Abdul Jabbar - Academia.edu (original) (raw)

Papers by Abdul Jabbar

Natural Product Communications, 2011

Two new rotenoids, boerharotenoids A (1) and B (2), and four known compounds, boeravinone (3), 5,... more Two new rotenoids, boerharotenoids A (1) and B (2), and four known compounds, boeravinone (3), 5,7,3′-trihydroxycoumaronochromone (4), boeravinone F (5), and eupalitin-3- O-β-D-galactopyranoside (6), have been isolated from Boerhavia repens and their structures established by spectroscopic (1D and 2D NMR) and mass spectrometric comparison with literature values.

International Journal of Medical Science and Public Health, 2016

Patients with End Stage Renal Disease on maintenance hemodialysis are at a greater risk for bacte... more Patients with End Stage Renal Disease on maintenance hemodialysis are at a greater risk for bacterial infection particularly Staphylococcus aureus (S. aureus). Methicillin-resistant S. aureus (MRSA) is a challenge in clinical practice nowadays, because they resist a great range of antibiotics. This study mainly designed in order to determine the prevalence MRSA in anterior nares samples of hemodyalisis patients. The results of this study show that 153 (59.8%) out of 256 patients who had admitted for hemodialysis were colonized with S. aureus and more than half of these colonizations (51.6%) were with MRSA. Emerging of MRSA isolates that are resistant to vancomycin, as we found one in our study, can be an alarm for clinical practice.

Natural product communications

JPMA. The Journal of the Pakistan Medical Association, 2009

JPMA. The Journal of the Pakistan Medical Association, 2012

To assess the various recruitment strategies used by medical researchers and their response rates... more To assess the various recruitment strategies used by medical researchers and their response rates. The observational study, part of a larger retrospective cohort, was done at the Aga Khan University Hospital, Karachi, Pakistan, from May 2008-December 2010, covering a period from 1999 to 2005. We used a multi-mode contact approach for including participants in the study. This comprised an invitational letter that described the study sent along with a mail-back, postage-paid envelope and multiple phone calls for recruitment of participants. The response to each mode was noted and described as frequency and percentage. There were 1335 participants eligible for recruitment in the study. Of them, 1247 (93.4%) were sent mailouts to which only 84 (6.7%) responded. Besides, 1133 participants,whose phone numbers were available, were called. Overall, the number of people that we were able to contact was low. The response to postage paid mail was very poor whereas the majority of participants ...

Diabetes Research and Clinical Practice, 2015

trolled diabetes mellitus (UDM) in a community setting in Pakistan. Methodology: A single-center,... more trolled diabetes mellitus (UDM) in a community setting in Pakistan. Methodology: A single-center, cross-sectional study, conducted in a community-based specialized care center (SCC) for diabetes in District Central Karachi, in 2003, registered 452 type 2 DM participants, tested for HbA1c and interviewed face-to-face for other information. Logistic regression analysis was conducted to identify factors associated with UDM. Results: Prevalence of UDM among diabetes patients was found to be 38.9% (95% CI: 34.4-43.4%). Multivariable logistic regression model analysis indicated that age <50 years (OR: 1.9; 95% CI: 1.2-2.9), being diagnosed in a hospital (vs. a clinic) (OR: 1.8; 95% CI: 1.1-2.8), diabetes information from a doctor or nurse only (vs. multiple sources) (OR: 1.8; 95% CI: 1.2-2.9), higher monthly treatment cost (OR: 1.3; 95% CI: 1.1-1.6; for every extra 500 PKR), and higher consumption of tea (OR: 1.5; 95% CI: 1.0-2.2; for every 2 extra cups) were independently associated with UDM. Conclusion: The prevalence of UDM was approximately 39% among persons with type 2 diabetes visiting a community based SCC for diabetes. Modifiable risk factors such as sources of diabetes information and black tea consumption can be considered as potential targets of interventions in Karachi.

... Jabbar , Abdul Jabbar (2008) Studies of Anti Microbial Activity of Medicinal Plants with the ... more ... Jabbar , Abdul Jabbar (2008) Studies of Anti Microbial Activity of Medicinal Plants with the help of Essential Elements of Fungi Causing Skin Diseases. PhD thesis, University of Sindh, Jamshoro. ... ID Code: 3168. Deposited By: Mr. Javed Memon. Deposited On: 22 Jun 2010 12:30. ...

Postharvest Biology and Technology, 2014

Firmness of kiwifruit (Actinidia deliciosa (A. Chev) C.F. Liang et A.R. Ferguson cv. Hayward) is ... more Firmness of kiwifruit (Actinidia deliciosa (A. Chev) C.F. Liang et A.R. Ferguson cv. Hayward) is an important determinant of quality. Batches of fruit vary not only in firmness at time of harvest but also in time to reach eating ripeness (0.5-1.0 kg f). Failure to identify batches with rapid rate of firmness breakdown results in economic loss to the industry. Understanding variability in softening rate and its relation with at-harvest measures may lead to opportunities for industry to segregate batches for storage potential. The objective of this paper was to model batch-specific softening behaviour of kiwifruit and investigate if predictive models could be determined from at-harvest maturity measures. Data for 'Hayward' kiwifruit softening at 20 • C were collected over 21 d for 108 batches across two seasons (2011 and 2012). In model creation, application of both Complementary Gompertz (CG) equation and a time shift (TSCG) alternative version resulted in a mean absolute error (MAE) of 0.11-1.55 kg f and 0.14-1.44 kg f respectively for 54 batches. Model parameters were fitted using a non-linear mixed effects procedure. The resulting batch-dependent softening description parameters (B, Ä and) were best associated with at-harvest firmness and the SSC:firmness ratio. For prediction validation, at-harvest quality indicators of an alternative set of 54 batches were used to predict softening descriptive model parameters and subsequent batch-dependent softening behaviour at 20 • C. When B and Ä were predicted from firmness and the SSC:firmness ratio respectively in the validation batches, MAE of firmness prediction by CG ranged from 0.17 to 2.75 kg f with 46% of the batches having MAE of less than 0.5 kg f. Likewise, when was predicted from firmness, MAE of firmness prediction by TSCG ranged from 0.17 to 2.78 kg f and approximately 30% of batches had MAE less than 0.5 kg f. This paper demonstrates the potential for predicting softening variability of kiwifruit batches from at-harvest fruit maturity measures. Future work is required to ascertain if a similar modelling protocol may enable prediction of kiwifruit softening at commercial storage conditions (0 • C).

Parasites & Vectors, 2013

Background: Parasitic nematodes can cause substantial clinical and subclinical problems in alpaca... more Background: Parasitic nematodes can cause substantial clinical and subclinical problems in alpacas and anthelmintics are regularly used to control parasitic nematodes in alpacas. Although anthelmintic resistance has been reported in ruminants worldwide, very little is known about anthelmintic resistance in alpacas. The present study was carried out to confirm a suspected case of anthelmintic resistance in Haemonchus contortus in alpacas in Australia. Methods: Post mortem examination of an alpaca was conducted to determine the cause of its death. To confirm a suspected case of macrocyclic lactone (ML) resistance in H. contortus in alpacas, a faecal egg count reduction test (FECRT) was performed using closantel (7.5 mg/kg) and ivermectin (0.2 mg/kg). Nematode species were identified by morphological and molecular methods. Results: Post mortem examination of a 1-year-old female alpaca that had died following a brief period of lethargy, anorexia and recumbency revealed severe anaemia, hypoproteinaemia and gastric parasitism by adult Haemonchus contortus, despite recent abamectin (0.2 mg/kg) treatment. Based on these findings and the exclusive use of MLs in the herd over the preceding six years, ML resistance in parasitic nematodes of alpacas on this farm was suspected. FECRT revealed that the efficacy of closantel was 99% (95% CI 93-100), whereas that of ivermectin was 35% (95% CI 0-78), indicating that the treatment failure was likely due to the presence of ML-resistant nematodes. Larval culture of faecal samples collected following ivermectin treatment consisted of 99% H. contortus and 1% Cooperia oncophora, a result confirmed using a PCR assay. Conclusions: This study provides the first evidence of ML resistance in H. contortus in alpacas in Australia. Based on the extent of anthelmintic resistance in sheep gastrointestinal nematodes in Australia, veterinarians and alpaca owners should be encouraged to implement integrated parasite management strategies to improve nematode control in alpacas.

Molecular and Cellular Probes, 2010

We genetically classified Echinococcus granulosus from humans, cattle and camels in Libya utilizi... more We genetically classified Echinococcus granulosus from humans, cattle and camels in Libya utilizing DNA regions (designated pcox1 and pnad1) within the cytochrome c oxidase subunit 1 (cox1) and NADH dehydrogenase 1 (nad1) mitochondrial genes, respectively. Polymerase chain reaction (PCR)-based single-strand conformation polymorphism (SSCP) analysis of pcox1 and pnad1 amplicons derived from genomic DNA samples from individual cysts (n = 176) revealed four distinct electrophoretic profiles for each locus. Direct sequencing of selected amplicons representing each of these profiles defined four different sequence types for each locus, which were present in five different combinations (designated haplotypes A-E) amongst all 176 isolates. Phylogenetic analysis of concatenated sequence data for these five haplotypes, together with a range of well-defined reference sequences, inferred that all cyst isolates from humans (n = 55) and a small number from cattle (13% of 38) belonged to the G1-G3 complex of E. granulosus (or E. granulosus sensu stricto), whereas most (87%) cysts from cattle and all 83 of them from camels were linked to the G6-G10 complex (or Echinococcus canadensis). The present study provides a foundation for future large-scale studies of the epidemiology and ecology of E. granulosus in Libya and other African countries.

Molecular and Cellular Probes, 2012

Pneumothorax was diagnosed in a dog presenting with progressive exercise intolerance and tachypno... more Pneumothorax was diagnosed in a dog presenting with progressive exercise intolerance and tachypnoea. Needle thoracocentesis failed to resolve the pneumothorax, and an exploratomy thoracotomy was performed. Upon inspection of the thoracic cavity, numerous white nodules (2 to 4mm) were present throughout the mediastinum, parietal pleura and the lung lobes. The owners of the dog elected intra-operative euthanasia, and a post mortem examination was performed. At necropsy, structures consistent with the plerocercoid (larval) stage of a tapeworm were identified in association with inflammation of the pleural cavity. Molecular methods were used to identify the parasite as Spirometra erinacei. Molecular diagnosis, along with the clinical presentation and pathological findings, allowed the diagnosis of proliferative sparganosis.

The Journal of the American Dental Association, 2002

Background. Access to dental care for low-income children is limited. The authors examined the im... more Background. Access to dental care for low-income children is limited. The authors examined the impact of a new state children's health insurance program, or SCHIP, in North Carolina on children's access to dental care. Methods. Parents of 639 school-aged children responded to two surveys that asked about their child's access to dental services before enrollment and one year after enrollment in the new program. The authors used two-tailed McNemar tests to detect statistically significant changes within subjects. Results. The percentage of school-aged children with a visit to a dentist in the previous year increased from 48 percent at baseline to 65 percent after one year in the program. Reported unmet dental need decreased from 43 percent at baseline to 18 percent after one year of enrollment. The proportion of children reported to have a usual source of dental care improved after enrollment in the program. Conclusion. The SCHIP model in North Carolina is an innovative program that has made a significant impact on access to dental care for school-aged children. Practice Implications. SCHIP dental programs that resemble private insurance models and reimburse dentists at rates close to market rates hold the potential to address problems associated with dental access for low-income children.

Journal of Ethnopharmacology, 2007

Both plants exhibited dose-and time-dependent anthelmintic effects by causing mortality of worms ... more Both plants exhibited dose-and time-dependent anthelmintic effects by causing mortality of worms and inhibition of egg hatching. Caesalpinia crista (LC 50 = 0.134 mg/mL) was found to be more potent than Chenopodium album (LC 50 = 0.449 mg/mL) in egg hatch test. In vivo, ...

Journal of Ethnopharmacology, 2006

A survey was conducted in southern Punjab, Pakistan, in order to document existing ethnobotanical... more A survey was conducted in southern Punjab, Pakistan, in order to document existing ethnobotanical knowledge by the herdsmen/key respondents about anthelmintics in ruminants. A 3-satge process was used to document the plants being used to treat and/or control helminthes. This paper describes 29 plants to treat helminthosis in ruminants. The main plants used were Lamium amplexicaule L., Mallotus philippinensis Muell., Withania somnifera (L.) Dunal., Azadirachta indica A. Juss., and Citrullus colocynthis (L.) Schrad. A few of these plants have been scientifically validated for their claim by herdsmen on modern lines while majority of them still needs investigations. This documentation could provide a foundation for the scientific study and verification of those plants which merit such study.

Journal of Asian Natural Products Research, 2010

The variety…

Journal of Asian Natural Products Research, 2013

Chromatographic purification of ethyl acetate soluble fraction of the methanolic extract of the f... more Chromatographic purification of ethyl acetate soluble fraction of the methanolic extract of the flowers of Aerva javanica yielded three new acylated flavone glycosides: kaempferol-3-O-β-d-[4‴-E-p-coumaroyl-α-l-rhamnosyl(1 → 6)]-galactoside (1), kaempferol-3-O-β-d-[4‴-E-p-coumaroyl-α-l-rhamnosyl(1 → 6)]-(3″-E-p-coumaroyl)galactoside (2), and kaempferol-3-O-β-d-[4‴-E-p-coumaroyl-α-l-rhamnosyl(1 → 6)]-(4″-E-p-coumaroyl)galactoside (3), along with p-coumaric acid (4), caffeic acid (5), gallic acid (6), eicosanyl-trans-p-coumarate (7), hexadecyl ferulate (8), and hexacosyl ferulate (9). The compounds 1-9 were characterized using 1D ((1)H, (13)C) and 2D NMR (HMQC, HMBC, and COSY) spectroscopy and mass spectrometry (EI-MS, HR-EI-MS, FAB-MS, and HR-FAB-MS) and in comparison with the reported data in the literature. Compound 1 showed weak inhibitory activity against enzymes, such as acetylcholinesterase, butyrylcholinesterase, and lipoxygenase with IC50 values 205.1, 304.1, and 212.3 μM, respectively, whereas compounds 2 and 3 were only weakly active against the enzyme acetylcholinesterase.