Abd Elazeez Shabaan - Academia.edu (original) (raw)

Papers by Abd Elazeez Shabaan

Egyptian Journal of Phycology

is one of the main sources of water supply for 3 governments in the Nile delta, Egypt. The invest... more is one of the main sources of water supply for 3 governments in the Nile delta, Egypt. The investigation was carried out on the relationship between some physico-chemical parameters and phytoplankton biomass of El Rayah El Tawfiky in the Nile delta, Egypt. Water and phytoplankton samples were collected seasonally from five stations along El Rayah El Tawfiky (from Kafr Moeys in Banha city to Aga in El-Mansoura city) for one year (from October 2018 to September 2019). The highest water temperature was recorded in the spring season, whereas the lowest degree was recorded in the winter season. The pH values of water in El Rayah El Tawfiky at all stations ranged from slightly alkaline to alkaline. There was a wide range in the degree of turbidity during the seasons. There was a relative increase in the nitrite, nitrate, and Orthophosphate contents during the winter. The detected phytoplankton community consisted of 132 species of five systematic algal divisions (Chlorophyta, Bacillariophyta, Cyanophyta, Pyrrophyta, and Euglenophyta). Qualitatively, Chlorophyta was the dominant division followed by Bacillariophyta, Cyanophyta, Euglenophyta, and Pyrrophyta. On the other hand, the quantitative study showed that Bacillariophyta was the most dominant division, followed by Chlorophyta, Pyrrophyta, and Euglenophyta. The highest biomass was recorded during the winter, this may be related to the presence of excess nutrients especially orthophosphate, nitrate, and nitrite during this season. Additionally, the lowest biomass was recorded during the spring; this may be attributed to the presence of small amounts of nutrients and an increase in water turbidity. Moreover, the current study revealed that there were different relationships between total phytoplankton biomass and physico-chemical parameters. Phytoplankton biomass had a positive relationship with nitrite, and orthophosphate meanwhile a negative relationship with temperature. Moreover, there was a very strong positive relationship between nitrate and Cyanophyta and also a very strong positive correlation between Euglenophyta and ammonia concentrations. Phytoplankton biomass is regarded as an easy and useful indicator means to assess the quality of freshwater ecosystems.

Journal of Perinatology, 2020

Despite widespread phototherapy usage, many new-born infants remain in need of other invasive lin... more Despite widespread phototherapy usage, many new-born infants remain in need of other invasive lines of therapy, such as intravenous immunoglobulins and exchange transfusions. Assessment of the efficacy and the safety of adding fenofibrate to phototherapy for the treatment of pathological jaundice in full-term infants. We conducted a double blinded randomized control study on 180 full-term infants with pathological unconjugated hyperbilirubinemia admitted to the NICU at Mansoura University Children’s Hospital. They were randomly assigned to receive either oral fenofibrate 10 mg/kg/day for 1 day or 2 days or placebo in addition to phototherapy. The primary outcome was total serum bilirubin values after 12, 24, 36, 48, and 72 h from intervention. Secondary outcomes were total duration of treatment, need for exchange transfusions and intravenous immunoglobulin, exclusive breast-feeding on discharge, and adverse effects of fenofibrate. This study was registered at www.clinicaltrials.gov (NCT04418180). A total of 180 full-term infants were included, 60 in each group. Infants in group I and II showed significant reduction of bilirubin levels at 36, 48, and 72 h from intervention compared to group III, respectively. Fenofibrate administration was associated with significantly shorter duration of phototherapy, shorter hospital stay, and higher frequency of exclusive breast-feeding compared to phototherapy alone. Fenofibrate as an adjuvant to phototherapy in term neonate with pathological jaundice is well tolerated and associated with significant reduction of serum bilirubin levels, a shorter duration of phototherapy, shorter hospital stay and higher frequency of exclusive breast-feeding, without significant adverse effects in either the single or double dosage.

Objective: To evaluate the efficacy and the safety of inhaled salbutamol and epinephrine in the t... more Objective: To evaluate the efficacy and the safety of inhaled salbutamol and epinephrine in the treatment of TTN. Design: Double-blinded randomized control pilot study was carried out on 135 near and full-term infants with TTN in the NICU of Mansoura University children's hospital. They were randomly assigned to receive either a single dose of epinephrine, salbutamol, or placebo inhalation. The primary outcome was the level of TTN Downe’s score and the required respiratory support. PaO2 and PaCO2, duration of oxygen therapy, hospital stay, and the adverse effects were considered secondary outcomes. registered at www.clinicaltrials.gov (NCT05006235). Results: Downe’s score, CPAP requirement, and PaCO2 were significantly less in the salbutamol and epinephrine groups, in addition to a shorter duration of oxygen support and hospital stay with tolerable adverse effects. Conclusion: Epinephrine or salbutamol inhalation in treatment of TTN is safe, well tolerated, and effective in redu...

African Journal of Microbiology Research, 2021

Carbapenems are group of extended-spectrum β-lactam antimicrobials frequently used for treating m... more Carbapenems are group of extended-spectrum β-lactam antimicrobials frequently used for treating multidrug-resistant Gram-negative bacilli (GNB) infections. This study aimed at detecting and characterizing carbapenem resistance (CR) genes among GNB isolated from patients treated in neonatal intensive care unit (NICU) of Mansoura University Children's Hospital (MUCH), Egypt. It is a prospective study conducted from 2015 to 2016. A total of 158 GNB isolates were examined for CR both phenotypically and genotypically. Among 158 Gram negative isolates, there were 58 (36.7%) CR strains. Extended-spectrum β-lactamase (ESBL) production was confirmed in all 58 (100%) isolates. Carbapenemase production was detected in 52 (89.5%) strains while metallo beta-lactamase (MBL) production was found in 33 (56.9%) strains. Molecular characterization of CR strains revealed that 57 (98.3%) isolates were positive for carbapenemase encoding genes. KPC gene was the most frequent detected gene (34/58). VIM, IPM, OXA and NDM genes were also detected in 15, 13, 9 and 1 isolate, respectively. Only one isolate was negative for all encoding resistance genes despite positive for ESBL phenotype. Infection with CR strains has been increasing in clinical settings which limit the use of carbapenems.

Egyptian Journal of Bronchology, 2018

Introduction Asthma is a heterogeneous disease and presents in different clinical patterns ‘pheno... more Introduction Asthma is a heterogeneous disease and presents in different clinical patterns ‘phenotypes’ as a result of diverse pathobiological background ‘endotypes’. Objectives The aim of this study was to study serum interleukin-13 (IL-13) levels and the frequency of (IL-13) +1923C/T gene polymorphism in Egyptian children with asthma and to study glucocorticoids circadian rhythm in nocturnal asthma. Patients and methods The frequency of (IL-13) +1923C/T gene polymorphism genotypes was determined in 114 asthmatic Egyptian children and compared with a matched group of 152 healthy controls using PCR. Serum IL-13 and cortisol a.m. and p.m. concentrations in serum were assessed using enzyme linked immunosorbent assay. Results Serum IL-13 was found to be significantly higher in asthmatic patients when compared with the control group (P<0.0001). In the asthmatic group, forced expiratory volume in 1 s showed a significant negative correlation with serum IL-13 (ρ=−0.2, P=0.03), whereas ...

Egyptian Journal of Pediatrics, 2016

Eastern Mediterranean Health Journal, 2014

Factors affecting parents' decision to involve their children in clinical research have not been ... more Factors affecting parents' decision to involve their children in clinical research have not been studied in all cultural backgrounds. We aimed to explore the attitudes and beliefs influencing parents' decision to involve their children in clinical research in Mansoura, Egypt. Of 523 families approached, 357 filled the questionnaire. Only 98 (27.5%) parents consented to involve their child in clinical research. The children of consenters were significantly older than refusers: 8.6 (SD 7.2) versus 2.6 (SD 1.2) years. Factors favouring consent were: research of benefit to child (84.7%), enough explanation about the benefits (40.8%) and to learn more about child's condition (29.6%). Factors favouring refusal were: use of new drugs or vaccines (89.6%) and invasive procedures (84.2%). Parents' rate of consent was positively correlated with the research being non-invasive and the belief that research was of benefit to their child and negatively correlated with belief that refusal may negatively affect the care provided to their child.

Paediatrics and international child health, Jan 23, 2017

Rapunzel syndrome is a rare form of gastric trichobezoar. A 4-year-old girl presented with genera... more Rapunzel syndrome is a rare form of gastric trichobezoar. A 4-year-old girl presented with generalised oedema and an epigastric mass. Her family was of a relatively low socio-economic background. There was microcytic hypochromic anaemia, hypoalbuminaemia and an elevated α1-antitrypsin clearance. Abdominal ultrasound and non-contrast computed tomography demonstrated a heterogeneous mass related to the stomach. Upper gastro-intestinal tract endoscopy failed to remove it. Surgical laparotomy was undertaken through a single anterior gastrotomy incision and a large mass was extracted which was a cast of the duodenum and stomach and had a tail of approximately 60 cm in length which extended to the jejunum. Low socio-economic status, child neglect and pica are risk factors for trichobezoars. Surgical laparotomy is the optimal treatment of large bezoars.

Jornal de pediatria, Jan 13, 2017

To study the microbiological pattern of late onset neonatal sepsis cultures and to assess the dia... more To study the microbiological pattern of late onset neonatal sepsis cultures and to assess the diagnostic performance of serum (1,3)-β-d-glucan level for early diagnosis of invasive fungemia in high-risk infants admitted to a neonatal intensive care unit. A prospective multicenter clinical trial conducted on infants at high risk for invasive fungal infections, with suspected late onset sepsis, admitted to a neonatal intensive care unit at Mansoura University Children's Hospital and Mansoura General Hospital between March 2014 and February 2016. A total of 77 newborn infants with high risk of invasive fungal infection were classified based on blood culture into three groups: no fungemia (41 neonates with proven bacterial sepsis), suspected fungemia (25 neonates with negative blood culture), and definite fungemia group (11 neonates with culture-proven Candida). The growing organisms were Klebsiella spp. (14/54); Escherichia coli (12/54); Staphylococcus spp. (12/54; coagulase-negati...

European Journal of Clinical Microbiology & Infectious Diseases, 2016

This study was aimed to determine the risk factors of Carbapenem-resistant Enterobacteriaceae (CR... more This study was aimed to determine the risk factors of Carbapenem-resistant Enterobacteriaceae (CRE) nosocomial infections and assess the clinical outcomes. A case-casecontrol design was used to compare two groups of case patients with control patients from March 2010 to November 2014 in China. Risk factors for the acquisition of CRE infections and clinical outcomes were analyzed by univariable and multivariable analysis. A total of 94 patients with CRE infections, 93 patients with Carbapenem-susceptible Enterobacteriaceae (CSE) infections, and 93 patients with organisms other than Enterobacteriaceae infections were enrolled in this study. Fifty-five isolates were detected as the carbapenemase gene. KPC-2 was the most common carbapenemase (65.5 %, 36/55), followed by NDM-1 (16.4 %, 9/55), IMP-4 (14.5 %, 8/55), NDM-5 (1.8 %, 1/55), and NDM-7 (1.8 %, 1/55). Multivariable analysis implicated previous use of third or fourth generation cephalosporins (odds ratio [OR], 4.557; 95 % confidence interval [CI], 1.971-10.539; P < 0.001) and carbapenems (OR, 4.058; 95 % CI, 1.753-9.397; P = 0.001) as independent risk factors associated with CRE infection. The in-hospital mortality of the CRE group was 57.4 %. In the population of CRE infection, presence of central venous catheters (OR, 4.464; 95 % CI, 1.332-14.925; P = 0.015) and receipt of immunosuppressors (OR, 7.246; 95 % CI, 1.217-43.478; P = 0.030) were independent risk factors for mortality. Appropriate definitive treatment (OR, 0.339; 95 % CI, 0.120-0.954; P = 0.040) was a protective factor for in-hospital death of CRE infection. Kaplan-Meier curves of the CRE group had the shortest survival time compared with the other two groups. Survival time of patients infected with Enterobacteriaceae with a high meropenem MIC (≥8 mg/L) was shorter than that of patients with a low meropenem MIC (2,4, and ≤ 1 mg/L). In conclusion, CRE nosocomial infections are associated with prior exposure to third or fourth generation cephalosporins and carbapenems. Patients infected with CRE had poor outcome and high mortality, especially high meropenem MIC (≥8 mg/L). Appropriate definitive treatment to CRE infections in the patient is essential.

World Journal of Clinical Pediatrics, 2015

Caffeine is the most commonly used medication for treatment of apnea of prematurity. Its effect h... more Caffeine is the most commonly used medication for treatment of apnea of prematurity. Its effect has been well established in reducing the frequency of apnea, intermittent hypoxemia, and extubation failure in mechanically ventilated preterm infants. Evidence for additional short-term benefits on reducing the incidence of bronchopulmonary dysplasia and patent ductus arteriosus has also been suggested. Controversies exist among various neonatal intensive care units in terms of drug efficacy compared to other methylxanthines, dosage regimen, time of initiation, duration of therapy, drug safety and value of therapeutic drug monitoring. In the current review, we will summarize the available evidence for the best practice in using caffeine therapy in preterm infants.

Pediatric Infectious Disease Journal, 2015

The role of pentoxifylline (PTX) in reducing mortality associated with neonatal sepsis is not wel... more The role of pentoxifylline (PTX) in reducing mortality associated with neonatal sepsis is not well established. We aimed to assess the efficacy and safety of PTX as an adjunct to antibiotics on mortality and morbidity in preterm infants with late-onset sepsis (LOS). Double blind, randomized controlled trial was conducted on 120 preterm infants with LOS. They were randomly assigned to receive either intravenous PTX 5 mg/kg/hr for 6 hours on 6 successive days or placebo. Death before hospital discharge was our primary outcome and secondary outcomes were length of hospital stay, duration of respiratory support, duration of antibiotics use, short-term morbidity of preterm infants, tumor necrosis factor-alpha concentrations, C-reactive protein concentrations, and adverse effects of PTX. A total of 120 infants were enrolled, 60 in each group, 78 (65%) infants had confirmed and 42 (35%) had suspected LOS. There were no significant differences between groups regarding mortality [6 (10%) in PTX vs. 10 (16.5%) in placebo, P = 0.44], short-term morbidity and combined mortality and/or short-term morbidity [18 (30%) vs. 24 (40%), P = 0.23]. PTX therapy was associated with significant reduction of serum tumor necrosis factor-alpha and C-reactive protein concentrations. The length of hospital stay, durations of respiratory support and antibiotic therapy were significantly shorter in the PTX group. Patients in PTX group had less need for vasopressors, lower incidence of metabolic acidosis, disseminated intravascular coagulopathy and thrombocytopenia. No adverse effects to PTX were reported. PTX has a beneficial adjuvant effect to antibiotic therapy in preterm infants with LOS without significant impact on neonatal mortality and morbidity.

European Journal of Pediatrics, 2015

The optimum caffeine dose in preterm infants has not been well investigated. We aimed to compare ... more The optimum caffeine dose in preterm infants has not been well investigated. We aimed to compare the efficacy and safety of high versus low-dose caffeine citrate on apnea of prematurity (AOP) and successful extubation of preterm infants from mechanical ventilation. We compared high-dose (loading 40 mg/kg/day and maintenance of 20 mg/kg/day) versus low-dose (loading 20 mg/kg/day and maintenance of 10 mg/kg/day) caffeine citrate in preterm infants &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;32 weeks gestation, presented with AOP within the first 10 days of life. A total of 120 neonates (60 in each group) were enrolled. High-dose caffeine was associated with a significant reduction in extubation failure in mechanically ventilated preterm infants (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05), the frequency of apnea (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001), and days of documented apnea (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001). High-dose caffeine was associated with significant increase in episodes of tachycardia (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05) without a significant impact on physician decision to withhold caffeine. Conclusion: The use of higher, than current standard, dose of caffeine may decrease the chance of extubation failure in mechanically ventilated preterm infants and frequency of AOP without significant side effects. What is Known: • Caffeine therapy for treatment of apnea of prematurity has been well established over the past few years. The optimal loading and maintenance dose of caffeine in preterm infants is not well-studied. What is New: • This double blind randomized controlled trial demonstrated that using a higher, than current standard, loading and maintenance doses of caffeine for treatment of apnea in preterm infants is well tolerated and significantly decrease the frequency of apnea.

BioMed Research International, 2013

Patent ductus arteriosus (PDA) is a common clinical condition in preterm infants. Preterm newborn... more Patent ductus arteriosus (PDA) is a common clinical condition in preterm infants. Preterm newborns with PDA are at greater risk for several morbidities, including higher rates of bronchopulmonary dysplasia (BPD), decreased perfusion of vital organs, and mortality. Therefore, cyclooxygenase (COX) inhibitors and surgical interventions for ligation of PDA are widely used. However, these interventions were reported to be associated with side effects. In the absence of clear restricted rules for application of these interventions, different strategies are adopted by neonatologists. Three different approaches have been investigated including prophylactic treatment shortly after birth irrespective of the state of PDA, presymptomatic treatment using echocardiography at variable postnatal ages to select infants for treatment prior to the duct becoming clinically significant, and symptomatic treatment once PDA becomes clinically apparent or hemodynamically significant. Future appropriately de...

Journal of Clinical Neonatology, 2014

mandibular pattern of distribution with sparing of the upper lips. In addition, the newborn was n... more mandibular pattern of distribution with sparing of the upper lips. In addition, the newborn was noted to have a midline sternal cleft whose lower half was covered by raphe [Figure 1] and talipes equinovarus deformity. Furthermore, ophthalmologic examination, laryngoscopy, abdominal sonogram, echocardiography and magnetic resonance imaging/angiography of the head, neck and chest revealed normal results. A study published in 1996, Frieden et al. were the fi rst to coin the acronym of PHACE syndrome to describe a neurocutaneous syndrome, which includes Posterior fossa malformations, Hemangiomas, Arterial anomalies, Cardiac defects/Coarctation of the aorta and Eye abnormalities [1] and since then several cases have been reported.

Journal of American …, 2012

Abstract: Background: Attention–deficit/hyperactivity disorder (ADHD) is the most common neurobeh... more Abstract: Background: Attention–deficit/hyperactivity disorder (ADHD) is the most common neurobehavioral disorder in children. The relationship between ADHD and subclinical epileptiform abnormalities still vague. In addition, there are controversies about the use of ...

The Journal of Pediatrics, 2003

Low superior vena cava (SVC) flow is common in very preterm infants in the first day and strongly... more Low superior vena cava (SVC) flow is common in very preterm infants in the first day and strongly associated with periventricular hemorrhage and disability. We examined the effect of high-frequency oscillatory ventilation (HFOV) compared with conventional ventilation (CV) on SVC flow and right ventricular output. Forty-five infants &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;29 weeks were randomized before 1 hour of age to HFOV or CV. Echocardiography was performed on 43 infants at 3, 10, and 24 hours of age. Infants with low SVC flow (&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;50 mL/kg/min) or hypotension (mean blood pressure &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; or =20) were treated with volume and inotrope. Infants allocated to HFOV (n=23) and to CV (n=20) were well matched. There was a nonsignificant trend toward more infants on HFOV having SVC flow &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;50 mL/kg/min (48% vs 20%) and receiving volume and inotropes (61% vs 40%). There were no significant differences in mean SVC flow or right ventricular output at 3, 10, or 24 hours. Infants on HFOV had a significantly higher calculated upper body vascular resistance at 10 hours and mean blood pressure at 24 hours. There were no significant adverse effects of HFOV on systemic blood flow in very preterm infants during the first 24 hours of life.

Macedonia: The Politics of Identity and Difference, …, 2000

Multiculturalism' was a relatively unknown term in Greece until the mid 1980s. During the 1980s t... more Multiculturalism' was a relatively unknown term in Greece until the mid 1980s. During the 1980s the discourse of multiculturalism was gradually introduced in Greece by the use of the term 'multicultural' in fashion magazines, in discussions about interior decoration and in articles examining new trends in music published in magazines and daily journals. In a second stage, 'multiculturalism' appeared in a number of studies conducted by sociologists, teachers and researchers within the education field. It was only in the 1990s that the word came into wider use as an analytical or descriptive term in an attempt to understand the current changes in Greek society. 1 'Multiculturalism' (in Greek, polypolitismikotita) is not a native Greek concept. It has been introduced into Greece by scholars, journalists, NGO activists and policymakers who are aware of the multicultural societies of North America, Australia and western Europe. Although it is clear that even in these societies 'there are as many multiculturalisms as there are political arenas for collective action' (Werbner 1997: 264), a number of commonly accepted features are related to the various discourses of multiculturalism both as an analytical category and a political project. To start with, multiculturalism is strongly related with the flow of ideas, images, people, finance and commodities embodied in the globalisation process of late modernity. Second, multiculturalism recognises the coexistence of different cultures in the same society (Kahn 1995). Third, societies which embrace multiculturalism as a political project actively encourage, through specific social, cultural and educational policies, the reproduction of the various cultures (Rex 1995).