Олена Панасюк - Academia.edu (original) (raw)

Papers by Олена Панасюк

ScienceRise, 2015

In the article it was presented an analysis of etiological structure, clinical and diagnostic pec... more In the article it was presented an analysis of etiological structure, clinical and diagnostic peculiarities of mixt-herpesvirus neuroinfections. Aim of the work: To study clinical and diagnostic peculiarities of mixt-herpesvirus neuroinfections. Materials and methods: There was carried out a retrospective analysis of examination and therapy of 976 patients who underwent a hospital treatment in intensive care and detoxification department of SI "Institute of epidemiology and infectious diseases of L.V. Gromashevsky, NAMS of Ukraine" during the last 12 years. Results of research: According to the study of biological mediums (liquor, blood, saliva) monoinfection was diagnosed in 653 (66,9 %) patients, mixt-infection-in 323 (33,1 %) patients. Virus-virus infections considerably dominated in the structure of mixt-neuroinfections-246 (76,2 %). Among virus-virus infections mixt-herpesvirus infection was observed in 192 (78,1 %) patients and most often was presented as combination of HSV+CMV-57 (29,7 %); HSV+EBV-45 (23,4 %), EBV+HHV6-34 (17,7 %). In patients with mixt-herpesvirus infection (192 cases) it was observed the most diversity of clinical forms: in 8 (4,2 %) patients-meningoencephalitis, in 4 (2,1 %)-leukoencephalitis, in 64 (33,3 %)-menongoencerebritis, in 47 (24,8 %)-disseminated encephalomyelitis, in 43 (22,4 %)-encephalomyelopolyradiculoneuritis, in 26 (13,5 %)-encephalomyelitis. Combined forms of nervous system injuries with demyelinization were registered reliably more often. Conclusions: Causative agents capable for the long persistence namely herpesviruses (78,1 %) play the main role in development of mixt-virus neuroinfection. Prognosis of disease in these cases depends on timely diagnostics, individual approach to treating tactics and dispensary care. The heavy combined forms of nervous system injuries with demyelinization especially leukoencephalitis and disseminated encephalomyelitis are registered reliably more often in patients with mixt-virus neuroinfection. There were detected reliable differences in neurological manifestations of herpesvirus injury of nervous system in patients with mono-and mixt-infection. The main diagnostic syndromes in this case are psychopathic, cognitive, extra pyramid, epileptiform and neuroendocrine ones

ScienceRise, 2015

In the article it was presented an analysis of etiological structure, clinical and diagnostic pec... more In the article it was presented an analysis of etiological structure, clinical and diagnostic peculiarities of mixt-herpesvirus neuroinfections. Aim of the work: To study clinical and diagnostic peculiarities of mixt-herpesvirus neuroinfections. Materials and methods: There was carried out a retrospective analysis of examination and therapy of 976 patients who underwent a hospital treatment in intensive care and detoxification department of SI "Institute of epidemiology and infectious diseases of L.V. Gromashevsky, NAMS of Ukraine" during the last 12 years. Results of research: According to the study of biological mediums (liquor, blood, saliva) monoinfection was diagnosed in 653 (66,9 %) patients, mixt-infection-in 323 (33,1 %) patients. Virus-virus infections considerably dominated in the structure of mixt-neuroinfections-246 (76,2 %). Among virus-virus infections mixt-herpesvirus infection was observed in 192 (78,1 %) patients and most often was presented as combination of HSV+CMV-57 (29,7 %); HSV+EBV-45 (23,4 %), EBV+HHV6-34 (17,7 %). In patients with mixt-herpesvirus infection (192 cases) it was observed the most diversity of clinical forms: in 8 (4,2 %) patients-meningoencephalitis, in 4 (2,1 %)-leukoencephalitis, in 64 (33,3 %)-menongoencerebritis, in 47 (24,8 %)-disseminated encephalomyelitis, in 43 (22,4 %)-encephalomyelopolyradiculoneuritis, in 26 (13,5 %)-encephalomyelitis. Combined forms of nervous system injuries with demyelinization were registered reliably more often. Conclusions: Causative agents capable for the long persistence namely herpesviruses (78,1 %) play the main role in development of mixt-virus neuroinfection. Prognosis of disease in these cases depends on timely diagnostics, individual approach to treating tactics and dispensary care. The heavy combined forms of nervous system injuries with demyelinization especially leukoencephalitis and disseminated encephalomyelitis are registered reliably more often in patients with mixt-virus neuroinfection. There were detected reliable differences in neurological manifestations of herpesvirus injury of nervous system in patients with mono-and mixt-infection. The main diagnostic syndromes in this case are psychopathic, cognitive, extra pyramid, epileptiform and neuroendocrine ones