Abdulkarim Alzomor - Academia.edu (original) (raw)

Papers by Abdulkarim Alzomor

Universal Journal of Pharmaceutical Research

Background and objective: This study is focused to evaluate the in vitro bioequivalence of three ... more Background and objective: This study is focused to evaluate the in vitro bioequivalence of three brands of ciprofloxacin 500mg tablets from local producer and marketing in Yemen, with innovator brand using in vitro dissolution study under biowaiver conditions by UV spectrophotometer. Method: The Dissolution profile has been evaluated by testing in dissolution media were USP buffer solution at pH 1.2 (hydrochloric acid solution), pH 4.5 (acetate buffer solution) and pH 6.8 (phosphate buffer solution). Also, further general quality assessment tests of these tablets like weight variation, disintegration time hardness, friability and assay test were accomplished according to proven methods. Results: All brands conformed to the official specification for uniformity of weight, friability and disintegration time. Content uniformity of chosen tablets shown that all samples contained over 99% (w/w) of labeled chemical content. The profile dissolution finding of all the tablets formulation an...

Thamar University Journal of Natural & Applied Sciences

The aim of the present study was to develop and evaluate an oral disintegrant tablet of meloxicam... more The aim of the present study was to develop and evaluate an oral disintegrant tablet of meloxicam. Drug delivery systems became sophisticated and pharmaceutical scientists acquire a better understanding of the physicochemical and biochemical parameters pertinent to their performance. Over the past three decades, mouth dissolving or orally disintegrating tablets have gained considerable attention as a preferred alternative to conventional tablets due to better patient compliance. Orally is the most preferable route of drug administration which has some limited to drug candidate that show poor permeability across the gastric mucosa and those, which are sparingly soluble. A large majority of the new chemical entities and many new existing drug molecules are poorly soluble, thereby limiting their potential uses and increasing the difficulty of formulating bioavailable drug products, so lastly the purpose of this study was to grow mouth dissolve tablets of Meloxicam. Meloxicam is a non s...

Advances in Pharmacological and Pharmaceutical Sciences

Nausea and vomiting are symptoms associated with a lot of diseases and oral tablets may be unprof... more Nausea and vomiting are symptoms associated with a lot of diseases and oral tablets may be unprofitable for patients especially those suffering from nausea and vomiting. Therefore, this study aimed to formulate a new meclizine and pyridoxine combination formula for chewable tablets and provide rapid drug absorption and decrease motion sickness. The new chewable formulation has been prepared to provide fast action, is more acceptable, and could be used for all age categories. Seven trials haves been carried out to prepare to find the suitable one where formula 7 of the chewable gum preparation exhibited good taste and hardness, while the gelatin formulation give an accepted formula after four trials with better taste and good acceptance. The prepared formulations give a dissolution profile of meclizine (95.53–102.8%) and pyridoxine (99.25 ± 115%) and assay (98 + 0.05–99.3 ± 0.8%) for meclizine and (97 ± 0.9–100.0 ± 0.08%) for the pyridoxine in three prepared formulations of chewable ...

Saudi Journal of Medical and Pharmaceutical Sciences

Background: The liver is the largest gland that plays a role in the plant metabolism and the remo... more Background: The liver is the largest gland that plays a role in the plant metabolism and the removal of toxins from the body. Achillea millefolium is familiar herb in traditional medicine. Objective: to investigation the effect of achillea millefolium extract in experiment rats those exposed to hepatic damage by carbon tetrachloride. Methods: Achillea millefolium was collected in the province of Ibb, Yemen, and extracted by maceration method, then physical and phytochemical evaluation were performed for the extract. Finally, evaluation the effect of extract on liver function tests were done on twenty-one female rats were divided into seventh groups, two extract doses 100 mg/kg and 200 mg/kg were used, CCl4 was used for inducer liver toxicity, and liv52 drug used as positive control. Results: the extract has worthy hepatoprotective activity against CCl4 and the groups treated only Achillea millefolium extract as 100mg and 200mg the histological sections no showed any histopathologica...

The aim of the present study was to evaluate the antibacterial and antifungal activities of metha... more The aim of the present study was to evaluate the antibacterial and antifungal activities of methanolic and ethanolic leaf extracts of Argemone mexicana then formulate the best extract as topical semisolid formulations (cream and ointment). The extracts were subjected to qualitative tests, by screening of phytoconstituents that present in the extracts, and to quantitative tests by evaluation of antimicrobial activity using well agar diffusion method. The evaluation of antibacterial as well as antifungal activity were done against standard bacterial strains (Staphylococcus aureus and Pseudomonas euroginosa) and standard fungal strains (Asperigellus flavus and Candida albicans) respectively. Ciprofloxacin used as antibacterial positive control and fluconazole as antifungal positive control. Phytochemical screening showed the presence of alkaloids, flavonoids, tannins, phenolic, terpenoids, reducing sugars and steroids. The present study suggests the ethanolic leaf extract exhibit more ...

British Journal of Pharmaceutical Research, 2017

Aim of this Study: This study aimed to extract, formulate and evaluate an antibacterial ointment ... more Aim of this Study: This study aimed to extract, formulate and evaluate an antibacterial ointment from extracts of two Yemeni plants. Methods: The extraction of both Curcuma longa and Aloe vera was performed using alcoholic and hydro-alcoholic solvents, respectively. The in-vitro antibacterial activity of C. longa and A. vera extracts was investigated using well agar diffusion and disc diffusion method against Pseudomonas aeruginosa and Staphylococcus aureus, respectively. Finally, the ointment was prepared from a combination of these two extracts then stability study testing was performed and also the in-vitro activity antibacterial of this ointment against the above bacteria was done. Results: The extracts inhibited the growth of both bacteria with zone of inhibition between 6 mm-14mm at 0.52 mg-20 mg/100 µl. The MIC of C. longa and A. vera extract were 0.25 mg/100 µl and Original Research Article

British Journal of Pharmaceutical Research, 2015

Thai Journal of Pharmaceutical Sciences (TJPS), Mar 7, 2021

International Current Pharmaceutical Journal, 2014

Potash alum has different traditional application including deodorant and astringent. In order to... more Potash alum has different traditional application including deodorant and astringent. In order to wide advancement in development of pharmaceutical and cosmetic industries we preferred to work in this field as well as for improvement of safety and efficacy of traditionally used natural products. The aim of the present study was to formulate deodorant potash alum as lotion dosage form and astringent as cream and gel dosage forms. The activity of potash alum against axillaries normal microbiota was tested in vitro using wells diffusion agar method for different concentrations (0.1% to 9%) on Mueller Hinton (MH) agar and the minimum inhibitory concentration (MIC) was determined as 2% and also subculture was done to determine the activity of potash alum as bacteriostatic. Alum powder has wide traditional usage as astringent to prevent bleeding from minor cuts and for its accelerated healing. Therefore, a more appropriate dosage form was designed in a suitable concentration (2% gel) to e...

Oral suspensions of antibiotics are mainly available as dry powders for reconstitution; many reco... more Oral suspensions of antibiotics are mainly available as dry powders for reconstitution; many reconstituted antibiotic suspensions are to be kept refrigerated in order to get the optimal benefit from the drug. However, many patients do not keep to the specified storage conditions for different reasons like no refrigerator and irregular power supply that may result in various degrees of degradation of the product. The aim of the study was to determine the stability of cefuroxime axetil (Brand name) oral suspension (125mg/5ml) at different temperature storage conditions (stored at room temperature/25°C and refrigerated 2-8°C conditions). This study investigated stability of cefuroxime axetil oral suspension at different temperature storage conditions of erratic power supply and no refrigeration. Three different batches from cefuroxime axetil 125mg/5ml oral suspensions (Zinnat) were reconstituted and stored in refrigerator (2-8°C) and the same batches are stored at room temperature 25°C...

Rosemary leaves extract are known to have a significant antioxidant properties. This is because p... more Rosemary leaves extract are known to have a significant antioxidant properties. This is because presence of some compounds, mainly phenolic diterpenes, which is responsible for these antioxidant properties. This study aimed to extract rosemary and prepared as antiwrinkle cream and gel. These dosage forms were prepared using 0.5% concentrations of extract for cream and gel; after evaluate the antioxidant capacity of extract using DPPH method and that was compared against standard antioxidant, ascorbic acid. The results showed that rosemary has a high antioxidant capacity 71.17% compared with antioxidant capacity of ascorbic acid was 93.58%. Finally accelerated stability study was carried out at 25C with 65%RH and 40C with 75%±5%RH for one month and evaluation tests were done for pH, viscosity, spreadability, extrudability, and assay of antioxidant activity. The results of stability study showed no changes in formulations after keeping at different conditions for one month.

The development of controlled release drug delivery systems has increased, the release of drug fr... more The development of controlled release drug delivery systems has increased, the release of drug from the dose is the most important step in controlled release dosage form design and to confirm the release is done properly, the kinetic study must be take placed which described the overall release of drug from the dosage forms, because qualitative and quantitative changes in a formulation may alter drug release and in vivo performance, developing tools that facilitate product development by reducing the necessity of bio-studies is always desirable. In this regard, the use of in vitro drug dissolution data to predict in vivo bio-performance can be considered as the rational development of controlled release formulations. The aim of this study is to evaluate drug release parameters as per various release kinetic models. The tablets were characterized by physical and chemical parameters and results of assay% for the three batches were found as 102.07(S.D = 1.11), 99.87(S.D = 1.45) and 100...

Background: Jatropha variegata Vahl is a well-known Yemeni medicinal shrub, used traditionally to... more Background: Jatropha variegata Vahl is a well-known Yemeni medicinal shrub, used traditionally to treat wounds. Objectives: To investigate the wound-healing and antibacterial properties of the J. variegata extract as a new gel formula. Methods: The leaves and stems of J.variegata were collected from Ibb Province, Yemen, and extracted by maceration in methanol. To ensure the quality and effectivity of the extract, physicochemical and biological investigations were conducted. Finally, the extract was prepared as a gel dosage form for bacterial and experimental animal studies. Twelve female Albino rats were divided into three groups: each rat was inflicted by three wounds. The first wound was treated thrice a day using the gel containing the J. variegata extract, the second was treated by a gel without the extract, and the third was control. The first, second, and third groups were treated for 5, 10, and 15 days, respectively, with follow-up of the wounds’ diameters. After treatment,...

Pharmaceutical and Biomedical Research