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Papers by A. Hamrouni
Annals of Oncology, 2017
Background: The standard of care for oral squamous cell carcinoma (OSCC) at present, consist of s... more Background: The standard of care for oral squamous cell carcinoma (OSCC) at present, consist of surgical resection followed by adjuvant radiotherapy and chemotherapy as indicated. However, indications of induction chemotherapy (IC) in oral cancers are not clearly defined. This retrospective analysis aimed to investigate the efficacy, toxicity and impact of induction chemotherapy in locally advanced T4b oral cavity squamous cell cancers. Methods: Patients diagnosed with locally advanced T4b OSCC from January 2013 and March 2017 at our centre, who received 2-3 cycles of IC and then assessed for resectability, were reviewed retrospectively. Patients' profile, response and toxicity of IC, resectability status and overall survival (OS) were evaluated. Statistical analyses were done by SPSS version 17.0. Results: Total 134 patients received IC, and out of them 98 (73.1%) were males. Median age at diagnosis was 44 years (range 31-60 years). 107 (79.8%) of our patients received doublet chemotherapy (with paclitaxel þ cisplatin), and the rest of the patients received triplet regimen (with paclitaxel/docetaxel þ cisplatin þ 5-FU). Majority of the patients had buccal mucosa cancers (n ¼ 92), followed by gingivo-buccal sulcus (n ¼ 26) and oral tongue (n ¼ 16) primaries. After IC, partial response was achieved in 25 (18.7%) patients, stable disease in 83 (61.9%) patients and disease progression was noted in 26 (19.4%) patients. Post-induction chemotherapy, resectability was achieved in 28 (21%) of 134 patients, but 8 of them did not undergo surgery due to logistic and personal reasons. The median OS of patients who underwent surgery followed by adjuvant local therapy (n ¼ 20) was 18.7 months (95% CI: 16.2-21.5 months) and for those treated with non-surgical local therapy (n ¼ 114) was 7.9 months (95% CI: 6.2-9.2 months) (log-rank p ¼ 0.000). Conclusions: IC may improve the resectability in our patients with T4b OSCC with a manageable toxicity profile. Patients underwent resection had a significantly better median OS than those who received non-surgical local treatment. Legal entity responsible for the study: Kidwai cancer institute Funding: None Disclosure: All authors have declared no conflicts of interest.
ABSTRACT: This study was designed to examine the existence of a genotype × region interaction on ... more ABSTRACT: This study was designed to examine the existence of a genotype × region interaction on milk production traits in Holstein dairy cows in Tunisia. The data set for this study was provided by Tunisian Center for Genetic Improvement of the Livestock and Pasture Office. A total 63569 TD milk record of 6912 Holstein cows of Tunisia were used. Data were classified as belonging to three regions of the country: Northern, Central and Southern. Only data from sires with daughters in three regions were used in each analysis. Genetic parameters were estimated using residual maximum likelihood (REML). A multivariate model was applied. The estimated heritability for the milk production traits ranged between 0.11 to 0.14 for the Central region; 0.09 to 0.19 for the Northern region and 0.30 to 0.39 for the Southern region. The Pearson's correlations of the 26 sires represented in three regions were estimated. Genetic correlation estimates among milk yields traits in different regions ...
La Tunisie médicale, 1974
![Research paper thumbnail of ["Corset liver": syndrome from a past era?]](https://attachments.academia-assets.com/79414143/thumbnails/1.jpg)
](Journal de radiologie, 2011
Journal of the American …, 2007
Uniform CeO 2 /TiO 2 composite nanoparticles with different Ce/Ti molar ratios have been successf... more Uniform CeO 2 /TiO 2 composite nanoparticles with different Ce/Ti molar ratios have been successfully synthesized via the solgel method. The samples were characterized using differential thermal analysis (DTA), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and ...
Journal de Radiologie, 2008
Journal de Radiologie, 2007
Journal de Radiologie, 2007
Annals of Oncology, 2017
Background: The standard of care for oral squamous cell carcinoma (OSCC) at present, consist of s... more Background: The standard of care for oral squamous cell carcinoma (OSCC) at present, consist of surgical resection followed by adjuvant radiotherapy and chemotherapy as indicated. However, indications of induction chemotherapy (IC) in oral cancers are not clearly defined. This retrospective analysis aimed to investigate the efficacy, toxicity and impact of induction chemotherapy in locally advanced T4b oral cavity squamous cell cancers. Methods: Patients diagnosed with locally advanced T4b OSCC from January 2013 and March 2017 at our centre, who received 2-3 cycles of IC and then assessed for resectability, were reviewed retrospectively. Patients' profile, response and toxicity of IC, resectability status and overall survival (OS) were evaluated. Statistical analyses were done by SPSS version 17.0. Results: Total 134 patients received IC, and out of them 98 (73.1%) were males. Median age at diagnosis was 44 years (range 31-60 years). 107 (79.8%) of our patients received doublet chemotherapy (with paclitaxel þ cisplatin), and the rest of the patients received triplet regimen (with paclitaxel/docetaxel þ cisplatin þ 5-FU). Majority of the patients had buccal mucosa cancers (n ¼ 92), followed by gingivo-buccal sulcus (n ¼ 26) and oral tongue (n ¼ 16) primaries. After IC, partial response was achieved in 25 (18.7%) patients, stable disease in 83 (61.9%) patients and disease progression was noted in 26 (19.4%) patients. Post-induction chemotherapy, resectability was achieved in 28 (21%) of 134 patients, but 8 of them did not undergo surgery due to logistic and personal reasons. The median OS of patients who underwent surgery followed by adjuvant local therapy (n ¼ 20) was 18.7 months (95% CI: 16.2-21.5 months) and for those treated with non-surgical local therapy (n ¼ 114) was 7.9 months (95% CI: 6.2-9.2 months) (log-rank p ¼ 0.000). Conclusions: IC may improve the resectability in our patients with T4b OSCC with a manageable toxicity profile. Patients underwent resection had a significantly better median OS than those who received non-surgical local treatment. Legal entity responsible for the study: Kidwai cancer institute Funding: None Disclosure: All authors have declared no conflicts of interest.
ABSTRACT: This study was designed to examine the existence of a genotype × region interaction on ... more ABSTRACT: This study was designed to examine the existence of a genotype × region interaction on milk production traits in Holstein dairy cows in Tunisia. The data set for this study was provided by Tunisian Center for Genetic Improvement of the Livestock and Pasture Office. A total 63569 TD milk record of 6912 Holstein cows of Tunisia were used. Data were classified as belonging to three regions of the country: Northern, Central and Southern. Only data from sires with daughters in three regions were used in each analysis. Genetic parameters were estimated using residual maximum likelihood (REML). A multivariate model was applied. The estimated heritability for the milk production traits ranged between 0.11 to 0.14 for the Central region; 0.09 to 0.19 for the Northern region and 0.30 to 0.39 for the Southern region. The Pearson's correlations of the 26 sires represented in three regions were estimated. Genetic correlation estimates among milk yields traits in different regions ...
La Tunisie médicale, 1974
Journal de radiologie, 2011
Journal of the American …, 2007
Uniform CeO 2 /TiO 2 composite nanoparticles with different Ce/Ti molar ratios have been successf... more Uniform CeO 2 /TiO 2 composite nanoparticles with different Ce/Ti molar ratios have been successfully synthesized via the solgel method. The samples were characterized using differential thermal analysis (DTA), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and ...
Journal de Radiologie, 2008
Journal de Radiologie, 2007
Journal de Radiologie, 2007