Abhijith Valsalan - Academia.edu (original) (raw)

Papers by Abhijith Valsalan

Research paper thumbnail of Concealed left hepatic artery injury with liver trauma

Journal of Clinical and Scientific Research

Research paper thumbnail of Immunohistochemistry, ? – Catenin, Colorectal Carcinoma

Evaluation of Beta-Catenin Expression in Relation to Staging and Grading of Colorectal Carcinoma – A Study Conducted in Jubilee Mission Medical College and Research Institute, Thrissur, Sep 8, 2021

Research paper thumbnail of Lesser Sac Haematoma-Melioidosis - A Surgical Surprise

Journal of Evidence Based Medicine and Healthcare, 2021

Melioidosis, a potentially fatal disease endemic in South East Asia and Northern Australia is cau... more Melioidosis, a potentially fatal disease endemic in South East Asia and Northern Australia is caused by Burkholderia pseudomallei, a potential bioterror agent. It is a motile, aerobic non-spore forming gram negative bacillus often characterised by pneumonia and multiple abscesses, but it can also present as septic arthritis, cutaneous ulcer and osteomyelitis. Modes of acquisition are inhalation, inoculation and rarely ingestion from a contaminated environment.1 General and gastro surgeons rarely come across abdominal melioidosis and rare is a lesser sac haematoma secondary to mycotic aneurysm of splenic artery caused by melioidosis. Clinical manifestations can vary from asymptomatic infections to localised abscesses to fulminating diseases with multiorgan involvement and eventual death. Due to evolving lifestyle, extensive travel and climate changes the disease which was previously confined to specific countries has crossed its boundaries. Increase in cases of comorbid conditions li...

Research paper thumbnail of A Study on Respiratory Complications and Its Outcome in Acute Pancreatitis

Background: Respiratory complications are frequent in acute pancreatitis, and respiratory dysfunc... more Background: Respiratory complications are frequent in acute pancreatitis, and respiratory dysfunction, presenting as Acute lung injury (ALI) or Acute Respiratory Distress Syndrome (ARDS), is a major component of multiple organ dysfunction syndrome (MODS), with a frequent need for ventilator support, which contributes to early death in severe acute pancreatitis. The current study was done with the objective of assessing the morbidity and mortality of acute pancreatitis cases with respiratory complications and to find out whether there is any association between the aetiology of acute pancreatitis and respiratory complications. Methodology: It was a prospective observational study conducted in a tertiary care centre in Kerala. All participants admitted with symptoms suggestive of acute pancreatitis were screened for potential enrolment. The inclusion criteria employed were that the patients should be aged above 18 years, and presenting with the first episode of pancreatitis, irrespect...

Research paper thumbnail of Evaluation of -Catenin Expression in Relation to Staging and Grading of Colorectal Carcinoma – A Study Conducted in Jubilee Mission Medical College and Research Institute, Thrissur

Journal of Evidence Based Medicine and Healthcare, 2021

BACKGROUND Colorectal carcinoma is the most frequently encountered malignancy worldwide. The main... more BACKGROUND Colorectal carcinoma is the most frequently encountered malignancy worldwide. The main cause of mortality associated with colorectal malignancy is tumour invasion and metastasis. The major genomic alteration that has been found in colorectal carcinoma is mutation in the adenomatous polyposis gene. Mutated APC causes unrestricted action of the Wnt signalling pathway which results in accumulation of the β - catenin protein in the nucleus responsible for cell proliferation, differentiation and enhanced survival of colorectal epithelial cells. Role of β - catenin expression as a prognostic marker needs to be studied. It will help in aiding the possibility of the future of anti β - catenin targeted chemotherapy for the treatment of colorectal cancers. METHODS A total of 85 samples from histopathologically proven cases of adenocarcinoma colon were taken. Histomorphological features and their immunohistochemical expression of β - catenin were studied. Data thus obtained was anal...

Research paper thumbnail of Concealed left hepatic artery injury with liver trauma

Journal of Clinical and Scientific Research

Research paper thumbnail of Immunohistochemistry, ? – Catenin, Colorectal Carcinoma

Evaluation of Beta-Catenin Expression in Relation to Staging and Grading of Colorectal Carcinoma – A Study Conducted in Jubilee Mission Medical College and Research Institute, Thrissur, Sep 8, 2021

Research paper thumbnail of Lesser Sac Haematoma-Melioidosis - A Surgical Surprise

Journal of Evidence Based Medicine and Healthcare, 2021

Melioidosis, a potentially fatal disease endemic in South East Asia and Northern Australia is cau... more Melioidosis, a potentially fatal disease endemic in South East Asia and Northern Australia is caused by Burkholderia pseudomallei, a potential bioterror agent. It is a motile, aerobic non-spore forming gram negative bacillus often characterised by pneumonia and multiple abscesses, but it can also present as septic arthritis, cutaneous ulcer and osteomyelitis. Modes of acquisition are inhalation, inoculation and rarely ingestion from a contaminated environment.1 General and gastro surgeons rarely come across abdominal melioidosis and rare is a lesser sac haematoma secondary to mycotic aneurysm of splenic artery caused by melioidosis. Clinical manifestations can vary from asymptomatic infections to localised abscesses to fulminating diseases with multiorgan involvement and eventual death. Due to evolving lifestyle, extensive travel and climate changes the disease which was previously confined to specific countries has crossed its boundaries. Increase in cases of comorbid conditions li...

Research paper thumbnail of A Study on Respiratory Complications and Its Outcome in Acute Pancreatitis

Background: Respiratory complications are frequent in acute pancreatitis, and respiratory dysfunc... more Background: Respiratory complications are frequent in acute pancreatitis, and respiratory dysfunction, presenting as Acute lung injury (ALI) or Acute Respiratory Distress Syndrome (ARDS), is a major component of multiple organ dysfunction syndrome (MODS), with a frequent need for ventilator support, which contributes to early death in severe acute pancreatitis. The current study was done with the objective of assessing the morbidity and mortality of acute pancreatitis cases with respiratory complications and to find out whether there is any association between the aetiology of acute pancreatitis and respiratory complications. Methodology: It was a prospective observational study conducted in a tertiary care centre in Kerala. All participants admitted with symptoms suggestive of acute pancreatitis were screened for potential enrolment. The inclusion criteria employed were that the patients should be aged above 18 years, and presenting with the first episode of pancreatitis, irrespect...

Research paper thumbnail of Evaluation of -Catenin Expression in Relation to Staging and Grading of Colorectal Carcinoma – A Study Conducted in Jubilee Mission Medical College and Research Institute, Thrissur

Journal of Evidence Based Medicine and Healthcare, 2021

BACKGROUND Colorectal carcinoma is the most frequently encountered malignancy worldwide. The main... more BACKGROUND Colorectal carcinoma is the most frequently encountered malignancy worldwide. The main cause of mortality associated with colorectal malignancy is tumour invasion and metastasis. The major genomic alteration that has been found in colorectal carcinoma is mutation in the adenomatous polyposis gene. Mutated APC causes unrestricted action of the Wnt signalling pathway which results in accumulation of the β - catenin protein in the nucleus responsible for cell proliferation, differentiation and enhanced survival of colorectal epithelial cells. Role of β - catenin expression as a prognostic marker needs to be studied. It will help in aiding the possibility of the future of anti β - catenin targeted chemotherapy for the treatment of colorectal cancers. METHODS A total of 85 samples from histopathologically proven cases of adenocarcinoma colon were taken. Histomorphological features and their immunohistochemical expression of β - catenin were studied. Data thus obtained was anal...