coronavi... more The Coronavirus disease 2019 (Covid-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has led to unprecedented challenges for human life. During this pandemic, Turkish people have used various herbal remedies for both the prevention of Covid-19 and the alleviate of its symptoms. The present study aimed to investigate the herbal remedies used to prevent Covid-19 in Turkey and to determine whether the usage of herbal remedies was associated with sociodemographic properties. A cross-sectional study using an online questionnaire was conducted between November and December 2020. A total of 871 individuals (15 years of age or older) who lived in various provinces of Turkey participated in this study. Analysis was made in SPSS version 26.0 software using the descriptive statistics and appropriate tests of statistical significance for the comparisons. About 54.4% (n = 474) of the participants reported that they have used herbal remedies during the pandemic period. We identified a total of 45 plant species, the most frequently cited were ginger (Zingiber officinale Roscoe), linden (Tilia spp.), elderberry (Sambucus nigra L.), sage (Salvia spp.), and rosehip (Rosa canina L.), respectively. It has been found that the usage of herbal remedies was associated with several demographic variables. A considerable proportion of the participants reported the use of herbal remedies in order to prevent disease. This paper demonstrated the potential herbal remedies that can be used against Covid-19. Further research should be carried out to evaluate the efficacy of these medicinal plants and should control the flow of misleading information.

İstanbul Journal of Pharmacy, 2021

Background and Aims: In Turkey, there is a growing interest in ethnobotany due to the wealth of b... more Background and Aims: In Turkey, there is a growing interest in ethnobotany due to the wealth of biological and cultural diversity. The main purpose of this study is to record and highlight the medicinal plants used therapeutically in the Develi district. Methods: The data were obtained during different seasons of 2010-2011 through face-to-face interviews. Medicinal plants were collected with the guidance of the informants, and traditional uses was recorded. Botanical identification of all the species was made, and voucher specimens were deposited at Istanbul University, Herbarium of the Faculty of Pharmacy (ISTE). Results: The informants reported data on 14 medicinal plants belonging to 8 botanical families. These medicinal plants are used for about 26 different purposes. The most dominant family is Lamiaceae (6 species) followed by Asteraceae (2 species). Various plant parts such as leaf, fruit, flower, root, wood and fruity branch are used; the aerial part is consumed more frequen...

Phytotaxa, 2018

A comprehensive study based on seed morphology of perennial Euphorbia (Euphorbiaceae) sect. Pithy... more A comprehensive study based on seed morphology of perennial Euphorbia (Euphorbiaceae) sect. Pithyusa species occurring in Turkey is presented. A total of 14 species were studied. Seed characteristics were examined using scanning electron microscopy (SEM) as well as dissecting light microscopy. Significant features are: seed size, seed shape, shape of caruncle and seed surface ornamentation. Three different seed surface types (smooth, pitted, and wrinkled) were observed. Four main seed shapes (ovoid, oblong, quadrangular, and globose), as well as seven types of seed coat ornamentation (reticulate-areolate, areolate, alveolate, falsifoveate, pusticulate, colliculate and smooth) were found. The number of testa cells per 100 µm2 and also its range, from 8–12 to 57–63, are given.