Татьяна Байдина - Academia.edu (original) (raw)
Татьяна Байдина
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Perm Medical Journal, 2016
Aim. The aim of the study was to investigate the gender structure, peculiarities of fatigue syndr... more Aim. The aim of the study was to investigate the gender structure, peculiarities of fatigue syndrome and depressive disorders in patients with disseminated sclerosis (DS); to determine the cytokine status and neurotrophic mechanism, serotoninergic, semaphorin Sema4 (CD100) statuses of the above mentioned disease. Materials and methods. Patients with a reliable diagnosis of disseminated sclerosis were examined according to McDonald 2010 criteria with remittent type of disease course. Clinical method, psychometric testing, immune-enzyme analysis, immunological methods were used. Results. In process of disseminated sclerosis, patients' gender shifts to femininity. Fatigue and emotional disorders are inseparable symptoms of this disease. Neurochemistry of disseminated sclerosis is characterized by serotoninergic insufficiency and deficiency of neurotrophic mechanisms; inflammatory process does not stop in the phase of clinical remission, but semaphorin system is participating in for...
Perm Medical Journal, 2018
Aim. To study the antigen-presenting ability of B-cells, class IV semaphorin Sema4D (CD100) and C... more Aim. To study the antigen-presenting ability of B-cells, class IV semaphorin Sema4D (CD100) and CD72 receptor expression in the immune system of patients with multiple sclerosis (MS); to study the interaction between the KIF1B gene polymorphisms and the variants of response to preparation, changing the course of multiple sclerosis in MS patients. Materials and methods. Patients with the established diagnosis of “Multiple sclerosis” by McDonald criteria 2010 with remitting type of the disease course were examined. Clinical method, psychometric testing, immune-enzyme analysis, immunologic method, PCR technique were used. Results. Among patients with MS, the antigen-presenting function of B-lymphocytes was changed, semaphorin Sema4D/CD100 expression level on T-lymphocyte membrane was elevated, CD72 receptor expression on B-lymphocyte membrane was decreased. The studied phenomena are associated with a number of clinical characteristics that permits to consider them to participate in the...
Perm Medical Journal, 2016
Aim. The aim of the study was to investigate the gender structure, peculiarities of fatigue syndr... more Aim. The aim of the study was to investigate the gender structure, peculiarities of fatigue syndrome and depressive disorders in patients with disseminated sclerosis (DS); to determine the cytokine status and neurotrophic mechanism, serotoninergic, semaphorin Sema4 (CD100) statuses of the above mentioned disease. Materials and methods. Patients with a reliable diagnosis of disseminated sclerosis were examined according to McDonald 2010 criteria with remittent type of disease course. Clinical method, psychometric testing, immune-enzyme analysis, immunological methods were used. Results. In process of disseminated sclerosis, patients' gender shifts to femininity. Fatigue and emotional disorders are inseparable symptoms of this disease. Neurochemistry of disseminated sclerosis is characterized by serotoninergic insufficiency and deficiency of neurotrophic mechanisms; inflammatory process does not stop in the phase of clinical remission, but semaphorin system is participating in for...
Perm Medical Journal, 2018
Aim. To study the antigen-presenting ability of B-cells, class IV semaphorin Sema4D (CD100) and C... more Aim. To study the antigen-presenting ability of B-cells, class IV semaphorin Sema4D (CD100) and CD72 receptor expression in the immune system of patients with multiple sclerosis (MS); to study the interaction between the KIF1B gene polymorphisms and the variants of response to preparation, changing the course of multiple sclerosis in MS patients. Materials and methods. Patients with the established diagnosis of “Multiple sclerosis” by McDonald criteria 2010 with remitting type of the disease course were examined. Clinical method, psychometric testing, immune-enzyme analysis, immunologic method, PCR technique were used. Results. Among patients with MS, the antigen-presenting function of B-lymphocytes was changed, semaphorin Sema4D/CD100 expression level on T-lymphocyte membrane was elevated, CD72 receptor expression on B-lymphocyte membrane was decreased. The studied phenomena are associated with a number of clinical characteristics that permits to consider them to participate in the...