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Papers by Şenel YURTSEVER

PubMed, Jun 1, 2008

An 11-year-old girl with vesicles and eroded lesions on her oral mucosa and tongue was diagnosed ... more An 11-year-old girl with vesicles and eroded lesions on her oral mucosa and tongue was diagnosed as having pemphigus vulgaris. The diagnosis was confirmed by histopathologic and immunofluorescence studies. The patient was successfully treated with methylprednisolone and azathioprine. After two months maintenance therapy was started. She is still taking methylprednisolone and azathioprine as maintenance therapy and no recurrence has been observed.

African Journal of Microbiology Research, Oct 11, 2013

The aim of the present study was to investigate antifungal susceptibility of Candida strains isol... more The aim of the present study was to investigate antifungal susceptibility of Candida strains isolated from blood cultures in our tertiary hospital. Patients hospitalized between December 2008 and April 2011 whose more than one blood cultures revealed growth of Candida species and Candida strains isolated in these cultures were included in the study. In order to identify isolated yeast species, appearance and configuration of the colonies, germ tube test results and their morphological appearance in corn flour Tween 80 agar were evaluated. Within the study period, among 65 Candida strains isolated, 36 (55.4%) Candida parapsilosis, 17 (26.2%) Candida albicans, 6 (9.2%) Candida glabrata, 4 (6.2%) Candida tropicalis, and 2 (3.1%) Candida lusitaniae isolates were identified. According to Fungifast susceptibility panel, antifungal susceptibility rates were as follows: amphotericin B and flucytosine (100%) fluconazole (93.8%), itraconazole (87.6%) and voriconazole (96.9%). Antifungal susceptibility rates of Candida isolates based on E-test method were as follows: amphotericin B (100%), voriconazole (92.3 %) itraconazole (53.8%) and fluconazole (89.2%). In consideration of higher morbidity, mortality and economic burden of the cases with fungemia, measures against emergence of these infections convey crucial importance. Typing of fungi isolated from intensive care units in particular, and their antifungal susceptibility tests should be done regularly to reveal resistance patterns of pathogens, and any increase in resistance (if any) over time, must be determined with scientific methods. We think that similar studies will guide the clinician in planning treatment of Candida infections especially in patients at risk.

ANKEM …, 2009

Imipenem was the most effective antibiotic for E.coli strains. 29 % of S.aureus and 50 % of CNS s... more Imipenem was the most effective antibiotic for E.coli strains. 29 % of S.aureus and 50 % of CNS strains were found as methicillin resistant. There was no resistance to vancomycin in Gram positive bacteria. The highest ratio of positive cultures were abtained from surgical services.

JOURNAL OF BIOTECHNOLOGY AND STRATEGIC HEALTH RESEARCH

Objective: As long as immunosuppressive treatments are widely used, careful monitoring of HBVr is... more Objective: As long as immunosuppressive treatments are widely used, careful monitoring of HBVr is essential. We aimed to measure the awareness of Turkish physicians of certain specialties about the risk of hepatitis B virus reactivation (HBVr), HBV screening methods, prophylactic treatment practices and personal experiences in treating patients with biological agents. Methods: An electronic questionnaire link containing 21 questions about demographics and their applications to HBVr was sent to participants working in the various specialties across the country. Results: 227 participants took our survey (Female: 52.4%, n:119, Male: 47.6%, n:108), and consisted of 70 Hematologists, 65 Rheumatologists, 38 Gastroenterologists, 33 Oncologists, and 21 Dermatologists. We obtained extremely different results. It was found that all specialties are aware that the use of biological agents can cause HBVr (97.8%, n:222/227). Biological agents were used in 96% of the participants and HBVr was dete...

International Journal of Dermatology, 2004

A 66-year-old man with a past medical history of hypertension and arthritis was hospitalized and ... more A 66-year-old man with a past medical history of hypertension and arthritis was hospitalized and treated for bacterial pneumonia. Chest X-ray revealed a left-sided chest mass. Computed tomography (CT) scan of the chest demonstrated a large heterogeneously enhancing mass occupying most of the left lower lobe and extending to the inferior aspect of the hilum. It measured 16.6 × 12 cm and caused a mild shift of the mediastinum to the right. The patient declined further work-up or surgical resection of the mass. Dermatologic examination was unremarkable at that time. Over the next 5 months, numerous skin lesions erupted on the patient's trunk. He then experienced several syncopal episodes, at which time he was found to be profoundly hypoglycemic. It was suspected that the chest tumor was producing high serum levels of insulin-like growth factor (IGF) resulting in hypoglycemia and syncope. Serum laboratory investigations were significant for glucose of 20 mg / dL (normal, 60-120 mg / dL), IGF-1 of 39 ng / mL (normal, 152-494 ng / mL), IGF-2 of 927 ng / mL (normal, 210-750 ng / mL), and insulin of < 5.0 microunits (MCU)/ mL (normal, 0-30 MCU/mL). Surgical extirpation of the chest tumor was recommended. The dermatology service was consulted to evaluate whether the numerous skin lesions in the area of planned surgery would pose an increased risk of infection. Cutaneous examination revealed a dense aggregation of pigmented hyperkeratotic plaques with a "stuck-on" appearance, predominantly localized on the trunk. Many were unusually large or darkly pigmented. A particularly dense distribution was apparent on the left side of the chest (Fig. 1a). Numerous large acrochordons were evident on the lower eyelids and in the axillary vaults. Acanthosis nigricans was not present. A biopsy specimen from a hyperkeratotic lesion on the left upper back revealed an acanthotic, hyperpigmented epidermis with a lamellar horn, anastomosing rete, and pseudohorn cysts (Fig. 1b). Left thoracotomy and left lower lobectomy were performed, and surgeons extirpated an 18 × 17 × 10 cm cystic, multilobular, hard tumor (Fig. 2a) adhering to the left diaphragm, left lower lobe, and left parietal pleura. Pathologic examination revealed a highly cellular spindle cell tumor (Fig. 2b). The nuclei were relatively monotonous with few mitoses. No areas of necrosis were identified. These pathologic findings were diagnostic for solitary fibrous tumor of the pleura. After surgery, the patient experienced no further syncopal episodes. The truncal seborrheic keratoses decreased substantially in number, size, and density over the following 6 months. Post-operative laboratory data revealed normalization of the blood glucose, insulin, IGF-1 (191 ng/mL; normal, 71-290 ng / mL), and IGF-2 (515 ng / mL; normal, 358-854 ng / mL).

PubMed, Jun 1, 2008

An 11-year-old girl with vesicles and eroded lesions on her oral mucosa and tongue was diagnosed ... more An 11-year-old girl with vesicles and eroded lesions on her oral mucosa and tongue was diagnosed as having pemphigus vulgaris. The diagnosis was confirmed by histopathologic and immunofluorescence studies. The patient was successfully treated with methylprednisolone and azathioprine. After two months maintenance therapy was started. She is still taking methylprednisolone and azathioprine as maintenance therapy and no recurrence has been observed.

African Journal of Microbiology Research, Oct 11, 2013

The aim of the present study was to investigate antifungal susceptibility of Candida strains isol... more The aim of the present study was to investigate antifungal susceptibility of Candida strains isolated from blood cultures in our tertiary hospital. Patients hospitalized between December 2008 and April 2011 whose more than one blood cultures revealed growth of Candida species and Candida strains isolated in these cultures were included in the study. In order to identify isolated yeast species, appearance and configuration of the colonies, germ tube test results and their morphological appearance in corn flour Tween 80 agar were evaluated. Within the study period, among 65 Candida strains isolated, 36 (55.4%) Candida parapsilosis, 17 (26.2%) Candida albicans, 6 (9.2%) Candida glabrata, 4 (6.2%) Candida tropicalis, and 2 (3.1%) Candida lusitaniae isolates were identified. According to Fungifast susceptibility panel, antifungal susceptibility rates were as follows: amphotericin B and flucytosine (100%) fluconazole (93.8%), itraconazole (87.6%) and voriconazole (96.9%). Antifungal susceptibility rates of Candida isolates based on E-test method were as follows: amphotericin B (100%), voriconazole (92.3 %) itraconazole (53.8%) and fluconazole (89.2%). In consideration of higher morbidity, mortality and economic burden of the cases with fungemia, measures against emergence of these infections convey crucial importance. Typing of fungi isolated from intensive care units in particular, and their antifungal susceptibility tests should be done regularly to reveal resistance patterns of pathogens, and any increase in resistance (if any) over time, must be determined with scientific methods. We think that similar studies will guide the clinician in planning treatment of Candida infections especially in patients at risk.

ANKEM …, 2009

Imipenem was the most effective antibiotic for E.coli strains. 29 % of S.aureus and 50 % of CNS s... more Imipenem was the most effective antibiotic for E.coli strains. 29 % of S.aureus and 50 % of CNS strains were found as methicillin resistant. There was no resistance to vancomycin in Gram positive bacteria. The highest ratio of positive cultures were abtained from surgical services.

JOURNAL OF BIOTECHNOLOGY AND STRATEGIC HEALTH RESEARCH

Objective: As long as immunosuppressive treatments are widely used, careful monitoring of HBVr is... more Objective: As long as immunosuppressive treatments are widely used, careful monitoring of HBVr is essential. We aimed to measure the awareness of Turkish physicians of certain specialties about the risk of hepatitis B virus reactivation (HBVr), HBV screening methods, prophylactic treatment practices and personal experiences in treating patients with biological agents. Methods: An electronic questionnaire link containing 21 questions about demographics and their applications to HBVr was sent to participants working in the various specialties across the country. Results: 227 participants took our survey (Female: 52.4%, n:119, Male: 47.6%, n:108), and consisted of 70 Hematologists, 65 Rheumatologists, 38 Gastroenterologists, 33 Oncologists, and 21 Dermatologists. We obtained extremely different results. It was found that all specialties are aware that the use of biological agents can cause HBVr (97.8%, n:222/227). Biological agents were used in 96% of the participants and HBVr was dete...

International Journal of Dermatology, 2004

A 66-year-old man with a past medical history of hypertension and arthritis was hospitalized and ... more A 66-year-old man with a past medical history of hypertension and arthritis was hospitalized and treated for bacterial pneumonia. Chest X-ray revealed a left-sided chest mass. Computed tomography (CT) scan of the chest demonstrated a large heterogeneously enhancing mass occupying most of the left lower lobe and extending to the inferior aspect of the hilum. It measured 16.6 × 12 cm and caused a mild shift of the mediastinum to the right. The patient declined further work-up or surgical resection of the mass. Dermatologic examination was unremarkable at that time. Over the next 5 months, numerous skin lesions erupted on the patient's trunk. He then experienced several syncopal episodes, at which time he was found to be profoundly hypoglycemic. It was suspected that the chest tumor was producing high serum levels of insulin-like growth factor (IGF) resulting in hypoglycemia and syncope. Serum laboratory investigations were significant for glucose of 20 mg / dL (normal, 60-120 mg / dL), IGF-1 of 39 ng / mL (normal, 152-494 ng / mL), IGF-2 of 927 ng / mL (normal, 210-750 ng / mL), and insulin of < 5.0 microunits (MCU)/ mL (normal, 0-30 MCU/mL). Surgical extirpation of the chest tumor was recommended. The dermatology service was consulted to evaluate whether the numerous skin lesions in the area of planned surgery would pose an increased risk of infection. Cutaneous examination revealed a dense aggregation of pigmented hyperkeratotic plaques with a "stuck-on" appearance, predominantly localized on the trunk. Many were unusually large or darkly pigmented. A particularly dense distribution was apparent on the left side of the chest (Fig. 1a). Numerous large acrochordons were evident on the lower eyelids and in the axillary vaults. Acanthosis nigricans was not present. A biopsy specimen from a hyperkeratotic lesion on the left upper back revealed an acanthotic, hyperpigmented epidermis with a lamellar horn, anastomosing rete, and pseudohorn cysts (Fig. 1b). Left thoracotomy and left lower lobectomy were performed, and surgeons extirpated an 18 × 17 × 10 cm cystic, multilobular, hard tumor (Fig. 2a) adhering to the left diaphragm, left lower lobe, and left parietal pleura. Pathologic examination revealed a highly cellular spindle cell tumor (Fig. 2b). The nuclei were relatively monotonous with few mitoses. No areas of necrosis were identified. These pathologic findings were diagnostic for solitary fibrous tumor of the pleura. After surgery, the patient experienced no further syncopal episodes. The truncal seborrheic keratoses decreased substantially in number, size, and density over the following 6 months. Post-operative laboratory data revealed normalization of the blood glucose, insulin, IGF-1 (191 ng/mL; normal, 71-290 ng / mL), and IGF-2 (515 ng / mL; normal, 358-854 ng / mL).