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Research paper thumbnail of Acetylcholinesterase inhibitory activity of plants used as memory- enhancers in traditional South African medicine

South African Journal of Botany, 2004

Research paper thumbnail of Screening of plants used in southern Africa for epilepsy and convulsions in the GABAA-benzodiazepine receptor assay

Journal of Ethnopharmacology, 2004

A number of plants are traditionally used to treat mental diseases in South Africa. Aqueous and e... more A number of plants are traditionally used to treat mental diseases in South Africa. Aqueous and ethanol extracts of 43 plants that are traditionally used to treat against epilepsy and convulsions, were tested in the GABA A -benzodiazepine receptor binding assay, where the binding of 3 H-Ro 15-1788 (flumazenil) to the benzodiazepine site is measured. The GABA A -benzodiazepine receptor complex is involved in epilepsy and convulsions. Out of the 118 extracts tested, one aqueous and 18 ethanol extracts showed activity. The most active extracts were the ethanolic leaf extracts of Rhus tridentata, Rhus rehmanniana and Hoslundia opposita and the ethanolic corm extract of Hypoxis colchicifolia, which all showed good dose-dependent activity.

Research paper thumbnail of Acetylcholinesterase inhibitory activity of novel chitooligosaccharide derivatives

Carbohydrate Polymers, 2009

The objective of this study was to examine the effects of different storage conditions of star fr... more The objective of this study was to examine the effects of different storage conditions of star fruit (Averrhoa carambola) juice on the activity of acetylcholinesterase in various organs of Sprague Dawley (SD) rats. The effect of oral administration of star fruit on serum lipid profiles was also examined in this study. A total of 15 female rats were assigned into three groups with five animals per group (n=5). The first group served as control group and given only distilled water (vehicle) while the other two groups were given different star fruit preparations, i.e. freshly prepared star fruit juice and after 3 hours storage, respectively. From the results obtained, a significant decrease in the hepatic acetylcholinesterase activity was observed in rats treated with star fruit juice. In conclusion, the star fruit juice at different storage conditions is selectively targeted on the acetylcholinesterase activity in rat liver but not in kidney and heart.

Research paper thumbnail of Acetylcholinesterase inhibitory activity of plants used as memory- enhancers in traditional South African medicine

South African Journal of Botany, 2004

Research paper thumbnail of Screening of plants used in southern Africa for epilepsy and convulsions in the GABAA-benzodiazepine receptor assay

Journal of Ethnopharmacology, 2004

A number of plants are traditionally used to treat mental diseases in South Africa. Aqueous and e... more A number of plants are traditionally used to treat mental diseases in South Africa. Aqueous and ethanol extracts of 43 plants that are traditionally used to treat against epilepsy and convulsions, were tested in the GABA A -benzodiazepine receptor binding assay, where the binding of 3 H-Ro 15-1788 (flumazenil) to the benzodiazepine site is measured. The GABA A -benzodiazepine receptor complex is involved in epilepsy and convulsions. Out of the 118 extracts tested, one aqueous and 18 ethanol extracts showed activity. The most active extracts were the ethanolic leaf extracts of Rhus tridentata, Rhus rehmanniana and Hoslundia opposita and the ethanolic corm extract of Hypoxis colchicifolia, which all showed good dose-dependent activity.

Research paper thumbnail of Acetylcholinesterase inhibitory activity of novel chitooligosaccharide derivatives

Carbohydrate Polymers, 2009

The objective of this study was to examine the effects of different storage conditions of star fr... more The objective of this study was to examine the effects of different storage conditions of star fruit (Averrhoa carambola) juice on the activity of acetylcholinesterase in various organs of Sprague Dawley (SD) rats. The effect of oral administration of star fruit on serum lipid profiles was also examined in this study. A total of 15 female rats were assigned into three groups with five animals per group (n=5). The first group served as control group and given only distilled water (vehicle) while the other two groups were given different star fruit preparations, i.e. freshly prepared star fruit juice and after 3 hours storage, respectively. From the results obtained, a significant decrease in the hepatic acetylcholinesterase activity was observed in rats treated with star fruit juice. In conclusion, the star fruit juice at different storage conditions is selectively targeted on the acetylcholinesterase activity in rat liver but not in kidney and heart.

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