Adel Mustafa - Academia.edu (original) (raw)

Papers by Adel Mustafa

Research paper thumbnail of Imaging Evaluation of Abdominopelvic Gunshot Trauma

RadioGraphics, 2020

Firearm-related injuries, or gunshot wounds (GSWs), are among the most important worldwide public... more Firearm-related injuries, or gunshot wounds (GSWs), are among the most important worldwide public health problems, resulting in considerable annual morbidity, disability, and mortality. GSWs to the abdomen and pelvis are associated with substantial injuries to multiple organs and tissues. Imaging plays an important role in identifying these injuries, dictating nonoperative management, and determining imaging and clinical follow-up, as well as helping manage potential long-term complications. CT is the primary imaging modality used to evaluate these injuries and their complications, including use of reconstructed multiplanar volume-rendered images. The authors discuss the ballistics and mechanisms of firearm injury, CT findings, trajectory analysis, and applications of different imaging modalities above and beyond CT in evaluation of GSWs. Imaging findings and classifications of the severity of injuries to solid and hollow organs and vascular, musculoskeletal, and neurologic systems are reviewed. Key complications associated with gunshot injuries to the abdomen and pelvis are presented. The challenges of imaging in the acute trauma setting and potential pitfall mimics at imaging, particularly at CT, are also described. A step-by-step guide for thorough and comprehensive evaluation of GSWs to the abdomen and pelvis is introduced, with tips for optimizing effective communication with the clinical team.

Research paper thumbnail of Optimizing Image Quality When Evaluating Blood Flow at Doppler US: A Tutorial

RadioGraphics, 2019

is an essential component of nearly all diagnostic US procedures. In this era of increased awaren... more is an essential component of nearly all diagnostic US procedures. In this era of increased awareness of the effects of ionizing radiation and the side effects of iodine-and gadolinium-based contrast agents, Doppler US is poised to play an even bigger role in medical imaging. It is safe, cost-effective, portable, and highly accurate when performed by an experienced operator. The sensitivities and specificities of Doppler US for detecting blood flow and determining the direction and velocity of blood flow in various organs and vascular systems have increased dramatically in the past decade. With use of advanced flow techniques that are available for use with most modern equipment, US can provide vascular information that is comparable to or even more accurate than that obtained with other cross-sectional and interventional modalities. However, there remains concern that US (including newer more advanced flow-evaluating techniques) will not be used to its full potential owing to dependence on operator skill and expertise. Thorough understanding of image optimization techniques and expanded knowledge of the physical principles, instrumentation, application, advantages, and limitations of this modality are of utmost importance. The authors provide a simple practical guide for optimizing images for vascular flow detection by reviewing various cases and focusing on the parameters that should be optimized.

Research paper thumbnail of Risk of Radiation-Induced Cancer From Computed Tomography Angiography Use in Imaging Surveillance for Unruptured Cerebral Aneurysms

Stroke, 2019

Background and Purpose— Although computed tomography angiography (CTA) is an excellent, noninvasi... more Background and Purpose— Although computed tomography angiography (CTA) is an excellent, noninvasive imaging modality for surveillance of intracranial aneurysms, radiation concerns have been cited to restrict its use in surveillance imaging. The goal of this study was to estimate distributions of radiation-induced central nervous system cancer incidence from CTA surveillance for intracranial aneurysms, and the impact of frequency and duration of surveillance imaging using follow-up CTAs. Methods— Simulation-modeling approach was performed using data on CTA associated radiation risk. We used the Radiation Risk Assessment Tool, based on the data using the BEIR VII report (BEIR VII). Each CTA was assigned as a separate exposure event. Men and women, respectively, starting surveillance imaging at 30, 40, and 50 years and receiving annual CTAs were considered as separate subgroups. As a comparison, we also calculated the radiation-induced cancer risk in the same groups of patients but rec...

Research paper thumbnail of Protective effect of aminoguanidine against paraquat-induced oxidative stress in the lung of mice

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2002

The effect of aminoguanidine (AG) against toxicity of paraquat (PQ), an oxidative-stress inducing... more The effect of aminoguanidine (AG) against toxicity of paraquat (PQ), an oxidative-stress inducing substance, in mice was investigated. A single dose of PQ (50 mgykg, i.p.) induced lung-toxicity, manifested by significant decrease of the activity of angiotensin converting enzyme (ACE) in lung tissue indicating pulmonary capillary endothelial cell damage. Lung toxicity was further evidenced by significant decrease of total sulfhydryl (-SH) content and significant increase in lipid peroxidation measured as malondialdehyde (MDA) in lung tissues. Oral pretreatment of mice with AG (50 mgy kg) in drinking water, starting 5 days before PQ injection and continuing during the experimental period, ameliorated the lung toxicity induced by PQ.

Research paper thumbnail of Doses from Occupational Exposure

Health Physics, 1985

A bstract-The personal monitoring facility in the Ministry of Public Health's Radiation Protectio... more A bstract-The personal monitoring facility in the Ministry of Public Health's Radiation Protection Department has provided service to all users of ionizing radiation in medicine, research and industry in Kuwait. Exposure results during 1980-1983 were compared and analysed to examine the efficiency of protection measures adopted by each occupation. The results indicate that annual doses received by workers in different occupations in recent years. tend to begenerally low, but remain higher than those received by similar workers in other countries. Several overexposures to radiologists, radiology nurses, medical radiographers, and industrial radiographers increased the overall annual collective doses. As a result, protective measures designed for radiologists and nurses involved with special radiographical procedures should be improved. The recent use of the after-loading technique in intra-cavitary therapy was responsible for a significant reduction in the overall average doses received by workers involved in radiotherapy.

Research paper thumbnail of A densitometric method for quantitative analysis of the left ventricle performance using I.V. digital subtraction angiography

Computerized Medical Imaging and Graphics, 1991

In this paper we present a method we used to provide quantitative description of the systolic and... more In this paper we present a method we used to provide quantitative description of the systolic and diastolic temporal function of the left ventricle (LV). Additional parameters, such as peak filling and ejection rates, times to end systole and end diastole, and temporal changes in slow and fast filling are obtained. The volumes associated with these parameters are also calculated. Correlation between LV volume changes during the cardiac style and corresponding "density" variations was confirmed. Time-density curves were obtained from selected cardiac cycles in each study. We used the polynomial fitting technique to fit the time density curves and developed a computer algorithm for deriving the relevant parameters. Data from a total of 18 patients with ischemic heart or valvular diseases, who underwent I.V. ventriculography was analysed using our method. Some of these patients were forwarded for repeated digital subtraction angiography (DSA) examination before and after intervention therapy to evaluate the effectiveness of treatment. In comparison to the geometric method for the analysis of LV performance, our method is generally faster and simpler to employ. The method was effective in detecting variations in the peak ejection and filling rates in our group of patients before and after interventional therapy.

Research paper thumbnail of Pediatric CT radiation exposure: where we were, and where we are now

Pediatric Radiology, 2019

Since the turn of the last millennium, the pediatric radiology community has blazed a patient-qua... more Since the turn of the last millennium, the pediatric radiology community has blazed a patient-quality and safety trail in helping to effectively address the public and the news media's concerns about the implications of ionizing radiation from CT scanners in children. As such, this article (1) reviews the potential deleterious effects of ionizing radiation, (2) discusses why limiting radiation exposure in children is so important, (3) tells the history of pediatric CT radiation exposure concerns, (4) explains the interventions that took place to address these concerns and (5) touches on the current school of thought on pediatric CT dose reduction.

Research paper thumbnail of Effective Dose Equivalent and Associated Risks from Mass Chest Radiography in Kuwait

Health Phys, 1985

The number of x-ray examinations performed on persons undergoing mass chest radiography in Kuwait... more The number of x-ray examinations performed on persons undergoing mass chest radiography in Kuwait reached a maximum of 1.858 X 10(5) in 1982 with miniature radiography (70 mm) claiming more than 90% of the total number and the rest done with the large film technique. The annual prevalence of asymptomatic tuberculosis patients diagnosed by x rays, as reported by the project statistics, does not, in our opinion, justify exposing such a large population. In this paper, the effective dose equivalent is calculated from both miniature and large film mass chest radiography as applied in Kuwait. The values obtained are 283 mu Sv and 35.5 mu Sv, respectively. These figures yield calculated risks of fatal malignancies per examination of 3.37 X 10(-6) and 0.422 X 10(-6), respectively. The annual collective effective dose equivalent to the population undergoing mass chest radiography in Kuwait during the 7 y 1977-1983 is found to vary between 38-48 man-Sv. These figures are used to calculate an average of 0.5 additional cases of fatal malignancies per year, or about 12 excess fatalities in the forthcoming 25-y period if the number of mass chest x-ray examinations stays at its existing level. A total of 98% of these calculated excess fatalities result from the predominant technique, miniature radiography.

Research paper thumbnail of Imaging Evaluation of Abdominopelvic Gunshot Trauma

RadioGraphics, 2020

Firearm-related injuries, or gunshot wounds (GSWs), are among the most important worldwide public... more Firearm-related injuries, or gunshot wounds (GSWs), are among the most important worldwide public health problems, resulting in considerable annual morbidity, disability, and mortality. GSWs to the abdomen and pelvis are associated with substantial injuries to multiple organs and tissues. Imaging plays an important role in identifying these injuries, dictating nonoperative management, and determining imaging and clinical follow-up, as well as helping manage potential long-term complications. CT is the primary imaging modality used to evaluate these injuries and their complications, including use of reconstructed multiplanar volume-rendered images. The authors discuss the ballistics and mechanisms of firearm injury, CT findings, trajectory analysis, and applications of different imaging modalities above and beyond CT in evaluation of GSWs. Imaging findings and classifications of the severity of injuries to solid and hollow organs and vascular, musculoskeletal, and neurologic systems are reviewed. Key complications associated with gunshot injuries to the abdomen and pelvis are presented. The challenges of imaging in the acute trauma setting and potential pitfall mimics at imaging, particularly at CT, are also described. A step-by-step guide for thorough and comprehensive evaluation of GSWs to the abdomen and pelvis is introduced, with tips for optimizing effective communication with the clinical team.

Research paper thumbnail of Optimizing Image Quality When Evaluating Blood Flow at Doppler US: A Tutorial

RadioGraphics, 2019

is an essential component of nearly all diagnostic US procedures. In this era of increased awaren... more is an essential component of nearly all diagnostic US procedures. In this era of increased awareness of the effects of ionizing radiation and the side effects of iodine-and gadolinium-based contrast agents, Doppler US is poised to play an even bigger role in medical imaging. It is safe, cost-effective, portable, and highly accurate when performed by an experienced operator. The sensitivities and specificities of Doppler US for detecting blood flow and determining the direction and velocity of blood flow in various organs and vascular systems have increased dramatically in the past decade. With use of advanced flow techniques that are available for use with most modern equipment, US can provide vascular information that is comparable to or even more accurate than that obtained with other cross-sectional and interventional modalities. However, there remains concern that US (including newer more advanced flow-evaluating techniques) will not be used to its full potential owing to dependence on operator skill and expertise. Thorough understanding of image optimization techniques and expanded knowledge of the physical principles, instrumentation, application, advantages, and limitations of this modality are of utmost importance. The authors provide a simple practical guide for optimizing images for vascular flow detection by reviewing various cases and focusing on the parameters that should be optimized.

Research paper thumbnail of Risk of Radiation-Induced Cancer From Computed Tomography Angiography Use in Imaging Surveillance for Unruptured Cerebral Aneurysms

Stroke, 2019

Background and Purpose— Although computed tomography angiography (CTA) is an excellent, noninvasi... more Background and Purpose— Although computed tomography angiography (CTA) is an excellent, noninvasive imaging modality for surveillance of intracranial aneurysms, radiation concerns have been cited to restrict its use in surveillance imaging. The goal of this study was to estimate distributions of radiation-induced central nervous system cancer incidence from CTA surveillance for intracranial aneurysms, and the impact of frequency and duration of surveillance imaging using follow-up CTAs. Methods— Simulation-modeling approach was performed using data on CTA associated radiation risk. We used the Radiation Risk Assessment Tool, based on the data using the BEIR VII report (BEIR VII). Each CTA was assigned as a separate exposure event. Men and women, respectively, starting surveillance imaging at 30, 40, and 50 years and receiving annual CTAs were considered as separate subgroups. As a comparison, we also calculated the radiation-induced cancer risk in the same groups of patients but rec...

Research paper thumbnail of Protective effect of aminoguanidine against paraquat-induced oxidative stress in the lung of mice

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2002

The effect of aminoguanidine (AG) against toxicity of paraquat (PQ), an oxidative-stress inducing... more The effect of aminoguanidine (AG) against toxicity of paraquat (PQ), an oxidative-stress inducing substance, in mice was investigated. A single dose of PQ (50 mgykg, i.p.) induced lung-toxicity, manifested by significant decrease of the activity of angiotensin converting enzyme (ACE) in lung tissue indicating pulmonary capillary endothelial cell damage. Lung toxicity was further evidenced by significant decrease of total sulfhydryl (-SH) content and significant increase in lipid peroxidation measured as malondialdehyde (MDA) in lung tissues. Oral pretreatment of mice with AG (50 mgy kg) in drinking water, starting 5 days before PQ injection and continuing during the experimental period, ameliorated the lung toxicity induced by PQ.

Research paper thumbnail of Doses from Occupational Exposure

Health Physics, 1985

A bstract-The personal monitoring facility in the Ministry of Public Health's Radiation Protectio... more A bstract-The personal monitoring facility in the Ministry of Public Health's Radiation Protection Department has provided service to all users of ionizing radiation in medicine, research and industry in Kuwait. Exposure results during 1980-1983 were compared and analysed to examine the efficiency of protection measures adopted by each occupation. The results indicate that annual doses received by workers in different occupations in recent years. tend to begenerally low, but remain higher than those received by similar workers in other countries. Several overexposures to radiologists, radiology nurses, medical radiographers, and industrial radiographers increased the overall annual collective doses. As a result, protective measures designed for radiologists and nurses involved with special radiographical procedures should be improved. The recent use of the after-loading technique in intra-cavitary therapy was responsible for a significant reduction in the overall average doses received by workers involved in radiotherapy.

Research paper thumbnail of A densitometric method for quantitative analysis of the left ventricle performance using I.V. digital subtraction angiography

Computerized Medical Imaging and Graphics, 1991

In this paper we present a method we used to provide quantitative description of the systolic and... more In this paper we present a method we used to provide quantitative description of the systolic and diastolic temporal function of the left ventricle (LV). Additional parameters, such as peak filling and ejection rates, times to end systole and end diastole, and temporal changes in slow and fast filling are obtained. The volumes associated with these parameters are also calculated. Correlation between LV volume changes during the cardiac style and corresponding "density" variations was confirmed. Time-density curves were obtained from selected cardiac cycles in each study. We used the polynomial fitting technique to fit the time density curves and developed a computer algorithm for deriving the relevant parameters. Data from a total of 18 patients with ischemic heart or valvular diseases, who underwent I.V. ventriculography was analysed using our method. Some of these patients were forwarded for repeated digital subtraction angiography (DSA) examination before and after intervention therapy to evaluate the effectiveness of treatment. In comparison to the geometric method for the analysis of LV performance, our method is generally faster and simpler to employ. The method was effective in detecting variations in the peak ejection and filling rates in our group of patients before and after interventional therapy.

Research paper thumbnail of Pediatric CT radiation exposure: where we were, and where we are now

Pediatric Radiology, 2019

Since the turn of the last millennium, the pediatric radiology community has blazed a patient-qua... more Since the turn of the last millennium, the pediatric radiology community has blazed a patient-quality and safety trail in helping to effectively address the public and the news media's concerns about the implications of ionizing radiation from CT scanners in children. As such, this article (1) reviews the potential deleterious effects of ionizing radiation, (2) discusses why limiting radiation exposure in children is so important, (3) tells the history of pediatric CT radiation exposure concerns, (4) explains the interventions that took place to address these concerns and (5) touches on the current school of thought on pediatric CT dose reduction.

Research paper thumbnail of Effective Dose Equivalent and Associated Risks from Mass Chest Radiography in Kuwait

Health Phys, 1985

The number of x-ray examinations performed on persons undergoing mass chest radiography in Kuwait... more The number of x-ray examinations performed on persons undergoing mass chest radiography in Kuwait reached a maximum of 1.858 X 10(5) in 1982 with miniature radiography (70 mm) claiming more than 90% of the total number and the rest done with the large film technique. The annual prevalence of asymptomatic tuberculosis patients diagnosed by x rays, as reported by the project statistics, does not, in our opinion, justify exposing such a large population. In this paper, the effective dose equivalent is calculated from both miniature and large film mass chest radiography as applied in Kuwait. The values obtained are 283 mu Sv and 35.5 mu Sv, respectively. These figures yield calculated risks of fatal malignancies per examination of 3.37 X 10(-6) and 0.422 X 10(-6), respectively. The annual collective effective dose equivalent to the population undergoing mass chest radiography in Kuwait during the 7 y 1977-1983 is found to vary between 38-48 man-Sv. These figures are used to calculate an average of 0.5 additional cases of fatal malignancies per year, or about 12 excess fatalities in the forthcoming 25-y period if the number of mass chest x-ray examinations stays at its existing level. A total of 98% of these calculated excess fatalities result from the predominant technique, miniature radiography.