AJAY SWAMI - Academia.edu (original) (raw)

Papers by AJAY SWAMI

Nuclear Medicine Review

BACKGROUND. After a primary transluminal coronary angioplasty (PTCA) following AMI (acute myocard... more BACKGROUND. After a primary transluminal coronary angioplasty (PTCA) following AMI (acute myocardial infarction), the perfusion defect and LV (left ventricular) function recover/change over a period of time. The analysis immediately after the procedure may not be true depiction of the exact success of the procedure. There is varying and scanty information available on the natural course of changes in these parameters after a successful PTCA. We hypothesized that majority of change occurs at 3-4 month period. Hence, we undertook this study on the natural course of recovery/changes occurring in perfusion defect size and LV function in first 3 months after primary angioplasty. MATERIAL AND METHODS. 30 consecutive cases of first AMI who were taken up for Primary angioplasty were enrolled into the study. Resting MPI (Myocardial perfusion imaging) was done within 24-72 hrs of admission using Tc-99m-Tetrofosmin and after 10-14 weeks. Analysis of LVEF (left ventricular ejection fraction), summed segmental score and extent of perfusion defect was done. Images were processed using autocardiac software of emory tool box and quantification was done using QPS (quantitative perfusion SPECT) and QGS (qualitative perfusion SPECT) softwares. 20 segment scoring method was used for quantification on bull's eye images. Student t test (two tailed, dependent) was used to find the significance of study parameters on continuous scale within each group. Effect size was computed to find the effect. Pearson correlation between perfusion defect and LVEF was performed at acute stage and after 10-14 weeks. RESULTS. The average acute perfusion defect extent was 19.76 ± 12.89% which after 3 months became 16.79 ± 12.61%. The summed segmental score changed from 14.31 ± 10.58 to 11.38 ± 10.03 and LVEF improved from 48.40 ± 13.15% to 53.37 ± 12.8%. There was significant improvement in LVEF from acute setting to 10-14 weeks (p = 0.001). There was significant lowering of summed score (p = 0.007). Perfusion defect size showed significant reduction (p = 0.030). Three patients showed deterioration in perfusion defect size and in summed score with reduction in LVEF. Four patients had no change in any of the parameters. Correlation between perfusion defect and LVEF was strong both at baseline (r =-0.705, p < 0.001) and after 10-18 weeks (r =-0.766, p < 0.001). CONCLUSION. The changes we found in 3 months are similar to earlier studies and also to studies using follow up at 6 months to 1 year. We feel that 3 months is a good enough time to accurately assess the success of primary angioplasty.

Oxidation is one of the most important processes, which produce free radicals in food, chemicals ... more Oxidation is one of the most important processes, which produce free radicals in food, chemicals and even in living systems. Free radicals have an important role in the processes of food spoilage, chemical material degradation and also contribute to more than one hundred disorders in humans. The present study validates the use of extracts of aerial parts of Ficus racemosa L. as potent antioxidative agent. In the present study, the hydro-alcoholic extracts of aerial parts of Ficus racemosa L. viz. fruits, leaves and stem bark were evaluated for determination of in vitro antioxidant activity. The results showed that extracts of stem bark of the plant possessed significant antioxidant activity in comparison to fruits and leaves.

Journal of opioid management

The aim of this double-blind double-dummy randomized controlled trial was to investigate if there... more The aim of this double-blind double-dummy randomized controlled trial was to investigate if there was any difference in analgesia between the maximum recommended doses of rectal diclofenac and iv parecoxib after laparoscopic sterilization. The authors studied 55 ASA I-II patients undergoing gynecological laparoscopy; each patient received either preoperative rectal diclofenac 100 mg and 2 mL of normal saline at induction of anesthesia, or preoperative placebo suppository and 2 mL of parecoxib 40 mg at induction. Pain intensity, sedation, and nausea were measured using a 100-mm visual analogue scale on awakening and at 1, 2, and 3 hour postoperatively. Median (interquartile range) pain intensity at rest on awakening and at 1, 2, and 3 hour postoperatively were 15 (0-40), 37 (10-56), 16 (6-29), and 13 (2-32) mm, respectively, in the parecoxib group, and 3 (0-34), 22 (5-45), 24 (6-37), and 10 (4-21) mm, respectively, in the diclofenac group. There was no significant difference in these...

Plants have served as a source of new pharmaceutical products and inexpensive starting materials ... more Plants have served as a source of new pharmaceutical products and inexpensive starting materials for the synthesis of many known drugs. Besides angiosperms, gymnosperms are forming the important medicinal flora of Indian forests. These are the mega-plants forming the cultural and economic heritage of the country. In the present investigation the hydro-alcoholic and chloroform extracts of the leaves of Cycas revoluta plant were prepared in order to assess the antimicrobial and antioxidant potential of the plant. The hydro-alcoholic extracts of leaves of the plant showed promising antimicrobial and antioxidant activities. Hydro-alcoholic extracts of leaves of the plant showed potent antimicrobial activity against E.coli, Klebsiella pneumoniae and Saccharomyces cerevisae while chloroform extracts showed almost similar antimicrobial activity against E.coli and Saccharomyces cerevisae. It was observed that Lactococcus sp., Streptococcus pyogenes, Aspergillus niger and Candida albicans ar...

Nuclear Medicine Review

BACKGROUND. After a primary transluminal coronary angioplasty (PTCA) following AMI (acute myocard... more BACKGROUND. After a primary transluminal coronary angioplasty (PTCA) following AMI (acute myocardial infarction), the perfusion defect and LV (left ventricular) function recover/change over a period of time. The analysis immediately after the procedure may not be true depiction of the exact success of the procedure. There is varying and scanty information available on the natural course of changes in these parameters after a successful PTCA. We hypothesized that majority of change occurs at 3-4 month period. Hence, we undertook this study on the natural course of recovery/changes occurring in perfusion defect size and LV function in first 3 months after primary angioplasty. MATERIAL AND METHODS. 30 consecutive cases of first AMI who were taken up for Primary angioplasty were enrolled into the study. Resting MPI (Myocardial perfusion imaging) was done within 24-72 hrs of admission using Tc-99m-Tetrofosmin and after 10-14 weeks. Analysis of LVEF (left ventricular ejection fraction), summed segmental score and extent of perfusion defect was done. Images were processed using autocardiac software of emory tool box and quantification was done using QPS (quantitative perfusion SPECT) and QGS (qualitative perfusion SPECT) softwares. 20 segment scoring method was used for quantification on bull's eye images. Student t test (two tailed, dependent) was used to find the significance of study parameters on continuous scale within each group. Effect size was computed to find the effect. Pearson correlation between perfusion defect and LVEF was performed at acute stage and after 10-14 weeks. RESULTS. The average acute perfusion defect extent was 19.76 ± 12.89% which after 3 months became 16.79 ± 12.61%. The summed segmental score changed from 14.31 ± 10.58 to 11.38 ± 10.03 and LVEF improved from 48.40 ± 13.15% to 53.37 ± 12.8%. There was significant improvement in LVEF from acute setting to 10-14 weeks (p = 0.001). There was significant lowering of summed score (p = 0.007). Perfusion defect size showed significant reduction (p = 0.030). Three patients showed deterioration in perfusion defect size and in summed score with reduction in LVEF. Four patients had no change in any of the parameters. Correlation between perfusion defect and LVEF was strong both at baseline (r =-0.705, p < 0.001) and after 10-18 weeks (r =-0.766, p < 0.001). CONCLUSION. The changes we found in 3 months are similar to earlier studies and also to studies using follow up at 6 months to 1 year. We feel that 3 months is a good enough time to accurately assess the success of primary angioplasty.

Oxidation is one of the most important processes, which produce free radicals in food, chemicals ... more Oxidation is one of the most important processes, which produce free radicals in food, chemicals and even in living systems. Free radicals have an important role in the processes of food spoilage, chemical material degradation and also contribute to more than one hundred disorders in humans. The present study validates the use of extracts of aerial parts of Ficus racemosa L. as potent antioxidative agent. In the present study, the hydro-alcoholic extracts of aerial parts of Ficus racemosa L. viz. fruits, leaves and stem bark were evaluated for determination of in vitro antioxidant activity. The results showed that extracts of stem bark of the plant possessed significant antioxidant activity in comparison to fruits and leaves.

Journal of opioid management

The aim of this double-blind double-dummy randomized controlled trial was to investigate if there... more The aim of this double-blind double-dummy randomized controlled trial was to investigate if there was any difference in analgesia between the maximum recommended doses of rectal diclofenac and iv parecoxib after laparoscopic sterilization. The authors studied 55 ASA I-II patients undergoing gynecological laparoscopy; each patient received either preoperative rectal diclofenac 100 mg and 2 mL of normal saline at induction of anesthesia, or preoperative placebo suppository and 2 mL of parecoxib 40 mg at induction. Pain intensity, sedation, and nausea were measured using a 100-mm visual analogue scale on awakening and at 1, 2, and 3 hour postoperatively. Median (interquartile range) pain intensity at rest on awakening and at 1, 2, and 3 hour postoperatively were 15 (0-40), 37 (10-56), 16 (6-29), and 13 (2-32) mm, respectively, in the parecoxib group, and 3 (0-34), 22 (5-45), 24 (6-37), and 10 (4-21) mm, respectively, in the diclofenac group. There was no significant difference in these...

Plants have served as a source of new pharmaceutical products and inexpensive starting materials ... more Plants have served as a source of new pharmaceutical products and inexpensive starting materials for the synthesis of many known drugs. Besides angiosperms, gymnosperms are forming the important medicinal flora of Indian forests. These are the mega-plants forming the cultural and economic heritage of the country. In the present investigation the hydro-alcoholic and chloroform extracts of the leaves of Cycas revoluta plant were prepared in order to assess the antimicrobial and antioxidant potential of the plant. The hydro-alcoholic extracts of leaves of the plant showed promising antimicrobial and antioxidant activities. Hydro-alcoholic extracts of leaves of the plant showed potent antimicrobial activity against E.coli, Klebsiella pneumoniae and Saccharomyces cerevisae while chloroform extracts showed almost similar antimicrobial activity against E.coli and Saccharomyces cerevisae. It was observed that Lactococcus sp., Streptococcus pyogenes, Aspergillus niger and Candida albicans ar...