ANA TERESA CORTES DIAZ VELASCO (original) (raw)

Papers by ANA TERESA CORTES DIAZ VELASCO

Virchows Archiv, 2020

Microsatellite instability (MSI) is present in 15–20% of primary colorectal cancers. MSI status i... more Microsatellite instability (MSI) is present in 15–20% of primary colorectal cancers. MSI status is assessed to detect Lynch syndrome, guide adjuvant chemotherapy, determine prognosis, and use as a companion test for checkpoint blockade inhibitors. Traditionally, MSI status is determined by immunohistochemistry or molecular methods. The Idylla™ MSI Assay is a fully automated molecular method (including automated result interpretation), using seven novel MSI biomarkers (ACVR2A, BTBD7, DIDO1, MRE11, RYR3, SEC31A, SULF2) and not requiring matched normal tissue. In this real-world global study, 44 clinical centers performed Idylla™ testing on a total of 1301 archived colorectal cancer formalin-fixed, paraffin-embedded (FFPE) tissue sections and compared Idylla™ results against available results from routine diagnostic testing in those sites. MSI mutations detected with the Idylla™ MSI Assay were equally distributed over the seven biomarkers, and 84.48% of the MSI-high samples had ≥ 5 mut...

The Journal of Pathology, 2018

Many human cancers present PTEN deficiency and between 20-30% of colorectal tumors show PTEN loss... more Many human cancers present PTEN deficiency and between 20-30% of colorectal tumors show PTEN loss. The transcription factor E2F-1 exhibits tumor promoter or suppressive functions depending on cellular type and tissue context however its role in the progression and development of colorectal carcinogenesis was largely unknown. Here, using a tamoxifen-inducible PTEN knockout mouse model, we have demonstrated that loss of PTEN leads to the development of colorectal tumorigenesis through the serrated pathway. Next, we studied PTEN-loss driven colorectal lesions in the context of E2F-1 deficiency in vivo. Our results revealed that monoallelic and biallelic absence of E2F-1 lead to an increased incidence and progression of serrated tumorigenesis induced by PTEN loss. Finally, we investigated the mechanisms by which double PTEN/E2F-1 defficiency leads to enhanced tumorogenesis. We found that colorectal tumors from PTEN/E2F-1 double-knockout mice and the human colorectal carcinoma cell line HT29 with shRNA-mediated downregulation of PTEN and E2F-1 exhibit hyperactivation of the RAS-MAPK pathway, accumulation of DNA damage and resistance to apoptosis. To date, this is the first pre-clinical study evaluating the effect of genetic deletion of E2F-1 in colorectal malignancies driven by PTEN deficiency.

Stereotactic and Functional Neurosurgery, 1995

This is a report on a patient with intractable 'primary' generalized seizures and... more This is a report on a patient with intractable 'primary' generalized seizures and typical spike-wave EEG patterns, in whom an unexpected temporal lobe astrocytoma was detected by MRI studies. Clinical and electrophysiological studies were performed before and after surgical excision of the tumor and apical temporal lobectomy in an attempt to determine whether 'primary' generalized seizures and EEG patterns and the temporal lobe tumor were only coincident neurological disorders or were indeed related. Before resection, the patient consistently showed a typical spike-wave EEG pattern with no background and paroxysmal activities suggestive of 'secondary' bilateral synchrony in 10 consecutive conventional EEG recordings; neither spontaneous interictal nor ictal ECoG activities suggested focal temporal lobe epileptogenesis. After resection, the patient showed increased pentylenetetrazol (PTZ) convulsive threshold, and reduction in the number of 'primary' generalized seizures, although typical spike-wave EEG discharges persisted. These observations suggest that 'primary' generalized seizures, EEG patterns and the temporal tumor were physiopathologically interrelated, and that both reticulocortical and corticoreticular mechanisms may participate together in the genesis of 'primary' generalized clinical and EEG activities.

International Microbiology, Mar 17, 2010

Carbon dioxide fixation is a polyphyletic trait that has evolved in widely separated prokaryotic ... more Carbon dioxide fixation is a polyphyletic trait that has evolved in widely separated prokaryotic branches. The three principal CO 2-assimilation pathways are (i) the reductive pentose-phosphate cycle, i. e. the Calvin-Benson cycle; (ii) the reductive citric acid (or Arnon) cycle; and (iii) the net synthesis of acetyl-CoA from CO/CO 2 , or Wood pathway. Sequence analysis and the comparative biochemistry of these routes suggest that all of them were shaped to a considerable extent by the evolutionary recruitment of enzymes. Molecular phylogenetic trees show that the Calvin-Benson cycle was a relatively late development in the (eu)bacterial branch, suggesting that some form(s) of carbon assimilation may have been operative before chlorophyll-based photosynthesis. On the other hand, the ample phylogenetic distribution of both the Arnon and the Wood pathways does not allow us to infer which one of them is older. However, different lines of evidence, including experimental reports on the NiS/FeS-mediated CC bond formation from CO and CH 3 SH are used here to argue that the first CO 2-fixation route may have been a semienzymatic Wood-like pathway.

Revista Venezolana De Oncologia, May 1, 2007

OBJECTIVES: The musculoskeletal symptomatology could be initial manifestation of many tumours. Ou... more OBJECTIVES: The musculoskeletal symptomatology could be initial manifestation of many tumours. Our intention is to show relevant epidemiological finds in rhe...

Diversitas, 2010

Proyecto académico sin fines de lucro, desarrollado bajo la iniciativa de acceso abierto

Nutrición hospitalaria, 2014

Several studies have concluded that incidences of osteoporosis and osteoporosis-related fractures... more Several studies have concluded that incidences of osteoporosis and osteoporosis-related fractures vary across the European Union, the lowest incidence being reported in the Mediterranean area. The beneficial effect is mainly attributed to a specific eating pattern. The Mediterranean diet contain a complex array of naturally occurring bioactive molecules with antioxidant, anti-inflammatory and alkalinising properties that may contribute to the bone-sparing effect of the Mediterranean diet. The purpose of this review is to examine the evidence to date on the effects of Mediterranean diet on bone health. The search for articles came from extensive research in the following databases: PubMed, Scopus and Web of Science. We used the search terms "Mediterranean diet", "adherence", "fruit and vegetable", "olive oil", "fish" "legume", "cereal" "alcohol", "bone", "osteoporosis", "fracture&...

2011 Aerospace Conference, 2011

... com Ana Maria Velasco Tang IBR Services, LLC. 1971 E. 4th St. ... est. 25 million dol-lars ea... more ... com Ana Maria Velasco Tang IBR Services, LLC. 1971 E. 4th St. ... est. 25 million dol-lars each, not including acquisition, pointing, and adaptive optics) and utilize them to bring down clouds of small debris over longer periods of time. ...

Nature reviews. Neurology, 2014

Neurostimulation enables adjustable and reversible modulation of disease symptoms, including thos... more Neurostimulation enables adjustable and reversible modulation of disease symptoms, including those of epilepsy. Two types of brain neuromodulation, comprising anterior thalamic deep brain stimulation and responsive neurostimulation at seizure foci, are supported by Class I evidence of effectiveness, and many other sites in the brain have been targeted in small trials of neurostimulation therapy for seizures. Animal studies have mainly assisted in the identification of potential neurostimulation sites and parameters, but much of the clinical work is only loosely based on fundamental principles derived from the laboratory, and the mechanisms by which brain neurostimulation reduces seizures remain poorly understood. The benefits of stimulation tend to increase over time, with maximal effect seen typically 1-2 years after implantation. Typical reductions of seizure frequency are approximately 40% acutely, and 50-69% after several years. Seizure intensity might also be reduced. Complicat...

Topics in Neuromodulation Treatment, 2012

Arteterapia. Papeles de arteterapia y educación artística para la inclusión social, 2013

Se presenta un estudio de caso de una mujer que formó parte en el Taller El Encuentro de Crear en... more Se presenta un estudio de caso de una mujer que formó parte en el Taller El Encuentro de Crear en el Centro Hispano Marroquí, reflexionamos sobre su recorrido en el taller y las posibles aportaciones que pudo suponer en su vida.

International Journal of Neural Systems, 2009

We report two cases of chronic therapeutic stimulation of epileptic foci localized in motor areas... more We report two cases of chronic therapeutic stimulation of epileptic foci localized in motor areas. Case 1 is an adolescent with supplementary motor area seizures whose intracranial recordings showed a right SMA focus. Case 2 is a female teenager with primary motor seizures originating in the right motor cortex in the hand area as shown by her intracranial recordings and cortical mapping. Both had apparently normal MRI. Chronic stimulation of the epileptic focus decreased the number of seizures more than 90% the seizure number while preserving motor function. None of the patients had side effects. Neuromodulation is proposed as a safe, efficient surgical alternative for motor seizure control.

Neurosurgery, 2005

ABSTRACTOBJECTIVE:To present a review of evidence for an inhibitory thalamo-orbitofrontal system ... more ABSTRACTOBJECTIVE:To present a review of evidence for an inhibitory thalamo-orbitofrontal system related to physiopathology of major depression disorders (MDDs) and to postulate that interfering with hyperactivity of the thalamo-orbitofrontal system by means of chronic high-frequency electrical stimulation of its main fiber connection, the inferior thalamic peduncle (ITP), may result in an improvement in patients with MDD.METHODS:Experimentally, the thalamo-orbitofrontal system has been proposed as part of the nonspecific thalamic system. Under normal conditions, the nonspecific thalamic system induces characteristic electrocortical synchronization in the form of recruiting responses that mimic some sleep stages. It also inhibits input of irrelevant sensory stimuli, thus facilitating the process of selective attention. Permanent disruption of the system, via lesioning or temporary inactivation through cooling of the ITP with cryoprobes, results in a state of hyperkinesia, increased ...

The Lancet Infectious Diseases, 2009

Journal of Theoretical Biology, 2013

We study the presence of low complexity regions (LCRs) in HIV-1 gp120 protein. LCRs were identifi... more We study the presence of low complexity regions (LCRs) in HIV-1 gp120 protein. LCRs were identified in the hypervarible region V1, V2, V4 and V5. A high number of glycosylation sites were found in LCRs. Our results suggest that LCRs are an important source of antigenic variation in HIV-1 gp120 protein.

International Microbiology, 2003

The possibility of a high-temperature origin of life has gained support based on indirect evidenc... more The possibility of a high-temperature origin of life has gained support based on indirect evidence of a hot, early Earth and on the basal position of hyperthermophilic organisms in rRNA-based phylogenies. However, although the availability of more than 80 completely sequenced cellular genomes has led to the identification of hyperthermophilic-specific traits, such as a trend towards smaller genomes, reduced proteinencoding gene sizes, and glutamic-acid-rich simple sequences, none of these characteristics are in themselves an indication of primitiveness. There is no geological evidence for the physical setting in which life arose, but current models suggest that the Earth's surface cooled down rapidly. Moreover, at 100°C the half-lives of several organic compounds, including ribose, nucleobases, and amino acids, which are generally thought to have been essential for the emergence of the first living systems, are too short to allow for their accumulation in the prebiotic environment. Accordingly, if hyperthermophily is not truly primordial, then heat-loving lifestyles may be relics of a secondary adaptation that evolved after the origin of life, and before or soon after separation of the major lineages.

Revista de Ciencias …, 2006

Información del artículo Análisis de la propuesta de un modelo de planificación por impactos en a... more Información del artículo Análisis de la propuesta de un modelo de planificación por impactos en aquaeróbic.

Epilepsia, 1993

A study was performed of EEG-magnetic resonance imaging (MRI) abnormalities in 7 Lennox-Gastaut s... more A study was performed of EEG-magnetic resonance imaging (MRI) abnormalities in 7 Lennox-Gastaut syndrome (LGS) children and 3 epilepsia partialis continua (EPC) children with intractable generalized and partial motor seizures, respectively. In 4 children with LGS and 3 children with EPC, depth electrodes were implanted in the centromedian thalamic nuclei (CM) for seizure control. In all children with LGS, hyperdense, T2-weighted MRI signals were observed at the mesencephalic level of the brainstem, whereas none of the 3 children with EPC had this finding. Patients with idiopathic LGS without cerebral hemisphere MRI abnormalities showed generalized bilateral and symmetrical spike-wave EEG activity. Patients with symptomatic LGS with unilateral hemispheric MRI abnormalities demonstrated asymmetrical EEG activity with higher amplitude spike-and-wave over the normal hemisphere. Patients with EPC with unilateral hemispheric lesions had lateralized higher amplitude spike-wave over the damaged hemisphere. These data suggest that abnormal mesencephalic MRIs are a sign of bad prognosis in patients with LGS but not with EPC. Maximal amplitude paroxysmal EEG activities may indicate the abnormal hemisphere in patients with EPC or the normal hemisphere in those with LGS.

Epilepsia, 1993

Twenty-three patients with various intractable seizure patterns were divided into four groups bas... more Twenty-three patients with various intractable seizure patterns were divided into four groups based on their most frequent seizure type and their clinical and EEG response to chronic electrical stimulation of the centromedian thalamic nuclei (ESCM): group A, generalized tonic-clonic (GTC, n = 9); group B, partial motor (Rasmussen type) (n = 3); group C, complex partial seizures (CPS, n = 5); and group D, generalized tonic seizures (Lennox-Gastaut type) (n = 6). CM were radiologically and electrophysiologically localized by means of stereotaxic landmarks and by thalamically induced scalp recruiting-like responses and desynchronization. ESCM consisted of daily 2-h stimulation sessions for 3 months. Each stimulus consisted of a 1-min train of square pulses with a 4-min interstimulus interval, alternating right and left CM. Each pulse was 1.0 ms in duration at 60/s frequency and 8-15 V (400-1,250 microA) amplitude. Voltage (V), current flow (microA) and impedance (k omega) at the electrode tips were kept constant. A significant decrease in the number of seizures per month and paroxysmal EEG waves per 10-s spochs occurred in group A patients between the baseline period (BL) and the ESCM period. These changes persisted for > 3 months after discontinuation of ESCM (poststimulation period, Post). Post was accompanied by a significant decrease in the number of paroxysmal EEG discharges. A substantial decrease in seizures and paroxysmal discharges was also observed in patients of group B. In contrast, patients of groups C and D showed no significant changes from BL to ESCM and Post periods, except for a significant decrease in the number of seizures in group D patients from BL to Post periods.

Virchows Archiv, 2020

Microsatellite instability (MSI) is present in 15–20% of primary colorectal cancers. MSI status i... more Microsatellite instability (MSI) is present in 15–20% of primary colorectal cancers. MSI status is assessed to detect Lynch syndrome, guide adjuvant chemotherapy, determine prognosis, and use as a companion test for checkpoint blockade inhibitors. Traditionally, MSI status is determined by immunohistochemistry or molecular methods. The Idylla™ MSI Assay is a fully automated molecular method (including automated result interpretation), using seven novel MSI biomarkers (ACVR2A, BTBD7, DIDO1, MRE11, RYR3, SEC31A, SULF2) and not requiring matched normal tissue. In this real-world global study, 44 clinical centers performed Idylla™ testing on a total of 1301 archived colorectal cancer formalin-fixed, paraffin-embedded (FFPE) tissue sections and compared Idylla™ results against available results from routine diagnostic testing in those sites. MSI mutations detected with the Idylla™ MSI Assay were equally distributed over the seven biomarkers, and 84.48% of the MSI-high samples had ≥ 5 mut...

The Journal of Pathology, 2018

Many human cancers present PTEN deficiency and between 20-30% of colorectal tumors show PTEN loss... more Many human cancers present PTEN deficiency and between 20-30% of colorectal tumors show PTEN loss. The transcription factor E2F-1 exhibits tumor promoter or suppressive functions depending on cellular type and tissue context however its role in the progression and development of colorectal carcinogenesis was largely unknown. Here, using a tamoxifen-inducible PTEN knockout mouse model, we have demonstrated that loss of PTEN leads to the development of colorectal tumorigenesis through the serrated pathway. Next, we studied PTEN-loss driven colorectal lesions in the context of E2F-1 deficiency in vivo. Our results revealed that monoallelic and biallelic absence of E2F-1 lead to an increased incidence and progression of serrated tumorigenesis induced by PTEN loss. Finally, we investigated the mechanisms by which double PTEN/E2F-1 defficiency leads to enhanced tumorogenesis. We found that colorectal tumors from PTEN/E2F-1 double-knockout mice and the human colorectal carcinoma cell line HT29 with shRNA-mediated downregulation of PTEN and E2F-1 exhibit hyperactivation of the RAS-MAPK pathway, accumulation of DNA damage and resistance to apoptosis. To date, this is the first pre-clinical study evaluating the effect of genetic deletion of E2F-1 in colorectal malignancies driven by PTEN deficiency.

Stereotactic and Functional Neurosurgery, 1995

This is a report on a patient with intractable 'primary' generalized seizures and... more This is a report on a patient with intractable 'primary' generalized seizures and typical spike-wave EEG patterns, in whom an unexpected temporal lobe astrocytoma was detected by MRI studies. Clinical and electrophysiological studies were performed before and after surgical excision of the tumor and apical temporal lobectomy in an attempt to determine whether 'primary' generalized seizures and EEG patterns and the temporal lobe tumor were only coincident neurological disorders or were indeed related. Before resection, the patient consistently showed a typical spike-wave EEG pattern with no background and paroxysmal activities suggestive of 'secondary' bilateral synchrony in 10 consecutive conventional EEG recordings; neither spontaneous interictal nor ictal ECoG activities suggested focal temporal lobe epileptogenesis. After resection, the patient showed increased pentylenetetrazol (PTZ) convulsive threshold, and reduction in the number of 'primary' generalized seizures, although typical spike-wave EEG discharges persisted. These observations suggest that 'primary' generalized seizures, EEG patterns and the temporal tumor were physiopathologically interrelated, and that both reticulocortical and corticoreticular mechanisms may participate together in the genesis of 'primary' generalized clinical and EEG activities.

International Microbiology, Mar 17, 2010

Carbon dioxide fixation is a polyphyletic trait that has evolved in widely separated prokaryotic ... more Carbon dioxide fixation is a polyphyletic trait that has evolved in widely separated prokaryotic branches. The three principal CO 2-assimilation pathways are (i) the reductive pentose-phosphate cycle, i. e. the Calvin-Benson cycle; (ii) the reductive citric acid (or Arnon) cycle; and (iii) the net synthesis of acetyl-CoA from CO/CO 2 , or Wood pathway. Sequence analysis and the comparative biochemistry of these routes suggest that all of them were shaped to a considerable extent by the evolutionary recruitment of enzymes. Molecular phylogenetic trees show that the Calvin-Benson cycle was a relatively late development in the (eu)bacterial branch, suggesting that some form(s) of carbon assimilation may have been operative before chlorophyll-based photosynthesis. On the other hand, the ample phylogenetic distribution of both the Arnon and the Wood pathways does not allow us to infer which one of them is older. However, different lines of evidence, including experimental reports on the NiS/FeS-mediated CC bond formation from CO and CH 3 SH are used here to argue that the first CO 2-fixation route may have been a semienzymatic Wood-like pathway.

Revista Venezolana De Oncologia, May 1, 2007

OBJECTIVES: The musculoskeletal symptomatology could be initial manifestation of many tumours. Ou... more OBJECTIVES: The musculoskeletal symptomatology could be initial manifestation of many tumours. Our intention is to show relevant epidemiological finds in rhe...

Diversitas, 2010

Proyecto académico sin fines de lucro, desarrollado bajo la iniciativa de acceso abierto

Nutrición hospitalaria, 2014

Several studies have concluded that incidences of osteoporosis and osteoporosis-related fractures... more Several studies have concluded that incidences of osteoporosis and osteoporosis-related fractures vary across the European Union, the lowest incidence being reported in the Mediterranean area. The beneficial effect is mainly attributed to a specific eating pattern. The Mediterranean diet contain a complex array of naturally occurring bioactive molecules with antioxidant, anti-inflammatory and alkalinising properties that may contribute to the bone-sparing effect of the Mediterranean diet. The purpose of this review is to examine the evidence to date on the effects of Mediterranean diet on bone health. The search for articles came from extensive research in the following databases: PubMed, Scopus and Web of Science. We used the search terms "Mediterranean diet", "adherence", "fruit and vegetable", "olive oil", "fish" "legume", "cereal" "alcohol", "bone", "osteoporosis", "fracture&...

2011 Aerospace Conference, 2011

... com Ana Maria Velasco Tang IBR Services, LLC. 1971 E. 4th St. ... est. 25 million dol-lars ea... more ... com Ana Maria Velasco Tang IBR Services, LLC. 1971 E. 4th St. ... est. 25 million dol-lars each, not including acquisition, pointing, and adaptive optics) and utilize them to bring down clouds of small debris over longer periods of time. ...

Nature reviews. Neurology, 2014

Neurostimulation enables adjustable and reversible modulation of disease symptoms, including thos... more Neurostimulation enables adjustable and reversible modulation of disease symptoms, including those of epilepsy. Two types of brain neuromodulation, comprising anterior thalamic deep brain stimulation and responsive neurostimulation at seizure foci, are supported by Class I evidence of effectiveness, and many other sites in the brain have been targeted in small trials of neurostimulation therapy for seizures. Animal studies have mainly assisted in the identification of potential neurostimulation sites and parameters, but much of the clinical work is only loosely based on fundamental principles derived from the laboratory, and the mechanisms by which brain neurostimulation reduces seizures remain poorly understood. The benefits of stimulation tend to increase over time, with maximal effect seen typically 1-2 years after implantation. Typical reductions of seizure frequency are approximately 40% acutely, and 50-69% after several years. Seizure intensity might also be reduced. Complicat...

Topics in Neuromodulation Treatment, 2012

Arteterapia. Papeles de arteterapia y educación artística para la inclusión social, 2013

Se presenta un estudio de caso de una mujer que formó parte en el Taller El Encuentro de Crear en... more Se presenta un estudio de caso de una mujer que formó parte en el Taller El Encuentro de Crear en el Centro Hispano Marroquí, reflexionamos sobre su recorrido en el taller y las posibles aportaciones que pudo suponer en su vida.

International Journal of Neural Systems, 2009

We report two cases of chronic therapeutic stimulation of epileptic foci localized in motor areas... more We report two cases of chronic therapeutic stimulation of epileptic foci localized in motor areas. Case 1 is an adolescent with supplementary motor area seizures whose intracranial recordings showed a right SMA focus. Case 2 is a female teenager with primary motor seizures originating in the right motor cortex in the hand area as shown by her intracranial recordings and cortical mapping. Both had apparently normal MRI. Chronic stimulation of the epileptic focus decreased the number of seizures more than 90% the seizure number while preserving motor function. None of the patients had side effects. Neuromodulation is proposed as a safe, efficient surgical alternative for motor seizure control.

Neurosurgery, 2005

ABSTRACTOBJECTIVE:To present a review of evidence for an inhibitory thalamo-orbitofrontal system ... more ABSTRACTOBJECTIVE:To present a review of evidence for an inhibitory thalamo-orbitofrontal system related to physiopathology of major depression disorders (MDDs) and to postulate that interfering with hyperactivity of the thalamo-orbitofrontal system by means of chronic high-frequency electrical stimulation of its main fiber connection, the inferior thalamic peduncle (ITP), may result in an improvement in patients with MDD.METHODS:Experimentally, the thalamo-orbitofrontal system has been proposed as part of the nonspecific thalamic system. Under normal conditions, the nonspecific thalamic system induces characteristic electrocortical synchronization in the form of recruiting responses that mimic some sleep stages. It also inhibits input of irrelevant sensory stimuli, thus facilitating the process of selective attention. Permanent disruption of the system, via lesioning or temporary inactivation through cooling of the ITP with cryoprobes, results in a state of hyperkinesia, increased ...

The Lancet Infectious Diseases, 2009

Journal of Theoretical Biology, 2013

We study the presence of low complexity regions (LCRs) in HIV-1 gp120 protein. LCRs were identifi... more We study the presence of low complexity regions (LCRs) in HIV-1 gp120 protein. LCRs were identified in the hypervarible region V1, V2, V4 and V5. A high number of glycosylation sites were found in LCRs. Our results suggest that LCRs are an important source of antigenic variation in HIV-1 gp120 protein.

International Microbiology, 2003

The possibility of a high-temperature origin of life has gained support based on indirect evidenc... more The possibility of a high-temperature origin of life has gained support based on indirect evidence of a hot, early Earth and on the basal position of hyperthermophilic organisms in rRNA-based phylogenies. However, although the availability of more than 80 completely sequenced cellular genomes has led to the identification of hyperthermophilic-specific traits, such as a trend towards smaller genomes, reduced proteinencoding gene sizes, and glutamic-acid-rich simple sequences, none of these characteristics are in themselves an indication of primitiveness. There is no geological evidence for the physical setting in which life arose, but current models suggest that the Earth's surface cooled down rapidly. Moreover, at 100°C the half-lives of several organic compounds, including ribose, nucleobases, and amino acids, which are generally thought to have been essential for the emergence of the first living systems, are too short to allow for their accumulation in the prebiotic environment. Accordingly, if hyperthermophily is not truly primordial, then heat-loving lifestyles may be relics of a secondary adaptation that evolved after the origin of life, and before or soon after separation of the major lineages.

Revista de Ciencias …, 2006

Información del artículo Análisis de la propuesta de un modelo de planificación por impactos en a... more Información del artículo Análisis de la propuesta de un modelo de planificación por impactos en aquaeróbic.

Epilepsia, 1993

A study was performed of EEG-magnetic resonance imaging (MRI) abnormalities in 7 Lennox-Gastaut s... more A study was performed of EEG-magnetic resonance imaging (MRI) abnormalities in 7 Lennox-Gastaut syndrome (LGS) children and 3 epilepsia partialis continua (EPC) children with intractable generalized and partial motor seizures, respectively. In 4 children with LGS and 3 children with EPC, depth electrodes were implanted in the centromedian thalamic nuclei (CM) for seizure control. In all children with LGS, hyperdense, T2-weighted MRI signals were observed at the mesencephalic level of the brainstem, whereas none of the 3 children with EPC had this finding. Patients with idiopathic LGS without cerebral hemisphere MRI abnormalities showed generalized bilateral and symmetrical spike-wave EEG activity. Patients with symptomatic LGS with unilateral hemispheric MRI abnormalities demonstrated asymmetrical EEG activity with higher amplitude spike-and-wave over the normal hemisphere. Patients with EPC with unilateral hemispheric lesions had lateralized higher amplitude spike-wave over the damaged hemisphere. These data suggest that abnormal mesencephalic MRIs are a sign of bad prognosis in patients with LGS but not with EPC. Maximal amplitude paroxysmal EEG activities may indicate the abnormal hemisphere in patients with EPC or the normal hemisphere in those with LGS.

Epilepsia, 1993

Twenty-three patients with various intractable seizure patterns were divided into four groups bas... more Twenty-three patients with various intractable seizure patterns were divided into four groups based on their most frequent seizure type and their clinical and EEG response to chronic electrical stimulation of the centromedian thalamic nuclei (ESCM): group A, generalized tonic-clonic (GTC, n = 9); group B, partial motor (Rasmussen type) (n = 3); group C, complex partial seizures (CPS, n = 5); and group D, generalized tonic seizures (Lennox-Gastaut type) (n = 6). CM were radiologically and electrophysiologically localized by means of stereotaxic landmarks and by thalamically induced scalp recruiting-like responses and desynchronization. ESCM consisted of daily 2-h stimulation sessions for 3 months. Each stimulus consisted of a 1-min train of square pulses with a 4-min interstimulus interval, alternating right and left CM. Each pulse was 1.0 ms in duration at 60/s frequency and 8-15 V (400-1,250 microA) amplitude. Voltage (V), current flow (microA) and impedance (k omega) at the electrode tips were kept constant. A significant decrease in the number of seizures per month and paroxysmal EEG waves per 10-s spochs occurred in group A patients between the baseline period (BL) and the ESCM period. These changes persisted for > 3 months after discontinuation of ESCM (poststimulation period, Post). Post was accompanied by a significant decrease in the number of paroxysmal EEG discharges. A substantial decrease in seizures and paroxysmal discharges was also observed in patients of group B. In contrast, patients of groups C and D showed no significant changes from BL to ESCM and Post periods, except for a significant decrease in the number of seizures in group D patients from BL to Post periods.