Aditya Saini - Academia.edu (original) (raw)

Papers by Aditya Saini

55th AIAA Aerospace Sciences Meeting, 2017

ArXiv, 2021

Owing to tremendous performance improvements in dataintensive domains, machine learning (ML) has ... more Owing to tremendous performance improvements in dataintensive domains, machine learning (ML) has garnered immense interest in the research community. However these ML models turn out to be black boxes, which are tough to interpret, resulting in a direct decrease in productivity. Local Interpretable Model-Agnostic Explanations (LIME) is a popular technique for explaining prediction of a single instance. Although LIME is simple and versatile, it suffers from instability in the generated explanations. In this paper, we propose a Gaussian process (GP) based variation of locally interpretable models. We employ a smart sampling strategy based on the acquisition functions in Bayesian optimization. Further, we employ the automatic relevance determination based covariance function in GP, with separate length-scale parameters for each feature, where the reciprocal of lengthscale parameters serve as feature explanations. We illustrate the performance of the proposed technique on two realworld ...

American Journal of Case Reports, 2020

BACKGROUND Coronavirus disease 2019 (COVID-19) is primarily a respiratory illness. However, with ... more BACKGROUND Coronavirus disease 2019 (COVID-19) is primarily a respiratory illness. However, with rising numbers of cases, multiple reports of cardiovascular manifestations have emerged. We present a case of COVID-19 infection complicated by myopericarditis and tamponade requiring drainage. CASE REPORT An 82-year-old woman with multiple comorbidities presented with five days of productive cough, fever with chills, and intermittent diarrhea. She tested positive for COVID-19. Index EKG revealed new diffuse T-wave inversions and a prolonged QT interval (>500 ms). Troponin was mildly elevated without any anginal symptoms. Hydroxychloroquine and azithromycin were not initiated due to concerns about QT prolongation. The echocardiogram revealed preserved left ventricular (LV) function, a small global pericardial effusion, and apical hypokinesis. Serial echocardiograms revealed an enlarging circumferential pericardial effusion with pacemaker wire reported as 'piercing' the right ventricular (RV) apex alongside early diastolic collapse of the right ventricle, suggesting echocardiographic tamponade. Chest CT revealed extension of the RV pacemaker lead into the pericardial fat. Interestingly, on comparison with a previous chest CT from 2019, similar lead positions were confirmed. Pericardiocentesis was performed with removal of 400 cc exudate. CONCLUSIONS Acute myopericarditis and pericardial effusion can occur in COVID-19 infection, even in the absence of severe pulmonary disease. This case highlights the importance of awareness of rare cardiac manifestations of COVID-19 in the form of acute myopericarditis and cardiac tamponade and their early diagnosis and management.

Journal of the American College of Cardiology, 2020

American Journal of Case Reports, 2020

BACKGROUND Acute bacterial pericarditis is rare, and the incidence numbers have been declining in... more BACKGROUND Acute bacterial pericarditis is rare, and the incidence numbers have been declining in the modern antibiotic era. Purulent bacterial pericarditis is a fatal disease in which mortality rates can reach 100% if left untreated. CASE REPORT We present a case of primary purulent bacterial pericarditis with polymicrobial growth including Micromonas micro, Prevotella intermedia and Fusobacterium species, all of which are anaerobic flora of the oral cavity. Constant re-accumulation of the purulent pericardial effusion led the patient to have recurrent echocardiographic and clinical cardiac tamponade requiring recurrent pericardiocentesis' and eventually a pericardial window. CONCLUSIONS Although rare, bacterial pericarditis has been noted to lead to clinical and echocardiographic tamponade. Early diagnosis and treatment are necessary for improving clinical outcomes. It is important to have a suspicion for purulent pericarditis, due to its high level of mortality, in patients who present with non-specific symptoms and pleuritic chest pain.

Journal of Research in Dentistry, 2018

Aim: The present study is conducted to explore the knowledge, attitude towards impact of periodon... more Aim: The present study is conducted to explore the knowledge, attitude towards impact of periodontal diseases on cardiac health among general practitioners.Material and Methods: The present study is a Cross-sectional questionnaire descriptive study. The present study was conducted in a city in Chhattisgarh state among the general dental and medical practitioners running their private clinic. Dental and medical practitioners present on day of survey in the clinic and given their written informed consent were interviewed by the single investigator.Results: To the questions regarding impact of periodontal diseases on cardiac health, 23 (56%) of dental practitioners agree with this fact while for 21 (55%) of medical practitioners says that there is no impact. Majority of study subjects 71 (90%) agree with the statement that patients diagnosed with cardiovascular disease are more likely to have periodontal disease. Forty-two (53%) of study participants agree with the fact that controllin...

Pacing and Clinical Electrophysiology, 2019

Circulation: Arrhythmia and Electrophysiology, 2019

Background: The 12-lead ECG is considered the gold standard to differentiate between selective (S... more Background: The 12-lead ECG is considered the gold standard to differentiate between selective (S), nonselective (NS) His bundle pacing (HBP), and right ventricular septal capture in routine clinical practice. We sought to assess the utility of device EGM recordings as a tool to identify the type of HBP morphology. Methods: One hundred forty-eight consecutive patients underwent HBP with a 3830 Select Secure lead (Medtronic, Inc) at 3 centers between October 2016 and October 2017. The near field V-EGM morphology (NF EGM), near field V-EGM time to peak (NF Time to peak ), and far-field EGM QRS duration (QRSd) were recorded while pacing the His lead with simultaneous 12-lead ECG rhythm strips. Results: Indications for HBP were sinus node dysfunction, atrioventricular conduction disease, and cardiac resynchronization therapy in 68 (46%), 56 (38%), and 24 (16%) patients, respectively. Baseline QRSd was 108±38 ms with QRSd >120 ms in 57 (39%) patients (27 right bundle branch block, 18 ...

JACC: Clinical Electrophysiology, 2019

The patient was an 81-year-old woman with a history of mitral valve repair, atrial fibrillation, ... more The patient was an 81-year-old woman with a history of mitral valve repair, atrial fibrillation, and sick sinus syndrome status post–His bundle pacemaker (HBP) implant using a Select Secure lead (model 3830, 69 cm; Medtronic Inc., Minneapolis, Minnesota) who presented with progressive dyspnea and

European journal of public health, Jan 28, 2018

To examine the relationship between forgone healthcare and involvement in intimate partner violen... more To examine the relationship between forgone healthcare and involvement in intimate partner violence (IPV) as victims, perpetrators or both. This cross-sectional multicentre study assessed community non-institutionalized residents (n = 3496, aged 18-64) randomly selected from six European cities: Athens, Budapest, London, Östersund, Porto, Stuttgart. A common questionnaire was used, including self-reports of IPV and forgone healthcare ('Have you been in need of a certain care service in the past year, but did not seek any help?'). Odds ratios (ORs), 95% confidence intervals (CIs) were computed fitting logistic regression models adjusted for city, chronic disease, self-assessed health status and financial strain. Participants experiencing past year IPV (vs. no violence) reported more often to forgone healthcare (n = 3279, 18.6% vs. 15.3%, P = 0.016). IPV experienced as both a victim and perpetrator was associated with forgone healthcare (adjusted OR, 95%CI: 1.32, 1.02-1.70). I...

Case Reports in Oncological Medicine, 2017

Background. Ibrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor approved for second-line trea... more Background. Ibrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor approved for second-line treatment for mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), and Waldenström macroglobulinemia. Ibrutinib use has been linked to increased incidence of atrial fibrillation and hypertension in multiple studies. Other forms of cardiac toxicities have also been reported in isolated case reports. Bradycardia and asystole have not been associated with ibrutinib use in the past. Case Report. We present a case of a 76-year-old female with no prior cardiac history, who initiated treatment with ibrutinib for relapsing mantle cell lymphoma and was noted to have symptomatic bradycardia, greater than 20 second long pauses on her cardiac monitor requiring placement of a permanent pacemaker. Conclusion. This is the first case associating bradycardia and asystole with tyrosine kinase inhibitor use. Irreversible inhibition of certain cardioprotective tyrosine kinases has been a growing topi...

Journal of atrial fibrillation

Atrial fibrillation (AF) ablation has emerged as the preferred rhythm control strategy for sympto... more Atrial fibrillation (AF) ablation has emerged as the preferred rhythm control strategy for symptomatic paroxysmal AF refractory or intolerant to at least one class I or III antiarrhythmic medication. Since the initial observation by Haissaguerre and colleagues, of pulmonary vein triggers initiating atrial fibrillation (AF), pulmonary vein isolation (PVI) has become the cornerstone for paroxysmal AF ablation therapy.