Adem Par - Academia.edu (original) (raw)

Papers by Adem Par

Research paper thumbnail of The effect of levothyroxine replacement therapy on lipid profile and oxidative stress parameters in patients with subclinical hypothyroid

Archives of Pharmacal Research

The purpose of this present study is to investigate the levels of oxidative stress parameters in ... more The purpose of this present study is to investigate the levels of oxidative stress parameters in patients with subclinical hypothyroidism (SH) and the effects of levothyroxine (LT4) replacement therapy on these parameters and lipid profile. At the beginning of the study blood samples were collected from the patients in order to analyse oxidative stress parameters, lipid profile and biochemical markers. After replacement therapy with LT4, in the third month, same tests were performed again. At the baseline superoxide dismutase (SOD) levels were found to be higher in SH patients, compared to the euthyroid group. After LT4 therapy, statistically significant decreases in SOD and catalase levels and increase in HDL-C levels were noticed. LT4 treatment was found to have positive effects on oxidative stress indicators and HDL-C levels.

Research paper thumbnail of Elevated pentraxin-3 levels are related to blood pressure levels in hypertensive patients: an observational study

Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology, 2012

Objective: In this study, relationship between systolic and diastolic blood pressure and pentraxi... more Objective: In this study, relationship between systolic and diastolic blood pressure and pentraxin-3 (PTX3) levels in hypertensive patients was investigated. Methods: Overall, 80 patients with stage 1 hypertension between 40-61 years of age without any disease and 80 healthy volunteers were included to the study. Blood samples obtained to measure PTX3 levels and biochemical analysis. Relationship between PTX3 levels and clinical and biochemical parameters were analyzed using multivariate regression analysis. Results: Although systolic and diastolic blood pressures were significant different, there were no differences regarding age and gender between hypertensives and normotensives. In each group, significant statistical differences were found between PTX3 and CRP levels (PTX3 (ng/mL) 35.25±5.45 and 0.27±0.24, p<0.001; CRP (mg/dL) 10.03±5.81 and 4.30±3.38, p<0.001; in hypertensive and normotensive groups respectively). It was observed that increase in PTX3 levels accompanies the increase in systolic and diastolic blood pressures (r 2 =0.78). It was observed that PTX3 levels are not effected from CRP, lipid levels and body mass index (p>0.05). On multivariate regression analysis PTX3 was found to strongly affect blood pressure (beta=0.82, 95% CI 0.644-0.799, p<0.001, and beta=0.84, 95% CI 0.422-0.799, p<0.001, respectively for systolic and diastolic blood pressures), CRP and total cholesterol are found to affect moderately (beta=0.115-0.265, 95% CI 0.101-0.572, p<0.05 and beta=0.107-0.141, 95% CI 0.041-0.110, p<0.05, respectively). Conclusion: This study showed that PTX3 levels are higher in newly diagnosed hypertensive patients than in healthy individuals. In addition, it was noticed that increased PTX3 levels were associated with elevated systolic and diastolic blood pressures. (Anadolu Kardiyol Derg 2012 Jun 1; 12(4): 000-000)

Research paper thumbnail of DERLEME Melanoma Genel Bakış

ZET Kutanöz melanom özellikle artan UV maruziyeti nedeniyle insidansı tüm dünyada artış gösteren ... more ZET Kutanöz melanom özellikle artan UV maruziyeti nedeniyle insidansı tüm dünyada artış gösteren bir malignitedir. Tüm deri kanserlerinin yalnızca %4'ünü oluşturmasına rağmen deri kanserleri ile ilişkili ölümlerin başlıca nedeni olarak karşımıza çıkmaktadır. Hastalık ilerledikçe hem prognozu kötüleşmekte hem de tedavi maliyeti artmaktadır. Erken evrede saptanabilen melanomlarda lokal eksizyon ile %90'ın üzerinde tedavi sağlanabilirken ileri evre melanomlarda 5 yıllık sağ kalım oranı cerrahi ve kemoterapi uygulamasına rağmen ancak %20 civarındadır. Melanomun evrelemesi, hastaların tedavilerinin planlanması ve prognozlarının tayininde önemlidir. Bugüne kadar melanom evrelemesi hakkında farklı sistemler geliştirilmiştir ama birçoğunun yetersiz olduğu değerlendirilmiştir. Bilimdeki gelişmelere paralel olarak, görüntüleme ve genetik çalışmalardaki yenilikler melanom evrelemesinde ve tedavisinde de bir takım değişiklikleri beraberinde getirmiştir. Doksanlı yılların başlarında dene...

Research paper thumbnail of The effect of levothyroxine replacement therapy on lipid profile and oxidative stress parameters in patients with subclinical hypothyroid

Archives of Pharmacal Research

The purpose of this present study is to investigate the levels of oxidative stress parameters in ... more The purpose of this present study is to investigate the levels of oxidative stress parameters in patients with subclinical hypothyroidism (SH) and the effects of levothyroxine (LT4) replacement therapy on these parameters and lipid profile. At the beginning of the study blood samples were collected from the patients in order to analyse oxidative stress parameters, lipid profile and biochemical markers. After replacement therapy with LT4, in the third month, same tests were performed again. At the baseline superoxide dismutase (SOD) levels were found to be higher in SH patients, compared to the euthyroid group. After LT4 therapy, statistically significant decreases in SOD and catalase levels and increase in HDL-C levels were noticed. LT4 treatment was found to have positive effects on oxidative stress indicators and HDL-C levels.

Research paper thumbnail of Elevated pentraxin-3 levels are related to blood pressure levels in hypertensive patients: an observational study

Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology, 2012

Objective: In this study, relationship between systolic and diastolic blood pressure and pentraxi... more Objective: In this study, relationship between systolic and diastolic blood pressure and pentraxin-3 (PTX3) levels in hypertensive patients was investigated. Methods: Overall, 80 patients with stage 1 hypertension between 40-61 years of age without any disease and 80 healthy volunteers were included to the study. Blood samples obtained to measure PTX3 levels and biochemical analysis. Relationship between PTX3 levels and clinical and biochemical parameters were analyzed using multivariate regression analysis. Results: Although systolic and diastolic blood pressures were significant different, there were no differences regarding age and gender between hypertensives and normotensives. In each group, significant statistical differences were found between PTX3 and CRP levels (PTX3 (ng/mL) 35.25±5.45 and 0.27±0.24, p<0.001; CRP (mg/dL) 10.03±5.81 and 4.30±3.38, p<0.001; in hypertensive and normotensive groups respectively). It was observed that increase in PTX3 levels accompanies the increase in systolic and diastolic blood pressures (r 2 =0.78). It was observed that PTX3 levels are not effected from CRP, lipid levels and body mass index (p>0.05). On multivariate regression analysis PTX3 was found to strongly affect blood pressure (beta=0.82, 95% CI 0.644-0.799, p<0.001, and beta=0.84, 95% CI 0.422-0.799, p<0.001, respectively for systolic and diastolic blood pressures), CRP and total cholesterol are found to affect moderately (beta=0.115-0.265, 95% CI 0.101-0.572, p<0.05 and beta=0.107-0.141, 95% CI 0.041-0.110, p<0.05, respectively). Conclusion: This study showed that PTX3 levels are higher in newly diagnosed hypertensive patients than in healthy individuals. In addition, it was noticed that increased PTX3 levels were associated with elevated systolic and diastolic blood pressures. (Anadolu Kardiyol Derg 2012 Jun 1; 12(4): 000-000)

Research paper thumbnail of DERLEME Melanoma Genel Bakış

ZET Kutanöz melanom özellikle artan UV maruziyeti nedeniyle insidansı tüm dünyada artış gösteren ... more ZET Kutanöz melanom özellikle artan UV maruziyeti nedeniyle insidansı tüm dünyada artış gösteren bir malignitedir. Tüm deri kanserlerinin yalnızca %4'ünü oluşturmasına rağmen deri kanserleri ile ilişkili ölümlerin başlıca nedeni olarak karşımıza çıkmaktadır. Hastalık ilerledikçe hem prognozu kötüleşmekte hem de tedavi maliyeti artmaktadır. Erken evrede saptanabilen melanomlarda lokal eksizyon ile %90'ın üzerinde tedavi sağlanabilirken ileri evre melanomlarda 5 yıllık sağ kalım oranı cerrahi ve kemoterapi uygulamasına rağmen ancak %20 civarındadır. Melanomun evrelemesi, hastaların tedavilerinin planlanması ve prognozlarının tayininde önemlidir. Bugüne kadar melanom evrelemesi hakkında farklı sistemler geliştirilmiştir ama birçoğunun yetersiz olduğu değerlendirilmiştir. Bilimdeki gelişmelere paralel olarak, görüntüleme ve genetik çalışmalardaki yenilikler melanom evrelemesinde ve tedavisinde de bir takım değişiklikleri beraberinde getirmiştir. Doksanlı yılların başlarında dene...