ANU MATHEW - Academia.edu (original) (raw)

Papers by ANU MATHEW

Research paper thumbnail of Low skeletal muscle mass is associated with liver fibrosis in individuals with type 2 diabetes and nonalcoholic fatty liver disease

Journal of Gastroenterology and Hepatology, 2021

Type 2 diabetes (T2D) and low skeletal muscle mass (SMM) are associated with increased risk of no... more Type 2 diabetes (T2D) and low skeletal muscle mass (SMM) are associated with increased risk of nonalcoholic fatty liver disease (NAFLD). However, data regarding the association between low SMM and NAFLD‐related liver fibrosis in individuals with T2D are scarce. Therefore, we aimed to investigate the association between low SMM and liver fibrosis in individuals with T2D and NAFLD.

Research paper thumbnail of Short term follow-up of patients presenting with acute onset diabetes and diabetic ketoacidosis during an episode of COVID-19

Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2020

Background: The liver is the most common site of colorectal cancer metastasis. Liver metastasecto... more Background: The liver is the most common site of colorectal cancer metastasis. Liver metastasectomy provides potentially curative treatment for a certain portion of patients with liver metastases. Novel biomarkers predicting patient survival in this specific clinical scenario are urgently needed. Determination of circulating cell-free tumor DNA (ctDNA) can be used as a liquid biopsy method for minimally invasive assessment of the disease course. In this study, we assessed the possibility of liquid biopsy based on KRAS-oncogene mutated ctDNA from peripheral blood to predict survival of colorectal cancer patients undergoing liver metastasectomy.

Research paper thumbnail of Bimodal glucose distribution in Asian Indian pregnant women: Relevance in gestational diabetes mellitus diagnosis

Journal of Clinical & Translational Endocrinology, 2018

Presence of bimodality in plasma glucose distribution (BPG) and its relevance for gestational dia... more Presence of bimodality in plasma glucose distribution (BPG) and its relevance for gestational diabetes mellitus (GDM) diagnosis were studied in Asian Indian pregnant women. Methods: Fasting (FPG) and two hour plasma glucose (2-h PG) values of oral glucose tolerance tests performed in 36,530 pregnant women for GDM screening (2006-16 period), were analyzed for BPG. A unimodal normal and a mixture of two normal distributions were fitted to log-transformed FPG and 2-h PG data. The mixture model was compared to unimodal model for BPG using likelihood ratio test (LRT) and the comparison was further verified by bootstrapping. The cut points of the two normal distribution curves in the mixture models of FPG and 2-h PG were noted. Results: Fasting and 2-h PG distribution was bimodal in all pregnant women. The comparison of mixture and unimodal models using LRT revealed p value < 0.001 in all age groups. The cut points for FPG and 2-h PG were 5.81 mmol/L (95% CI: 5.69-5.92) and 8.41 mmol/l (95% CI: 8.09-8.75) respectively. Conclusion: BPG is noted for both FPG and 2-hPG in Asian Indian pregnant women. The cutpoints of normal distribution curves are close to threshold values for FPG and 2-h PG proposed in NICE (National Institute for health and Care Excellence) and IADPSG (International Association of Diabetes and Pregnancy Study Group) GDM diagnostic criteria respectively. Further research on BPG in pregnant women of racial groups with high GDM prevalence, is likely to be of value in GDM diagnosis.

Research paper thumbnail of Bimodal distribution of fasting, one and two hour post load plasma glucose in Asian Indian pregnant women without pre-gestational diabetes: Gestational age related changes

Journal of Clinical & Translational Endocrinology, 2019

'hyperglycemia first detected in pregnancy' [15]. The women with FPG ≥ 126 mg /dl, 2-h PG ≥ 200 m... more 'hyperglycemia first detected in pregnancy' [15]. The women with FPG ≥ 126 mg /dl, 2-h PG ≥ 200 mg/dl or random plasma glucose ≥ 200 mg/dl are classified as 'diabetes mellitus in pregnancy'. The

Research paper thumbnail of Acute myocardial injury and rhabdomyolysis caused by multiple bee stings

The Journal of the Association of Physicians of India, 2011

Massive envenomation by honey bees is capable of causing multiorgan dysfunction as a result of di... more Massive envenomation by honey bees is capable of causing multiorgan dysfunction as a result of direct toxic effect of massive envenomation and secondary to systemic anaphylactic reactions. Acute myocardial ischemia due to bee envenomation is a rare event. We report the case of a 65 year old lady who presented with acute myocardial ischemia, severe rhabdomyolysis and angioedema following massive bee envenomation.

Research paper thumbnail of Glycated haemoglobin in the first trimester: A predictor of gestational diabetes mellitus in pregnant Asian Indian women

Diabetes Research and Clinical Practice, 2019

To assess the efficacy of first trimester glycated hemoglobin (HbA1c-FT) in diagnosing or predict... more To assess the efficacy of first trimester glycated hemoglobin (HbA1c-FT) in diagnosing or predicting gestational diabetes mellitus (GDM) in Asian Indian women. Methods: This retrospective cohort study involved 2275 women who underwent both HbA1c-FT estimation and GDM screening with a one-step 75 g oral glucose tolerance test. Receiver Operating Characteristic (ROC) curve statistics were applied to assess the discriminative ability of HbA1c-FT in GDM diagnosis. A multivariable logistic regression analysis after adjusting for plausible confounders was used to evaluate the independent effect of HbA1c-FT on GDM diagnosis. Results: The mean HbA1c-FT of GDM (n = 578) and non-GDM women (n = 1697) were 5.04 + 0.04% and 4.9 + 0.37%, respectively (p < 0.001). Compared to women with a HbA1c-FT < 5.2%, the adjusted odds ratio to develop GDM of women with an HbA1c-FT range of 5.2-5.5% and those >5.6% to develop GDM were 1.627 (p < 0.004) and 2.6 (p < 0.001), respectively. The area under the ROC curve to detect GDM was 0.606 (95% CI: 0.519-0.633 p < 0.001), but the sensitivity and specificity of the HbA1c-FT were not sufficient to diagnose, rule in or rule out GDM. Conclusions: HbA1c-FT is an independent GDM predictor in Asian Indian women but lacks sufficient sensitivity or specificity for use as a diagnostic test.

Research paper thumbnail of Low skeletal muscle mass is associated with liver fibrosis in individuals with type 2 diabetes and nonalcoholic fatty liver disease

Journal of Gastroenterology and Hepatology, 2021

Type 2 diabetes (T2D) and low skeletal muscle mass (SMM) are associated with increased risk of no... more Type 2 diabetes (T2D) and low skeletal muscle mass (SMM) are associated with increased risk of nonalcoholic fatty liver disease (NAFLD). However, data regarding the association between low SMM and NAFLD‐related liver fibrosis in individuals with T2D are scarce. Therefore, we aimed to investigate the association between low SMM and liver fibrosis in individuals with T2D and NAFLD.

Research paper thumbnail of Short term follow-up of patients presenting with acute onset diabetes and diabetic ketoacidosis during an episode of COVID-19

Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2020

Background: The liver is the most common site of colorectal cancer metastasis. Liver metastasecto... more Background: The liver is the most common site of colorectal cancer metastasis. Liver metastasectomy provides potentially curative treatment for a certain portion of patients with liver metastases. Novel biomarkers predicting patient survival in this specific clinical scenario are urgently needed. Determination of circulating cell-free tumor DNA (ctDNA) can be used as a liquid biopsy method for minimally invasive assessment of the disease course. In this study, we assessed the possibility of liquid biopsy based on KRAS-oncogene mutated ctDNA from peripheral blood to predict survival of colorectal cancer patients undergoing liver metastasectomy.

Research paper thumbnail of Bimodal glucose distribution in Asian Indian pregnant women: Relevance in gestational diabetes mellitus diagnosis

Journal of Clinical & Translational Endocrinology, 2018

Presence of bimodality in plasma glucose distribution (BPG) and its relevance for gestational dia... more Presence of bimodality in plasma glucose distribution (BPG) and its relevance for gestational diabetes mellitus (GDM) diagnosis were studied in Asian Indian pregnant women. Methods: Fasting (FPG) and two hour plasma glucose (2-h PG) values of oral glucose tolerance tests performed in 36,530 pregnant women for GDM screening (2006-16 period), were analyzed for BPG. A unimodal normal and a mixture of two normal distributions were fitted to log-transformed FPG and 2-h PG data. The mixture model was compared to unimodal model for BPG using likelihood ratio test (LRT) and the comparison was further verified by bootstrapping. The cut points of the two normal distribution curves in the mixture models of FPG and 2-h PG were noted. Results: Fasting and 2-h PG distribution was bimodal in all pregnant women. The comparison of mixture and unimodal models using LRT revealed p value < 0.001 in all age groups. The cut points for FPG and 2-h PG were 5.81 mmol/L (95% CI: 5.69-5.92) and 8.41 mmol/l (95% CI: 8.09-8.75) respectively. Conclusion: BPG is noted for both FPG and 2-hPG in Asian Indian pregnant women. The cutpoints of normal distribution curves are close to threshold values for FPG and 2-h PG proposed in NICE (National Institute for health and Care Excellence) and IADPSG (International Association of Diabetes and Pregnancy Study Group) GDM diagnostic criteria respectively. Further research on BPG in pregnant women of racial groups with high GDM prevalence, is likely to be of value in GDM diagnosis.

Research paper thumbnail of Bimodal distribution of fasting, one and two hour post load plasma glucose in Asian Indian pregnant women without pre-gestational diabetes: Gestational age related changes

Journal of Clinical & Translational Endocrinology, 2019

'hyperglycemia first detected in pregnancy' [15]. The women with FPG ≥ 126 mg /dl, 2-h PG ≥ 200 m... more 'hyperglycemia first detected in pregnancy' [15]. The women with FPG ≥ 126 mg /dl, 2-h PG ≥ 200 mg/dl or random plasma glucose ≥ 200 mg/dl are classified as 'diabetes mellitus in pregnancy'. The

Research paper thumbnail of Acute myocardial injury and rhabdomyolysis caused by multiple bee stings

The Journal of the Association of Physicians of India, 2011

Massive envenomation by honey bees is capable of causing multiorgan dysfunction as a result of di... more Massive envenomation by honey bees is capable of causing multiorgan dysfunction as a result of direct toxic effect of massive envenomation and secondary to systemic anaphylactic reactions. Acute myocardial ischemia due to bee envenomation is a rare event. We report the case of a 65 year old lady who presented with acute myocardial ischemia, severe rhabdomyolysis and angioedema following massive bee envenomation.

Research paper thumbnail of Glycated haemoglobin in the first trimester: A predictor of gestational diabetes mellitus in pregnant Asian Indian women

Diabetes Research and Clinical Practice, 2019

To assess the efficacy of first trimester glycated hemoglobin (HbA1c-FT) in diagnosing or predict... more To assess the efficacy of first trimester glycated hemoglobin (HbA1c-FT) in diagnosing or predicting gestational diabetes mellitus (GDM) in Asian Indian women. Methods: This retrospective cohort study involved 2275 women who underwent both HbA1c-FT estimation and GDM screening with a one-step 75 g oral glucose tolerance test. Receiver Operating Characteristic (ROC) curve statistics were applied to assess the discriminative ability of HbA1c-FT in GDM diagnosis. A multivariable logistic regression analysis after adjusting for plausible confounders was used to evaluate the independent effect of HbA1c-FT on GDM diagnosis. Results: The mean HbA1c-FT of GDM (n = 578) and non-GDM women (n = 1697) were 5.04 + 0.04% and 4.9 + 0.37%, respectively (p < 0.001). Compared to women with a HbA1c-FT < 5.2%, the adjusted odds ratio to develop GDM of women with an HbA1c-FT range of 5.2-5.5% and those >5.6% to develop GDM were 1.627 (p < 0.004) and 2.6 (p < 0.001), respectively. The area under the ROC curve to detect GDM was 0.606 (95% CI: 0.519-0.633 p < 0.001), but the sensitivity and specificity of the HbA1c-FT were not sufficient to diagnose, rule in or rule out GDM. Conclusions: HbA1c-FT is an independent GDM predictor in Asian Indian women but lacks sufficient sensitivity or specificity for use as a diagnostic test.