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Papers by Abhijit Pethkar
Indian Journal of Gynecologic Oncology, Feb 14, 2019
Objective/BackgroundSynovial sarcoma (SS) is a clinically, morphologically, and genotypically dis... more Objective/BackgroundSynovial sarcoma (SS) is a clinically, morphologically, and genotypically distinctive neoplasm, accounting for approximately 10% of soft tissue sarcomas, which usually afflicts young-to-middle-aged adults and typically occurs in the deep soft tissues of the extremities, particularly the thigh and knee regions. The aim of this study is to describe a case of metastatic synovial sarcoma of vaginal wall with primary in the thigh. This is the first report documenting its occurrence in the vagina as a metastatic tumour. This is the first case of vaginal synovial sarcoma in the Indian literature.MethodA 57-year-old female presented with vaginal bleed. A thorough workup was done including clinical examination, histopathological examination of the biopsy from vaginal mass, IHC, and review of slides from the thigh swelling. A systematic literature review was conducted by searching the PubMed and National Centre for Biotechnology Information database.ResultPhysical examination revealed fleshy mass at the anterior vaginal wall and a thigh swelling. On histopathological examination of the vaginal mass followed by IHC, a diagnosis of synovial sarcoma was made and the slides of the thigh mass were reviewed which revealed similar morphology and IHC profile. Hence, a final diagnosis of synovial sarcoma of thigh with metastasis to vaginal wall was made. Four case reports of primary SS of the vagina were found on reviewing the literature.ConclusionTo the best of our knowledge, this is the first report documenting the occurrence of synovial sarcoma in the vagina as a metastatic tumour and overall fifth report to document its occurrence in the vagina. All other four previously reported cases were primary SS of the vagina.
The clear cell variant of mucoepidermoid carcinoma (MEC) has been described in the major and mino... more The clear cell variant of mucoepidermoid carcinoma (MEC) has been described in the major and minor salivary glands, oral cavity, skin and the bronchus. We report a case of clear cell variant of MEC of maxillary region in a 60 year old male who presented with a huge, disfiguring, lobulated maxillary mass. To our knowledge, this variant has not been previously reported in the maxillary region.
Background: Primary Plasma Cell Leukaemia (PPCL) in young patients has been evaluated in very few... more Background: Primary Plasma Cell Leukaemia (PPCL) in young patients has been evaluated in very few studies in the English literature. The aim of this study is to describe a case of PPCL in a young HIV infected male associated with EBV. This is first such case in Indian literature. This is an interesting study that reported a rare case where primary plasma cell leukaemia is observed in a young HIV infected male, which will be valuable case for future studies. Thorough clinical examinations were done and reported in detail. Methods: A 35 years old male presented with abdominal pain, backache and asthenia. A thorough workup was done including clinical examination, CBP, KFT, LFT, serology (HIV, HBsAg), Serum electrophoresis, radiology and bone marrow examination. A systematic literature review was conducted by searching the Pub Med and National Centre for Biotechnology Information database. Results: Patient had hepatosplenomegaly and icterus. Peripheral smear revealed atypical plasma cells (53%). Serum protein electrophoresis showed a monoclonal IgG-K paraprotein at a concentration of 4.56 (45 g/l) (Ref-0.10-0.40). Patient had hypoalbuminemia and raised liver enzymes. The serology test for HIV was reactive for HIV-I and II. Bone marrow examination showed
The clear cell variant of mucoepidermoid carcinoma (MEC) has been described in the major and mino... more The clear cell variant of mucoepidermoid carcinoma (MEC) has been described in the major and minor salivary glands, oral cavity, skin and the bronchus. We report a case of clear cell variant of MEC of maxillary region in a 60 year old male who presented with a huge, disfiguring, lobulated maxillary mass. To our knowledge, this variant has not been previously reported in the maxillary region. Introduction:
Background: Primary Plasma Cell Leukaemia (PPCL) in young patients has been evaluated in very few... more Background: Primary Plasma Cell Leukaemia (PPCL) in young patients has been evaluated in very few studies in the English literature. The aim of this study is to describe a case of PPCL in a young HIV infected male associated with EBV. This is first such case in Indian literature. This is an interesting study that reported a rare case where primary plasma cell leukaemia is observed in a young HIV infected male, which will be valuable case for future studies. Thorough clinical examinations were done and reported in detail. Methods: A 35 years old male presented with abdominal pain, backache and asthenia. A thorough workup was done including clinical examination, CBP, KFT, LFT, serology (HIV, HBsAg), Serum electrophoresis, radiology and bone marrow examination. A systematic literature review was conducted by searching the Pub Med and National Centre for Biotechnology Information database. Results: Patient had hepatosplenomegaly and icterus. Peripheral smear revealed atypical plasma cel...
The clear cell variant of mucoepidermoid carcinoma (MEC) has been described in the major and mino... more The clear cell variant of mucoepidermoid carcinoma (MEC) has been described in the major and minor salivary glands, oral cavity, skin and the bronchus. We report a case of clear cell variant of MEC of maxillary region in a 60 year old male who presented with a huge, disfiguring, lobulated maxillary mass. To our knowledge, this variant has not been previously reported in the maxillary region.
Indian Journal of Gynecologic Oncology
Objective/BackgroundSynovial sarcoma (SS) is a clinically, morphologically, and genotypically dis... more Objective/BackgroundSynovial sarcoma (SS) is a clinically, morphologically, and genotypically distinctive neoplasm, accounting for approximately 10% of soft tissue sarcomas, which usually afflicts young-to-middle-aged adults and typically occurs in the deep soft tissues of the extremities, particularly the thigh and knee regions. The aim of this study is to describe a case of metastatic synovial sarcoma of vaginal wall with primary in the thigh. This is the first report documenting its occurrence in the vagina as a metastatic tumour. This is the first case of vaginal synovial sarcoma in the Indian literature.MethodA 57-year-old female presented with vaginal bleed. A thorough workup was done including clinical examination, histopathological examination of the biopsy from vaginal mass, IHC, and review of slides from the thigh swelling. A systematic literature review was conducted by searching the PubMed and National Centre for Biotechnology Information database.ResultPhysical examination revealed fleshy mass at the anterior vaginal wall and a thigh swelling. On histopathological examination of the vaginal mass followed by IHC, a diagnosis of synovial sarcoma was made and the slides of the thigh mass were reviewed which revealed similar morphology and IHC profile. Hence, a final diagnosis of synovial sarcoma of thigh with metastasis to vaginal wall was made. Four case reports of primary SS of the vagina were found on reviewing the literature.ConclusionTo the best of our knowledge, this is the first report documenting the occurrence of synovial sarcoma in the vagina as a metastatic tumour and overall fifth report to document its occurrence in the vagina. All other four previously reported cases were primary SS of the vagina.
![Research paper thumbnail of Specific recognition of formaldehyde by a cucurbit[10]uril-based porous supramolecular assembly incorporating adsorbed 1,8-diaminonaphthalene](https://attachments.academia-assets.com/83136600/thumbnails/1.jpg)
](Journal of Materials Chemistry C
We report herein a cucurbit[10]uril-based porous supramolecular assembly (A) that is readily obta... more We report herein a cucurbit[10]uril-based porous supramolecular assembly (A) that is readily obtained in the presence of [ZnCl4]2− as a structure-directing agent in HCl solution.
International journal of clinical and experimental pathology, 2015
Endometrial carcinoma is the most common gynecological malignancy among women worldwide. Although... more Endometrial carcinoma is the most common gynecological malignancy among women worldwide. Although treatment for EC has improved with the introduction of Paclitaxel (Tax) chemotherapy, the majority of patients will develop resistance to the treatment, leading to poor prognosis. One of the causes of chemoresistance is the increased ability to undergo autophagy. In this study, we identified that miR-218 was significantly down-regulated in Tax-resistant EC cells compared to the non-drug resistant cell lines, and overexpression of miR-218 sensitized paclitaxel resistant EC cells to paclitaxel. Moreover, we demonstrated that miR-218 directly binds to the 3'-UTR of HMGB1 gene. HMGB1 was upregulated in paclitaxel resistant EC cells, it mediated autophagy and contributed to chemotherapy resistance in endometrial carcinoma in vitro. HMGB1-mediated autophagy could be suppressed by miR-218 overexpression in Tax resistant EC cells. In summary, we determined the targeting role of miR-218 to H...
Indian Journal of Gynecologic Oncology, Feb 14, 2019
Objective/BackgroundSynovial sarcoma (SS) is a clinically, morphologically, and genotypically dis... more Objective/BackgroundSynovial sarcoma (SS) is a clinically, morphologically, and genotypically distinctive neoplasm, accounting for approximately 10% of soft tissue sarcomas, which usually afflicts young-to-middle-aged adults and typically occurs in the deep soft tissues of the extremities, particularly the thigh and knee regions. The aim of this study is to describe a case of metastatic synovial sarcoma of vaginal wall with primary in the thigh. This is the first report documenting its occurrence in the vagina as a metastatic tumour. This is the first case of vaginal synovial sarcoma in the Indian literature.MethodA 57-year-old female presented with vaginal bleed. A thorough workup was done including clinical examination, histopathological examination of the biopsy from vaginal mass, IHC, and review of slides from the thigh swelling. A systematic literature review was conducted by searching the PubMed and National Centre for Biotechnology Information database.ResultPhysical examination revealed fleshy mass at the anterior vaginal wall and a thigh swelling. On histopathological examination of the vaginal mass followed by IHC, a diagnosis of synovial sarcoma was made and the slides of the thigh mass were reviewed which revealed similar morphology and IHC profile. Hence, a final diagnosis of synovial sarcoma of thigh with metastasis to vaginal wall was made. Four case reports of primary SS of the vagina were found on reviewing the literature.ConclusionTo the best of our knowledge, this is the first report documenting the occurrence of synovial sarcoma in the vagina as a metastatic tumour and overall fifth report to document its occurrence in the vagina. All other four previously reported cases were primary SS of the vagina.
The clear cell variant of mucoepidermoid carcinoma (MEC) has been described in the major and mino... more The clear cell variant of mucoepidermoid carcinoma (MEC) has been described in the major and minor salivary glands, oral cavity, skin and the bronchus. We report a case of clear cell variant of MEC of maxillary region in a 60 year old male who presented with a huge, disfiguring, lobulated maxillary mass. To our knowledge, this variant has not been previously reported in the maxillary region.
Background: Primary Plasma Cell Leukaemia (PPCL) in young patients has been evaluated in very few... more Background: Primary Plasma Cell Leukaemia (PPCL) in young patients has been evaluated in very few studies in the English literature. The aim of this study is to describe a case of PPCL in a young HIV infected male associated with EBV. This is first such case in Indian literature. This is an interesting study that reported a rare case where primary plasma cell leukaemia is observed in a young HIV infected male, which will be valuable case for future studies. Thorough clinical examinations were done and reported in detail. Methods: A 35 years old male presented with abdominal pain, backache and asthenia. A thorough workup was done including clinical examination, CBP, KFT, LFT, serology (HIV, HBsAg), Serum electrophoresis, radiology and bone marrow examination. A systematic literature review was conducted by searching the Pub Med and National Centre for Biotechnology Information database. Results: Patient had hepatosplenomegaly and icterus. Peripheral smear revealed atypical plasma cells (53%). Serum protein electrophoresis showed a monoclonal IgG-K paraprotein at a concentration of 4.56 (45 g/l) (Ref-0.10-0.40). Patient had hypoalbuminemia and raised liver enzymes. The serology test for HIV was reactive for HIV-I and II. Bone marrow examination showed
The clear cell variant of mucoepidermoid carcinoma (MEC) has been described in the major and mino... more The clear cell variant of mucoepidermoid carcinoma (MEC) has been described in the major and minor salivary glands, oral cavity, skin and the bronchus. We report a case of clear cell variant of MEC of maxillary region in a 60 year old male who presented with a huge, disfiguring, lobulated maxillary mass. To our knowledge, this variant has not been previously reported in the maxillary region. Introduction:
Background: Primary Plasma Cell Leukaemia (PPCL) in young patients has been evaluated in very few... more Background: Primary Plasma Cell Leukaemia (PPCL) in young patients has been evaluated in very few studies in the English literature. The aim of this study is to describe a case of PPCL in a young HIV infected male associated with EBV. This is first such case in Indian literature. This is an interesting study that reported a rare case where primary plasma cell leukaemia is observed in a young HIV infected male, which will be valuable case for future studies. Thorough clinical examinations were done and reported in detail. Methods: A 35 years old male presented with abdominal pain, backache and asthenia. A thorough workup was done including clinical examination, CBP, KFT, LFT, serology (HIV, HBsAg), Serum electrophoresis, radiology and bone marrow examination. A systematic literature review was conducted by searching the Pub Med and National Centre for Biotechnology Information database. Results: Patient had hepatosplenomegaly and icterus. Peripheral smear revealed atypical plasma cel...
The clear cell variant of mucoepidermoid carcinoma (MEC) has been described in the major and mino... more The clear cell variant of mucoepidermoid carcinoma (MEC) has been described in the major and minor salivary glands, oral cavity, skin and the bronchus. We report a case of clear cell variant of MEC of maxillary region in a 60 year old male who presented with a huge, disfiguring, lobulated maxillary mass. To our knowledge, this variant has not been previously reported in the maxillary region.
Indian Journal of Gynecologic Oncology
Objective/BackgroundSynovial sarcoma (SS) is a clinically, morphologically, and genotypically dis... more Objective/BackgroundSynovial sarcoma (SS) is a clinically, morphologically, and genotypically distinctive neoplasm, accounting for approximately 10% of soft tissue sarcomas, which usually afflicts young-to-middle-aged adults and typically occurs in the deep soft tissues of the extremities, particularly the thigh and knee regions. The aim of this study is to describe a case of metastatic synovial sarcoma of vaginal wall with primary in the thigh. This is the first report documenting its occurrence in the vagina as a metastatic tumour. This is the first case of vaginal synovial sarcoma in the Indian literature.MethodA 57-year-old female presented with vaginal bleed. A thorough workup was done including clinical examination, histopathological examination of the biopsy from vaginal mass, IHC, and review of slides from the thigh swelling. A systematic literature review was conducted by searching the PubMed and National Centre for Biotechnology Information database.ResultPhysical examination revealed fleshy mass at the anterior vaginal wall and a thigh swelling. On histopathological examination of the vaginal mass followed by IHC, a diagnosis of synovial sarcoma was made and the slides of the thigh mass were reviewed which revealed similar morphology and IHC profile. Hence, a final diagnosis of synovial sarcoma of thigh with metastasis to vaginal wall was made. Four case reports of primary SS of the vagina were found on reviewing the literature.ConclusionTo the best of our knowledge, this is the first report documenting the occurrence of synovial sarcoma in the vagina as a metastatic tumour and overall fifth report to document its occurrence in the vagina. All other four previously reported cases were primary SS of the vagina.
Journal of Materials Chemistry C
We report herein a cucurbit[10]uril-based porous supramolecular assembly (A) that is readily obta... more We report herein a cucurbit[10]uril-based porous supramolecular assembly (A) that is readily obtained in the presence of [ZnCl4]2− as a structure-directing agent in HCl solution.
International journal of clinical and experimental pathology, 2015
Endometrial carcinoma is the most common gynecological malignancy among women worldwide. Although... more Endometrial carcinoma is the most common gynecological malignancy among women worldwide. Although treatment for EC has improved with the introduction of Paclitaxel (Tax) chemotherapy, the majority of patients will develop resistance to the treatment, leading to poor prognosis. One of the causes of chemoresistance is the increased ability to undergo autophagy. In this study, we identified that miR-218 was significantly down-regulated in Tax-resistant EC cells compared to the non-drug resistant cell lines, and overexpression of miR-218 sensitized paclitaxel resistant EC cells to paclitaxel. Moreover, we demonstrated that miR-218 directly binds to the 3'-UTR of HMGB1 gene. HMGB1 was upregulated in paclitaxel resistant EC cells, it mediated autophagy and contributed to chemotherapy resistance in endometrial carcinoma in vitro. HMGB1-mediated autophagy could be suppressed by miR-218 overexpression in Tax resistant EC cells. In summary, we determined the targeting role of miR-218 to H...