Abdullah Gul - Academia.edu (original) (raw)

Papers by Abdullah Gul

Urology Journal, Sep 7, 2022

Van Sağlık Bilimleri Dergisi, Dec 15, 2018

Üri ner si stemi n en s ık kans eri ol an mes ane kans erl eri ni n % 90'dan fazl ası nı ürotely ... more Üri ner si stemi n en s ık kans eri ol an mes ane kans erl eri ni n % 90'dan fazl ası nı ürotely al kans erl er ol uş turur (Siegel ve ark., 2017; Spi ess ve ark., 2017). Ürotely al kans er, y aş amı n 6. dekatı nda pik y apan, 40 y aşı n al tı nda nadi r görül en bi r has tal ıktı r (Pol etajew v e ark., 2012). Genç y aş grubunun geneli nde kas i nv azyonu görülmezken, yaş ilerledikçe kas invazyon oranı artmaktadı r (Poletajew v e ark., 2012).

Van Medical Journal, 2017

Archivos espanoles de urologia, 2020

OBJECTIVES Although the association between 5 alpha reductase inhibitors used for the treatment o... more OBJECTIVES Although the association between 5 alpha reductase inhibitors used for the treatment of both androgenetic alopecia and benign prostatichy perplasia and their side effects is well established, the impact of dutasteride on testicular structure is not clear. To evaluate the alterations in spermatogenesis and serum FSH, LH, testosterone and dihydrotestosterone concentrations along with the oxidative status in testes and blood of the rats treated with daily dutasteride. METHODS A total of 18 male Sprague-Dawley rats have been divided into 2 groups as control (n=8) and dutasteride (n=10). After chronically administered, rats were sacrificed and their testes were harvested for histopathologica land biochemical evaluation. Johnsen's criteria were used to assess spermatogenesis. Serum hormone concentrations and levels of reactive oxygenspecies (ROS) in both testicular tissue and serum were measured by ECLIA and ELISA, respectively. Results were compared with Mann- Whitney U t...

Urologia Internationalis, 2021

Purpose: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted primarily vi... more Purpose: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted primarily via respiratory droplets and enters host cells through angiotensin-converting enzyme 2 (ACE-2) receptors. ACE-2 receptors have been identified in many tissues including testes. The aim of the study has been to investigate the long-term effects of SARS-CoV-2 infection (COVID-19) and its relative treatment on male reproductive health. Methods: Cross-sectional analysis has been performed on 49 recovered COVID-19 patients who had semen analysis prior to the COVID-19 pandemic. Those who had a recovery time lag of at least 3 months have been re-examined, and 29 eligible patients with no andrological problems have been enrolled in the study. Following a detailed physical examination and retrieval of medical history, the values of semen analysis and serum sex hormone parameters have been collected and compared before and after COVID-19 infection. The p value of <0.05 has been considered signifi...

Investigative and Clinical Urology, 2020

Like in a DNA double helix, the progress in the capacity to design detection devices runs paralle... more Like in a DNA double helix, the progress in the capacity to design detection devices runs parallel with the advances in the creation of genetically modified microorganisms. The links of these two spirals is constituted by the extensive and freely available information on the new detectors development and research and experimentation with microorganisms. In a near future, this phenomenon could lead to a race between detection devices designers and proliferators or terrorist groups that may access to the information and technology required to counter them. This paper highlights the relevance of protecting critical know-how and intangible technology in order to deter or limit the capacity of proliferators in the biological arena.

Archivio Italiano di Urologia e Andrologia, 2020

Objectives: Urinary tract infection (UTI) is the second most common cause of infection among all ... more Objectives: Urinary tract infection (UTI) is the second most common cause of infection among all infectious diseases at hospitals. Antibiogram results are needed to maintain treatment in patients with suspected UTI. However, empirical antibiotic treatment is initiated in patients since it takes time to obtain the results of antibiograms. The aim of this study was to evaluate the urine culture and antibiogram results of patients who were admitted to our hospital with suspected UTI and compare the results with other studies. Methods: Urine cultures requested from the hospital information system database between January of 2018 and 2019 were analyzed. Microorganism-positive urine samples and antibiogram results were evaluated and included in the study. Results: Of the patients, 748 (61.8%) were female and 463 (38.2%) were male. The average age of all patients was 44.9 years. Escherichia coli was the most frequently isolated microorganisms from urine cultures (n = 828, 68.4%). Among all...

Prostate International, 2020

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

The Bulletin of Urooncology, 2020

Prostate sarcomas originate from the mesenchymal tissues including smooth muscle, fibromuscular s... more Prostate sarcomas originate from the mesenchymal tissues including smooth muscle, fibromuscular stroma, paraganglia, nerves, and blood vessels. They account for less than 0.1% of all prostate tumors and often present with obstructive symptoms. Patients with leiomyosarcoma of the prostate commonly have poor prognosis and their life expectancy varies between 0% and 60% depending on the stage of the disease at the initial diagnosis. Histopathological examination is essential for definitive diagnosis, and can be performed at an early stage using guided transrectal prostate biopsy. Since prostate specific antigen levels are generally normal, digital rectal examinations are extremely important. We report on a 50-year-old man who was diagnosed with leiomyosarcoma based on the histopathology of his transurethral prostatectomy specimen.

Archivos españoles de urología, 2020

espanolOBJETIVOS: Aunque la asociacion entre los inhibidores de la 5’alfa reductasa y el tratamie... more espanolOBJETIVOS: Aunque la asociacion entre los inhibidores de la 5’alfa reductasa y el tratamiento de la alopecia y de la hiperplasia benigna de prostata esta bien establecido, el impacto de dutasteride en la estructura testicular no esta claro. El objetivo de este trabajo es evaluar las alteraciones en la espermatogenesis y concentraciones de FSH, LH, testosterona y dihidrotestosterona junto con el estado oxidativo del testiculo y en sangre de ratas con la administracion diaria dedutasteride. METODOS: Un total de 18 ratas Sprague Dawle fueron divididas en 2 grupos: control (n=8) y dutasteride (n=10). Despues de una administracion cronica de dutasteride, las ratas fueron sacrificadas y los testiculos se analizaron del punto de vista anatomopatologico y bioquimico. Los criterios de Johnsen fueron utilizados para valorar la espermatogenesis. Los niveles sericos hormonales y de especias reactivas del oxigeno en el tejido testicular y serum fueron medidos con ECLIA y ELISA respectivam...

The Aging Male, 2020

Aim: To investigate the effect of tadalafil in rats administered with daily dutasteride. Methods:... more Aim: To investigate the effect of tadalafil in rats administered with daily dutasteride. Methods: Twenty-four Sprague–Dawley male rats were allocated to three groups as control (group C), dutasteride (group D) and dutasteride plus tadalafil (group D + T). After a month of treatment, serum samples were obtained from rats to measure dihydrotestosterone and total testosterone. Nitric oxide (NO) synthase (NOS) immunoreactivity and levels of NOS enzyme isoforms, NO and cyclic guanosine monophosphate (cGMP) were evaluated in the harvested penile tissues. Also, corporal smooth muscle and collagen were examined. Results: Staining intensities of neuronal NOS and endothelial NOS were significantly lower in group D (p < .05). They were similar between group C and group D + T. Immunoreactivity of inducible NOS was observed higher in group D than group C (p = .01) whereas group D + T had the highest iNOS (p<.001). ELISA revealed similar outcomes in terms of NOS enzyme isoform levels. The...

Klinefelter syndrome (KS) is one of the most common congenital chromosomal abnormalities and one ... more Klinefelter syndrome (KS) is one of the most common congenital chromosomal abnormalities and one of the most common causes of infertility in men. As there are mosaic forms (eg. 47,XXY/46,XY; 47,XXY/46,XX), there are also non-mosaic forms (eg. 47,XXY; 48,XXY; 49,XXXXY; 48,XXYY) of the disease. Although the clinical findings are variable, the mosaic forms have milder phenotype than non-mosaic forms. In addition to common features, some rare findings such as Persistent Mullerian Duct Syndrome, micropenis, cryptorchidism, and hypospadias may accompany the disease. We report here a 27-year-old male 47,XXY/46,XY (80%/20% respectively) mosaic type KS patient with unusual abnormalities like scrotal hyperpigmentation and evident intellectual disability as well as known ones and discuss it in the context of the literature.

Medeniyet Medical Journal, 2018

Renal artery occlusion results commonly from thromboembolism to renal artery from distant vascula... more Renal artery occlusion results commonly from thromboembolism to renal artery from distant vascular system. Hyperhomocysteinemia is one of the hereditary hypercoagulability reasons. In order to elicit ethiology in the cases of arterial thrombosis, necessity of hypercoagulopathy screening tests is still controversial. Diagnosis of renal artery thromboembolism should be remembered in the patients who develop postoperative anuria and renal angiographic intervention must be performed immediately for thrombolytic therapy after renovascular imaging. We report a case of a 54-year-old woman with renal artery embolism on the contralateral kidney due to hyperhomocysteinemia after an open left radical nephrectomy.

Eastern Journal Of Medicine, 2018

Aromatic amines and polycyclic aromatic hydrocarbons are chemical carcinogens that stimulate urot... more Aromatic amines and polycyclic aromatic hydrocarbons are chemical carcinogens that stimulate urothelial cell dysplasia and result in bladder cancer. Bladder outlet obstruction due to BPH may increase the contact time of any potential carcinogens in the urine to the bladder urothelium. We aimed to compare the post-void residual (PVR) urine volume between recurrent and nonrecurrent nonmuscle invasive bladder cancer (NMIBC) patients with concomitant lower urinary tract symptoms (LUTS). A total of 480 patients with NMIBC were operated at our institution between May 2014 and May 2018. Of these patients, 93 men with concomitant LUTS were identified. After excluding 40 men who quitted smoking, 53 smoker men were included in study. Patient age, smoking habits, grade and stage of tumor, risk group of the tumor were recorded along with presence of recurrence. PVR urine volume was compared between patients with recurrent and nonrecurrent NMIBC. The mean age was similar between patients with recurrent (n=17) and nonrecurrent (n=36) NMIBC (p = 0.475). The amount of smoking (pack year) was not different between the two groups (p = 0.407). The grade and stage of tumors were also statistically insignificant in both groups. Mean PVR urine volume was higher in patients with recurrent (88 mL) compared to nonrecurrent(62 mL) group. However, these results were not statistically significant (p = 0.548). We believe that the lower PVR urine volume, the lower risk for bladder cancer recurrence, although we couldn't prove this hypothesis statistically. Further clinical studies are needed to confirm the relationship between those.

Eastern Journal Of Medicine, 2017

Dermoid cysts are developmental benign anomalies and comprise at least two germ layer tissue. Der... more Dermoid cysts are developmental benign anomalies and comprise at least two germ layer tissue. Dermoid cyst is usually known to be of primordial germ cell origin; however, there are some rare cases in which they have been noticed in other midline and paraxial organs. Although they generally settle in ovaries, they might be found in other tissues such as urinary bladder. Dermoid cyst should be kept in mind as a differential diagnosis for unusual presentation and histopathological appearances in bladder mass and should also be known that there is no need for further following up. We report a case of a 47-year-old woman with bladder dermoid cyst being the first case report from Turkey as a bladder mass resected endoscopically.

Translational Surgery, 2018

Aim: There are several treatment modalities for testosterone replacement therapy (TRT), including... more Aim: There are several treatment modalities for testosterone replacement therapy (TRT), including topical gels, subcutaneous testosterone pellets, transdermal patches, intramuscular injectables and oral forms. Despite the increasing usage of testosterone, there is limited information concerning patient adherence and compatibility of TRT. The aim of this study is to evaluate the factors which may have an impact on patients' adherence to TRT with topical gel. Methods: Between January 2013 and September 2013, 60 men from a tertiary urology clinic, who were prescribed 50 mg testosterone topical gel, were telephonically contacted to know if they continued or discontinued TRT, and when discontinued, the reasons for the same. Results: The mean age of the patients was 40.9 ± 9.9 (range: 21–59) years. The participation rate for the study through telephone was 51.6% (31/60). The most common reason for discontinued TRT was lack of perceived efficacy [n = 11 (35.5%)]. Factors, including age, weight, height, relationship status, and presence of comorbidity, were not associated with TRT adherence. The mean (standard error) time to TRT withdrawal was 5.9 (0.9) months. Conclusion: Most men voluntarily decided to discontinue testosterone and thus a close monitoring of patients by clinicians is essential to increase TRT adherence rate, with testosterone topical gel.

Türk Üroloji Dergisi/Turkish Journal of Urology, 2019

printing of pelvic fracture urethral injuries-fusion of technology and urethroplasty.

Urolithiasis, 2019

Various analgesic applications can be used during extracorporeal shock wave lithotripsy (SWL) for... more Various analgesic applications can be used during extracorporeal shock wave lithotripsy (SWL) for pain relief and maximal success rate. Intracutaneous sterile water injection (ISWI) has been shown to be effective in several types of pain, but a gap exists about its use during SWL. In this paper, we aimed to evaluate the effect of ISWI during SWL and compare that with diclofenac sodium injection used commonly to provide ideal patient contentment. Patients with kidney stone were randomized to have either ISWI therapy or intramuscular non-steroid anti-inflammatory drug (diclofenac sodium) injection. Using a syringe, 2-3 ml of sterile water was administered to the triangle area bounded by the 12th costal margin, the iliac crest and the vertebral spine in prone position. Visual analog scale (VAS) was employed to record pain scores of patients. Other parameters including stone size, SWL duration, total shock waves given, used energy and the necessity of rescue analgesia were also noted. A total of 524 patients were recruited, of those 216 patients were treated with ISWI and 308 patients had diclofenac sodium injections. The characteristics of the patients and shockwave therapy did not differ significantly between the two groups. Although the mean VAS scores prior to SWL and at every voltage increment during the procedure did not differ, more patients in the diclofenac sodium injection group required rescue analgesia with significantly greater side effects. ISWI is found to be as effective as the diclofenac sodium injection for pain management during SWL with lower adverse event rates.

Revista Internacional de Andrología, 2018

Introduction and objectives: Although nocturnal emission (NE) is an integral part of normal sexua... more Introduction and objectives: Although nocturnal emission (NE) is an integral part of normal sexual function of males, little information has been documented in the literature. We aimed to assess masturbation habits and frequency of NE among virgin male religious Muslim teenagers. Materials and methods: A questionnaire was administered to students staying in a religious dormitory or attending a religion course. Data of 113 male-respondents including demographic characteristics, masturbation habits and frequency of NE were collected. Results: The mean age of students was 15.88 ± 1.47 (range: 13-20) years. Of the students, 46(41.4%) reported that they never masturbated and 19 (17.3%) never experienced NEs. NE frequency was not correlated with age (p = 0.092). Having NEs was not related to the time since last masturbation either (p = 0.479). Subjects watching TV more than 3 h/day had more NEs than the ones watching less (p = 0.006). Of the subjects 13.6%, 12.6% and 67% believed that masturbation is halal, permissible and forbidden by religion, respectively whereas these rates were 59.1%, 20.4% and 7.5% for NE. Conclusions: Although masturbation and NE are frequent among virgin male religious Muslim teenagers, a significant proportion of young men believe that only masturbation, but not NE, is forbidden by religion. Watching TV seems to be associated with the frequency of NEs. Further studies are required to elicit the factors affecting frequency of NEs.

Androloji Bülteni, 2018

Serum total prostat spesifik antijen (PSA) keşfedildiğinden beri prostat kanserinin (PCa) taramas... more Serum total prostat spesifik antijen (PSA) keşfedildiğinden beri prostat kanserinin (PCa) taramasında yaygın olarak kullanılan çok önemli bir belirteç olmaya devam etmektedir. [1,2] PSA seviyesi, PCa'ya spesifik olmayıp ek olarak benign prostat hiperplazisi (BPH) ve akut veya kronik prostatit gibi benign durumlar ile üretral enstrümantasyon ve ABSTRACT OBJECTIVE: Inflammation is one of the most common histological evidence when prostate biopsy specimens of patients presenting with high PSA (Prostatespecific antigen) levels are examined, but little is known about its effect on PSA levels. This study was conducted to evaluate whether C-reactive protein (CRP) and sterile pyuria has clinical significance in histologically-detected asymptomatic prostatitis cases. MATERIAL and METHODS: In this article, the data were obtained by a crosssectional and prospective clinical study. One hundred eleven consecutive patients without clinical prostatitis had normal digital rectal examination findings, PSA levels ranging from 3 to 20 ng/mL, and sterile urine culture results. All of them underwent transrectal ultrasound-guided 12-core prostatic biopsy. Preoperatively, patients who had urinary leukocyte count 3 or less than 3/high power field (h.p.f) were classified as non-pyuria, while those with urinary leukocyte count more than 3/high power field (h.p.f) were classified as pyuria. The serum CRP level was also used to categorize patients before the biopsy. The subgroups were compared regarding a number of clinical variables. RESULTS: Histological examination revealed inflammation in 69% of pyuria patients and 38.9% of non-pyuria patients. Histologically-detected inflammation rate was significantly different in the groups (p=0.008). The pyuria group exhibited significantly higher total PSA levels compared to the non-pyuria group (p=0.041), as well as significantly higher serum CRP levels (p=0.001). CRP positive and negative groups were similar regarding clinical variables and histologically-detected inflammation rates. CONCLUSION: It has been shown that prostatic inflammation can be detected more reliably with urinary leukocyte count rather than serum CRP. Patients with pyuria exhibited high levels of serum PSA. Sterile pyuria should be kept in mind as a cause of elevated PSA in patients without clinical prostatitis findings. Urinary leukocyte count should be incorporated in routine urological evaluation thanks to its simplicity, convenience, and non-invasiveness.