Abdulsamie Alta'ee - Academia.edu (original) (raw)

Papers by Abdulsamie Alta'ee

Journal of Biomedicine and Biochemistry

Background The peptide hormones parathyroid hormone (PTH) and calcitonin (CT) both work on osteob... more Background The peptide hormones parathyroid hormone (PTH) and calcitonin (CT) both work on osteoblasts (bone-forming cells) and osteoclasts (bone-resorbing cells) to regulate calcium homeostasis. Aims of the study This study aimed to evaluate the changes in serum levels of parathyroid hormone and calcitonin in pregnant and non-pregnant women in Babylon Governorate, Iraq. Materials and methods This study designs as a case-control study performed on pregnant women who attended Women's and Children's Hospital in Hilla and Shomali General Hospital in Babylon Governorate. Forty pregnant women with a range age (18-40 years) and 50 healthy subjects with non-pregnant women with range age (18-40 years) visited the hospital for routine checkups without any history of chronic diseases, acute illness and infection. The biochemical parameters were determined by the sandwich ELISA technique. Results The results show a significant increase in levels of parathyroid hormone (PTH) and calcitonin (CAL) in pregnant as compared with the non-pregnant group (277.7 ± 47.87 ng/mL),(72.58 ± 12.76 ng/mL) and (21.89 ± 4.412 ng/mL), (9.65 ± 1.921 ng/mL) respectively. The significant difference (p-value < 0.0001). Conclusion In conclusion, the present study finds that pregnant women experience significant hormonal changes in PTH and CT, which indicates the necessity of diagnosing these changes and treating them for the success of this pregnancy.

Monatshefte für Chemie - Chemical Monthly

Medical Journal of Babylon, 2004

International journal of health sciences

Androgens play critical roles in prostate carcinogenesis as well as prostate cancer progression. ... more Androgens play critical roles in prostate carcinogenesis as well as prostate cancer progression. Androgen-deprivation therapy (ADT), which reduces testosterone production and inhibits androgen action in prostate cancer cells, has been the criterion standard therapy for metastatic prostate cancer (1). Although initially most prostate cancers respond well to ADT, most patients eventually progress to castration-resistant prostate cancer (CRPC), which is mainly thought to be because androgen receptor reactivation is induced by several mechanisms. One of those mechanisms have been identified to be intratumoral androgen synthesis mostly from adrenal precursor steroids and at least in part due to de novo synthesis from cholesterol which is supported by increased expression of several genes encoding steroidogenic enzymes including HSD3B, HSD17B, and SRD5A in CRPC. Among them, HSD3B1 gene encodes 3β-hydroxysteroid dehydrogenase-1, which is mainly expressed in peripheral tissues including the...

Journal of Forensic Medicine, 2020

Background: The heritability of rheumatoid arthritis (RA) is approximately 40% to 65% for seropos... more Background: The heritability of rheumatoid arthritis (RA) is approximately 40% to 65% for seropositive RA and 20% for seronegative RA. The risk of developing RA has been associated with human leukocyte antigen HLA-DRB1 alleles: HLA-DRB1*04, HLA-DRB1*01, and HLA-DRB1*010 in deferent ethnocentrism. These HLA-DRB1 alleles contain a stretch of conserved five amino acid sequence, the shared epitope (SE), in the third hypervariable region of their DRB1 chain, which has been associated with the risk of developing Aim of the study: to study the possible association of HLA-DRB1 gene polymorphism of Arabic ethnocentrism PA patients in Babylon Province, Iraq. Patients and methods: The present case control study was conducted on sixty one patients (18 males and 43 females) of Arabic ethnocentrism RA patients admitted to Rheumatoid Unit in Merjan Teaching Medical City, Babylon Province, Iraq, as well as 127 apparently healthy control subjects (41 males, 86 females) as control group. Results: T...

International Journal of Fertility & Sterility, 2020

Background Uric acid (UA) is crucial for sperm metabolism as it protects seminal plasma against o... more Background Uric acid (UA) is crucial for sperm metabolism as it protects seminal plasma against oxidative dam- age. Zinc also plays a central role in sperm metabolism. The current study was designed to investigate the role of zinc supplementation on qualitative and quantitative properties of seminal fluid, in parallel with the UA level and urate pathway enzymes in the semen of patients with asthenozoospermia. Materials and Methods The study was designed as a randomized controlled trial of 60 asthenozoospermic subfertile men. The current study, which was conducted during one year, involved 60 fertile and 60 asthenozoospermic subfertile men belonging to Hilla City, Iraq. Semen samples were obtained from the participants before and after treatment with zinc supplements. The levels of UA, xanthine oxidase (XO), adenosine deaminase (ADA) and 5'-nucleotidase (5'-NU) activities were determined in spermatozoa and seminal plasma of both groups. Results UA levels (P=0.034) and 5'-...

Diabetes mellitus is a chronic illness required ongoing medical care. As a result, laboratory tes... more Diabetes mellitus is a chronic illness required ongoing medical care. As a result, laboratory testing has become an essential part of the evaluation and monitoring process in diabetes management. Further tests are required to establish the correlation between hyperglycemia and other disease parameter. Therefore, the correlation between cardiovascular disease risk factor values and uric acid levels in sera of adult patients with type 1 diabetes mellitus (without renal diseases) and healthy controls have been studied. Total cholesterol, HDL-cholesterol and uric acid in sera of 52 patients (36 males and 16 females) with poor hyperglycemic control type 1 diabetes mellitus and 30 healthy controls (19 males and 11 females) were determined. Results of present study show significantly higher risk factor values (P < 0.001), which means increasing in the probability of atherosclerosis incidence. Also hyperglycemia found to be associated with hyperuricemia in type 1 diabetic patients.

Archives of Dermatological Research, 2012

The pathogenesis of seborrheic dermatitis (SD) has not been clearly identified, and many factors ... more The pathogenesis of seborrheic dermatitis (SD) has not been clearly identified, and many factors are thought to play a role in its development. Recently, new studies have focused on increased oxidative stress (OS) in T cell-mediated skin diseases like psoriasis, contact dermatitis, and atopic dermatitis. However, there is no study investigating the status of OS in SD. In this study, we aimed to determine the status of OS in SD and the correlation of disease severity with OS. Fifty-four patients who were clinically and/or histopathologically diagnosed with SD were included in the study. Fifty-four healthy volunteers constituted the control group. Disease severity in patients with SD was scored according to the Seborrheic Dermatitis Area and Severity Index (SDASI). Serum total antioxidant status (TAS) and total oxidative status (TOS) were measured, and the oxidative stress index (OSI) was calculated in all patients and control subjects. The mean TAS values were significantly lower in the patient group than in the control group (p = 0.024). However, patients had significantly higher TOS and OSI values than the controls (p \ 0.05). There was no correlation between SDASI and TAS, TOS, and OSI values. In this study, the association of oxidative stress and disease activity has first investigated in seborrheic dermatitis. It was found that OS was significantly higher in SD patients than in healthy subjects. In conclusion, our findings point to the possible role of the OS for the etiopathogenesis of SD.

Research Journal of Pharmacy and Technology, 2018

Journal of Global Pharma Technology, 2018

Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease affects 0.5-1% of the worl... more Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease affects 0.5-1% of the worldwide population, of unknown etiology, characterized by chronic inflammation of the synovial joints, hyperplasia, and overgrowth of synoviocytes, with the destruction of articular cartilage that can cause serious weakness and inability to work. Objective: The present study aims to investigate the possible association between tumor necrosis factor alpha (TNF-α) levels and (-308 G/A) TNF-α promoter polymorphism in patients with RA in Babylon Province. Patients and Methods: This study was designed as a case control. Forty-five (10 males, 35 females) patients with RA and forty-five (9 males, 36 females) apparently healthy persons as control with the compatible age and sex were enrolled in this study. Serum level of TNF-α and anti-cyclic citrullinated peptide antibodies (ACCPA) were measured using enzyme-linked immunosorbent assay (ELISA) method. Disease activity of RA patients was assessed u...

Indian Journal of Public Health Research and Development, 2020

Polycystic ovary syndrome (PCOS) is the commonest gynecological endocrinopathy, is characterizedb... more Polycystic ovary syndrome (PCOS) is the commonest gynecological endocrinopathy, is characterizedby chronic anovulation and hyperandrogenism and is also associated with increase insulin secretion andmetabolic disease and insulin resistance. Present study aims to examine the association between the singlenucleotide polymorphism (rs1799817) of exon 17 of the insulin receptor (INSR) gene and polycystic ovarysyndrome (PCOS) in a Babylon women. Fifty women with PCOS and fifty healthy Iraqi women, age andBMI matching were achieved between study groups. Biochemical parameters that estimated were fastingglucose, fasting insulin, luteinizing hormone, testosterone. His 1058 C/T polymorphism at the tyrosinekinase domain in the INSR gene was analyzed by restriction fragment length polymorphism (RFLPPCR). Significant increase in the levels of fasting glucose fasting insulin, HOMA-IR, LH, testosteronewere noticed in patient when compared with control. TT genotype frequency was higher in PCOS patie...

Background: There is accumulating evidence for a link between posttraumatic stress disorder (PTSD... more Background: There is accumulating evidence for a link between posttraumatic stress disorder (PTSD) and reduced health status for terror attack victims. Objective: To assess the oxidants/ antioxidant status in patients with PTSD. Patients and Methods: 70 Iraqi subjects (59 males, 11 females) witnessed on Alnasej Factory explosion occurred at 10 June 2010 in Hilla city of Iraq, as well as 35 apparently healthy persons served as a controls group (21 males, 14 females) were subjected to present study. Participants were grouped to four groups according to PTSD Checklist (PCL) scores. Antioxidant enzymes superoxide dismutase (SOD) catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), and lipid peroxidation were determined using spectrophotometric methods Results: The antioxidant enzymes activities, SOD, GPx, and peroxidation product MDA, found to be insignificantly increased in the present study, whereas, the antioxidant enzyme activity CAT and non-enzymatic antioxidant...

Adenomyosis is a commonly encountered benign uterine disease, affecting 19.5% of women of reprodu... more Adenomyosis is a commonly encountered benign uterine disease, affecting 19.5% of women of reproductive age. Histopathologically it is characterized by the presence of ectopic endometrial tissue (endometrial glands and/or stroma) in the myometrium, surrounded by hyperplastic and hypertrophic smooth muscle. This study aims to determine if moesin (MSN) is a useful biomarker for detecting of women with adenomyosis and if there possible association with oxidative stress. The study included 90 women divided into two groups (45) healthy and (45) patients, and experimental research work was conducted during the period (from first of October 2020 to the end of January 2021) ELISA technique was used to measures human MSN and total antioxidant capacity (TAOC) in the blood. The current study found a highly significant difference between patients and control groups in concentration of MSN where (p = 0.002) the level being higher in patients group. and there was no significant difference between ...

Journal of Global Pharma Technology, 2018

Psoriasis is multi-factorial disease resulted in response to increase secretion of inflammatory c... more Psoriasis is multi-factorial disease resulted in response to increase secretion of inflammatory cytokines or deficiency in certain vitamins such as vitamin D 3 . This study aims to evaluate the levels of vitamin D 3 and its receptor (VDR) in psoriatic patients and healthy control, additionally to determine the ratio between vitamin/receptor and their relative risk in the pathogenesis of psoriasis. This study was design as a case-control study and includes 45 psoriatic subjects and 45 healthy controls. The results of currents study were found a significant decrease in vitamin D 3 , VDR levels and vitamin D 3 / VDR ratio when compared with the healthy control group. The relative risk for VDR levels with psoriasis found to be positively significantly associated, whereas those for vitamin D 3 levels with psoriasis were insignificant. In conclusion, the relative risk for VDR is more than that for calicitriol and this support the pathogenic role of VDR abnormality in psoriasis. Key words:...

١٧ Abstract The use of black seed (Nigella sativa) capsules as a herbal therapy to lower blood gl... more ١٧ Abstract The use of black seed (Nigella sativa) capsules as a herbal therapy to lower blood glucose in diabetic patients are associated with menstrual cycle irregularities. The present study was designed to analyses and to compare between two types of Nigella sativa (N.sativa) agricultures in Mosul region and those imports from Saudi Arabia Kingdom, and to investigate the levels of hormones in volatile oil of black seed that regulate menstrual cycle that might be present in Nigella sativa. Volatile oil of N.sativa was extracted by steam distillation using diethyl ether as an organic solvent.Then, hormones analysis were done using (miniVIDAS software version) instrument. Results of present study showed a presence of considerable amount of sex hormones estradiol, progesterone, prolactin, testosterone, FSH and LH .This might interpret the cause of menstrual cycle irregularities occur when black seed capsule was taken as a herbal therapy to lower blood glucose in diabetic patients. ة...

Journal of Natural Sciences Research, 2014

Natural products have been used for centuries in treating human disease . The present study aimed... more Natural products have been used for centuries in treating human disease . The present study aimed to determine the antibacterial ability of aluminum potassium sulfate (alum) and Syzygium aromaticum (clove) extract against different types of pathogenic bacteria in scientific way. Antimicrobial activity of crude extract from two commonly used medicinally materials, alum and clove were evaluated against four microorganisms over different concentration (10, 20, 30, 40 and 50) w/v %. Minimum inhibitory concentration (MIC) and the diameter of inhibition zone were determined by in vitro bioassay using agar well diffusion method against S . aureus , S. epidermidis , E. coli , Klebsiella pneumonia . The two medicinal materials exhibited antibacterial activity and inhibition growth of gram positive and gram negative bacteria isolated from different sites of infection. The inhibition effect of these extracts compared with standard antibiotics cefotaxime. In conclusions, the results of present ...

Medical Journal of Babylon, 2012

Background: Thyroid hormones are important at cellular level, affecting nearly every type of tiss... more Background: Thyroid hormones are important at cellular level, affecting nearly every type of tissue in the body. Objectives: The present study was carried out to determine whether thyroid hormones affect lipid profile in patients with hyperthyroidism. Materials and Methods: This study was carried out on 22 hyperthyroid patients (11 men and 11 women), with mean age 48.5±13.1 years and 24 apparently healthy control (12 men and 12 wome), with mean age 49.5±11.4 years). Serum levels of, thyroid stimulated hormone TSH, thyroxine (T4) and triiodothyronine (T3) were measured by ELISA technique, and total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and Triglyceride (TG) were measured spectrophotometrically, while lowdensity lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C ) were calculated. Results: Thyroid stimulated hormone TSH, lipids and lipoproteins (TC, TG, HDL-C, LDL-C, VLDL-C ) levels of patients were significantly lower than t...

Journal of Biomedicine and Biochemistry

Background The peptide hormones parathyroid hormone (PTH) and calcitonin (CT) both work on osteob... more Background The peptide hormones parathyroid hormone (PTH) and calcitonin (CT) both work on osteoblasts (bone-forming cells) and osteoclasts (bone-resorbing cells) to regulate calcium homeostasis. Aims of the study This study aimed to evaluate the changes in serum levels of parathyroid hormone and calcitonin in pregnant and non-pregnant women in Babylon Governorate, Iraq. Materials and methods This study designs as a case-control study performed on pregnant women who attended Women's and Children's Hospital in Hilla and Shomali General Hospital in Babylon Governorate. Forty pregnant women with a range age (18-40 years) and 50 healthy subjects with non-pregnant women with range age (18-40 years) visited the hospital for routine checkups without any history of chronic diseases, acute illness and infection. The biochemical parameters were determined by the sandwich ELISA technique. Results The results show a significant increase in levels of parathyroid hormone (PTH) and calcitonin (CAL) in pregnant as compared with the non-pregnant group (277.7 ± 47.87 ng/mL),(72.58 ± 12.76 ng/mL) and (21.89 ± 4.412 ng/mL), (9.65 ± 1.921 ng/mL) respectively. The significant difference (p-value < 0.0001). Conclusion In conclusion, the present study finds that pregnant women experience significant hormonal changes in PTH and CT, which indicates the necessity of diagnosing these changes and treating them for the success of this pregnancy.

Monatshefte für Chemie - Chemical Monthly

Medical Journal of Babylon, 2004

International journal of health sciences

Androgens play critical roles in prostate carcinogenesis as well as prostate cancer progression. ... more Androgens play critical roles in prostate carcinogenesis as well as prostate cancer progression. Androgen-deprivation therapy (ADT), which reduces testosterone production and inhibits androgen action in prostate cancer cells, has been the criterion standard therapy for metastatic prostate cancer (1). Although initially most prostate cancers respond well to ADT, most patients eventually progress to castration-resistant prostate cancer (CRPC), which is mainly thought to be because androgen receptor reactivation is induced by several mechanisms. One of those mechanisms have been identified to be intratumoral androgen synthesis mostly from adrenal precursor steroids and at least in part due to de novo synthesis from cholesterol which is supported by increased expression of several genes encoding steroidogenic enzymes including HSD3B, HSD17B, and SRD5A in CRPC. Among them, HSD3B1 gene encodes 3β-hydroxysteroid dehydrogenase-1, which is mainly expressed in peripheral tissues including the...

Journal of Forensic Medicine, 2020

Background: The heritability of rheumatoid arthritis (RA) is approximately 40% to 65% for seropos... more Background: The heritability of rheumatoid arthritis (RA) is approximately 40% to 65% for seropositive RA and 20% for seronegative RA. The risk of developing RA has been associated with human leukocyte antigen HLA-DRB1 alleles: HLA-DRB1*04, HLA-DRB1*01, and HLA-DRB1*010 in deferent ethnocentrism. These HLA-DRB1 alleles contain a stretch of conserved five amino acid sequence, the shared epitope (SE), in the third hypervariable region of their DRB1 chain, which has been associated with the risk of developing Aim of the study: to study the possible association of HLA-DRB1 gene polymorphism of Arabic ethnocentrism PA patients in Babylon Province, Iraq. Patients and methods: The present case control study was conducted on sixty one patients (18 males and 43 females) of Arabic ethnocentrism RA patients admitted to Rheumatoid Unit in Merjan Teaching Medical City, Babylon Province, Iraq, as well as 127 apparently healthy control subjects (41 males, 86 females) as control group. Results: T...

International Journal of Fertility & Sterility, 2020

Background Uric acid (UA) is crucial for sperm metabolism as it protects seminal plasma against o... more Background Uric acid (UA) is crucial for sperm metabolism as it protects seminal plasma against oxidative dam- age. Zinc also plays a central role in sperm metabolism. The current study was designed to investigate the role of zinc supplementation on qualitative and quantitative properties of seminal fluid, in parallel with the UA level and urate pathway enzymes in the semen of patients with asthenozoospermia. Materials and Methods The study was designed as a randomized controlled trial of 60 asthenozoospermic subfertile men. The current study, which was conducted during one year, involved 60 fertile and 60 asthenozoospermic subfertile men belonging to Hilla City, Iraq. Semen samples were obtained from the participants before and after treatment with zinc supplements. The levels of UA, xanthine oxidase (XO), adenosine deaminase (ADA) and 5'-nucleotidase (5'-NU) activities were determined in spermatozoa and seminal plasma of both groups. Results UA levels (P=0.034) and 5'-...

Diabetes mellitus is a chronic illness required ongoing medical care. As a result, laboratory tes... more Diabetes mellitus is a chronic illness required ongoing medical care. As a result, laboratory testing has become an essential part of the evaluation and monitoring process in diabetes management. Further tests are required to establish the correlation between hyperglycemia and other disease parameter. Therefore, the correlation between cardiovascular disease risk factor values and uric acid levels in sera of adult patients with type 1 diabetes mellitus (without renal diseases) and healthy controls have been studied. Total cholesterol, HDL-cholesterol and uric acid in sera of 52 patients (36 males and 16 females) with poor hyperglycemic control type 1 diabetes mellitus and 30 healthy controls (19 males and 11 females) were determined. Results of present study show significantly higher risk factor values (P < 0.001), which means increasing in the probability of atherosclerosis incidence. Also hyperglycemia found to be associated with hyperuricemia in type 1 diabetic patients.

Archives of Dermatological Research, 2012

The pathogenesis of seborrheic dermatitis (SD) has not been clearly identified, and many factors ... more The pathogenesis of seborrheic dermatitis (SD) has not been clearly identified, and many factors are thought to play a role in its development. Recently, new studies have focused on increased oxidative stress (OS) in T cell-mediated skin diseases like psoriasis, contact dermatitis, and atopic dermatitis. However, there is no study investigating the status of OS in SD. In this study, we aimed to determine the status of OS in SD and the correlation of disease severity with OS. Fifty-four patients who were clinically and/or histopathologically diagnosed with SD were included in the study. Fifty-four healthy volunteers constituted the control group. Disease severity in patients with SD was scored according to the Seborrheic Dermatitis Area and Severity Index (SDASI). Serum total antioxidant status (TAS) and total oxidative status (TOS) were measured, and the oxidative stress index (OSI) was calculated in all patients and control subjects. The mean TAS values were significantly lower in the patient group than in the control group (p = 0.024). However, patients had significantly higher TOS and OSI values than the controls (p \ 0.05). There was no correlation between SDASI and TAS, TOS, and OSI values. In this study, the association of oxidative stress and disease activity has first investigated in seborrheic dermatitis. It was found that OS was significantly higher in SD patients than in healthy subjects. In conclusion, our findings point to the possible role of the OS for the etiopathogenesis of SD.

Research Journal of Pharmacy and Technology, 2018

Journal of Global Pharma Technology, 2018

Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease affects 0.5-1% of the worl... more Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease affects 0.5-1% of the worldwide population, of unknown etiology, characterized by chronic inflammation of the synovial joints, hyperplasia, and overgrowth of synoviocytes, with the destruction of articular cartilage that can cause serious weakness and inability to work. Objective: The present study aims to investigate the possible association between tumor necrosis factor alpha (TNF-α) levels and (-308 G/A) TNF-α promoter polymorphism in patients with RA in Babylon Province. Patients and Methods: This study was designed as a case control. Forty-five (10 males, 35 females) patients with RA and forty-five (9 males, 36 females) apparently healthy persons as control with the compatible age and sex were enrolled in this study. Serum level of TNF-α and anti-cyclic citrullinated peptide antibodies (ACCPA) were measured using enzyme-linked immunosorbent assay (ELISA) method. Disease activity of RA patients was assessed u...

Indian Journal of Public Health Research and Development, 2020

Polycystic ovary syndrome (PCOS) is the commonest gynecological endocrinopathy, is characterizedb... more Polycystic ovary syndrome (PCOS) is the commonest gynecological endocrinopathy, is characterizedby chronic anovulation and hyperandrogenism and is also associated with increase insulin secretion andmetabolic disease and insulin resistance. Present study aims to examine the association between the singlenucleotide polymorphism (rs1799817) of exon 17 of the insulin receptor (INSR) gene and polycystic ovarysyndrome (PCOS) in a Babylon women. Fifty women with PCOS and fifty healthy Iraqi women, age andBMI matching were achieved between study groups. Biochemical parameters that estimated were fastingglucose, fasting insulin, luteinizing hormone, testosterone. His 1058 C/T polymorphism at the tyrosinekinase domain in the INSR gene was analyzed by restriction fragment length polymorphism (RFLPPCR). Significant increase in the levels of fasting glucose fasting insulin, HOMA-IR, LH, testosteronewere noticed in patient when compared with control. TT genotype frequency was higher in PCOS patie...

Background: There is accumulating evidence for a link between posttraumatic stress disorder (PTSD... more Background: There is accumulating evidence for a link between posttraumatic stress disorder (PTSD) and reduced health status for terror attack victims. Objective: To assess the oxidants/ antioxidant status in patients with PTSD. Patients and Methods: 70 Iraqi subjects (59 males, 11 females) witnessed on Alnasej Factory explosion occurred at 10 June 2010 in Hilla city of Iraq, as well as 35 apparently healthy persons served as a controls group (21 males, 14 females) were subjected to present study. Participants were grouped to four groups according to PTSD Checklist (PCL) scores. Antioxidant enzymes superoxide dismutase (SOD) catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), and lipid peroxidation were determined using spectrophotometric methods Results: The antioxidant enzymes activities, SOD, GPx, and peroxidation product MDA, found to be insignificantly increased in the present study, whereas, the antioxidant enzyme activity CAT and non-enzymatic antioxidant...

Adenomyosis is a commonly encountered benign uterine disease, affecting 19.5% of women of reprodu... more Adenomyosis is a commonly encountered benign uterine disease, affecting 19.5% of women of reproductive age. Histopathologically it is characterized by the presence of ectopic endometrial tissue (endometrial glands and/or stroma) in the myometrium, surrounded by hyperplastic and hypertrophic smooth muscle. This study aims to determine if moesin (MSN) is a useful biomarker for detecting of women with adenomyosis and if there possible association with oxidative stress. The study included 90 women divided into two groups (45) healthy and (45) patients, and experimental research work was conducted during the period (from first of October 2020 to the end of January 2021) ELISA technique was used to measures human MSN and total antioxidant capacity (TAOC) in the blood. The current study found a highly significant difference between patients and control groups in concentration of MSN where (p = 0.002) the level being higher in patients group. and there was no significant difference between ...

Journal of Global Pharma Technology, 2018

Psoriasis is multi-factorial disease resulted in response to increase secretion of inflammatory c... more Psoriasis is multi-factorial disease resulted in response to increase secretion of inflammatory cytokines or deficiency in certain vitamins such as vitamin D 3 . This study aims to evaluate the levels of vitamin D 3 and its receptor (VDR) in psoriatic patients and healthy control, additionally to determine the ratio between vitamin/receptor and their relative risk in the pathogenesis of psoriasis. This study was design as a case-control study and includes 45 psoriatic subjects and 45 healthy controls. The results of currents study were found a significant decrease in vitamin D 3 , VDR levels and vitamin D 3 / VDR ratio when compared with the healthy control group. The relative risk for VDR levels with psoriasis found to be positively significantly associated, whereas those for vitamin D 3 levels with psoriasis were insignificant. In conclusion, the relative risk for VDR is more than that for calicitriol and this support the pathogenic role of VDR abnormality in psoriasis. Key words:...

١٧ Abstract The use of black seed (Nigella sativa) capsules as a herbal therapy to lower blood gl... more ١٧ Abstract The use of black seed (Nigella sativa) capsules as a herbal therapy to lower blood glucose in diabetic patients are associated with menstrual cycle irregularities. The present study was designed to analyses and to compare between two types of Nigella sativa (N.sativa) agricultures in Mosul region and those imports from Saudi Arabia Kingdom, and to investigate the levels of hormones in volatile oil of black seed that regulate menstrual cycle that might be present in Nigella sativa. Volatile oil of N.sativa was extracted by steam distillation using diethyl ether as an organic solvent.Then, hormones analysis were done using (miniVIDAS software version) instrument. Results of present study showed a presence of considerable amount of sex hormones estradiol, progesterone, prolactin, testosterone, FSH and LH .This might interpret the cause of menstrual cycle irregularities occur when black seed capsule was taken as a herbal therapy to lower blood glucose in diabetic patients. ة...

Journal of Natural Sciences Research, 2014

Natural products have been used for centuries in treating human disease . The present study aimed... more Natural products have been used for centuries in treating human disease . The present study aimed to determine the antibacterial ability of aluminum potassium sulfate (alum) and Syzygium aromaticum (clove) extract against different types of pathogenic bacteria in scientific way. Antimicrobial activity of crude extract from two commonly used medicinally materials, alum and clove were evaluated against four microorganisms over different concentration (10, 20, 30, 40 and 50) w/v %. Minimum inhibitory concentration (MIC) and the diameter of inhibition zone were determined by in vitro bioassay using agar well diffusion method against S . aureus , S. epidermidis , E. coli , Klebsiella pneumonia . The two medicinal materials exhibited antibacterial activity and inhibition growth of gram positive and gram negative bacteria isolated from different sites of infection. The inhibition effect of these extracts compared with standard antibiotics cefotaxime. In conclusions, the results of present ...

Medical Journal of Babylon, 2012

Background: Thyroid hormones are important at cellular level, affecting nearly every type of tiss... more Background: Thyroid hormones are important at cellular level, affecting nearly every type of tissue in the body. Objectives: The present study was carried out to determine whether thyroid hormones affect lipid profile in patients with hyperthyroidism. Materials and Methods: This study was carried out on 22 hyperthyroid patients (11 men and 11 women), with mean age 48.5±13.1 years and 24 apparently healthy control (12 men and 12 wome), with mean age 49.5±11.4 years). Serum levels of, thyroid stimulated hormone TSH, thyroxine (T4) and triiodothyronine (T3) were measured by ELISA technique, and total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and Triglyceride (TG) were measured spectrophotometrically, while lowdensity lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C ) were calculated. Results: Thyroid stimulated hormone TSH, lipids and lipoproteins (TC, TG, HDL-C, LDL-C, VLDL-C ) levels of patients were significantly lower than t...