拓志 奥坂 - Academia.edu (original) (raw)
拓志 奥坂
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Japanese Journal of Clinical Oncology, 1998
The vast majority of pancreatic cancer patients have advanced disease at the time of diagnosis an... more The vast majority of pancreatic cancer patients have advanced disease at the time of diagnosis and they eventually become so emaciated that death primarily occurs from cancer cachexia. Cancer cachexia may be mediated by certain cytokines such as interleukin-6. In this study, we measured serum interleukin-6 levels in 55 patients with histologically proven pancreatic cancer and investigated theirrelationships to the clinical status of pancreatic cancer. A control population of 20 normal healthy adults and 25 chronic pancreatitis patients with comparable gender and agedistribution characteristics wasalso studied. Serum interleukin-6 levels were measured using a quantitative sandwich enzyme-linked immunosorbent assay. Thirty pancreatic cancer patients (54.5°,/0) had detectable levels, although interleukin-6 levels were detectable inonlyonehealthy control and in two chronic pancreatitis patients. The specificity of serum interleukin-6 in this population was 93.3°,/0, resulting in high diagnostic accuracy (72.0°,/0). Among the pancreatic cancer patients, the detection rates of serum interleukin-6 levels increased significantly with the disease extent (p < 0.01). Moreover, a significant difference wasalso found in the detection rates between the 30 pancreatic cancer patients with bodyweight loss (76.7%) and the remaining 25 patients without weight loss (28.00/0, p < 0.01). These results may provide new insight into both diagnosis and treatment of pancreatic cancer, because the diagnostic accuracy of serum interleukin-6 was high and because anti-interleukin-6 therapeutics could improve symptoms in pancreatic cancer patients with high interleukin-6Ievels.
Japanese Journal of Clinical Oncology, 1998
The vast majority of pancreatic cancer patients have advanced disease at the time of diagnosis an... more The vast majority of pancreatic cancer patients have advanced disease at the time of diagnosis and they eventually become so emaciated that death primarily occurs from cancer cachexia. Cancer cachexia may be mediated by certain cytokines such as interleukin-6. In this study, we measured serum interleukin-6 levels in 55 patients with histologically proven pancreatic cancer and investigated theirrelationships to the clinical status of pancreatic cancer. A control population of 20 normal healthy adults and 25 chronic pancreatitis patients with comparable gender and agedistribution characteristics wasalso studied. Serum interleukin-6 levels were measured using a quantitative sandwich enzyme-linked immunosorbent assay. Thirty pancreatic cancer patients (54.5°,/0) had detectable levels, although interleukin-6 levels were detectable inonlyonehealthy control and in two chronic pancreatitis patients. The specificity of serum interleukin-6 in this population was 93.3°,/0, resulting in high diagnostic accuracy (72.0°,/0). Among the pancreatic cancer patients, the detection rates of serum interleukin-6 levels increased significantly with the disease extent (p < 0.01). Moreover, a significant difference wasalso found in the detection rates between the 30 pancreatic cancer patients with bodyweight loss (76.7%) and the remaining 25 patients without weight loss (28.00/0, p < 0.01). These results may provide new insight into both diagnosis and treatment of pancreatic cancer, because the diagnostic accuracy of serum interleukin-6 was high and because anti-interleukin-6 therapeutics could improve symptoms in pancreatic cancer patients with high interleukin-6Ievels.