Adnan A Badwan - Academia.edu (original) (raw)

Papers by Adnan A Badwan

Research paper thumbnail of Dr Badwan CV summrized

Research paper thumbnail of Composition Comprising Covalent Conjugates of Chitosan and an Acidic Drug and Parenteral Administration

Research paper thumbnail of Highly soluble binary cyclodextrin inclusion complexes

Research paper thumbnail of Chitosan and Xanthan Gum Mixtures as Excipient for Controlled Release of Ambroxol HCl: In- vitro drug Release and Swelling Behavior

Journal of Excipients and Food Chemicals, Jun 25, 2014

Research paper thumbnail of Bromhexine Hydrochloride Adsorption by Some Solid Excipients Used in the Formulation of Tablets

Drug Develop Ind Pharm, 1988

Research paper thumbnail of Microemulsified drug formulation

Research paper thumbnail of Chitosan-silicon dioxide coprecipitate and use as excipient in solid dosage forms

Research paper thumbnail of Dipyridamole/b-cyclodextrin complexation: effect of buffer species, thermodynamics, and guest-host interactions probed by 1 H-NMR and molecular modeling studies

J Incl Phenom Macrocycl Chem, 2009

Research paper thumbnail of High Pressure Liquid Chromatographic Analysis and Dissolution of Famotidine in Tablet Formulation

Analytical Letters, Sep 1, 1989

Research paper thumbnail of Compressibility and compactibility studies of chitosan, xanthan gum, and their mixtures

Journal of Materials Science, Jan 14, 2009

Research paper thumbnail of Influence of glucosamine on the bioactivity of insulin delivered subcutaneously and in an oral nanodelivery system

Drug Design, Development and Therapy, 2015

The aim of the work reported herein was to study the effect of glucosamine HCl (GlcN·HCl) on the ... more The aim of the work reported herein was to study the effect of glucosamine HCl (GlcN·HCl) on the bioactivity (BA) of insulin, administered via subcutaneous (SC) and oral routes, in adult male Sprague Dawley rats. The oral insulin delivery system (insulin-chitosan reverse micelle [IC-RM]) was prepared by solubilizing insulin-chitosan (13 kDa) polyelectrolyte complex in a RM system consisting of oleic acid, PEG-8 caprylic/capric glycerides, and polyglycerol-6-dioleate. The BA of insulin in vivo was evaluated by measuring blood glucose level using a blood glucose meter; the results revealed that the extent of hypoglycemic activity of SC insulin was GlcN·HCl dose dependent when they were administered simultaneously. A significant reduction in blood glucose levels (P<0.05) was found for the insulin:GlcN·HCl at mass ratios of 1:10 and 1:20, whereas lower ratios (eg, 1:1 and 1:4) showed no significant reduction. Furthermore, enhancement of the action of SC insulin was achieved by oral administration of GlcN·HCl for 5 consecutive days prior to insulin injection (P<0.05). For oral insulin administration via the IC-RM system, the presence of GlcN·HCl increased the hypoglycemic activity of insulin (P<0.05). The relative BA were 6.7% and 5.4% in the presence and absence of GlcN·HCl (ie, the increase in the relative BA was approximately 23% due to incorporating GlcN·HCl in the IC-RM system), respectively. The aforementioned findings offer an opportunity to incorporate GlcN·HCl in oral insulin delivery systems in order to enhance a reduction in blood glucose levels.

Research paper thumbnail of Rigorous analysis of S2L-type phase solubility diagrams to obtain individual formation and solubility product constants of both SL-and S2L-type complexes

International Journal of Pharmaceutics, 1997

Research paper thumbnail of Pharmaceutical Excipient, Method for Its Preparation and Use Thereof

Research paper thumbnail of Nanocapsules for oral delivery of proteins

The present invention relates in general to the field of drug delivery. More precisely, the prese... more The present invention relates in general to the field of drug delivery. More precisely, the present invention relates to a novel type of nanocapsule. In addition, the present invention concerns the use of such a nanocapsule for the delivery of an active component, such as a protein or polypeptide, such as, for example, insulin, a method for manufacturing such a nanocapsule and a pharmaceutical composition comprising such a nanocapsule.

Research paper thumbnail of Multi-component herbal composition for the treatment of male erectile dysfunction

The present invention relates to a combination of herbal extracts to treat male sexual dysfunctio... more The present invention relates to a combination of herbal extracts to treat male sexual dysfunction. More precisely, the present invention relates to a combination of five different herbal extracts including Ginseng extract, Tongkat AIi extract, Epimedium extract, Gotu Kola extract and flower pollen extract to restore male erectile function. The composition has a promoting effect on penile erectility, so that it can be effectively used for the improvement of erectile dysfunction.

Research paper thumbnail of High performance liquid chromatography method for determination of methyl-5-benzoyl-2-benzimidazole carbamate (mebendazole) and its main degradation product in pharmaceutical dosage forms

Talanta, 1999

Methyl-5-benzoyl-2-benzimidazole carbamate (mebendazole) is a drug used as an anthelmintic. A hig... more Methyl-5-benzoyl-2-benzimidazole carbamate (mebendazole) is a drug used as an anthelmintic. A high performance liquid chromatography method has been developed in this study to determine mebendazole and its degradation product in the pharmaceutical dosage forms (tablets and suspension). The expected major degradation product of mebendazole in the dosage forms has been prepared, and identified as 2-amino-5-benzoylbenzimidazole. The proposed HPLC assay was

Research paper thumbnail of Further investigation on the degree of deacetylation of chitosan determined by potentiometric titration

The degree of deacetylation (DDA) of various low molecular weight chitosan (LMWC) species as the ... more The degree of deacetylation (DDA) of various low molecular weight chitosan (LMWC) species as the hydrochloride and free base (amine form) was determined by direct and back potentiometric titration,respectively. The DDA values obtained for the chitosan hydrochloride by direct titration were greater than 93% for all oligomers tested (Molecular weight (Mwt) between about 1.3 to 30.0 kDa). However, the DDA values obtained for chitosan amine oligomers using back titration were significantly lower, especially for the relatively high molecular weight (30.0 kDa) chitosan amine oligomers. Furthermore, after using the back titration method, greater DDA values were obtained for the same samples of chitosan amine after the chitosan solution had been heated to 60EC before titration. In addition, the DDA values showed a significant decrease with increased concentration for a given chitosan oligomer. Although the effects of hydration time,ionic strength and method specific behavior were not explic...

Research paper thumbnail of Molecular dynamics simulations and MM–PBSA calculations of the cyclodextrin inclusion complexes with 1-alkanols, para-substituted phenols and substituted imidazoles

Journal of Molecular Structure: THEOCHEM, 2008

Research paper thumbnail of Preparation, characterisation and transformation of terfenadine polymorphic forms

International Journal of Pharmaceutics, 1996

Research paper thumbnail of Influence of Glutathione on the Bioactivity of Subcutaneously or Orally Administered Insulin to Rats

Protein and peptide letters, Jan 21, 2015

The effect of reduced (GSH) and oxidized (GSSG) glutathione on the bioactivity of insulin was stu... more The effect of reduced (GSH) and oxidized (GSSG) glutathione on the bioactivity of insulin was studied. A polyelectrolyte complex (PEC) of insulin with low molecular weight chitosan (13 kDa) was prepared and characterized. The PEC was then solubilized, in the presence and absence of GSH and GSSG, in a reverse micelle consisting of oleic acid and two surfactants (PEG-8 caprylic/capric glycerides and polyglycerol-6-dioleate). The in vitro and in vivo performances of the reverse micelle formulations (RMFs) were evaluated in rats. At pH 6.5 the association efficiency of the PEC was 76.2%. In vitro insulin release from the RMs was negligible at pH 1.2 and was markedly increased at pH 6.8. The hypoglycemic activity of insulin in the PEC was reduced when administered via the subcutaneous route, regardless of the GSH content. On the other hand, the presence of GSSG significantly enhanced hypoglycemia. When the RMF was administered via the oral route, the presence of GSH had no effect on the ...

Research paper thumbnail of Dr Badwan CV summrized

Research paper thumbnail of Composition Comprising Covalent Conjugates of Chitosan and an Acidic Drug and Parenteral Administration

Research paper thumbnail of Highly soluble binary cyclodextrin inclusion complexes

Research paper thumbnail of Chitosan and Xanthan Gum Mixtures as Excipient for Controlled Release of Ambroxol HCl: In- vitro drug Release and Swelling Behavior

Journal of Excipients and Food Chemicals, Jun 25, 2014

Research paper thumbnail of Bromhexine Hydrochloride Adsorption by Some Solid Excipients Used in the Formulation of Tablets

Drug Develop Ind Pharm, 1988

Research paper thumbnail of Microemulsified drug formulation

Research paper thumbnail of Chitosan-silicon dioxide coprecipitate and use as excipient in solid dosage forms

Research paper thumbnail of Dipyridamole/b-cyclodextrin complexation: effect of buffer species, thermodynamics, and guest-host interactions probed by 1 H-NMR and molecular modeling studies

J Incl Phenom Macrocycl Chem, 2009

Research paper thumbnail of High Pressure Liquid Chromatographic Analysis and Dissolution of Famotidine in Tablet Formulation

Analytical Letters, Sep 1, 1989

Research paper thumbnail of Compressibility and compactibility studies of chitosan, xanthan gum, and their mixtures

Journal of Materials Science, Jan 14, 2009

Research paper thumbnail of Influence of glucosamine on the bioactivity of insulin delivered subcutaneously and in an oral nanodelivery system

Drug Design, Development and Therapy, 2015

The aim of the work reported herein was to study the effect of glucosamine HCl (GlcN·HCl) on the ... more The aim of the work reported herein was to study the effect of glucosamine HCl (GlcN·HCl) on the bioactivity (BA) of insulin, administered via subcutaneous (SC) and oral routes, in adult male Sprague Dawley rats. The oral insulin delivery system (insulin-chitosan reverse micelle [IC-RM]) was prepared by solubilizing insulin-chitosan (13 kDa) polyelectrolyte complex in a RM system consisting of oleic acid, PEG-8 caprylic/capric glycerides, and polyglycerol-6-dioleate. The BA of insulin in vivo was evaluated by measuring blood glucose level using a blood glucose meter; the results revealed that the extent of hypoglycemic activity of SC insulin was GlcN·HCl dose dependent when they were administered simultaneously. A significant reduction in blood glucose levels (P<0.05) was found for the insulin:GlcN·HCl at mass ratios of 1:10 and 1:20, whereas lower ratios (eg, 1:1 and 1:4) showed no significant reduction. Furthermore, enhancement of the action of SC insulin was achieved by oral administration of GlcN·HCl for 5 consecutive days prior to insulin injection (P<0.05). For oral insulin administration via the IC-RM system, the presence of GlcN·HCl increased the hypoglycemic activity of insulin (P<0.05). The relative BA were 6.7% and 5.4% in the presence and absence of GlcN·HCl (ie, the increase in the relative BA was approximately 23% due to incorporating GlcN·HCl in the IC-RM system), respectively. The aforementioned findings offer an opportunity to incorporate GlcN·HCl in oral insulin delivery systems in order to enhance a reduction in blood glucose levels.

Research paper thumbnail of Rigorous analysis of S2L-type phase solubility diagrams to obtain individual formation and solubility product constants of both SL-and S2L-type complexes

International Journal of Pharmaceutics, 1997

Research paper thumbnail of Pharmaceutical Excipient, Method for Its Preparation and Use Thereof

Research paper thumbnail of Nanocapsules for oral delivery of proteins

The present invention relates in general to the field of drug delivery. More precisely, the prese... more The present invention relates in general to the field of drug delivery. More precisely, the present invention relates to a novel type of nanocapsule. In addition, the present invention concerns the use of such a nanocapsule for the delivery of an active component, such as a protein or polypeptide, such as, for example, insulin, a method for manufacturing such a nanocapsule and a pharmaceutical composition comprising such a nanocapsule.

Research paper thumbnail of Multi-component herbal composition for the treatment of male erectile dysfunction

The present invention relates to a combination of herbal extracts to treat male sexual dysfunctio... more The present invention relates to a combination of herbal extracts to treat male sexual dysfunction. More precisely, the present invention relates to a combination of five different herbal extracts including Ginseng extract, Tongkat AIi extract, Epimedium extract, Gotu Kola extract and flower pollen extract to restore male erectile function. The composition has a promoting effect on penile erectility, so that it can be effectively used for the improvement of erectile dysfunction.

Research paper thumbnail of High performance liquid chromatography method for determination of methyl-5-benzoyl-2-benzimidazole carbamate (mebendazole) and its main degradation product in pharmaceutical dosage forms

Talanta, 1999

Methyl-5-benzoyl-2-benzimidazole carbamate (mebendazole) is a drug used as an anthelmintic. A hig... more Methyl-5-benzoyl-2-benzimidazole carbamate (mebendazole) is a drug used as an anthelmintic. A high performance liquid chromatography method has been developed in this study to determine mebendazole and its degradation product in the pharmaceutical dosage forms (tablets and suspension). The expected major degradation product of mebendazole in the dosage forms has been prepared, and identified as 2-amino-5-benzoylbenzimidazole. The proposed HPLC assay was

Research paper thumbnail of Further investigation on the degree of deacetylation of chitosan determined by potentiometric titration

The degree of deacetylation (DDA) of various low molecular weight chitosan (LMWC) species as the ... more The degree of deacetylation (DDA) of various low molecular weight chitosan (LMWC) species as the hydrochloride and free base (amine form) was determined by direct and back potentiometric titration,respectively. The DDA values obtained for the chitosan hydrochloride by direct titration were greater than 93% for all oligomers tested (Molecular weight (Mwt) between about 1.3 to 30.0 kDa). However, the DDA values obtained for chitosan amine oligomers using back titration were significantly lower, especially for the relatively high molecular weight (30.0 kDa) chitosan amine oligomers. Furthermore, after using the back titration method, greater DDA values were obtained for the same samples of chitosan amine after the chitosan solution had been heated to 60EC before titration. In addition, the DDA values showed a significant decrease with increased concentration for a given chitosan oligomer. Although the effects of hydration time,ionic strength and method specific behavior were not explic...

Research paper thumbnail of Molecular dynamics simulations and MM–PBSA calculations of the cyclodextrin inclusion complexes with 1-alkanols, para-substituted phenols and substituted imidazoles

Journal of Molecular Structure: THEOCHEM, 2008

Research paper thumbnail of Preparation, characterisation and transformation of terfenadine polymorphic forms

International Journal of Pharmaceutics, 1996

Research paper thumbnail of Influence of Glutathione on the Bioactivity of Subcutaneously or Orally Administered Insulin to Rats

Protein and peptide letters, Jan 21, 2015

The effect of reduced (GSH) and oxidized (GSSG) glutathione on the bioactivity of insulin was stu... more The effect of reduced (GSH) and oxidized (GSSG) glutathione on the bioactivity of insulin was studied. A polyelectrolyte complex (PEC) of insulin with low molecular weight chitosan (13 kDa) was prepared and characterized. The PEC was then solubilized, in the presence and absence of GSH and GSSG, in a reverse micelle consisting of oleic acid and two surfactants (PEG-8 caprylic/capric glycerides and polyglycerol-6-dioleate). The in vitro and in vivo performances of the reverse micelle formulations (RMFs) were evaluated in rats. At pH 6.5 the association efficiency of the PEC was 76.2%. In vitro insulin release from the RMs was negligible at pH 1.2 and was markedly increased at pH 6.8. The hypoglycemic activity of insulin in the PEC was reduced when administered via the subcutaneous route, regardless of the GSH content. On the other hand, the presence of GSSG significantly enhanced hypoglycemia. When the RMF was administered via the oral route, the presence of GSH had no effect on the ...