Abdul Malik - Academia.edu (original) (raw)
Papers by Abdul Malik
Environmental monitoring and assessment, 2002
Journal of digestive diseases, 2007
Nonalcoholic fatty liver disease (NAFLD) is increasing rapidly in the Asia-Pacific region. There ... more Nonalcoholic fatty liver disease (NAFLD) is increasing rapidly in the Asia-Pacific region. There has been a paucity of studies from the region. The aims of this study were to define the demographic, anthropometric, metabolic and histological characteristics of patients with NAFLD in our local population and to determine independent predictors of severe liver fibrosis. Patients with persistently raised liver enzymes and/or fatty liver detected on ultrasonography with exclusion of other liver disorders were prospectively recruited. Their insulin resistance was assessed using the homeostasis model assessment of insulin resistance score. A liver biopsy was performed in all cases for grading (for steatohepatitis) and staging (for fibrosis) of NAFLD. Independent risk factors for fibrosis were determined using multiple logistic regression analysis. Seventy-five patients were recruited: 39 men (52%) and 36 women (48%). The mean age of the patients was 47.0+/-12.2 years. Of these, 58 patients (77.3%) were centrally obese, 29 patients (38.7%) were diabetic and 15 patients (20.0%) had impaired glucose tolerance. Insulin resistance was diagnosed in 62 out of 64 (96.9%) patients. Benign steatosis, nonalcoholic steatohepatitis and cirrhosis were diagnosed in three (4.3%), 59 (84.3%) and eight (11.4%) of 70 patients, respectively. Significant independent predictors of liver fibrosis were; male sex (P=0.019, OR=5.55, CI=1.33-23.18) and Indian race (P=0.013, OR=8.21, CI=1.56-43.16). The full histological spectrum of NAFLD was seen in our patients. The majority of patients were insulin resistant, centrally obese and either diabetic or had impaired glucose tolerance. The predictors of severe liver fibrosis were male sex and Indian race.
Heterocycles, 1991
... Titre du document / Document title. The pyrrolizidine alkaloids from Senecio racemosus. Auteu... more ... Titre du document / Document title. The pyrrolizidine alkaloids from Senecio racemosus. Auteur(s) / Author(s). WASIM AHMED ; ZAHEER AHMED ; ABDUL MALIK ; Affiliation(s) du ou des auteurs / Author(s) Affiliation(s). Univ. Karachi, HEJ res. inst. ...
Magnetic Resonance in Chemistry, 2004
Ramosine, a new sesquiterpene lactone, was isolated from the chloroform fraction of Amberboa ramo... more Ramosine, a new sesquiterpene lactone, was isolated from the chloroform fraction of Amberboa ramosa and the structure was assigned as 4β-(hydroxymethyl)-3β,4α-dihydroxy-8α-[(S)-3-hydroxy-2-ethylenepropionyloxy]-1αH, 5αH,6βH,7αH,11βH,11α-methylguaia-10(14)-en-6, 12-olide by extensive NMR studies. Copyright © 2004 John Wiley & Sons, Ltd.
American Journal of Hypertension, 2007
Alterations in microvascular and conduit artery function contribute to target organ damage in hyp... more Alterations in microvascular and conduit artery function contribute to target organ damage in hypertension. We investigated the association of cardiovascular (CV) risk factors with microvascular and conduit artery function in hypertensive subjects.Participants included 504 hypertensives (aged 62.1 ± 9.8 years, 42% men) from the community, without history of symptomatic CV disease. Brachial artery ultrasound was performed to measure forearm blood flow (FBF) at rest and during reactive hyperemia (markers of microvascular function) and flow-mediated dilatation (FMD) of the brachial artery (a marker of conduit artery endothelial function). The association of conventional and novel (homocysteine, C-reactive protein, fibrinogen, and lipoprotein a CV risk factors with microvascular function and FMD was tested in multivariable regression models.Variables independently associated with higher resting FBF were male sex, higher body mass index (BMI), smoking, and lower HDL-cholesterol; variables associated with lower hyperemic FBF included greater age, female sex, and diabetes. Higher plasma homocysteine was associated with lower hyperemic FBF in obese subjects (P for log homocysteine × BMI interaction = .0008). Variables independently associated with lower FMD were greater age, sex gender, history of smoking, and not using statins. Higher homocysteine was associated with lower FMD in subjects with higher systolic blood pressure (P for interaction = .0004). Hyperemic flow velocity was independently associated with FMD (P = .0006), but its inclusion as a covariate did not influence the association of CV risk factors with FMD.In asymptomatic subjects with essential hypertension, select CV risk factors were associated with microvascular and conduit artery function. Furthermore, the association of CV risk factors with conduit artery function appeared to be independent of downstream microvascular function.
Magnetic Resonance in Chemistry, 2006
Two new ursene-type triterpenes, nudicauline A and nudicauline B, have been isolated from Launaea... more Two new ursene-type triterpenes, nudicauline A and nudicauline B, have been isolated from Launaea nudicaulis. Their structures have been assigned as 3β-hydroxy-urs-11-ene (1) and 3β-acetyl-urs-11-ene (2), respectively, by extensive NMR studies. In addition, olean-11,13(18)-diene (3), 3β-hydroxy-13(28)-epoxy-urs-11-ene (4) and 3-keto-13(28)-epoxy-urs-11-ene (5) are also reported for the first time from this species. Copyright © 2006 John Wiley & Sons, Ltd.
Chemical & Pharmaceutical Bulletin, 2004
Article not found.
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](Pakistan journal of pharmaceutical sciences, 2014
Journal of Natural Products, 2004
Journal of Natural Products, 1991
Natural Product Letters, 2002
Pakistan journal of pharmaceutical sciences, 2014
Heart (British Cardiac Society), 2015
Polyimides are used extensively in the semiconductor industry as passivation layers, interlayers ... more Polyimides are used extensively in the semiconductor industry as passivation layers, interlayers and dielectrics because of their excellent properties. These properties include thermal stability, superior chemical resistance, high mechanical strength and low dielectric constant. Most polyimide used in the semiconductor industry is the negative-type photosensitive polyimide due to its direct patternability. The purpose of this paper is to study the effect of process time delay during the polyamic ester formation to the final imidized polyimide. Post Coat Delay (PCD) is the delay time after coating before undergoing exposing while Post Expose Delay (PED) is the delay time after exposing before undergoing development. Samples of imide coated on bare wafers with after cure thickness of 6 Em are used. The image from Microscope inspection shows that the sample that is processed immediately is different from those other samples. The results of the after cure thickness of polyimides show that all the samples are within specification limit. Fourier Transform Infra Red (FTIR) is used to check for the chemical bonding. All the samples are fully imidized without peaks indicating the existence of PAE precursor. The imidization rate is lower as the delay time increase for both PCD and PED. Further investigation need to be done to verified the results.
Phytochemistry, 1999
From the whole plant extract of Daphne oleoides, two dimeric guaianolides seemarin and anabsinthi... more From the whole plant extract of Daphne oleoides, two dimeric guaianolides seemarin and anabsinthin were isolated and characterized as new natural products. The structures of these lactones were determined by NMR spectral studies as well as by chemical methods.
Journal of Asian Natural Products Research, 2012
Vicarin (1), a new isoflavone, has been isolated from the ethyl acetate-soluble fraction of the e... more Vicarin (1), a new isoflavone, has been isolated from the ethyl acetate-soluble fraction of the ethanolic extract of Eremostachys vicaryi, along with soforanarin B (2), luteolin 7-O-β-d-glucopyranoside (3), and hamighriprasin (4). Their structures were elucidated on the basis of their spectral data including MS and 2D NMR.
Journal of Asian Natural Products Research, 2009
Aitchisonides A (1) and B (2), new iridoid glucosides, were isolated from the n-butanolic fractio... more Aitchisonides A (1) and B (2), new iridoid glucosides, were isolated from the n-butanolic fraction of Aitchisonia rosea along with deacetylasperulosidic acid (3) and nepetanudoside B (4), which were reported for the first time from the genus Aitchisonia. Their structures have been assigned on the basis of spectral analysis including 1H and 13C NMR spectra and by DEPT, 2D COSY, NOESY, and HMBC experiments.
…, 2001
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cheminform, 2010
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Journal of Stroke and Cerebrovascular Diseases, 2014
Environmental monitoring and assessment, 2002
Journal of digestive diseases, 2007
Nonalcoholic fatty liver disease (NAFLD) is increasing rapidly in the Asia-Pacific region. There ... more Nonalcoholic fatty liver disease (NAFLD) is increasing rapidly in the Asia-Pacific region. There has been a paucity of studies from the region. The aims of this study were to define the demographic, anthropometric, metabolic and histological characteristics of patients with NAFLD in our local population and to determine independent predictors of severe liver fibrosis. Patients with persistently raised liver enzymes and/or fatty liver detected on ultrasonography with exclusion of other liver disorders were prospectively recruited. Their insulin resistance was assessed using the homeostasis model assessment of insulin resistance score. A liver biopsy was performed in all cases for grading (for steatohepatitis) and staging (for fibrosis) of NAFLD. Independent risk factors for fibrosis were determined using multiple logistic regression analysis. Seventy-five patients were recruited: 39 men (52%) and 36 women (48%). The mean age of the patients was 47.0+/-12.2 years. Of these, 58 patients (77.3%) were centrally obese, 29 patients (38.7%) were diabetic and 15 patients (20.0%) had impaired glucose tolerance. Insulin resistance was diagnosed in 62 out of 64 (96.9%) patients. Benign steatosis, nonalcoholic steatohepatitis and cirrhosis were diagnosed in three (4.3%), 59 (84.3%) and eight (11.4%) of 70 patients, respectively. Significant independent predictors of liver fibrosis were; male sex (P=0.019, OR=5.55, CI=1.33-23.18) and Indian race (P=0.013, OR=8.21, CI=1.56-43.16). The full histological spectrum of NAFLD was seen in our patients. The majority of patients were insulin resistant, centrally obese and either diabetic or had impaired glucose tolerance. The predictors of severe liver fibrosis were male sex and Indian race.
Heterocycles, 1991
... Titre du document / Document title. The pyrrolizidine alkaloids from Senecio racemosus. Auteu... more ... Titre du document / Document title. The pyrrolizidine alkaloids from Senecio racemosus. Auteur(s) / Author(s). WASIM AHMED ; ZAHEER AHMED ; ABDUL MALIK ; Affiliation(s) du ou des auteurs / Author(s) Affiliation(s). Univ. Karachi, HEJ res. inst. ...
Magnetic Resonance in Chemistry, 2004
Ramosine, a new sesquiterpene lactone, was isolated from the chloroform fraction of Amberboa ramo... more Ramosine, a new sesquiterpene lactone, was isolated from the chloroform fraction of Amberboa ramosa and the structure was assigned as 4β-(hydroxymethyl)-3β,4α-dihydroxy-8α-[(S)-3-hydroxy-2-ethylenepropionyloxy]-1αH, 5αH,6βH,7αH,11βH,11α-methylguaia-10(14)-en-6, 12-olide by extensive NMR studies. Copyright © 2004 John Wiley & Sons, Ltd.
American Journal of Hypertension, 2007
Alterations in microvascular and conduit artery function contribute to target organ damage in hyp... more Alterations in microvascular and conduit artery function contribute to target organ damage in hypertension. We investigated the association of cardiovascular (CV) risk factors with microvascular and conduit artery function in hypertensive subjects.Participants included 504 hypertensives (aged 62.1 ± 9.8 years, 42% men) from the community, without history of symptomatic CV disease. Brachial artery ultrasound was performed to measure forearm blood flow (FBF) at rest and during reactive hyperemia (markers of microvascular function) and flow-mediated dilatation (FMD) of the brachial artery (a marker of conduit artery endothelial function). The association of conventional and novel (homocysteine, C-reactive protein, fibrinogen, and lipoprotein a CV risk factors with microvascular function and FMD was tested in multivariable regression models.Variables independently associated with higher resting FBF were male sex, higher body mass index (BMI), smoking, and lower HDL-cholesterol; variables associated with lower hyperemic FBF included greater age, female sex, and diabetes. Higher plasma homocysteine was associated with lower hyperemic FBF in obese subjects (P for log homocysteine × BMI interaction = .0008). Variables independently associated with lower FMD were greater age, sex gender, history of smoking, and not using statins. Higher homocysteine was associated with lower FMD in subjects with higher systolic blood pressure (P for interaction = .0004). Hyperemic flow velocity was independently associated with FMD (P = .0006), but its inclusion as a covariate did not influence the association of CV risk factors with FMD.In asymptomatic subjects with essential hypertension, select CV risk factors were associated with microvascular and conduit artery function. Furthermore, the association of CV risk factors with conduit artery function appeared to be independent of downstream microvascular function.
Magnetic Resonance in Chemistry, 2006
Two new ursene-type triterpenes, nudicauline A and nudicauline B, have been isolated from Launaea... more Two new ursene-type triterpenes, nudicauline A and nudicauline B, have been isolated from Launaea nudicaulis. Their structures have been assigned as 3β-hydroxy-urs-11-ene (1) and 3β-acetyl-urs-11-ene (2), respectively, by extensive NMR studies. In addition, olean-11,13(18)-diene (3), 3β-hydroxy-13(28)-epoxy-urs-11-ene (4) and 3-keto-13(28)-epoxy-urs-11-ene (5) are also reported for the first time from this species. Copyright © 2006 John Wiley & Sons, Ltd.
Chemical & Pharmaceutical Bulletin, 2004
Article not found.
Pakistan journal of pharmaceutical sciences, 2014
Journal of Natural Products, 2004
Journal of Natural Products, 1991
Natural Product Letters, 2002
Pakistan journal of pharmaceutical sciences, 2014
Heart (British Cardiac Society), 2015
Polyimides are used extensively in the semiconductor industry as passivation layers, interlayers ... more Polyimides are used extensively in the semiconductor industry as passivation layers, interlayers and dielectrics because of their excellent properties. These properties include thermal stability, superior chemical resistance, high mechanical strength and low dielectric constant. Most polyimide used in the semiconductor industry is the negative-type photosensitive polyimide due to its direct patternability. The purpose of this paper is to study the effect of process time delay during the polyamic ester formation to the final imidized polyimide. Post Coat Delay (PCD) is the delay time after coating before undergoing exposing while Post Expose Delay (PED) is the delay time after exposing before undergoing development. Samples of imide coated on bare wafers with after cure thickness of 6 Em are used. The image from Microscope inspection shows that the sample that is processed immediately is different from those other samples. The results of the after cure thickness of polyimides show that all the samples are within specification limit. Fourier Transform Infra Red (FTIR) is used to check for the chemical bonding. All the samples are fully imidized without peaks indicating the existence of PAE precursor. The imidization rate is lower as the delay time increase for both PCD and PED. Further investigation need to be done to verified the results.
Phytochemistry, 1999
From the whole plant extract of Daphne oleoides, two dimeric guaianolides seemarin and anabsinthi... more From the whole plant extract of Daphne oleoides, two dimeric guaianolides seemarin and anabsinthin were isolated and characterized as new natural products. The structures of these lactones were determined by NMR spectral studies as well as by chemical methods.
Journal of Asian Natural Products Research, 2012
Vicarin (1), a new isoflavone, has been isolated from the ethyl acetate-soluble fraction of the e... more Vicarin (1), a new isoflavone, has been isolated from the ethyl acetate-soluble fraction of the ethanolic extract of Eremostachys vicaryi, along with soforanarin B (2), luteolin 7-O-β-d-glucopyranoside (3), and hamighriprasin (4). Their structures were elucidated on the basis of their spectral data including MS and 2D NMR.
Journal of Asian Natural Products Research, 2009
Aitchisonides A (1) and B (2), new iridoid glucosides, were isolated from the n-butanolic fractio... more Aitchisonides A (1) and B (2), new iridoid glucosides, were isolated from the n-butanolic fraction of Aitchisonia rosea along with deacetylasperulosidic acid (3) and nepetanudoside B (4), which were reported for the first time from the genus Aitchisonia. Their structures have been assigned on the basis of spectral analysis including 1H and 13C NMR spectra and by DEPT, 2D COSY, NOESY, and HMBC experiments.
…, 2001
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cheminform, 2010
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Journal of Stroke and Cerebrovascular Diseases, 2014