A. Martino - Academia.edu (original) (raw)
Papers by A. Martino
![Research paper thumbnail of [Prognosis of ruptured aneurysms of the abdominal aorta in aged patients]](https://a.academia-assets.com/images/blank-paper.jpg)
](Minerva cardioangiologica, 1998
Minerva cardioangiologica, 1980
Journal of Pediatric Surgery, 2015
Colture Protette, 2003
... Different salt concentrations of MS environment and sucrose on the in vitro multiplication of... more ... Different salt concentrations of MS environment and sucrose on the in vitro multiplication of Zantedeschia aethiopica L. Spreng. (Calla lily) by Ribeiro, M. de NO; Pasqual, M.;Silva, AB da; Rodrigues, VA (Jan-Mar 2008) in Portuguese. ...
Journal of Pediatric Surgery, 2001
Phyllodes tumor of the breast is a very rare neoplasm, particularly in adolescent girls and young... more Phyllodes tumor of the breast is a very rare neoplasm, particularly in adolescent girls and young women. It usually presents as unilateral palpable mass. The authors report the case of an adolescent girl who presented at the Emergency Department with bloody nipple discharge. Although the clinical signs suggested an intraductal tumor, the histologic examination showed a phyllodes tumor. The management and the biologic behavior of this uncommon tumor are discussed with particular regard to the very unusual clinical presentation in this patient. J Pediatr Surg 36:941-943.
Journal of Leukocyte Biology, 2004
Human monocytes can differentiate into dendritic cells (DCs) according to the nature of environme... more Human monocytes can differentiate into dendritic cells (DCs) according to the nature of environmental signals. We tested here whether the infection with the live tuberculosis vaccine bacillus Calmette-Guerin (BCG), which is known to be limited in preventing pulmonary tuberculosis, modulates monocyte and DC differentiation. We found that monocytes infected with BCG differentiate into CD1a -DCs (BCG-DCs) in the presence of granulocyte macrophage-colony stimulating factor and interleukin (IL)-4 and acquired a mature phenotype in the absence of maturation stimuli. In addition, BCG-DCs produced proinflammatory cytokines (tumor necrosis factor ␣, IL-1, IL-6) and IL-10 but not IL-12. BCG-DCs were able to stimulate allogeneic T lymphocytes to a similar degree as DCs generated in the absence of infection. However, BCG-DCs induced IL-4 production when cocultured with human cord-blood mononuclear cells. The induction of IL-4 production by DCs generated by BCG-infected monocytes could explain the failure of the BCG vaccine to prevent pulmonary tuberculosis. J. Leukoc. Biol. 76: 827-834; 2004.
The Journal of Immunology, 2009
Several subsets of ␣ regulatory T cells (Tregs) have been described and studied intensively, but... more Several subsets of ␣ regulatory T cells (Tregs) have been described and studied intensively, but the potential regulatory role of ␥␦ T cells remains largely unclear. Lymphocytes expressing ␥␦ TCR are involved in both innate and adaptive immune responses, and their major adult human peripheral blood subset (V␥9V␦2) displays a broad reactivity against microbial agents and tumors. In this study we report that ␥␦ T lymphocytes with regulatory functions (V␦2 Tregs) are induced in vitro in the presence of specific Ag stimulation and cytokines (TGF-1 and IL-15). These cells express FOXP3 and, similarly as ␣ Tregs, suppress the proliferation of anti-CD3/anti-CD28 stimulated-PBMC. Phenotypic and functional analyses of V␦2 Tregs will very likely improve our understanding about the role of ␥␦ T cells in the pathogenesis of autoimmune, infectious, and neoplastic diseases.
European Journal of Vascular and Endovascular Surgery, 2007
Objectives. To evaluate the effects of iloprost, in addition to surgery, on the outcome of acute ... more Objectives. To evaluate the effects of iloprost, in addition to surgery, on the outcome of acute lower limb ischemia (ALLI). Design. Post-hoc analysis of a randomized, double-blind, placebo-controlled study. Methods. In the context of the ILAILL (ILoprost in Acute Ischemia of Lower Limbs) study, 192 elderly patients (>70 years old) undergoing surgery for ALLI were assigned to receive perioperative iloprost (intra-arterial, intra-operative bolus of 3000 ng, plus intravenous infusion of 0.5e2.0 ng/kg/min for six hours/day for 4e7 days following surgery), or placebo (iloprost: n ¼ 100; placebo: n ¼ 92). Patients were followed-up for three-months following surgical revascularization. Results. The combined incidence of death and amputation (primary study end-point) was significantly reduced in patients treated with iloprost (16.0% vs 27.2% in the placebo group; hazard ratio 1.99, 95% confidence interval 1.05e3.75, p ¼ 0.03). A statistically significant lower mortality (6.0%) was reported in patients receiving iloprost, compared to controls (15.2%) (hazard ratio 2.93, 1.11e7.71, p ¼ 0.03). The overall incidence of death and major cardiovascular events was lower in patients receiving iloprost compared to those assigned placebo (24.0% and 35.9%, respectively), at the limits of statistical significance (relative risk 1.64, 0.97e2.79, p ¼ 0.06). Conclusions. These results confirm the poor outcome in elderly patients with ALLI. Based on a subgroup analysis iloprost, as an adjuvant to surgery, appears to reduce the combined end-point of death and amputation.
Current Molecular Medicine, 2001
Human macrophages represent the first line of defense for the containment of Mycobacterium tuberc... more Human macrophages represent the first line of defense for the containment of Mycobacterium tuberculosis infection. After phagocytosis, macrophages express activation surface markers and produce proinflammatory cytokines and chemokines whose main role is to control pathogen spreading by recruiting peripheral lymphocytes and monocytes at the site of inflammation. However, in the case of a concomitant human immunodeficiency virus (HIV) infection, these signals strongly enhance the susceptibility to viral infection both at the viral entry and replication levels. Under these conditions, viral expansion extends beyond tissue macrophages to T cells and viceversa, according to the emerging viral phenotype. In absence of an efficient immune response, Mycobacterium tuberculosis can replicate in macrophages in an uncontrolled fashion culminating in macrophage death by apoptosis. As a consequence, a more severe form of immunedepression, involving both innate and specific immune responses, could be responsible for both ematogenous mycobacterial dissemination and extrapulmonary form of tuberculosis in HIV-infected patients.
Minerva cardioangiologica, 1998
Minerva cardioangiologica, 1980
Journal of Pediatric Surgery, 2015
Colture Protette, 2003
... Different salt concentrations of MS environment and sucrose on the in vitro multiplication of... more ... Different salt concentrations of MS environment and sucrose on the in vitro multiplication of Zantedeschia aethiopica L. Spreng. (Calla lily) by Ribeiro, M. de NO; Pasqual, M.;Silva, AB da; Rodrigues, VA (Jan-Mar 2008) in Portuguese. ...
Journal of Pediatric Surgery, 2001
Phyllodes tumor of the breast is a very rare neoplasm, particularly in adolescent girls and young... more Phyllodes tumor of the breast is a very rare neoplasm, particularly in adolescent girls and young women. It usually presents as unilateral palpable mass. The authors report the case of an adolescent girl who presented at the Emergency Department with bloody nipple discharge. Although the clinical signs suggested an intraductal tumor, the histologic examination showed a phyllodes tumor. The management and the biologic behavior of this uncommon tumor are discussed with particular regard to the very unusual clinical presentation in this patient. J Pediatr Surg 36:941-943.
Journal of Leukocyte Biology, 2004
Human monocytes can differentiate into dendritic cells (DCs) according to the nature of environme... more Human monocytes can differentiate into dendritic cells (DCs) according to the nature of environmental signals. We tested here whether the infection with the live tuberculosis vaccine bacillus Calmette-Guerin (BCG), which is known to be limited in preventing pulmonary tuberculosis, modulates monocyte and DC differentiation. We found that monocytes infected with BCG differentiate into CD1a -DCs (BCG-DCs) in the presence of granulocyte macrophage-colony stimulating factor and interleukin (IL)-4 and acquired a mature phenotype in the absence of maturation stimuli. In addition, BCG-DCs produced proinflammatory cytokines (tumor necrosis factor ␣, IL-1, IL-6) and IL-10 but not IL-12. BCG-DCs were able to stimulate allogeneic T lymphocytes to a similar degree as DCs generated in the absence of infection. However, BCG-DCs induced IL-4 production when cocultured with human cord-blood mononuclear cells. The induction of IL-4 production by DCs generated by BCG-infected monocytes could explain the failure of the BCG vaccine to prevent pulmonary tuberculosis. J. Leukoc. Biol. 76: 827-834; 2004.
The Journal of Immunology, 2009
Several subsets of ␣ regulatory T cells (Tregs) have been described and studied intensively, but... more Several subsets of ␣ regulatory T cells (Tregs) have been described and studied intensively, but the potential regulatory role of ␥␦ T cells remains largely unclear. Lymphocytes expressing ␥␦ TCR are involved in both innate and adaptive immune responses, and their major adult human peripheral blood subset (V␥9V␦2) displays a broad reactivity against microbial agents and tumors. In this study we report that ␥␦ T lymphocytes with regulatory functions (V␦2 Tregs) are induced in vitro in the presence of specific Ag stimulation and cytokines (TGF-1 and IL-15). These cells express FOXP3 and, similarly as ␣ Tregs, suppress the proliferation of anti-CD3/anti-CD28 stimulated-PBMC. Phenotypic and functional analyses of V␦2 Tregs will very likely improve our understanding about the role of ␥␦ T cells in the pathogenesis of autoimmune, infectious, and neoplastic diseases.
European Journal of Vascular and Endovascular Surgery, 2007
Objectives. To evaluate the effects of iloprost, in addition to surgery, on the outcome of acute ... more Objectives. To evaluate the effects of iloprost, in addition to surgery, on the outcome of acute lower limb ischemia (ALLI). Design. Post-hoc analysis of a randomized, double-blind, placebo-controlled study. Methods. In the context of the ILAILL (ILoprost in Acute Ischemia of Lower Limbs) study, 192 elderly patients (>70 years old) undergoing surgery for ALLI were assigned to receive perioperative iloprost (intra-arterial, intra-operative bolus of 3000 ng, plus intravenous infusion of 0.5e2.0 ng/kg/min for six hours/day for 4e7 days following surgery), or placebo (iloprost: n ¼ 100; placebo: n ¼ 92). Patients were followed-up for three-months following surgical revascularization. Results. The combined incidence of death and amputation (primary study end-point) was significantly reduced in patients treated with iloprost (16.0% vs 27.2% in the placebo group; hazard ratio 1.99, 95% confidence interval 1.05e3.75, p ¼ 0.03). A statistically significant lower mortality (6.0%) was reported in patients receiving iloprost, compared to controls (15.2%) (hazard ratio 2.93, 1.11e7.71, p ¼ 0.03). The overall incidence of death and major cardiovascular events was lower in patients receiving iloprost compared to those assigned placebo (24.0% and 35.9%, respectively), at the limits of statistical significance (relative risk 1.64, 0.97e2.79, p ¼ 0.06). Conclusions. These results confirm the poor outcome in elderly patients with ALLI. Based on a subgroup analysis iloprost, as an adjuvant to surgery, appears to reduce the combined end-point of death and amputation.
Current Molecular Medicine, 2001
Human macrophages represent the first line of defense for the containment of Mycobacterium tuberc... more Human macrophages represent the first line of defense for the containment of Mycobacterium tuberculosis infection. After phagocytosis, macrophages express activation surface markers and produce proinflammatory cytokines and chemokines whose main role is to control pathogen spreading by recruiting peripheral lymphocytes and monocytes at the site of inflammation. However, in the case of a concomitant human immunodeficiency virus (HIV) infection, these signals strongly enhance the susceptibility to viral infection both at the viral entry and replication levels. Under these conditions, viral expansion extends beyond tissue macrophages to T cells and viceversa, according to the emerging viral phenotype. In absence of an efficient immune response, Mycobacterium tuberculosis can replicate in macrophages in an uncontrolled fashion culminating in macrophage death by apoptosis. As a consequence, a more severe form of immunedepression, involving both innate and specific immune responses, could be responsible for both ematogenous mycobacterial dissemination and extrapulmonary form of tuberculosis in HIV-infected patients.