A. Nejatisafa - Academia.edu (original) (raw)

Papers by A. Nejatisafa

Research paper thumbnail of Influence of citicoline on citalopram-induced antidepressant activity in depressive-like symptoms in male mice

Physiology & Behavior, 2018

Depression is associated with significant functional disabilities. Application of new drugs which... more Depression is associated with significant functional disabilities. Application of new drugs which could enhance the effectiveness of antidepressants drug and reduce side effects of their long-term use seems necessary. Citicoline is used as an effective chemical agent for improving the symptoms of some neurodegenerative diseases. Therefore, in this survey, the application of citicoline as an adjuvant drug was evaluated in mice model of depression. A total of 180 adult NMRI male albino mice were used in this study. All groups were exposed to chronic unexpected mild stress (CUMS) followed by treatment with various doses of citalopram or/and citicoline or saline for 21 days. Sucrose preference (SP), open field (OF), and forced swimming test (FST) were applied to evaluate depression symptoms in the groups. The results indicated that only citicoline at the 5 mg/kg dose had shifted its status from being noneffective to become significantly effective in the co-administered group. The means of SP, OFT, and FST of the treatment groups were significantly different in favor of coadministered group compared with the other groups as well as the control group. Based on the results, it can be concluded that administration of citicoline, as an adjuvant drug, in combination with citalopram, enhanced the effectiveness of selective serotonin reuptake inhibitors (SSRI) drugs for depression treatment.

Research paper thumbnail of The Impact of Mindfulness-Based Stress Reduction on Emotional Wellbeing and Glycemic Control of Patients with Type 2 Diabetes Mellitus

Journal of Diabetes Research, 2018

Objective. The aim of the study was to determine the effect of mindfulness-based stress reduction... more Objective. The aim of the study was to determine the effect of mindfulness-based stress reduction (MBSR) intervention on emotion regulation and glycemic control of patients with type 2 diabetes. Materials and Methods. Sixty patients with type 2 diabetes were recruited for this randomized controlled trial from an outpatient clinic at Imam Hospital in Iran. The intervention group participated in 8 sessions of MBSR, and the control group continued the treatment as usual. Fasting blood sugar and HbA1c were measured as two indices of glycemic control. Overall mental health, depression, and anxiety were measured using the General Health Questionnaire (GHQ-28), Hamilton Depression Rating Scale (HDRS), and Hamilton Anxiety Rating Scale (HARS), respectively. All the assessments were performed at baseline and after 8 weeks and 3 months as follow-up. Results. In comparison with the control group, the MBSR intervention group showed a significant reduction on all outcome measures including FBS, ...

Research paper thumbnail of 297 The Effect of Ambulatory Care Educational System on Clinical Competency and Quality of Supervision of Psychiatry Residents

Asian Journal of Psychiatry, 2011

would end the MMT, what would you do?" "If miracles do not happen the rest of your life, what wou... more would end the MMT, what would you do?" "If miracles do not happen the rest of your life, what would you do?" The group was videotaped and the manuscripts were encoded and analyzed by the researchers. Findings: The members in the second group were more conscientious about themselves and their families. Instead of saying "I will inject enough heroin to fly me to the heaven." They would talk more about bringing something to their family. They were also determined to contribute more to their communities. To live a happy life was not as important as it was in the first group. Conclusions: Building healthy ways to have fun, improving empathy for others, and re-deciding their life, were found to be the most meaningful outcomes for the second group.

Research paper thumbnail of Quality of life in a group of patients with bipolar disorder and some of their clinical characteristics

Objectives: The aim of the present study was to evaluate the quality of life in a group of patien... more Objectives: The aim of the present study was to evaluate the quality of life in a group of patients with bipolar disorder at admission, discharge and six month after hospitalization in

Research paper thumbnail of Analysis of mental health research in the Islamic Republic of Iran over 3 decades: a scientometric study

Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit, 2008

This study described the characteristics of mental health research from the Islamic Republic of I... more This study described the characteristics of mental health research from the Islamic Republic of Iran published from 1973-2002. Research articles in psychiatry, psychology and neuroscience published in local or international journals were drawn from IranPsych, a national database of research in mental health and related disciplines. Of 3113 articles, 21.8% appeared in international journals, but there was international collaboration among the authors in only 2.3%. There was a marked increase in the number of publications over time, especially in the last 5 years. Analysis of research areas showed a proportionate rise in neuroscience research and a decline in mental health service research. Our study provides an empirical basis for policy-making and strategy planning in the nation's mental health research.

Research paper thumbnail of Pre-transplantation psychosocial status of candidates for liver or kidney transplantation and its correlation with post-transplantation mental health and adherence to treatments

Journal of Psychosomatic Research

Research paper thumbnail of History and models of psychosomatic medicine and a brief review of Its current status in Iran and Germany

Research paper thumbnail of Analysis of mental health research in the Islamic Republic of Iran over 3 decades: a scientometric study

Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ

This study described the characteristics of mental health research from the Islamic Republic of I... more This study described the characteristics of mental health research from the Islamic Republic of Iran published from 1973-2002. Research articles in psychiatry, psychology and neuroscience published in local or international journals were drawn from IranPsych, a national database of research in mental health and related disciplines. Of 3113 articles, 21.8% appeared in international journals, but there was international collaboration among the authors in only 2.3%. There was a marked increase in the number of publications over time, especially in the last 5 years. Analysis of research areas showed a proportionate rise in neuroscience research and a decline in mental health service research. Our study provides an empirical basis for policy-making and strategy planning in the nation's mental health research.

Research paper thumbnail of 403 Mental Health Services in Tehran University of Medical Sciences' General Hospitals: General Status and Pattern of Service Delivery in 2010

Background and Aim: Studies generally describe the relationship between physical fitness and cogn... more Background and Aim: Studies generally describe the relationship between physical fitness and cognitive function by measuring only one or two specific cognitive tasks. In addition, in spite of the significant increase in life expectancy, the age of participants in these studies does not extend beyond a mean age of 70 years. This study was thus designed to examine the relationship between physical fitness and function in multiple neurocognitive domains in subjects older than those previously reported. Methods: Thirty-eight individuals, aged 65.3 to 85.3 years, performed a graded, progressive, maximal exercise test. Based on a median score of peak VO 2 , participants were divided into lowfitness and moderately-fit groups. Cognitive function was assessed by means of a computerized neuropsychological battery. Results: The moderately-fit group achieved significantly better scores on the global cognitive score (U = 97, p = 0.04), and a significant correlation was found between peak VO 2 and attention, executive function, and global cognitive score (r s = 0.37, 0.39, 0.38 respectively). The trend for superior cognitive scores in the moderate-fitness compared to the low-fitness groups was unequivocal, both in terms of accuracy and reaction time. Conclusion: Maintenance of higher levels of cardiovascular fitness may help protect against cognitive deterioration, even at an advanced age. An adequately powered randomized controlled trial should be performed to further evaluate this hypothesis.

Research paper thumbnail of Patient outcomes in a liver transplant program in Iran

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2014

The first liver transplant program in Tehran was started at Tehran University of Medical Sciences... more The first liver transplant program in Tehran was started at Tehran University of Medical Sciences in 2002. The purpose of this study was to evaluate patient outcomes in this program. From January 2002 to February 2013, there were 172 deceased-donor orthotopic liver transplants performed in 166 patients, including revision transplant in 6 patients. Outcomes were evaluated for 4 phases of the program: (1) phase 1 (2002 to 2005; 9 transplants); (2) phase 2 (2006 to 2009; 41 transplants); (3) phase 3 (2010 to 2011; 49 transplants); and (4) phase 4 (2012 to 2013; 73 transplants). The most frequent indications for liver transplant included cryptogenic cirrhosis, autoimmune hepatitis, and hepatitis B and C cirrhosis. During the progression from phase 1 to 4, there were significant decreases in median cold ischemia time, operative time, and transfusions (platelets, packed red blood cells, and fresh frozen plasma). The most frequent complications included infection and acute rejection. The o...

Research paper thumbnail of Diagnoses, requests and timing of 503 psychiatric consultations in two general hospitals

Acta medica Iranica, 2012

The high comorbidity of medical and psychiatric diagnoses in the general hospital population requ... more The high comorbidity of medical and psychiatric diagnoses in the general hospital population requires collaboration between various medical fields to provide comprehensive health care. This study aims to find the rate of psychiatric consultations, their timing and overall diagnostic trend in comparison to previous studies. Tehran University of Medical Sciences has got an active psychiatric consultation-liaison service which includes services provided by four faculty psychiatrists (two full-time and two part-time). This study was done in two general hospitals by simple sampling in available cases. For each consultation, a board-certified faculty psychiatrist conducted a clinical evaluation based on DSM-IV-TR. Other than psychiatric diagnoses, socio-demographic variables, relative consultation rates, reasons for referral, medical diagnoses and the time stay after admission were assessed. Among 503 patients who were visited by the consultation-liaison service, there were 54.3% female w...

Research paper thumbnail of Screening for depression and anxiety in oncologic patients: Comparison of nurses reports vs Hospital Anxiety and Depression Scale

Research paper thumbnail of Autistic spectrum symptoms and its correlates: the impact of subject of study among Masters and PhD students

Research paper thumbnail of Establishing a Liver Transplantation Program at Tehran University of Medical Sciences, Iran: A Report of Ten Years of Experience

ABSTRACT In 2001, a Liver Transplantation (LT) program was commenced in Imam Khomeini Hospital Co... more ABSTRACT In 2001, a Liver Transplantation (LT) program was commenced in Imam Khomeini Hospital Complex as the first one in the capital city of Tehran which is the second liver transplantation center in Iran. This study presents the results of our 10-year experience with LT.

Research paper thumbnail of Comparative Study of Quality of Life in Multiple Myeloma Patients after Bone Marrow Transplantation in Outpatient and Inpatient Setting

SSU_Journals, 2010

... لﺎﻬﺳا )07/0 (P= اﺰﻓا ﻳ ﻨﻌﻣ ﺶ ﻲ راد وﻳ ﺮﻘﺗ ﺎ ﻳ ﻨﻌﻣ ًﺎﺒ ﻲ راد ي ﺖﺳا ﻪﺘﺷاد . ﺘﻧﻴ ﻪﺠ ﮔﻴ ﺮ ي: ﭘ شو... more ... لﺎﻬﺳا )07/0 (P= اﺰﻓا ﻳ ﻨﻌﻣ ﺶ ﻲ راد وﻳ ﺮﻘﺗ ﺎ ﻳ ﻨﻌﻣ ًﺎﺒ ﻲ راد ي ﺖﺳا ﻪﺘﺷاد . ﺘﻧﻴ ﻪﺠ ﮔﻴ ﺮ ي: ﭘ شور ود ﺮﻫ ﺪﻨﭼﺮﻫ ﻴ ﺎﻘﺗرا ﺖﻬﺟ ﺪﻧﻮ ي ﻛ ﻴ ﻔﻴ ﮔﺪﻧز ﺖ ﻲ ﻟو ﺪﻧراد ار دﻮﺧ ﻦﺳﺎﺤﻣ ﻲ ﻛ ندﻮـﺑ ﺮﺘﻬﺑ ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ ﻴﻔـﻴ ﮔﺪـﻧز ﺖ ﻲ ﺎﭘﺮﺳ هوﺮﮔ ﻳﻲ ﻀﻌﺑ رد ﻲ ﭘ شور ،دﺎﻌﺑا زا ﻴ ﺎﭘﺮﺳ ﺪﻧﻮ ﻳﻲ ﻣ ﻲ ﺗ ﺪﻧاﻮﺗ ﺄﺛﻴ اﺰﺴﺑ ﺮ ﻳﻲ ﻛ ءﺎﻘﺗرا رد ﻴﻔﻴ ﮔﺪﻧز ﺖ ﻲﺑ ﻴ ﺪﺷﺎﺑ ﻪﺘﺷاد نارﺎﻤ . ...

Research paper thumbnail of Hindsight bias in psychiatrists' diagnoses

European Psychiatry, 2008

This is a qualitative-phenomenological study. Participants in this study were 12 youth with subst... more This is a qualitative-phenomenological study. Participants in this study were 12 youth with substance dependency with range of 18 to 30 years old that was selected with purposive sampling method. Data were collected with in-depth interview and analysis was done via Colaizzi method. Results: Three themes or main concepts were derived from this study that each of these themes has any subthems. These are including Personal factors, Family factors and Social factors. Conclusions: The findings of this study indicated that people underlined of different factors such as personal, family and social factors refer to the consumption of opioid and finally depend to this substance. Regarding to findings of present study, the researchers of this study believed that the first level of prevention can useful about this. Thus in this level of prevention, three approaches of individual centered, family centered and community centered suggested.

Research paper thumbnail of P02-284 - Screening for depression and anxiety in patients admitted for coronary artery bypass graft: comparison of nurses’ reports vs. hospital anxiety and depression scale

European Psychiatry, 2011

AimsTo evaluate the validity of nurses’ reports as a screening tool for anxiety and depression in... more AimsTo evaluate the validity of nurses’ reports as a screening tool for anxiety and depression in hospitalized patients admitted for Coronary Artery Bypass Graft.MethodsWithin 72 hours of admission, the patients were assessed using the Hospital Anxiety and Depression Scale (HADS). Simultaneously, the nurses who provided care for the patients were asked whether they believed the patients had significant levels of depression or anxiety. They were also asked to rate the degree of depression and anxiety of their patients in a 5 point Likert scale. Assessments were completed for 150 patients.ResultsAccording to HADS score, 67 (44.66%) patients had probable depressive disorders (HADS-D score > 7) and 57(38%) had probable anxiety disorders (HADS-A score>7). Nurses recognized 31(20.66%) patients had depressive disorder and 24(16%) had anxiety disorders. The correlation coefficient between nursing diagnosis and diagnosis according to HADS was small (phi = 0.24, P < 0.01). No signifi...

Research paper thumbnail of Relationship between anxiety and depression and service satisfaction in a sample of Iranian inpatients admitted in a general hospital

European Psychiatry, 2008

post-dose) included: 100-mm Visual Analogue Scale for Anxiety (VAS-A; primary outcome); 100-mm VA... more post-dose) included: 100-mm Visual Analogue Scale for Anxiety (VAS-A; primary outcome); 100-mm VAS-Sedation (VAS-S); and Time-to-Onset of Action Scale (TOAS), which rates anti-anxiety drug benefit (0-10, noefull benefit). Results: VAS-A scores at baseline were higher on PGB (70.2) compared to ALP (57.4) or PBO (64.1). On a mixed-model analysis, VAS-A improvement slopes were greater for PGB (t¼-2.47; P¼0.014) and ALP (t¼-2.39; P¼0.018) vs PBO. Significant improvement on TOAS was seen at hour 2 and hour 3 through endpoint for ALP and PGB subjects, respectively (P0.05 vs PBO, both groups). VAS-S scores were significantly higher vs PBO for PGB at hours 2.5-4.0, and at hours 2 until endpoint for ALP (P0.05 both groups). Spearman analysis showed similar levels of correlation between the TOAS and VAS-S (r¼ +0.58) and VAS-A (r¼-0.50), suggesting that the VAS-S may be measuring an efficacy outcome in this model. Both PGB and ALP were well-tolerated. Conclusion: Clinically meaningful anxiolytic effect occurred within 3-4 hours after single-dose PGB in this dental-anxiety model.

Research paper thumbnail of Prevalence, recognition and treatment of depression and anxiety in a general hospital inpatients: A report from Iran

European Psychiatry, 2008

positive(23.35%) and negative group(3,30%) while in sporadic cases outbred cases are more in numb... more positive(23.35%) and negative group(3,30%) while in sporadic cases outbred cases are more in number(39.43%). Discussion: This study shows consanguinity as an important factor in the onset of mental illness and is a fertile base for further molecular genetic studies to locate genes contributing in the development of illness P0291

Research paper thumbnail of The study of correlation between depression, quality of life and glycemic control in a sample of Iranian diabetic patients

European Psychiatry, 2008

(n¼151) and placebo (n¼157). Primary endpoint: baseline to Week 6 change in MADRS total score. Se... more (n¼151) and placebo (n¼157). Primary endpoint: baseline to Week 6 change in MADRS total score. Secondary variables included: baseline to Week 6 change in HAM-D total and Item 1 (depressed mood) scores. Safety assessments included AE reporting. Results: Mean MADRS total score (overall baseline mean, 30.15) was significantly reduced at Week 6 by quetiapine XR 150mg/day, 300mg/day and duloxetine versus placebo (À14.81, À15.29, À14.64, À11.18, respectively; p 0.001). At Week 6, mean HAM-D total scores (overall baseline mean, 25.25) were significantly reduced versus placebo (À10.26) by quetiapine XR 150mg/day, 300mg/day (À13.12, À14.02, respectively, p 0.001) and duloxetine (À12.37, p<0.05). Mean HAM-D item 1 scores (overall baseline mean, 3.03) were significantly reduced versus placebo (À1.07) by quetiapine XR 150mg/day, 300mg/day (À1.49, À1.56, respectively, p 0.001) and duloxetine (À1.53, p<0.001). Incidence of serious AEs were low (2%) in all groups. Most common AEs (>10%) were dry mouth, sedation, somnolence, dizziness, headache and nausea with quetiapine; dizziness and headache with placebo; and dry mouth, sedation, somnolence, dizziness, headache, constipation, nausea, diarrhoea and insomnia with duloxetine. Most AEs were mild-to-moderate in intensity. Conclusion: Quetiapine XR monotherapy at 150 and 300mg/day was effective and well tolerated in the treatment of patients with MDD.

Research paper thumbnail of Influence of citicoline on citalopram-induced antidepressant activity in depressive-like symptoms in male mice

Physiology & Behavior, 2018

Depression is associated with significant functional disabilities. Application of new drugs which... more Depression is associated with significant functional disabilities. Application of new drugs which could enhance the effectiveness of antidepressants drug and reduce side effects of their long-term use seems necessary. Citicoline is used as an effective chemical agent for improving the symptoms of some neurodegenerative diseases. Therefore, in this survey, the application of citicoline as an adjuvant drug was evaluated in mice model of depression. A total of 180 adult NMRI male albino mice were used in this study. All groups were exposed to chronic unexpected mild stress (CUMS) followed by treatment with various doses of citalopram or/and citicoline or saline for 21 days. Sucrose preference (SP), open field (OF), and forced swimming test (FST) were applied to evaluate depression symptoms in the groups. The results indicated that only citicoline at the 5 mg/kg dose had shifted its status from being noneffective to become significantly effective in the co-administered group. The means of SP, OFT, and FST of the treatment groups were significantly different in favor of coadministered group compared with the other groups as well as the control group. Based on the results, it can be concluded that administration of citicoline, as an adjuvant drug, in combination with citalopram, enhanced the effectiveness of selective serotonin reuptake inhibitors (SSRI) drugs for depression treatment.

Research paper thumbnail of The Impact of Mindfulness-Based Stress Reduction on Emotional Wellbeing and Glycemic Control of Patients with Type 2 Diabetes Mellitus

Journal of Diabetes Research, 2018

Objective. The aim of the study was to determine the effect of mindfulness-based stress reduction... more Objective. The aim of the study was to determine the effect of mindfulness-based stress reduction (MBSR) intervention on emotion regulation and glycemic control of patients with type 2 diabetes. Materials and Methods. Sixty patients with type 2 diabetes were recruited for this randomized controlled trial from an outpatient clinic at Imam Hospital in Iran. The intervention group participated in 8 sessions of MBSR, and the control group continued the treatment as usual. Fasting blood sugar and HbA1c were measured as two indices of glycemic control. Overall mental health, depression, and anxiety were measured using the General Health Questionnaire (GHQ-28), Hamilton Depression Rating Scale (HDRS), and Hamilton Anxiety Rating Scale (HARS), respectively. All the assessments were performed at baseline and after 8 weeks and 3 months as follow-up. Results. In comparison with the control group, the MBSR intervention group showed a significant reduction on all outcome measures including FBS, ...

Research paper thumbnail of 297 The Effect of Ambulatory Care Educational System on Clinical Competency and Quality of Supervision of Psychiatry Residents

Asian Journal of Psychiatry, 2011

would end the MMT, what would you do?" "If miracles do not happen the rest of your life, what wou... more would end the MMT, what would you do?" "If miracles do not happen the rest of your life, what would you do?" The group was videotaped and the manuscripts were encoded and analyzed by the researchers. Findings: The members in the second group were more conscientious about themselves and their families. Instead of saying "I will inject enough heroin to fly me to the heaven." They would talk more about bringing something to their family. They were also determined to contribute more to their communities. To live a happy life was not as important as it was in the first group. Conclusions: Building healthy ways to have fun, improving empathy for others, and re-deciding their life, were found to be the most meaningful outcomes for the second group.

Research paper thumbnail of Quality of life in a group of patients with bipolar disorder and some of their clinical characteristics

Objectives: The aim of the present study was to evaluate the quality of life in a group of patien... more Objectives: The aim of the present study was to evaluate the quality of life in a group of patients with bipolar disorder at admission, discharge and six month after hospitalization in

Research paper thumbnail of Analysis of mental health research in the Islamic Republic of Iran over 3 decades: a scientometric study

Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit, 2008

This study described the characteristics of mental health research from the Islamic Republic of I... more This study described the characteristics of mental health research from the Islamic Republic of Iran published from 1973-2002. Research articles in psychiatry, psychology and neuroscience published in local or international journals were drawn from IranPsych, a national database of research in mental health and related disciplines. Of 3113 articles, 21.8% appeared in international journals, but there was international collaboration among the authors in only 2.3%. There was a marked increase in the number of publications over time, especially in the last 5 years. Analysis of research areas showed a proportionate rise in neuroscience research and a decline in mental health service research. Our study provides an empirical basis for policy-making and strategy planning in the nation's mental health research.

Research paper thumbnail of Pre-transplantation psychosocial status of candidates for liver or kidney transplantation and its correlation with post-transplantation mental health and adherence to treatments

Journal of Psychosomatic Research

Research paper thumbnail of History and models of psychosomatic medicine and a brief review of Its current status in Iran and Germany

Research paper thumbnail of Analysis of mental health research in the Islamic Republic of Iran over 3 decades: a scientometric study

Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ

This study described the characteristics of mental health research from the Islamic Republic of I... more This study described the characteristics of mental health research from the Islamic Republic of Iran published from 1973-2002. Research articles in psychiatry, psychology and neuroscience published in local or international journals were drawn from IranPsych, a national database of research in mental health and related disciplines. Of 3113 articles, 21.8% appeared in international journals, but there was international collaboration among the authors in only 2.3%. There was a marked increase in the number of publications over time, especially in the last 5 years. Analysis of research areas showed a proportionate rise in neuroscience research and a decline in mental health service research. Our study provides an empirical basis for policy-making and strategy planning in the nation's mental health research.

Research paper thumbnail of 403 Mental Health Services in Tehran University of Medical Sciences' General Hospitals: General Status and Pattern of Service Delivery in 2010

Background and Aim: Studies generally describe the relationship between physical fitness and cogn... more Background and Aim: Studies generally describe the relationship between physical fitness and cognitive function by measuring only one or two specific cognitive tasks. In addition, in spite of the significant increase in life expectancy, the age of participants in these studies does not extend beyond a mean age of 70 years. This study was thus designed to examine the relationship between physical fitness and function in multiple neurocognitive domains in subjects older than those previously reported. Methods: Thirty-eight individuals, aged 65.3 to 85.3 years, performed a graded, progressive, maximal exercise test. Based on a median score of peak VO 2 , participants were divided into lowfitness and moderately-fit groups. Cognitive function was assessed by means of a computerized neuropsychological battery. Results: The moderately-fit group achieved significantly better scores on the global cognitive score (U = 97, p = 0.04), and a significant correlation was found between peak VO 2 and attention, executive function, and global cognitive score (r s = 0.37, 0.39, 0.38 respectively). The trend for superior cognitive scores in the moderate-fitness compared to the low-fitness groups was unequivocal, both in terms of accuracy and reaction time. Conclusion: Maintenance of higher levels of cardiovascular fitness may help protect against cognitive deterioration, even at an advanced age. An adequately powered randomized controlled trial should be performed to further evaluate this hypothesis.

Research paper thumbnail of Patient outcomes in a liver transplant program in Iran

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2014

The first liver transplant program in Tehran was started at Tehran University of Medical Sciences... more The first liver transplant program in Tehran was started at Tehran University of Medical Sciences in 2002. The purpose of this study was to evaluate patient outcomes in this program. From January 2002 to February 2013, there were 172 deceased-donor orthotopic liver transplants performed in 166 patients, including revision transplant in 6 patients. Outcomes were evaluated for 4 phases of the program: (1) phase 1 (2002 to 2005; 9 transplants); (2) phase 2 (2006 to 2009; 41 transplants); (3) phase 3 (2010 to 2011; 49 transplants); and (4) phase 4 (2012 to 2013; 73 transplants). The most frequent indications for liver transplant included cryptogenic cirrhosis, autoimmune hepatitis, and hepatitis B and C cirrhosis. During the progression from phase 1 to 4, there were significant decreases in median cold ischemia time, operative time, and transfusions (platelets, packed red blood cells, and fresh frozen plasma). The most frequent complications included infection and acute rejection. The o...

Research paper thumbnail of Diagnoses, requests and timing of 503 psychiatric consultations in two general hospitals

Acta medica Iranica, 2012

The high comorbidity of medical and psychiatric diagnoses in the general hospital population requ... more The high comorbidity of medical and psychiatric diagnoses in the general hospital population requires collaboration between various medical fields to provide comprehensive health care. This study aims to find the rate of psychiatric consultations, their timing and overall diagnostic trend in comparison to previous studies. Tehran University of Medical Sciences has got an active psychiatric consultation-liaison service which includes services provided by four faculty psychiatrists (two full-time and two part-time). This study was done in two general hospitals by simple sampling in available cases. For each consultation, a board-certified faculty psychiatrist conducted a clinical evaluation based on DSM-IV-TR. Other than psychiatric diagnoses, socio-demographic variables, relative consultation rates, reasons for referral, medical diagnoses and the time stay after admission were assessed. Among 503 patients who were visited by the consultation-liaison service, there were 54.3% female w...

Research paper thumbnail of Screening for depression and anxiety in oncologic patients: Comparison of nurses reports vs Hospital Anxiety and Depression Scale

Research paper thumbnail of Autistic spectrum symptoms and its correlates: the impact of subject of study among Masters and PhD students

Research paper thumbnail of Establishing a Liver Transplantation Program at Tehran University of Medical Sciences, Iran: A Report of Ten Years of Experience

ABSTRACT In 2001, a Liver Transplantation (LT) program was commenced in Imam Khomeini Hospital Co... more ABSTRACT In 2001, a Liver Transplantation (LT) program was commenced in Imam Khomeini Hospital Complex as the first one in the capital city of Tehran which is the second liver transplantation center in Iran. This study presents the results of our 10-year experience with LT.

Research paper thumbnail of Comparative Study of Quality of Life in Multiple Myeloma Patients after Bone Marrow Transplantation in Outpatient and Inpatient Setting

SSU_Journals, 2010

... لﺎﻬﺳا )07/0 (P= اﺰﻓا ﻳ ﻨﻌﻣ ﺶ ﻲ راد وﻳ ﺮﻘﺗ ﺎ ﻳ ﻨﻌﻣ ًﺎﺒ ﻲ راد ي ﺖﺳا ﻪﺘﺷاد . ﺘﻧﻴ ﻪﺠ ﮔﻴ ﺮ ي: ﭘ شو... more ... لﺎﻬﺳا )07/0 (P= اﺰﻓا ﻳ ﻨﻌﻣ ﺶ ﻲ راد وﻳ ﺮﻘﺗ ﺎ ﻳ ﻨﻌﻣ ًﺎﺒ ﻲ راد ي ﺖﺳا ﻪﺘﺷاد . ﺘﻧﻴ ﻪﺠ ﮔﻴ ﺮ ي: ﭘ شور ود ﺮﻫ ﺪﻨﭼﺮﻫ ﻴ ﺎﻘﺗرا ﺖﻬﺟ ﺪﻧﻮ ي ﻛ ﻴ ﻔﻴ ﮔﺪﻧز ﺖ ﻲ ﻟو ﺪﻧراد ار دﻮﺧ ﻦﺳﺎﺤﻣ ﻲ ﻛ ندﻮـﺑ ﺮﺘﻬﺑ ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ ﻴﻔـﻴ ﮔﺪـﻧز ﺖ ﻲ ﺎﭘﺮﺳ هوﺮﮔ ﻳﻲ ﻀﻌﺑ رد ﻲ ﭘ شور ،دﺎﻌﺑا زا ﻴ ﺎﭘﺮﺳ ﺪﻧﻮ ﻳﻲ ﻣ ﻲ ﺗ ﺪﻧاﻮﺗ ﺄﺛﻴ اﺰﺴﺑ ﺮ ﻳﻲ ﻛ ءﺎﻘﺗرا رد ﻴﻔﻴ ﮔﺪﻧز ﺖ ﻲﺑ ﻴ ﺪﺷﺎﺑ ﻪﺘﺷاد نارﺎﻤ . ...

Research paper thumbnail of Hindsight bias in psychiatrists' diagnoses

European Psychiatry, 2008

This is a qualitative-phenomenological study. Participants in this study were 12 youth with subst... more This is a qualitative-phenomenological study. Participants in this study were 12 youth with substance dependency with range of 18 to 30 years old that was selected with purposive sampling method. Data were collected with in-depth interview and analysis was done via Colaizzi method. Results: Three themes or main concepts were derived from this study that each of these themes has any subthems. These are including Personal factors, Family factors and Social factors. Conclusions: The findings of this study indicated that people underlined of different factors such as personal, family and social factors refer to the consumption of opioid and finally depend to this substance. Regarding to findings of present study, the researchers of this study believed that the first level of prevention can useful about this. Thus in this level of prevention, three approaches of individual centered, family centered and community centered suggested.

Research paper thumbnail of P02-284 - Screening for depression and anxiety in patients admitted for coronary artery bypass graft: comparison of nurses’ reports vs. hospital anxiety and depression scale

European Psychiatry, 2011

AimsTo evaluate the validity of nurses’ reports as a screening tool for anxiety and depression in... more AimsTo evaluate the validity of nurses’ reports as a screening tool for anxiety and depression in hospitalized patients admitted for Coronary Artery Bypass Graft.MethodsWithin 72 hours of admission, the patients were assessed using the Hospital Anxiety and Depression Scale (HADS). Simultaneously, the nurses who provided care for the patients were asked whether they believed the patients had significant levels of depression or anxiety. They were also asked to rate the degree of depression and anxiety of their patients in a 5 point Likert scale. Assessments were completed for 150 patients.ResultsAccording to HADS score, 67 (44.66%) patients had probable depressive disorders (HADS-D score > 7) and 57(38%) had probable anxiety disorders (HADS-A score>7). Nurses recognized 31(20.66%) patients had depressive disorder and 24(16%) had anxiety disorders. The correlation coefficient between nursing diagnosis and diagnosis according to HADS was small (phi = 0.24, P < 0.01). No signifi...

Research paper thumbnail of Relationship between anxiety and depression and service satisfaction in a sample of Iranian inpatients admitted in a general hospital

European Psychiatry, 2008

post-dose) included: 100-mm Visual Analogue Scale for Anxiety (VAS-A; primary outcome); 100-mm VA... more post-dose) included: 100-mm Visual Analogue Scale for Anxiety (VAS-A; primary outcome); 100-mm VAS-Sedation (VAS-S); and Time-to-Onset of Action Scale (TOAS), which rates anti-anxiety drug benefit (0-10, noefull benefit). Results: VAS-A scores at baseline were higher on PGB (70.2) compared to ALP (57.4) or PBO (64.1). On a mixed-model analysis, VAS-A improvement slopes were greater for PGB (t¼-2.47; P¼0.014) and ALP (t¼-2.39; P¼0.018) vs PBO. Significant improvement on TOAS was seen at hour 2 and hour 3 through endpoint for ALP and PGB subjects, respectively (P0.05 vs PBO, both groups). VAS-S scores were significantly higher vs PBO for PGB at hours 2.5-4.0, and at hours 2 until endpoint for ALP (P0.05 both groups). Spearman analysis showed similar levels of correlation between the TOAS and VAS-S (r¼ +0.58) and VAS-A (r¼-0.50), suggesting that the VAS-S may be measuring an efficacy outcome in this model. Both PGB and ALP were well-tolerated. Conclusion: Clinically meaningful anxiolytic effect occurred within 3-4 hours after single-dose PGB in this dental-anxiety model.

Research paper thumbnail of Prevalence, recognition and treatment of depression and anxiety in a general hospital inpatients: A report from Iran

European Psychiatry, 2008

positive(23.35%) and negative group(3,30%) while in sporadic cases outbred cases are more in numb... more positive(23.35%) and negative group(3,30%) while in sporadic cases outbred cases are more in number(39.43%). Discussion: This study shows consanguinity as an important factor in the onset of mental illness and is a fertile base for further molecular genetic studies to locate genes contributing in the development of illness P0291

Research paper thumbnail of The study of correlation between depression, quality of life and glycemic control in a sample of Iranian diabetic patients

European Psychiatry, 2008

(n¼151) and placebo (n¼157). Primary endpoint: baseline to Week 6 change in MADRS total score. Se... more (n¼151) and placebo (n¼157). Primary endpoint: baseline to Week 6 change in MADRS total score. Secondary variables included: baseline to Week 6 change in HAM-D total and Item 1 (depressed mood) scores. Safety assessments included AE reporting. Results: Mean MADRS total score (overall baseline mean, 30.15) was significantly reduced at Week 6 by quetiapine XR 150mg/day, 300mg/day and duloxetine versus placebo (À14.81, À15.29, À14.64, À11.18, respectively; p 0.001). At Week 6, mean HAM-D total scores (overall baseline mean, 25.25) were significantly reduced versus placebo (À10.26) by quetiapine XR 150mg/day, 300mg/day (À13.12, À14.02, respectively, p 0.001) and duloxetine (À12.37, p<0.05). Mean HAM-D item 1 scores (overall baseline mean, 3.03) were significantly reduced versus placebo (À1.07) by quetiapine XR 150mg/day, 300mg/day (À1.49, À1.56, respectively, p 0.001) and duloxetine (À1.53, p<0.001). Incidence of serious AEs were low (2%) in all groups. Most common AEs (>10%) were dry mouth, sedation, somnolence, dizziness, headache and nausea with quetiapine; dizziness and headache with placebo; and dry mouth, sedation, somnolence, dizziness, headache, constipation, nausea, diarrhoea and insomnia with duloxetine. Most AEs were mild-to-moderate in intensity. Conclusion: Quetiapine XR monotherapy at 150 and 300mg/day was effective and well tolerated in the treatment of patients with MDD.