Alexey Moskalev - Academia.edu (original) (raw)
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Frontiers in Genetics, 2015
GeroScope is a proprietary software that can predict geroprotective potential of drugs tested. By... more GeroScope is a proprietary software that can predict geroprotective potential of drugs tested. By comparing mRNA expression profiles of young and old cells it identifies signalling pathways that were up-or down-regulated with aging. It can then rate substances with known molecular targets according to their ability to retrieve pathway activation strengths of old cells to the levels of young ones.
Аннотация The attempt in made to estimate a role of programmed cell death (apoptosis) in radiatio... more Аннотация The attempt in made to estimate a role of programmed cell death (apoptosis) in radiation-induced life span alteration and aging. It was shown with the use of mutant Drosophila melanogaster laboratory strains, that the disfunction of a reaper-dependent apoptosis pathway, together with the action of ionizing radiation and/or apoptosis inductor etoposide, could lead to change of life span and a pace of aging. In Drosophila strain with defect of proapoptosis gene reaper, the increase of life span after irradiation and ...
This is the result of studying on a problem of radio-induced ageing. From the point of view of ra... more This is the result of studying on a problem of radio-induced ageing. From the point of view of radiation genetics it is perspective to investigate influence of low doze irradiation on individuals with the mutant phenotypes that allows to assume a role of separate genes and mechanisms controllable by them in determination of life span and ageing. The role of a reaper-dependent way of apoptosis regulation in the induced change of life span is shown. The assumption is put forward that apoptosis has the important role during ageing an animal organism.
the complete decipherment of functions and interaction of elements of the riboflavin biosynthesis... more the complete decipherment of functions and interaction of elements of the riboflavin biosynthesis operon (rib operon) of Bacillus subtilis is necessary for the development of superproducers of this important vitamin. the function of its terminal ribt gene has not been established up to date. In this work, the search for homologs of the hypothetical amino acid sequence of the gene product through databases as well as an analysis of the homolgs were performed, the distribution of secondary structure elements was theoretically predicted, and the tertiary structure of the ribt protein was proposed. the real possibility of ribt protein production in quantities sufficient for further investigation of its structure and functional activity was demonstrated.
Frontiers in Genetics, 2015
GeroScope is a proprietary software that can predict geroprotective potential of drugs tested. By... more GeroScope is a proprietary software that can predict geroprotective potential of drugs tested. By comparing mRNA expression profiles of young and old cells it identifies signalling pathways that were up-or down-regulated with aging. It can then rate substances with known molecular targets according to their ability to retrieve pathway activation strengths of old cells to the levels of young ones.
Аннотация The attempt in made to estimate a role of programmed cell death (apoptosis) in radiatio... more Аннотация The attempt in made to estimate a role of programmed cell death (apoptosis) in radiation-induced life span alteration and aging. It was shown with the use of mutant Drosophila melanogaster laboratory strains, that the disfunction of a reaper-dependent apoptosis pathway, together with the action of ionizing radiation and/or apoptosis inductor etoposide, could lead to change of life span and a pace of aging. In Drosophila strain with defect of proapoptosis gene reaper, the increase of life span after irradiation and ...
This is the result of studying on a problem of radio-induced ageing. From the point of view of ra... more This is the result of studying on a problem of radio-induced ageing. From the point of view of radiation genetics it is perspective to investigate influence of low doze irradiation on individuals with the mutant phenotypes that allows to assume a role of separate genes and mechanisms controllable by them in determination of life span and ageing. The role of a reaper-dependent way of apoptosis regulation in the induced change of life span is shown. The assumption is put forward that apoptosis has the important role during ageing an animal organism.
the complete decipherment of functions and interaction of elements of the riboflavin biosynthesis... more the complete decipherment of functions and interaction of elements of the riboflavin biosynthesis operon (rib operon) of Bacillus subtilis is necessary for the development of superproducers of this important vitamin. the function of its terminal ribt gene has not been established up to date. In this work, the search for homologs of the hypothetical amino acid sequence of the gene product through databases as well as an analysis of the homolgs were performed, the distribution of secondary structure elements was theoretically predicted, and the tertiary structure of the ribt protein was proposed. the real possibility of ribt protein production in quantities sufficient for further investigation of its structure and functional activity was demonstrated.