Abdul Samad - Academia.edu (original) (raw)

Papers by Abdul Samad

Recently there have been many revelations of importance of RNAs to cellular functions and thus fa... more Recently there have been many revelations of importance of RNAs to cellular functions and thus fast-growing interests in computational prediction of RNA tertiary, which is a significant challenge nevertheless. Even for a short RNA sequence, the space of tertiary conformations is immense; existing methods to identify native-like conformations mostly resort to random sampling of conformations for computation feasibility. To avoid compromise in accuracy, such methods may also be guided with knowledge of local tertiary motifs or secondary structure. However, due to lack of effective, global constraints on the RNA tertiary structure, existing methods have yet to deliver the desired prediction accuracy for RNAs of length beyond 50. In this work, we approach the ab initio tertiary structure prediction problem with a key step to predict nucleotide interactions that constitute the desired tertiary structure. Our work is established on a novel graph model, called k-tree, to constrain nucleoti...

Bioinformatics (Oxford, England), Jan 16, 2015

Given the importance of non-coding RNAs to cellular regulatory functions, it would be highly desi... more Given the importance of non-coding RNAs to cellular regulatory functions, it would be highly desirable to have accurate computational prediction of RNA 3D structure, a task which remains challenging. Even for a short RNA sequence, the space of tertiary conformations is immense; existing methods to identify native-like conformations mostly resort to random sampling of conformations to achieve computational feasibility. However, native conformations may not be examined and prediction accuracy may be compromised due to sampling. State-of-the-art methods have yet to deliver satisfactory predictions for RNAs of length beyond 50 nucleotides. This paper presents a method to tackle a key step in the RNA 3D structure prediction problem, the prediction of the nucleotide interactions that constitute the desired 3D structure. The research is based on a novel graph model, called a backbone k-tree, to tightly constrain the nucleotide interaction relationships considered for RNA 3D structures. It ...

JPMA. The Journal of the Pakistan Medical Association, 2005

To determine the proportion and timing for suspecting the diagnosis of gall bladder carcinoma in ... more To determine the proportion and timing for suspecting the diagnosis of gall bladder carcinoma in patients undergoing cholecystectomy for cholelithiasis. A retrospective study conducted at the Aga Khan University Hospital, Karachi over a period of six years, included medical records of patients, with cholecystectomy for cholelithiasis and a histopathological diagnosis of gall bladder carcinoma. An extensive review was done with special reference to the features of suspected or unsuspected gall bladder carcinoma. Timing of suspicion was categorized on the basis of clinical features, investigations, operative and histopathological findings. Out of 1396 cholecystectomies performed during the period of study, sixteen patients (1.15%) were diagnosed as gall bladder carcinoma. Only three patients had pre-operative ultrasonographic features to raise suspicion for gall bladder malignancy whereas eight patients were suspected to have a malignant lesion, on the operative findings. Five patient...

Journal of Asian Natural Products Research, 2014

A phytochemical investigation on the ethyl acetate soluble fraction of Zanthoxylum armatum led in... more A phytochemical investigation on the ethyl acetate soluble fraction of Zanthoxylum armatum led in the isolation of two new prenylated alkaloids 2,6,7-trimethoxy-8-(3-methyl-2-butenyl)carbazole-3-carbaldehyde (1) and methyl-2,6,7-trimethoxy-8-(3-methyl-2-butenyl)carbazole-3-carboxylate (2), along with three known lignans cisamin (3), methyl pirpirtol (4), and fargesin (5) and one known alkaloid dictamine (6). Their structures were established on the basis of spectroscopic and crystallographic analysis and by comparison of the data with those in the literature. All the isolated compounds were screened for the DPPH free radical scavenging activity. Compounds 1, 2, and 6 showed profound activity while compounds 3-5 showed moderate activity.

International Journal of Information and Electronics Engineering, 2013

Pakistan Journal of Medical Sciences, 2013

JSLS : Journal of the Society of Laparoendoscopic Surgeons, 2010

Journal of Phytopathology, 1993

Journal of Pediatric Urology, 2010

Experimental Cell Research, 2007

The transient receptor potential channel of melastatin type 8 (TRPM8), which is gated by low (&am... more The transient receptor potential channel of melastatin type 8 (TRPM8), which is gated by low (&amp;amp;amp;amp;amp;amp;lt;25 °C) temperature and chemical compounds, is regulated by protein kinase C-mediated phosphorylation in a way opposite to that observed with the transient receptor potential channel of vanilloid type 1 (TRPV1), i.e. by being desensitized and not sensitized. As TRPV1 is sensitized also by protein kinase

pharmainfo.net

Skip to Main Content Area. ...

Proceedings of the 1st International Conference on Natural Resources Engineering & Technology 200... more Proceedings of the 1st International Conference on Natural Resources Engineering & Technology 2006 24-25th July 2006; Putrajaya, Malaysia, 562-575 ... Comparison Product Optimization Performance of Fed-batch Fermentation Processes for Penicillin G Production

Developing critical thinking and mastering its skills has been a vital priority for the curriculu... more Developing critical thinking and mastering its skills has been a vital priority for the curriculum in Swedish upper-secondary school. The National Curriculum for upper-secondary school and the syllabus for the English subject emphasize the importance of implementing and enhancing the development of the students’ critical thinking which leads to having active learners who are able to think creatively and keeps them away from becoming narrow-minded. The purpose of this study is to explore the prospect of teaching critical thinking through reading literature. Guided by the critical thinking skills that are defined in The Delphi Report including (1) interpretation, (2) analysis, (3) evaluation, (4) inference, (5) explanation and (6) self-regulation, this study explores the possibility of promoting critical thinking skills through reading literature. The study also examines the efficacy of the reader-response approach in helping the students to be critical thinkers and active readers. Using qualitative data from conducting interviews, this study analyses teachers’ perspectives and considered the implications for teaching literature in terms of fostering the students’ critical thinking. The study showed that the teachers’ awareness of the significance of integrating literature in teaching English was found to play a great role in fostering the students as critical thinkers. The study also showed that teachers emphasized the importance of in-class discussions about literary works in order to expand the students’ thinking horizons and enhance their sense of self-confidence as contributors to the learning process. It also showed that the reader-response theory has a significant role in fostering the students’ critical thinking even though it is not clearly stated in the teachers’ perspectives on teaching literature