Heba Abdelrazek - Academia.edu (original) (raw)
Papers by Heba Abdelrazek
Pharmacological research. Natural products, Jun 1, 2024
Ethnopharmacological relevance: Cleome droserifolia treatment has potent antioxidant, antimicrobi... more Ethnopharmacological relevance: Cleome droserifolia treatment has potent antioxidant, antimicrobial, and immunomodulatory potentials, which can help recover the general health status. Aim of the study: This research aims to estimate the potential cardioprotective properties of the methanolic extract of Cleome droserifolia (MEC) against epinephrine-induced cardiac injury (MI) in rats. Materials and methods: Thirty-six male Wistar rats were separated equally into 6 groups. The control group (Cont) received oral distilled water for 30 uninterrupted days and was administered subcutaneous saline on the 31 and 32 days. The MEC 100 group received MEC 100mg/kg, P.O., for 30 uninterrupted days and administered subcutaneous saline on the 31 and 32 days. The MEC 200 group received MEC 200mg/kg,P.O. for 30 uninterrupted days and subcutaneous saline was administered on the 31 st and 32 nd days. The epinephrine group (EP) received distilled water orally for 30 uninterrupted days and administered subcutaneous epinephrine (2 mg/kg, s.c.) divided into two doses (1mg/kg, s.c) each on the 31 st and 32 nd days. MEC 100+Ep group received MEC 100mg/kg, P.O., for 30 uninterrupted days and administered subcutaneous epinephrine (2mg/kg, s.c.) divided into two doses (1mg/kg, s.c) each on the 31 st and 32 nd days. The MEC 200+EP received MEC 200 mg/kg, P.O. for 30 uninterrupted days and administered subcutaneous epinephrine (2mg/kg, s.c.) divided into two doses (1mg/kg, s.c) each on the 31st and 32 nd days. Electrocardiography (ECG), biochemical, oxidative stress, inflammatory mediators, histopathological, immunohistochemical analysis and the expression of phosphoinositide 3-kinases (PI3K) and protein kinase B (AKT) were assessed. Results: MEC reversed epinephrine-induced lessening of heart rate, prolonged QT interval and ST displacement. Pretreatment with MEC significantly reduced serum aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB) levels in MI rats. The MEC pretreatment promoted total antioxidant capacity (TAC), glutathione (GSH), and total oxidant status (TOS). In addition, it reduced interleukin-1β (IL-1β), interleukin-6 (IL-6), malondialdehyde (MDA), and tumour necrosis factor (TNF-α) in MI rats. Furthermore, MEC statistically reduced immunohistochemical promotion of nuclear factor–κB (NF-κB) and expression of AKT and PI3K in cardiac tissue and perfected histopathological changes. Conclusion: The MEC, rich in phenolic and flavonoid contents, had a cardioprotective effect on rats suffering from epinephrine-induced MI. Such effect was achieved via improving cardiac function, antioxidant status, attenuating ECG pattern and histological picture, as well as reducing IL-6, IL-1β, TNF-α and NF-κB, which its antioxidant and anti-inflammatory potential may partly arbitrate.
Records of Pharmaceutical and Biomedical Sciences, 2023
Acute coronary syndrome, which is the acute manifestation of ischemic heart disease, remains a ma... more Acute coronary syndrome, which is the acute manifestation of ischemic heart disease, remains a major cause of morbidity and mortality across the world and is mainly responsible for 1.8 million deaths per year. The pathophysiology of acute coronary syndrome is usually due to atherosclerotic plaque rupture which results in a sequence of inflammatory events, thrombus formation, and platelet aggregation causing an aggravation of insufficient perfusion to meet myocardial oxygen demand which can eventually lead to myocardial infarction. Serotonin a monoamine neurotransmitter and a hormone found in both the central nervous system and the peripheral nervous system is released during myocardial ischemia, acute inflammation, and tissue damage leading to platelets aggregation, thrombus formation, contraction of smooth muscle cells, and coronary artery spasms. Serotonin also plays an important role in the progression of myocardial cellular injury through various pathways. This review discusses the potential therapeutic role of targeting the serotonin system in the setting of acute coronary syndrome.
Advances in Environmental and Life Sciences, Jul 16, 2023
Neurochemistry International, Jun 1, 2023
The Egyptian Journal of Hospital Medicine, 2023
Background: Sodium nitrate has been used extensively as a meat additive to keep meat products fre... more Background: Sodium nitrate has been used extensively as a meat additive to keep meat products fresh. Several strategies have been implemented in counteracting such toxicity. Objective: The goal of the current investigation was to determine if ascorbic acid and crude honey extract can protect male rats from the harmful biochemical and histopathological effects of sodium nitrate. Materials and methods: 36 male Albino rats were alienated into 6 groups; control was given saline, honey group was given (2.5g/kg/day honey, ascorbic group was given (200mg/kg /day) L-ascorbic acid, NaNO3 group was given 200mg/kg/day, honey/ NaNO3 group rats given honey and nitrate with the former doses, and Ascorbic/ NaNO3 group was given L-ascorbic acid and NaNO3 with the former doses. Organs' relative weight, liver and kidney blood biochemical determinants, serum tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6), histology and histochemistry were determined. Results: The sodium nitrate had significantly increased liver, kidney and spleen relative weights while decreased thymus weight. Higher levels of AST, ALT, urea, creatinine, IL-6 and TNF-α were observed in NaNO3 treated group. Liver, kidney, and spleen of rats treated with NaNO3 revealed histological and histochemical alterations. The treatment with L-ascorbic acid and crude honeybee improved the later dysfunctions with more palliative effect for L-ascorbic acid. Conclusions: We can conclude that sodium nitrate has to be limited in use. L-ascorbic acid was therefore recommended to be used in reducing the harmful metabolic alterations induced by sodium nitrate better than the honeybee.
Environmental Science and Pollution Research
Monosodium glutamate (MSG) is a widespread flavor enhancer and stabilizer in manufactured or pack... more Monosodium glutamate (MSG) is a widespread flavor enhancer and stabilizer in manufactured or packaged foods that possess myriad adverse effects. This study aimed to evaluate the effect of MSG on placental progesterone receptors and fetal development. Thirty pregnant Wistar Albino rats were divided into three groups (ten/each). The control group (G1) gavaged distilled water only, low-dose treated group (G2) gavaged 3 g/kg MSG, and high-dose treated group (G3) gavaged 6 g/kg MSG from 1st to 18th days of gestation, and all pregnant rats were sacrificed on the 19th day of gestation. The effect of MSG on fetal weights, crown vertebral length (CVL), placental weight, placental ghrelin expression, and fetal skeleton examination were estimated. MSG induced a significant decrease in fetal weights, CVL lengths, placental weight, and ghrelin expression in both treatment groups compared to the control group. Several parts of the fetal skeleton showed incomplete ossification and delayed chondrif...
The Egyptian Journal of Hospital Medicine
Background: Monosodium glutamate (MSG) is a commercial food improver and is widely marketed as a ... more Background: Monosodium glutamate (MSG) is a commercial food improver and is widely marketed as a flavor enhancer. It is now utilized in many processed foods and by most fast-food chains. Honey is a potent antioxidant that acts in the body against many diseases. Objective: The aim of the current study is to investigate honey's ameliorative effect on kidney damage initiated by monosodium glutamate in adult male rats. Moreover, different polyphenolic compounds in the crude honey were evaluated. Material and methods: Forty adult male albino rats were equally divided into four groups (N=6): The Control group was administered 1 mL of saline daily orally, the MSG group (30 g/kg on diet), the Honey group (2.5 g/kg body weight/day, orally) and Honey/MSG group as the previous for one month. Results: Urea, creatinine, and uric acid were significantly increased in the MSG group and decreased in the honey/MSG group compared to the control group. MSG markedly destructed glomeruli of the kidney and increased the immunoexpressing of nuclear erythroid-related factor 2 (Nrf2) and tumor necrosis factor-alpha (TNF-). Conclusions: Administration of crude honey attenuates and improves the kidney pathological changes induced by MSG.
Records of Pharmaceutical and Biomedical Sciences
Myocardial infarction (MI) is the most severe manifestation of coronary artery disease which may ... more Myocardial infarction (MI) is the most severe manifestation of coronary artery disease which may lead to heart failure. One of the crucial mechanisms causing MI induced complications is inflammasome activation and subsequent release of inflammatory cytokines. A significant rise in troponin I, creatine kinase-MB (CK-MB), interleukin 1β (IL-1β) serum levels and nuclear factor-kappa B (NF-κB) were observed in MI. Moreover, increase in the expression of all inflammasome components was detected along with histopathological and electrocardiographic abnormalities. The current mini-review shows that targeting the inflammatory cascade through inflammasome inhibition may be a novel strategy for management of MI and preventing its complications.
Iranian journal of veterinary research, 2020
Background Implantation is a crucial period determining the success of a full pregnancy. Endocrin... more Background Implantation is a crucial period determining the success of a full pregnancy. Endocrine disruptors such as phytoestrogens (PEs) were thought to adversely influence embryonic implantations. However, the mechanism by which they upset implantation was not fully elucidated. Aims The effect of administering soy isoflavones on the implantation of Wistar rats was studied through the detection of progesterone receptors (PR), vascular endothelial growth factor (VEGF), and estradiol receptor alpha (ER-α) protein expression at gestation day 6 (GD6). Methods Eighteen cyclic female Wistar rats were distributed into two groups, group A: control (n=9) were fed with a casein based diet, and group B (n=9) were fed with a casein diet and gavaged 50 mg/kg/day soy isoflavones' extract 40% starting from gestation day zero (GD0) to GD6. Feed intake, body weight (BW), body gain, and uterine weights were recorded. At the end of GD6 the number of corpora lutae (CLs) and implantation rates wer...
BMC Veterinary Research
Background Natural feed supplements are gaining popularity in the animal production sector due to... more Background Natural feed supplements are gaining popularity in the animal production sector due to their safety and potential immunostimulatory properties, as well as the ban of some antibiotics and their negative residual effects. This study was carried out for 1 month to investigate the effect of Nannochloropsis oculata supplementation on growth performance and cell-mediated immunological status of rams assessed by leukogram assessment, lipid oxidation product malondialdehyde (MDA), total antioxidant capacity (TAC), interleukin assay after lymphocyte transformation test (LTT) including interleukin 6 (IL6), tumor necrosis factor-alpha (TNF-α), interleukin 12 (IL12), and gamma interferon (γ-IF), as well as Comet assay (% of DNA damage, tail length (px), % DNA in tail, tail moment and Olive tail moment). Methods Eighteen Barki rams (26.21 ± 0.64 kg) were divided into 3 equal treatment groups (6 sheep/each), G1: animals served as the control group that was fed the basal diet only, whil...
Biological Trace Element Research
This study was designed to determine the lead or cadmium exposure of Barki rams and the beneficia... more This study was designed to determine the lead or cadmium exposure of Barki rams and the beneficial role of Nannochlorposis oculata (N. oculata) 4% as a feed supplement, as well as its mitigating role against these elements’ impacts concerning performance, biochemical markers of liver enzymes and kidney function, thyroid hormone activity, and oxidative stress markers. Six groups of 36 Barki rams (33.63 ± 1.29 kg) were divided into G1: which served as control; G2: was given 4% dietary N. oculata; G3: was given oral 1 mg/kg cadmium chloride; G4: was given 5 mg/kg/day lead acetate; G5: was given oral 1 mg/kg cadmium chloride and 4% dietary N. oculata, and G6: was given oral 5 mg/kg/day lead acetate and 4% dietary N. oculata; and treatments were continued for 60 days. Cadmium and lead-exposed groups exhibited lower and weaker weight gain as well as feed conversion ratio, respectively, than the control and other groups. Additionally, levels of T3, T4, total proteins, albumin, and glutathi...
Biological Trace Element Research
The original version of this article unfortunately contained a mistake. The name of "Moharram Fou... more The original version of this article unfortunately contained a mistake. The name of "Moharram Fouad El-Bassiony" is now spelled out in the author group.
The Journal of Basic and Applied Zoology, 2021
Background The current study was carried out to investigate the effects of exogenous progesterone... more Background The current study was carried out to investigate the effects of exogenous progesterone on fetal development in rats. Results Placental weights did not vary in control and treated groups. Fetal weights were significantly reduced in the low- and high-dose progesterone groups. Fetal CVL was significantly reduced in both treatment groups compared to control group. In fetuses that received maternal treatment with low- and high-dose progesterone, several parts of the fetal skeleton showed incomplete ossification. Alkaline phosphatase was decreased in the bones of fetuses born to progesterone-treated dams. The testes and ovaries of the fetuses of the dams treated with low and high doses of progesterone showed degenerative seminiferous tubules and failed sex cord development into primordial follicles, respectively. Conclusions The administration of exogenous progesterone during pregnancy adversely influences fetal growth, skeletal construction, and sex organ development.
Pharmaceuticals
Myocardial infarction (MI) is a life-threatening ischemic disease and is one of the leading cause... more Myocardial infarction (MI) is a life-threatening ischemic disease and is one of the leading causes of morbidity and mortality worldwide. Serotonin (5-HT) release during myocardial ischemia plays an important role in the progression of myocardial cellular injury. This study was conducted to investigate the possible cardioprotective effect of flibanserin (FLP) against isoproterenol (ISO)-induced MI in rats. Rats were randomly divided into five groups and were treated orally (p.o.) with FLP (15, 30, and 45 mg/kg) for 28 days. ISO was administered subcutaneously (S.C.) (85 mg/kg) on the 27th and 28th days to induce MI. ISO-induced myocardial infarcted rats exhibited a significant increase in cardiac markers, oxidative stress markers, cardiac and serum 5-HT levels, and total cardiac calcium (Ca2+) concentration. ISO-induced myocardial infarcted rats also revealed a remarkable alteration of electrocardiogram (ECG) pattern and significantly upregulated expression of the 5-Hydroxytryptamine...
Egyptian Journal of Histology
Suez Canal Veterinary Medical Journal. SCVMJ
Egyptian Academic Journal of Biological Sciences. D, Histology and Histochemistry, Dec 13, 2022
Open Veterinary Journal
Background: The study was planned to explain the interactions of isoflavones with estrogen recept... more Background: The study was planned to explain the interactions of isoflavones with estrogen receptors alpha (ERα), beta (ERβ) and vascular endothelial growth factor (VEGF) expressions in ovarian and uterine tissues during different stages of estrous cycle of regular cyclic female Wistar rats. Methods: Thirty-two regular cyclic females were divided equally into control group: fed casein-based diet and isoflavones group: fed casein-based diet and gavaged 50 mg/kg/day soy isoflavones extract 40%. Regularity of estrus cycles was monitored. Final body weight (FBW), weight gain (BWG), ovarian and uterine weights were estimated. Histopathology and immunohistochemistry for ERα, ERβ and VEGF in ovarian and uterine tissues were performed. Results: All females (100 %, n=16) in control group showed regularity in estrous cycle compared to 62.5% (n=10) in isoflavones group. Estrus and diestrus phases revealed prolongation and shortening in isoflavones rats than control, respectively. Non-significa...
Pharmacological research. Natural products, Jun 1, 2024
Ethnopharmacological relevance: Cleome droserifolia treatment has potent antioxidant, antimicrobi... more Ethnopharmacological relevance: Cleome droserifolia treatment has potent antioxidant, antimicrobial, and immunomodulatory potentials, which can help recover the general health status. Aim of the study: This research aims to estimate the potential cardioprotective properties of the methanolic extract of Cleome droserifolia (MEC) against epinephrine-induced cardiac injury (MI) in rats. Materials and methods: Thirty-six male Wistar rats were separated equally into 6 groups. The control group (Cont) received oral distilled water for 30 uninterrupted days and was administered subcutaneous saline on the 31 and 32 days. The MEC 100 group received MEC 100mg/kg, P.O., for 30 uninterrupted days and administered subcutaneous saline on the 31 and 32 days. The MEC 200 group received MEC 200mg/kg,P.O. for 30 uninterrupted days and subcutaneous saline was administered on the 31 st and 32 nd days. The epinephrine group (EP) received distilled water orally for 30 uninterrupted days and administered subcutaneous epinephrine (2 mg/kg, s.c.) divided into two doses (1mg/kg, s.c) each on the 31 st and 32 nd days. MEC 100+Ep group received MEC 100mg/kg, P.O., for 30 uninterrupted days and administered subcutaneous epinephrine (2mg/kg, s.c.) divided into two doses (1mg/kg, s.c) each on the 31 st and 32 nd days. The MEC 200+EP received MEC 200 mg/kg, P.O. for 30 uninterrupted days and administered subcutaneous epinephrine (2mg/kg, s.c.) divided into two doses (1mg/kg, s.c) each on the 31st and 32 nd days. Electrocardiography (ECG), biochemical, oxidative stress, inflammatory mediators, histopathological, immunohistochemical analysis and the expression of phosphoinositide 3-kinases (PI3K) and protein kinase B (AKT) were assessed. Results: MEC reversed epinephrine-induced lessening of heart rate, prolonged QT interval and ST displacement. Pretreatment with MEC significantly reduced serum aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB) levels in MI rats. The MEC pretreatment promoted total antioxidant capacity (TAC), glutathione (GSH), and total oxidant status (TOS). In addition, it reduced interleukin-1β (IL-1β), interleukin-6 (IL-6), malondialdehyde (MDA), and tumour necrosis factor (TNF-α) in MI rats. Furthermore, MEC statistically reduced immunohistochemical promotion of nuclear factor–κB (NF-κB) and expression of AKT and PI3K in cardiac tissue and perfected histopathological changes. Conclusion: The MEC, rich in phenolic and flavonoid contents, had a cardioprotective effect on rats suffering from epinephrine-induced MI. Such effect was achieved via improving cardiac function, antioxidant status, attenuating ECG pattern and histological picture, as well as reducing IL-6, IL-1β, TNF-α and NF-κB, which its antioxidant and anti-inflammatory potential may partly arbitrate.
Records of Pharmaceutical and Biomedical Sciences, 2023
Acute coronary syndrome, which is the acute manifestation of ischemic heart disease, remains a ma... more Acute coronary syndrome, which is the acute manifestation of ischemic heart disease, remains a major cause of morbidity and mortality across the world and is mainly responsible for 1.8 million deaths per year. The pathophysiology of acute coronary syndrome is usually due to atherosclerotic plaque rupture which results in a sequence of inflammatory events, thrombus formation, and platelet aggregation causing an aggravation of insufficient perfusion to meet myocardial oxygen demand which can eventually lead to myocardial infarction. Serotonin a monoamine neurotransmitter and a hormone found in both the central nervous system and the peripheral nervous system is released during myocardial ischemia, acute inflammation, and tissue damage leading to platelets aggregation, thrombus formation, contraction of smooth muscle cells, and coronary artery spasms. Serotonin also plays an important role in the progression of myocardial cellular injury through various pathways. This review discusses the potential therapeutic role of targeting the serotonin system in the setting of acute coronary syndrome.
Advances in Environmental and Life Sciences, Jul 16, 2023
Neurochemistry International, Jun 1, 2023
The Egyptian Journal of Hospital Medicine, 2023
Background: Sodium nitrate has been used extensively as a meat additive to keep meat products fre... more Background: Sodium nitrate has been used extensively as a meat additive to keep meat products fresh. Several strategies have been implemented in counteracting such toxicity. Objective: The goal of the current investigation was to determine if ascorbic acid and crude honey extract can protect male rats from the harmful biochemical and histopathological effects of sodium nitrate. Materials and methods: 36 male Albino rats were alienated into 6 groups; control was given saline, honey group was given (2.5g/kg/day honey, ascorbic group was given (200mg/kg /day) L-ascorbic acid, NaNO3 group was given 200mg/kg/day, honey/ NaNO3 group rats given honey and nitrate with the former doses, and Ascorbic/ NaNO3 group was given L-ascorbic acid and NaNO3 with the former doses. Organs' relative weight, liver and kidney blood biochemical determinants, serum tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6), histology and histochemistry were determined. Results: The sodium nitrate had significantly increased liver, kidney and spleen relative weights while decreased thymus weight. Higher levels of AST, ALT, urea, creatinine, IL-6 and TNF-α were observed in NaNO3 treated group. Liver, kidney, and spleen of rats treated with NaNO3 revealed histological and histochemical alterations. The treatment with L-ascorbic acid and crude honeybee improved the later dysfunctions with more palliative effect for L-ascorbic acid. Conclusions: We can conclude that sodium nitrate has to be limited in use. L-ascorbic acid was therefore recommended to be used in reducing the harmful metabolic alterations induced by sodium nitrate better than the honeybee.
Environmental Science and Pollution Research
Monosodium glutamate (MSG) is a widespread flavor enhancer and stabilizer in manufactured or pack... more Monosodium glutamate (MSG) is a widespread flavor enhancer and stabilizer in manufactured or packaged foods that possess myriad adverse effects. This study aimed to evaluate the effect of MSG on placental progesterone receptors and fetal development. Thirty pregnant Wistar Albino rats were divided into three groups (ten/each). The control group (G1) gavaged distilled water only, low-dose treated group (G2) gavaged 3 g/kg MSG, and high-dose treated group (G3) gavaged 6 g/kg MSG from 1st to 18th days of gestation, and all pregnant rats were sacrificed on the 19th day of gestation. The effect of MSG on fetal weights, crown vertebral length (CVL), placental weight, placental ghrelin expression, and fetal skeleton examination were estimated. MSG induced a significant decrease in fetal weights, CVL lengths, placental weight, and ghrelin expression in both treatment groups compared to the control group. Several parts of the fetal skeleton showed incomplete ossification and delayed chondrif...
The Egyptian Journal of Hospital Medicine
Background: Monosodium glutamate (MSG) is a commercial food improver and is widely marketed as a ... more Background: Monosodium glutamate (MSG) is a commercial food improver and is widely marketed as a flavor enhancer. It is now utilized in many processed foods and by most fast-food chains. Honey is a potent antioxidant that acts in the body against many diseases. Objective: The aim of the current study is to investigate honey's ameliorative effect on kidney damage initiated by monosodium glutamate in adult male rats. Moreover, different polyphenolic compounds in the crude honey were evaluated. Material and methods: Forty adult male albino rats were equally divided into four groups (N=6): The Control group was administered 1 mL of saline daily orally, the MSG group (30 g/kg on diet), the Honey group (2.5 g/kg body weight/day, orally) and Honey/MSG group as the previous for one month. Results: Urea, creatinine, and uric acid were significantly increased in the MSG group and decreased in the honey/MSG group compared to the control group. MSG markedly destructed glomeruli of the kidney and increased the immunoexpressing of nuclear erythroid-related factor 2 (Nrf2) and tumor necrosis factor-alpha (TNF-). Conclusions: Administration of crude honey attenuates and improves the kidney pathological changes induced by MSG.
Records of Pharmaceutical and Biomedical Sciences
Myocardial infarction (MI) is the most severe manifestation of coronary artery disease which may ... more Myocardial infarction (MI) is the most severe manifestation of coronary artery disease which may lead to heart failure. One of the crucial mechanisms causing MI induced complications is inflammasome activation and subsequent release of inflammatory cytokines. A significant rise in troponin I, creatine kinase-MB (CK-MB), interleukin 1β (IL-1β) serum levels and nuclear factor-kappa B (NF-κB) were observed in MI. Moreover, increase in the expression of all inflammasome components was detected along with histopathological and electrocardiographic abnormalities. The current mini-review shows that targeting the inflammatory cascade through inflammasome inhibition may be a novel strategy for management of MI and preventing its complications.
Iranian journal of veterinary research, 2020
Background Implantation is a crucial period determining the success of a full pregnancy. Endocrin... more Background Implantation is a crucial period determining the success of a full pregnancy. Endocrine disruptors such as phytoestrogens (PEs) were thought to adversely influence embryonic implantations. However, the mechanism by which they upset implantation was not fully elucidated. Aims The effect of administering soy isoflavones on the implantation of Wistar rats was studied through the detection of progesterone receptors (PR), vascular endothelial growth factor (VEGF), and estradiol receptor alpha (ER-α) protein expression at gestation day 6 (GD6). Methods Eighteen cyclic female Wistar rats were distributed into two groups, group A: control (n=9) were fed with a casein based diet, and group B (n=9) were fed with a casein diet and gavaged 50 mg/kg/day soy isoflavones' extract 40% starting from gestation day zero (GD0) to GD6. Feed intake, body weight (BW), body gain, and uterine weights were recorded. At the end of GD6 the number of corpora lutae (CLs) and implantation rates wer...
BMC Veterinary Research
Background Natural feed supplements are gaining popularity in the animal production sector due to... more Background Natural feed supplements are gaining popularity in the animal production sector due to their safety and potential immunostimulatory properties, as well as the ban of some antibiotics and their negative residual effects. This study was carried out for 1 month to investigate the effect of Nannochloropsis oculata supplementation on growth performance and cell-mediated immunological status of rams assessed by leukogram assessment, lipid oxidation product malondialdehyde (MDA), total antioxidant capacity (TAC), interleukin assay after lymphocyte transformation test (LTT) including interleukin 6 (IL6), tumor necrosis factor-alpha (TNF-α), interleukin 12 (IL12), and gamma interferon (γ-IF), as well as Comet assay (% of DNA damage, tail length (px), % DNA in tail, tail moment and Olive tail moment). Methods Eighteen Barki rams (26.21 ± 0.64 kg) were divided into 3 equal treatment groups (6 sheep/each), G1: animals served as the control group that was fed the basal diet only, whil...
Biological Trace Element Research
This study was designed to determine the lead or cadmium exposure of Barki rams and the beneficia... more This study was designed to determine the lead or cadmium exposure of Barki rams and the beneficial role of Nannochlorposis oculata (N. oculata) 4% as a feed supplement, as well as its mitigating role against these elements’ impacts concerning performance, biochemical markers of liver enzymes and kidney function, thyroid hormone activity, and oxidative stress markers. Six groups of 36 Barki rams (33.63 ± 1.29 kg) were divided into G1: which served as control; G2: was given 4% dietary N. oculata; G3: was given oral 1 mg/kg cadmium chloride; G4: was given 5 mg/kg/day lead acetate; G5: was given oral 1 mg/kg cadmium chloride and 4% dietary N. oculata, and G6: was given oral 5 mg/kg/day lead acetate and 4% dietary N. oculata; and treatments were continued for 60 days. Cadmium and lead-exposed groups exhibited lower and weaker weight gain as well as feed conversion ratio, respectively, than the control and other groups. Additionally, levels of T3, T4, total proteins, albumin, and glutathi...
Biological Trace Element Research
The original version of this article unfortunately contained a mistake. The name of "Moharram Fou... more The original version of this article unfortunately contained a mistake. The name of "Moharram Fouad El-Bassiony" is now spelled out in the author group.
The Journal of Basic and Applied Zoology, 2021
Background The current study was carried out to investigate the effects of exogenous progesterone... more Background The current study was carried out to investigate the effects of exogenous progesterone on fetal development in rats. Results Placental weights did not vary in control and treated groups. Fetal weights were significantly reduced in the low- and high-dose progesterone groups. Fetal CVL was significantly reduced in both treatment groups compared to control group. In fetuses that received maternal treatment with low- and high-dose progesterone, several parts of the fetal skeleton showed incomplete ossification. Alkaline phosphatase was decreased in the bones of fetuses born to progesterone-treated dams. The testes and ovaries of the fetuses of the dams treated with low and high doses of progesterone showed degenerative seminiferous tubules and failed sex cord development into primordial follicles, respectively. Conclusions The administration of exogenous progesterone during pregnancy adversely influences fetal growth, skeletal construction, and sex organ development.
Pharmaceuticals
Myocardial infarction (MI) is a life-threatening ischemic disease and is one of the leading cause... more Myocardial infarction (MI) is a life-threatening ischemic disease and is one of the leading causes of morbidity and mortality worldwide. Serotonin (5-HT) release during myocardial ischemia plays an important role in the progression of myocardial cellular injury. This study was conducted to investigate the possible cardioprotective effect of flibanserin (FLP) against isoproterenol (ISO)-induced MI in rats. Rats were randomly divided into five groups and were treated orally (p.o.) with FLP (15, 30, and 45 mg/kg) for 28 days. ISO was administered subcutaneously (S.C.) (85 mg/kg) on the 27th and 28th days to induce MI. ISO-induced myocardial infarcted rats exhibited a significant increase in cardiac markers, oxidative stress markers, cardiac and serum 5-HT levels, and total cardiac calcium (Ca2+) concentration. ISO-induced myocardial infarcted rats also revealed a remarkable alteration of electrocardiogram (ECG) pattern and significantly upregulated expression of the 5-Hydroxytryptamine...
Egyptian Journal of Histology
Suez Canal Veterinary Medical Journal. SCVMJ
Egyptian Academic Journal of Biological Sciences. D, Histology and Histochemistry, Dec 13, 2022
Open Veterinary Journal
Background: The study was planned to explain the interactions of isoflavones with estrogen recept... more Background: The study was planned to explain the interactions of isoflavones with estrogen receptors alpha (ERα), beta (ERβ) and vascular endothelial growth factor (VEGF) expressions in ovarian and uterine tissues during different stages of estrous cycle of regular cyclic female Wistar rats. Methods: Thirty-two regular cyclic females were divided equally into control group: fed casein-based diet and isoflavones group: fed casein-based diet and gavaged 50 mg/kg/day soy isoflavones extract 40%. Regularity of estrus cycles was monitored. Final body weight (FBW), weight gain (BWG), ovarian and uterine weights were estimated. Histopathology and immunohistochemistry for ERα, ERβ and VEGF in ovarian and uterine tissues were performed. Results: All females (100 %, n=16) in control group showed regularity in estrous cycle compared to 62.5% (n=10) in isoflavones group. Estrus and diestrus phases revealed prolongation and shortening in isoflavones rats than control, respectively. Non-significa...