Aamna Habib - Academia.edu (original) (raw)

Papers by Aamna Habib

Additional file 1: Figure S1. Efficiency of analyte detection across all samples. The percentage ... more Additional file 1: Figure S1. Efficiency of analyte detection across all samples. The percentage of samples in which the analytes were detected > LOD is indicated by the fill darkness. All analytes detected > LOD in ≥ 75% of the samples (black and dark grey fill) were included in subsequent analyses. (A) Of the 145 potentially detectable lipids, 111 were detected > LOD in ≥ 75% of the samples. (B) The same lipids as in (A) but separated by lipid class. Detection efficiency was greatest for glycerophospholipids and sphingolipids. Figure S2. Contribution of each lipid analyte and indicator to the principal components PC1 and PC2, and the square root of the sum of their squares. The higher the absolute value, the higher the influence on the principal component. (A) Analysis based on concentrations of all 111 lipid analytes; (B) PC only; (C) SM only; (D) AC only; (E) lysoPC only; and (F) 47 metabolic indicators. Results are arranged in descending order according to the PC's...

Disaster Medicine and Public Health Preparedness, 2022

Objective: Coronavirus disease 2019 (COVID-19) pandemic has substantially affected students aroun... more Objective: Coronavirus disease 2019 (COVID-19) pandemic has substantially affected students around the globe due to the closure of educational institutes. However, student involvements and contributions are important in combating the disease; for this reason, the current study was designed to assess the knowledge-attitude-practice (KAP), preventive behavior, and risk perception among university students. Methods: A cross-sectional survey-based study was conducted among medical and non-medical university students, from April 1 to June 30, 2020. The 68-item questionnaire was used to evaluate responses using statistical approaches (Student’s t-test, regression-analysis, and co-relation analysis) by considering a P-value <0.05 as statistically significant. Results: A total of 503 university students (medical and nonmedical) were selected, where majority of participants were females (83%) and 64.5% were of age ranged from 16 to 21 years old. The participants (80%) reported good diseas...

Journal of Biomedical Research & Environmental Sciences, 2020

Hydrogels are water-swollen networks, which are cross-linked structures consisting of hydrophilic... more Hydrogels are water-swollen networks, which are cross-linked structures consisting of hydrophilic polymers. They are made three-dimensional by the creation of the cross-links by joining them through covalent or ionic bonds. Hydrogels have been used in various areas including industry and medicine due to their excellent characteristics such as high swelling capacity, high content of water, compatibility with other biological molecules, controlled chemical and physical properties, high mechanical integrity and biodegradability. They have been the center of attention of researchers from the past 50 years because of their promising applications in industries and other areas. They are used in different fields, in medicine, in the diagnosis of the diseases, in culturing of cells, in injuries as wound healers, in cosmetics, in skin diseases like pruritis, in environmental pollution reduction and other miscellaneous applications such as in diapers for babies and sanitary products. Extensive...

Journal of Translational Medicine, 2019

Background There continues to be a great need for better biomarkers and host-directed treatment t... more Background There continues to be a great need for better biomarkers and host-directed treatment targets for community-acquired pneumonia (CAP). Alterations in phospholipid metabolism may constitute a source of small molecule biomarkers for acute infections including CAP. Evidence from animal models of pulmonary infections and sepsis suggests that inhibiting acid sphingomyelinase (which releases ceramides from sphingomyelins) may reduce end-organ damage. Methods We measured concentrations of 105 phospholipids, 40 acylcarnitines, and 4 ceramides, as well as acid sphingomyelinase activity, in plasma from patients with CAP (n = 29, sampled on admission and 4 subsequent time points), chronic obstructive pulmonary disease exacerbation with infection (COPD, n = 13) as a clinically important disease control, and 33 age- and sex-matched controls. Results Phospholipid concentrations were greatly decreased in CAP and normalized along clinical improvement. Greatest changes were seen in phosphat...

International Journal of Nutrition, Pharmacology, Neurological Diseases, 2016

Additional file 1: Figure S1. Efficiency of analyte detection across all samples. The percentage ... more Additional file 1: Figure S1. Efficiency of analyte detection across all samples. The percentage of samples in which the analytes were detected > LOD is indicated by the fill darkness. All analytes detected > LOD in ≥ 75% of the samples (black and dark grey fill) were included in subsequent analyses. (A) Of the 145 potentially detectable lipids, 111 were detected > LOD in ≥ 75% of the samples. (B) The same lipids as in (A) but separated by lipid class. Detection efficiency was greatest for glycerophospholipids and sphingolipids. Figure S2. Contribution of each lipid analyte and indicator to the principal components PC1 and PC2, and the square root of the sum of their squares. The higher the absolute value, the higher the influence on the principal component. (A) Analysis based on concentrations of all 111 lipid analytes; (B) PC only; (C) SM only; (D) AC only; (E) lysoPC only; and (F) 47 metabolic indicators. Results are arranged in descending order according to the PC's...

Disaster Medicine and Public Health Preparedness, 2022

Objective: Coronavirus disease 2019 (COVID-19) pandemic has substantially affected students aroun... more Objective: Coronavirus disease 2019 (COVID-19) pandemic has substantially affected students around the globe due to the closure of educational institutes. However, student involvements and contributions are important in combating the disease; for this reason, the current study was designed to assess the knowledge-attitude-practice (KAP), preventive behavior, and risk perception among university students. Methods: A cross-sectional survey-based study was conducted among medical and non-medical university students, from April 1 to June 30, 2020. The 68-item questionnaire was used to evaluate responses using statistical approaches (Student’s t-test, regression-analysis, and co-relation analysis) by considering a P-value <0.05 as statistically significant. Results: A total of 503 university students (medical and nonmedical) were selected, where majority of participants were females (83%) and 64.5% were of age ranged from 16 to 21 years old. The participants (80%) reported good diseas...

Journal of Biomedical Research & Environmental Sciences, 2020

Hydrogels are water-swollen networks, which are cross-linked structures consisting of hydrophilic... more Hydrogels are water-swollen networks, which are cross-linked structures consisting of hydrophilic polymers. They are made three-dimensional by the creation of the cross-links by joining them through covalent or ionic bonds. Hydrogels have been used in various areas including industry and medicine due to their excellent characteristics such as high swelling capacity, high content of water, compatibility with other biological molecules, controlled chemical and physical properties, high mechanical integrity and biodegradability. They have been the center of attention of researchers from the past 50 years because of their promising applications in industries and other areas. They are used in different fields, in medicine, in the diagnosis of the diseases, in culturing of cells, in injuries as wound healers, in cosmetics, in skin diseases like pruritis, in environmental pollution reduction and other miscellaneous applications such as in diapers for babies and sanitary products. Extensive...

Journal of Translational Medicine, 2019

Background There continues to be a great need for better biomarkers and host-directed treatment t... more Background There continues to be a great need for better biomarkers and host-directed treatment targets for community-acquired pneumonia (CAP). Alterations in phospholipid metabolism may constitute a source of small molecule biomarkers for acute infections including CAP. Evidence from animal models of pulmonary infections and sepsis suggests that inhibiting acid sphingomyelinase (which releases ceramides from sphingomyelins) may reduce end-organ damage. Methods We measured concentrations of 105 phospholipids, 40 acylcarnitines, and 4 ceramides, as well as acid sphingomyelinase activity, in plasma from patients with CAP (n = 29, sampled on admission and 4 subsequent time points), chronic obstructive pulmonary disease exacerbation with infection (COPD, n = 13) as a clinically important disease control, and 33 age- and sex-matched controls. Results Phospholipid concentrations were greatly decreased in CAP and normalized along clinical improvement. Greatest changes were seen in phosphat...

International Journal of Nutrition, Pharmacology, Neurological Diseases, 2016