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Papers by A. Caspi

Journal of Protein Chemistry

中国动脉硬化 …, 2006

... ３１１－３１８［３］ＷｉＵｌｎｇＰＫ，ＷｕＢＪ，船ｙＭ，Ｓｏｕ＇￣ｌｌ—ｋｅｅ］ｙＰ，ＳｌｏｅｋｅｒＲ．Ｐｉｄａｘ￣ｉＩｏ－ｔｅｅｔｓａｇ血喊ｈｙｐｏｄｄｏｒｉ￣... more ... ３１１－３１８［３］ＷｉＵｌｎｇＰＫ，ＷｕＢＪ，船ｙＭ，Ｓｏｕ＇￣ｌｌ—ｋｅｅ］ｙＰ，ＳｌｏｅｋｅｒＲ．Ｐｉｄａｘ￣ｉＩｏ－ｔｅｅｔｓａｇ血喊ｈｙｐｏｄｄｏｒｉ￣ｅ－ｉｎｄｕｃｅｄｅｎｄｏｔ￣ｌｉａｌｄｙｌｆｌ￣ｔｉｏｎ ... ｔａｔｅ［Ｊ］．胁Ｃａｒｄ／ｏ／，２０１／２，５５（ｓｕｐ］１）：１７－２６［１０］ Ⅷ Ｏｏｓｔ￣ｏｍＡＪ，Ⅷ ｗ｜ｊｋＪ，ｃ且ｂ瞄蟹ＭＣ．Ｉｊｅｒｒ，ｊ Ⅲ ａｌ ...

Journal of Infection, 1998

Journal of Clinical Epidemiology, 1995

The association between fibrinogen measured in healthy individuals and subsequent development of ... more The association between fibrinogen measured in healthy individuals and subsequent development of ischemic heart disease is well established, but studies reporting fibrinogen levels in coronary heart disease patients are scarce. Plasma fibrinogen was determined for 5729 men and 728 women (aged 45 to 74) with established coronary heart disease, screened for participation in the Bezafibrate Infarction Prevention study, with the following lipid profile at the time of the first screening visit: total serum cholesterol < or = 270 mg/dl, high density lipoprotein cholesterol < or = 45 mg/dl and triglyceride < or = 300 mg/dl. Increased age was associated with augmented plasma fibrinogen values. Age-adjusted fibrinogen levels were higher in women than in men. A direct association was found between mean fibrinogen levels and low density lipoprotein cholesterol. On the other hand, the correlation with high density lipoprotein cholesterol was inverse. Fibrinogen was also associated with body mass index, behavioral variables and severity of coronary heart disease. In a multivariable linear regression analysis performed, risk factors considered explained merely 6 and 4% of fibrinogen variation for men and women, respectively. Therefore, most of the fibrinogen level variability in coronary heart disease patients is accounted for by factors that remain to be established by further research.

Journal of the Royal Society of Medicine, 1998

Journal of Agricultural and Food Chemistry, 2003

Comprehensive Psychiatry, 2014

Proceedings of the National Academy of Sciences of the United States of America, Jan 23, 2007

Stress in early life has been associated with insufficient glucocorticoid signaling in adulthood,... more Stress in early life has been associated with insufficient glucocorticoid signaling in adulthood, possibly affecting inflammation processes. Childhood maltreatment has been linked to increased risk of adult disease with potential inflammatory origin. However, the impact of early life stress on adult inflammation is not known in humans. We tested the life-course association between childhood maltreatment and adult inflammation in a birth cohort followed to age 32 years as part of the Dunedin Multidisciplinary Health and Development Study. Regression models were used to estimate the effect of maltreatment on inflammation, adjusting for co-occurring risk factors and potential mediating variables. Maltreated children showed a significant and graded increase in the risk for clinically relevant C-reactive protein levels 20 years later, in adulthood [risk ratio (RR)=1.80, 95% confidence interval (CI)=1.26-2.58]. The effect of childhood maltreatment on adult inflammation was independent of ...

Journal of child psychology and psychiatry, and allied disciplines, Jan 22, 2015

The creation of economically mixed communities has been proposed as one way to improve the life o... more The creation of economically mixed communities has been proposed as one way to improve the life outcomes of children growing up in poverty. However, whether low-income children benefit from living alongside more affluent neighbors is unknown. Prospectively gathered data on over 1,600 children from the Environmental Risk (E-Risk) Longitudinal Twin Study living in urban environments is used to test whether living alongside more affluent neighbors (measured via high-resolution geo-spatial indices) predicts low-income children's antisocial behavior (reported by mothers and teachers at the ages of 5, 7, 10, and 12). Results indicated that low-income boys (but not girls) surrounded by more affluent neighbors had higher levels of antisocial behavior than their peers embedded in concentrated poverty. The negative effect of growing up alongside more affluent neighbors on low-income boys' antisocial behavior held across childhood and after controlling for key neighborhood and family-l...