Adrián Lescano - Academia.edu (original) (raw)

Papers by Adrián Lescano

Annals of the Rheumatic Diseases, 2013

Journal of Pulmonary Medicine, 2020

Background: Pulmonary Arterial Hypertension (PAH) is a chronic and progressive disease characteri... more Background: Pulmonary Arterial Hypertension (PAH) is a chronic and progressive disease characterized by an increase in the pulmonary pressure and pulmonary vascular resistance that leads to high morbidity and mortality. Macitentan is an endothelin receptor antagonist (ERA), that has shown benefit in terms of morbidity and mortality (as a composite endpoint) in a randomized controlled trial (SERAPHIN), but information regarding the use of this drug in the daily clinical practice is limited in our region. Objective: To describe clinical outcomes in patients with a diagnosis of Pulmonary Hypertension (PH) treated with Macitentan in Argentina. Methods: Retrospective, observational study including adult patients with a diagnosis of PH, confirmed by right heart catheterization, who were treated with Macitentan in Argentina between March 2015 and April 2019. All the information was obtained from a designed database. Patients receiving Macitentan for at least 9 months were included and the clinical outcome was defined as improvement in the functional class (FC) from advanced (III/IV) to non-advanced (I/II) and in the 6-minute walk test (6MWT). Results: 126 patients with a median age of 46 years, with a predominance of female gender (74%) and PH group 1 (97%) were included. Before starting Macitentan, 78.9% of patients had advanced FC and the average number of meters walked in the 6MWT was 311 (SD 121 m). At six and twelve months, the percentage of patients in advanced FC was significantly reduced and the 6MWT distance increased to 360 and 361 meters respectively, both results with statistically significant benefit (p<0.001). Conclusions: In our cohort of patients, treatment with Macitentan was associated with a significant clinical benefit, with improvement both in FC and in the 6MWT distance at 6 and 12 months. This information is consistent with the results of the SERAPHIN study, and it is the first contribution on the use of this drug in a real-world scenario in our region.

Revista Costarricense de Cardiología, Sep 1, 2004

Revista Argentina de Cardiologia, Aug 1, 2020

Annals of the Rheumatic Diseases, Jun 1, 2013

Argentine Journal of Cardiology, Feb 13, 2014

1674 (1425) CABA RESUMEN Introducción La esclerodermia es una enfermedad del tejido conectivo que... more 1674 (1425) CABA RESUMEN Introducción La esclerodermia es una enfermedad del tejido conectivo que se caracteriza por extensa fibrosis cutánea y de diversos órganos. La insuficiencia cardíaca y la hipertensión pulmonar son síndromes cardiovasculares asociados con esta entidad que determinan pronóstico. La ecocardiografía Doppler cumple un papel fundamental en el examen anatómico y funcional de las estructuras cardíacas en la esclerodermia y permite el diagnóstico de alteraciones incipientes, en la relajación o la mecánica segmentaria ventricular, entre otras, además de la evaluación de la presencia y el grado de hipertensión pulmonar. Objetivo Describir los hallazgos ecocardiográficos relevantes en pacientes con diagnóstico de esclerodermia sin antecedentes cardiovasculares.

Revista Argentina de Cardiología, 2021

Background: The Coronavirus-2 (SARS-CoV-2) pandemic has generated negative psychological effects ... more Background: The Coronavirus-2 (SARS-CoV-2) pandemic has generated negative psychological effects in the whole population. Our objective was to describe this impact on health care workers of Argentina. Methods: This was a cross-sectional, multicenter study evaluating anxiety, depression, burnout, and alterations in lifestyle and interpersonal relationships by means of an anonymous survey carried out from June to September 2020. Results: A total of 1221 healthcare workers, with median age 42 years (IQR 34.5-52) and 65% women were surveyed for the study. Among them, 77.2% lived in the Autonomous City of Buenos Aires and the Buenos Aires province;66.7% were specialist physicians or nurses, 41.1% were clinical specialists, 29.8% intensive care or coronary care unit physicians and 10.2% kinesiologists or nurses. In 51.8% of cases, healthcare workers reported that all biosafety recommendations were not met in their workplaces. Anxiety was detected in 40.5% of cases, major depression in 22....

Annals of the Rheumatic Diseases, 2013

Background Digital ulcers (DU) occur in nearly more than half of the patients with systemic scler... more Background Digital ulcers (DU) occur in nearly more than half of the patients with systemic sclerosis (SSc). Non-digital ulcers (legs) have also been described in SSc patients. DU are usually multiple, painful and if they are not treated rapidly, infections and hospitalizations are frequent. DU causes different degrees of disability with high impact in daily activities.Treatment is often insufficient. Objectives To evaluate the incidence and treatments of DU, non–DU and digital tissue loss in SSc patients Methods A transversal study. We analyzed the medical charts of 86 SSc patients. Four patients with morphea were excluded. Patients signed inform consent. We considered: diffuse or limited SSc, presence of Raynaud, ulcer type(digital or non digital), ulcer status(healed, active), digital tissue loss, and treatments. Results Of 82 patients, 76 (92.7%) were female; mean age 53.9±13.9 years; mean evolution time of 7.2±6.0 years. Diffuse SSc (dSSC) was diagnosed in 56 (68.3%) patients and limited (lSSc) in 26 (31.7%). Raynaud was a manifestation referred by 97.8% of the patients with a mean evolution time of 11.1±9,6 years. 46 of 82 patients (56.1%) had ulcers: 43 had DU and 3 had leg ulcers (without DU). Pulmonary arterial hypertension (PAH) was screened in 64 patients by colour Doppler echocardiogram (PAH was confirmed in 15 patients by RHCT). 18 of 34 patients with DU and 13 of 31 patients without DU had high levels of PASP. Table 1. Patients distribution Patients n Gender Age, mean Diagnosis Mean time evolution Tobacco PAH (%) (years) (years) With DU 46 (56,1) F:41 54,5 dSSc:33 8,1 21 18 M:5 lSSc:13 Without DU 36 F:35 53,1 dSSc:23 6,1 15 13 M:1 lSSc:13 p value NS NS NS NS NS NS DU status in 46 patients:healed in 27 patients (58.7%); active DU in 24 patients (52.2%); digital tissue loss in 19 patients (41.3%). 18 patients (39.1%) had more than one type of lesion (active+healed+digital tissue loss). At the time of our evaluation, 12.5% of patients with active ulcers received no treatment, 29.1% received only one drug but at low doses and without dose escalation (calcium channel blockers or sildenafil or aspirin or cilostazol), 12.5% two, 37.5% three and 8.3% four drugs. Only 7 of the 19 patients under DU treatment received bosentan. Three of the seven patients with bosentan had leg ulcers. All the patients with DU, active or healed had diverse degrees of disability in their hands. One patient was hospitalized because of multiple DU Conclusions DU in SSc patients are frecuent. A rapid step up treatment algorithm and at full doses is needed to avoid tissue loss, disability and hospitalizations. References Natural history of ischemic digital ulcers in systemic sclerosis: single-center retrospective longitudinal study. Hachulla E, Clerson P, Launay D, et al. J Rheumatol 2007;34:2423-30 Digital ulcers: overt vascular disease in systemic sclerosis. Steen V, Denton CP, Pope JE, et al Rheumatology 2009; 48 (Suppl 3): 19-24 EULAR recommendations for the treatment of systemic sclerosis: a report from the EULAR Scleroderma Trials and Research group (EUSTAR). Kowal-Bielecka, Landewé R, Avouac J, et al. Ann Rheum Dis 2009; 68: 620-628 Disclosure of Interest None Declared

Argentine Journal of Cardiology, Sep 22, 2011

relación con la mortalidad y los eventos vasculares cerebrales y coronarios. Material y métodos E... more relación con la mortalidad y los eventos vasculares cerebrales y coronarios. Material y métodos Entre 2005 y 2007 ingresaron prospectivamente 601 pacientes (p) enviados para ecocardiograma transesofágico (ETE). Edad: 64,53±13,61 años. Sexo masculino: 337 p. Se registró: Motivo del estudio: foco embolígeno (37,7%), endocarditis (22,1%), precardioversión (11,5%), valvulopatía mitral (9,8%), otros (18,95%). Factores de riesgo: diabetes, tabaquismo, hipertensión arterial, dislipemia. Presencia de fibrilación auricular. Los p fueron agrupados en: a. Con placas aórticas <4 mm y no complicadas: p = 465. b. Con placas ≥ 4 mm y/o ulceradas, con trombos o debris (ateromatosis aórtica compleja [AAC]): p = 136. Seguimiento: 1596 días (media: 759 días). Se contactaron 520 p (86,52%), considerándose los siguientes eventos: accidente cerebrovascular transitorio o permanente, IAM, angina, revascularización y/o causa de muerte en dicho período. Se utilizó el análisis multivariado para hallar predictores independientes. Se consideró significativa un p < de 0,01. Resultados Mortalidad cardiovascular: 3,2% (13/407 p) en el grupo a y 18,6% (21/113 p) en el grupo b (p < 0,01). Eventos vasculares combinados: 91/407 p (22,4%) en el grupo a y 45/113 p (39,8%) en el grupo b (p < 0,01). En el análisis multivariado, la AAC fue predictora independiente de mortalidad cardiovascular (OR 4,54, 95% IC 1,52-13,58 p < 0,01) y de eventos vasculares cerebrales y/o coronarios (OR 3,33, 95% IC 1,66-6,67 p < 0,01). Conclusión En esta población, la AAC fue predictora independiente de mortalidad cardiovascular y de eventos vasculares combinados.

Background: The evaluation of the right heart cavities represents a challenge for echocardiograph... more Background: The evaluation of the right heart cavities represents a challenge for echocardiography, given the impossibility of their approach to a geometric model. Moreover, there are no recommendations on the need to adjust right heart dimensions to body surface area. Objective: The aim of this study was to establish the relationship between right heart chamber dimensions and body surface area in a population with no evidence of cardiopulmonary disease. Methods: The study included patients attending the echocardiography laboratory for a regular health examination. Patients with cardiac disease, right or left ventricular dysfunction, significant valve diseases, known pulmonary disease or pulmonary systolic pressure ≥45 mmHg were excluded from the study. Patients’ affiliation, weight (kg), height (meters), and body surface area (m2) data were recorded. Right heart measurements were based on guideline recommendations. The population was distributed in quartiles according to body surface area (25%-50%-75%-100%). Simple regression analysis was performed between each dimension of the right heart and body surface area. Results: A prospective, consecutive, observational and descriptive cohort study was performed including 1,045 patients with the following characteristics: mean age 41±15.1 years, 53% men, mean weight 77.4±19.6 kg, height 1.69±0.09 and BSA 1.89±0.87 m2. Significant differences were observed in each of the variables according to the distribution by quartiles. A positive correlation was demonstrated between all right heart dimensions and body surface area. Conclusions: Body surface area is an important determinant of right heart dimensions measured by echocardiography. We therefore suggest the use of measurements indexed by body surface area, since it could influence clinical decision making.

Revista de ecocardiografía práctica y otras técnicas de imagen cardíaca, Dec 31, 2016

Revista de ecocardiografía práctica y otras técnicas de imagen cardíaca RETIC 2016; 3: 19-24 Comp... more Revista de ecocardiografía práctica y otras técnicas de imagen cardíaca RETIC 2016; 3: 19-24 Compresión del tronco de la arteria coronaria izquierda por la arteria pulmonar dilatada Palabras clave RESUMEN ▻ Compresión del tronco de coronaria izquierda ▻ Hipertensión pulmonar La compresión del tronco de la arteria coronaria izquierda por la arteria pulmonar dilatada es una complicación escasamente considerada en los pacientes con hipertensión pulmonar, que puede vincularse a angina de pecho e incluso a muerte súbita. Se describe su diagnóstico en una mujer sintomática por disnea, dolor precordial y síncope. El tratamiento endovascular controlado por IVUS logró la remisión de los síntomas.

Revista Argentina de Cardiologia, Dec 1, 2017

Background: The evaluation of the right heart cavities represents a challenge for echocardiograph... more Background: The evaluation of the right heart cavities represents a challenge for echocardiography, given the impossibility of their approach to a geometric model. Moreover, there are no recommendations on the need to adjust right heart dimensions to body surface area. Objective: The aim of this study was to establish the relationship between right heart chamber dimensions and body surface area in a population with no evidence of cardiopulmonary disease. Methods: The study included patients attending the echocardiography laboratory for a regular health examination. Patients with cardiac disease, right or left ventricular dysfunction, significant valve diseases, known pulmonary disease or pulmonary systolic pressure ≥45 mmHg were excluded from the study. Patients’ affiliation, weight (kg), height (meters), and body surface area (m2) data were recorded. Right heart measurements were based on guideline recommendations. The population was distributed in quartiles according to body surface area (25%-50%-75%-100%). Simple regression analysis was performed between each dimension of the right heart and body surface area. Results: A prospective, consecutive, observational and descriptive cohort study was performed including 1,045 patients with the following characteristics: mean age 41±15.1 years, 53% men, mean weight 77.4±19.6 kg, height 1.69±0.09 and BSA 1.89±0.87 m2. Significant differences were observed in each of the variables according to the distribution by quartiles. A positive correlation was demonstrated between all right heart dimensions and body surface area. Conclusions: Body surface area is an important determinant of right heart dimensions measured by echocardiography. We therefore suggest the use of measurements indexed by body surface area, since it could influence clinical decision making.

Archivos de cardiolog�a de M�xico (English ed Internet), Dec 15, 2020

Atherosclerosis Supplements, May 1, 2008

POSTER SESSIONS more FDG-uptake than the non-dilated aortic wall (2,4±0,4 vs. 2,0± 0,5 respective... more POSTER SESSIONS more FDG-uptake than the non-dilated aortic wall (2,4±0,4 vs. 2,0± 0,5 respectively; p=0,004). The amount of FDG-uptake is not correlated with maximal aneurysm diameter (r=-0,14 CI;-0,58 < r < 0.36). Conclusions: FDG-uptake is increased in the wall of AAA. The amount of FDG-uptake in the aneurysm is irrespective of maximal diameter. FDG-PET is a promising technique to identify AAA with an increased risk of growth and rupture due to inflammation and provides a new target for future medical therapy.

Archivos de cardiología de México, Oct 1, 2020

Revista de Ecocardiografía Práctica y Otras Técnicas de Imagen Cardíaca

La miocardiopatía hipertrófica se define por la presencia de aumento del grosor de la pared del V... more La miocardiopatía hipertrófica se define por la presencia de aumento del grosor de la pared del VI que no se puede explicar únicamente por condiciones de carga anómalas. Se presenta un caso de una mujer joven con diagnóstico de miocardiopatía hipertrófica asimétrica (MCH) con obstrucción del TSVI e insuficiencia mitral asociada con resolución adecuada mediante miomectomía quirúrgica sin procedimientos adicionales sobre la válvula.

Atherosclerosis Supplements, 2008

POSTER SESSIONS more FDG-uptake than the non-dilated aortic wall (2,4±0,4 vs. 2,0± 0,5 respective... more POSTER SESSIONS more FDG-uptake than the non-dilated aortic wall (2,4±0,4 vs. 2,0± 0,5 respectively; p=0,004). The amount of FDG-uptake is not correlated with maximal aneurysm diameter (r=-0,14 CI;-0,58 < r < 0.36). Conclusions: FDG-uptake is increased in the wall of AAA. The amount of FDG-uptake in the aneurysm is irrespective of maximal diameter. FDG-PET is a promising technique to identify AAA with an increased risk of growth and rupture due to inflammation and provides a new target for future medical therapy.

Circulation, 2017

Introduction: Endothelin receptor antagonists (ERA) have shown to be beneficial in improving clin... more Introduction: Endothelin receptor antagonists (ERA) have shown to be beneficial in improving clinical, haemodynamic and echocardiographic variables in patients with group 1 pulmonary hypertension. ...

Annals of the Rheumatic Diseases, 2013

Journal of Pulmonary Medicine, 2020

Background: Pulmonary Arterial Hypertension (PAH) is a chronic and progressive disease characteri... more Background: Pulmonary Arterial Hypertension (PAH) is a chronic and progressive disease characterized by an increase in the pulmonary pressure and pulmonary vascular resistance that leads to high morbidity and mortality. Macitentan is an endothelin receptor antagonist (ERA), that has shown benefit in terms of morbidity and mortality (as a composite endpoint) in a randomized controlled trial (SERAPHIN), but information regarding the use of this drug in the daily clinical practice is limited in our region. Objective: To describe clinical outcomes in patients with a diagnosis of Pulmonary Hypertension (PH) treated with Macitentan in Argentina. Methods: Retrospective, observational study including adult patients with a diagnosis of PH, confirmed by right heart catheterization, who were treated with Macitentan in Argentina between March 2015 and April 2019. All the information was obtained from a designed database. Patients receiving Macitentan for at least 9 months were included and the clinical outcome was defined as improvement in the functional class (FC) from advanced (III/IV) to non-advanced (I/II) and in the 6-minute walk test (6MWT). Results: 126 patients with a median age of 46 years, with a predominance of female gender (74%) and PH group 1 (97%) were included. Before starting Macitentan, 78.9% of patients had advanced FC and the average number of meters walked in the 6MWT was 311 (SD 121 m). At six and twelve months, the percentage of patients in advanced FC was significantly reduced and the 6MWT distance increased to 360 and 361 meters respectively, both results with statistically significant benefit (p<0.001). Conclusions: In our cohort of patients, treatment with Macitentan was associated with a significant clinical benefit, with improvement both in FC and in the 6MWT distance at 6 and 12 months. This information is consistent with the results of the SERAPHIN study, and it is the first contribution on the use of this drug in a real-world scenario in our region.

Revista Costarricense de Cardiología, Sep 1, 2004

Revista Argentina de Cardiologia, Aug 1, 2020

Annals of the Rheumatic Diseases, Jun 1, 2013

Argentine Journal of Cardiology, Feb 13, 2014

1674 (1425) CABA RESUMEN Introducción La esclerodermia es una enfermedad del tejido conectivo que... more 1674 (1425) CABA RESUMEN Introducción La esclerodermia es una enfermedad del tejido conectivo que se caracteriza por extensa fibrosis cutánea y de diversos órganos. La insuficiencia cardíaca y la hipertensión pulmonar son síndromes cardiovasculares asociados con esta entidad que determinan pronóstico. La ecocardiografía Doppler cumple un papel fundamental en el examen anatómico y funcional de las estructuras cardíacas en la esclerodermia y permite el diagnóstico de alteraciones incipientes, en la relajación o la mecánica segmentaria ventricular, entre otras, además de la evaluación de la presencia y el grado de hipertensión pulmonar. Objetivo Describir los hallazgos ecocardiográficos relevantes en pacientes con diagnóstico de esclerodermia sin antecedentes cardiovasculares.

Revista Argentina de Cardiología, 2021

Background: The Coronavirus-2 (SARS-CoV-2) pandemic has generated negative psychological effects ... more Background: The Coronavirus-2 (SARS-CoV-2) pandemic has generated negative psychological effects in the whole population. Our objective was to describe this impact on health care workers of Argentina. Methods: This was a cross-sectional, multicenter study evaluating anxiety, depression, burnout, and alterations in lifestyle and interpersonal relationships by means of an anonymous survey carried out from June to September 2020. Results: A total of 1221 healthcare workers, with median age 42 years (IQR 34.5-52) and 65% women were surveyed for the study. Among them, 77.2% lived in the Autonomous City of Buenos Aires and the Buenos Aires province;66.7% were specialist physicians or nurses, 41.1% were clinical specialists, 29.8% intensive care or coronary care unit physicians and 10.2% kinesiologists or nurses. In 51.8% of cases, healthcare workers reported that all biosafety recommendations were not met in their workplaces. Anxiety was detected in 40.5% of cases, major depression in 22....

Annals of the Rheumatic Diseases, 2013

Background Digital ulcers (DU) occur in nearly more than half of the patients with systemic scler... more Background Digital ulcers (DU) occur in nearly more than half of the patients with systemic sclerosis (SSc). Non-digital ulcers (legs) have also been described in SSc patients. DU are usually multiple, painful and if they are not treated rapidly, infections and hospitalizations are frequent. DU causes different degrees of disability with high impact in daily activities.Treatment is often insufficient. Objectives To evaluate the incidence and treatments of DU, non–DU and digital tissue loss in SSc patients Methods A transversal study. We analyzed the medical charts of 86 SSc patients. Four patients with morphea were excluded. Patients signed inform consent. We considered: diffuse or limited SSc, presence of Raynaud, ulcer type(digital or non digital), ulcer status(healed, active), digital tissue loss, and treatments. Results Of 82 patients, 76 (92.7%) were female; mean age 53.9±13.9 years; mean evolution time of 7.2±6.0 years. Diffuse SSc (dSSC) was diagnosed in 56 (68.3%) patients and limited (lSSc) in 26 (31.7%). Raynaud was a manifestation referred by 97.8% of the patients with a mean evolution time of 11.1±9,6 years. 46 of 82 patients (56.1%) had ulcers: 43 had DU and 3 had leg ulcers (without DU). Pulmonary arterial hypertension (PAH) was screened in 64 patients by colour Doppler echocardiogram (PAH was confirmed in 15 patients by RHCT). 18 of 34 patients with DU and 13 of 31 patients without DU had high levels of PASP. Table 1. Patients distribution Patients n Gender Age, mean Diagnosis Mean time evolution Tobacco PAH (%) (years) (years) With DU 46 (56,1) F:41 54,5 dSSc:33 8,1 21 18 M:5 lSSc:13 Without DU 36 F:35 53,1 dSSc:23 6,1 15 13 M:1 lSSc:13 p value NS NS NS NS NS NS DU status in 46 patients:healed in 27 patients (58.7%); active DU in 24 patients (52.2%); digital tissue loss in 19 patients (41.3%). 18 patients (39.1%) had more than one type of lesion (active+healed+digital tissue loss). At the time of our evaluation, 12.5% of patients with active ulcers received no treatment, 29.1% received only one drug but at low doses and without dose escalation (calcium channel blockers or sildenafil or aspirin or cilostazol), 12.5% two, 37.5% three and 8.3% four drugs. Only 7 of the 19 patients under DU treatment received bosentan. Three of the seven patients with bosentan had leg ulcers. All the patients with DU, active or healed had diverse degrees of disability in their hands. One patient was hospitalized because of multiple DU Conclusions DU in SSc patients are frecuent. A rapid step up treatment algorithm and at full doses is needed to avoid tissue loss, disability and hospitalizations. References Natural history of ischemic digital ulcers in systemic sclerosis: single-center retrospective longitudinal study. Hachulla E, Clerson P, Launay D, et al. J Rheumatol 2007;34:2423-30 Digital ulcers: overt vascular disease in systemic sclerosis. Steen V, Denton CP, Pope JE, et al Rheumatology 2009; 48 (Suppl 3): 19-24 EULAR recommendations for the treatment of systemic sclerosis: a report from the EULAR Scleroderma Trials and Research group (EUSTAR). Kowal-Bielecka, Landewé R, Avouac J, et al. Ann Rheum Dis 2009; 68: 620-628 Disclosure of Interest None Declared

Argentine Journal of Cardiology, Sep 22, 2011

relación con la mortalidad y los eventos vasculares cerebrales y coronarios. Material y métodos E... more relación con la mortalidad y los eventos vasculares cerebrales y coronarios. Material y métodos Entre 2005 y 2007 ingresaron prospectivamente 601 pacientes (p) enviados para ecocardiograma transesofágico (ETE). Edad: 64,53±13,61 años. Sexo masculino: 337 p. Se registró: Motivo del estudio: foco embolígeno (37,7%), endocarditis (22,1%), precardioversión (11,5%), valvulopatía mitral (9,8%), otros (18,95%). Factores de riesgo: diabetes, tabaquismo, hipertensión arterial, dislipemia. Presencia de fibrilación auricular. Los p fueron agrupados en: a. Con placas aórticas <4 mm y no complicadas: p = 465. b. Con placas ≥ 4 mm y/o ulceradas, con trombos o debris (ateromatosis aórtica compleja [AAC]): p = 136. Seguimiento: 1596 días (media: 759 días). Se contactaron 520 p (86,52%), considerándose los siguientes eventos: accidente cerebrovascular transitorio o permanente, IAM, angina, revascularización y/o causa de muerte en dicho período. Se utilizó el análisis multivariado para hallar predictores independientes. Se consideró significativa un p < de 0,01. Resultados Mortalidad cardiovascular: 3,2% (13/407 p) en el grupo a y 18,6% (21/113 p) en el grupo b (p < 0,01). Eventos vasculares combinados: 91/407 p (22,4%) en el grupo a y 45/113 p (39,8%) en el grupo b (p < 0,01). En el análisis multivariado, la AAC fue predictora independiente de mortalidad cardiovascular (OR 4,54, 95% IC 1,52-13,58 p < 0,01) y de eventos vasculares cerebrales y/o coronarios (OR 3,33, 95% IC 1,66-6,67 p < 0,01). Conclusión En esta población, la AAC fue predictora independiente de mortalidad cardiovascular y de eventos vasculares combinados.

Background: The evaluation of the right heart cavities represents a challenge for echocardiograph... more Background: The evaluation of the right heart cavities represents a challenge for echocardiography, given the impossibility of their approach to a geometric model. Moreover, there are no recommendations on the need to adjust right heart dimensions to body surface area. Objective: The aim of this study was to establish the relationship between right heart chamber dimensions and body surface area in a population with no evidence of cardiopulmonary disease. Methods: The study included patients attending the echocardiography laboratory for a regular health examination. Patients with cardiac disease, right or left ventricular dysfunction, significant valve diseases, known pulmonary disease or pulmonary systolic pressure ≥45 mmHg were excluded from the study. Patients’ affiliation, weight (kg), height (meters), and body surface area (m2) data were recorded. Right heart measurements were based on guideline recommendations. The population was distributed in quartiles according to body surface area (25%-50%-75%-100%). Simple regression analysis was performed between each dimension of the right heart and body surface area. Results: A prospective, consecutive, observational and descriptive cohort study was performed including 1,045 patients with the following characteristics: mean age 41±15.1 years, 53% men, mean weight 77.4±19.6 kg, height 1.69±0.09 and BSA 1.89±0.87 m2. Significant differences were observed in each of the variables according to the distribution by quartiles. A positive correlation was demonstrated between all right heart dimensions and body surface area. Conclusions: Body surface area is an important determinant of right heart dimensions measured by echocardiography. We therefore suggest the use of measurements indexed by body surface area, since it could influence clinical decision making.

Revista de ecocardiografía práctica y otras técnicas de imagen cardíaca, Dec 31, 2016

Revista de ecocardiografía práctica y otras técnicas de imagen cardíaca RETIC 2016; 3: 19-24 Comp... more Revista de ecocardiografía práctica y otras técnicas de imagen cardíaca RETIC 2016; 3: 19-24 Compresión del tronco de la arteria coronaria izquierda por la arteria pulmonar dilatada Palabras clave RESUMEN ▻ Compresión del tronco de coronaria izquierda ▻ Hipertensión pulmonar La compresión del tronco de la arteria coronaria izquierda por la arteria pulmonar dilatada es una complicación escasamente considerada en los pacientes con hipertensión pulmonar, que puede vincularse a angina de pecho e incluso a muerte súbita. Se describe su diagnóstico en una mujer sintomática por disnea, dolor precordial y síncope. El tratamiento endovascular controlado por IVUS logró la remisión de los síntomas.

Revista Argentina de Cardiologia, Dec 1, 2017

Background: The evaluation of the right heart cavities represents a challenge for echocardiograph... more Background: The evaluation of the right heart cavities represents a challenge for echocardiography, given the impossibility of their approach to a geometric model. Moreover, there are no recommendations on the need to adjust right heart dimensions to body surface area. Objective: The aim of this study was to establish the relationship between right heart chamber dimensions and body surface area in a population with no evidence of cardiopulmonary disease. Methods: The study included patients attending the echocardiography laboratory for a regular health examination. Patients with cardiac disease, right or left ventricular dysfunction, significant valve diseases, known pulmonary disease or pulmonary systolic pressure ≥45 mmHg were excluded from the study. Patients’ affiliation, weight (kg), height (meters), and body surface area (m2) data were recorded. Right heart measurements were based on guideline recommendations. The population was distributed in quartiles according to body surface area (25%-50%-75%-100%). Simple regression analysis was performed between each dimension of the right heart and body surface area. Results: A prospective, consecutive, observational and descriptive cohort study was performed including 1,045 patients with the following characteristics: mean age 41±15.1 years, 53% men, mean weight 77.4±19.6 kg, height 1.69±0.09 and BSA 1.89±0.87 m2. Significant differences were observed in each of the variables according to the distribution by quartiles. A positive correlation was demonstrated between all right heart dimensions and body surface area. Conclusions: Body surface area is an important determinant of right heart dimensions measured by echocardiography. We therefore suggest the use of measurements indexed by body surface area, since it could influence clinical decision making.

Archivos de cardiolog�a de M�xico (English ed Internet), Dec 15, 2020

Atherosclerosis Supplements, May 1, 2008

POSTER SESSIONS more FDG-uptake than the non-dilated aortic wall (2,4±0,4 vs. 2,0± 0,5 respective... more POSTER SESSIONS more FDG-uptake than the non-dilated aortic wall (2,4±0,4 vs. 2,0± 0,5 respectively; p=0,004). The amount of FDG-uptake is not correlated with maximal aneurysm diameter (r=-0,14 CI;-0,58 < r < 0.36). Conclusions: FDG-uptake is increased in the wall of AAA. The amount of FDG-uptake in the aneurysm is irrespective of maximal diameter. FDG-PET is a promising technique to identify AAA with an increased risk of growth and rupture due to inflammation and provides a new target for future medical therapy.

Archivos de cardiología de México, Oct 1, 2020

Revista de Ecocardiografía Práctica y Otras Técnicas de Imagen Cardíaca

La miocardiopatía hipertrófica se define por la presencia de aumento del grosor de la pared del V... more La miocardiopatía hipertrófica se define por la presencia de aumento del grosor de la pared del VI que no se puede explicar únicamente por condiciones de carga anómalas. Se presenta un caso de una mujer joven con diagnóstico de miocardiopatía hipertrófica asimétrica (MCH) con obstrucción del TSVI e insuficiencia mitral asociada con resolución adecuada mediante miomectomía quirúrgica sin procedimientos adicionales sobre la válvula.

Atherosclerosis Supplements, 2008

POSTER SESSIONS more FDG-uptake than the non-dilated aortic wall (2,4±0,4 vs. 2,0± 0,5 respective... more POSTER SESSIONS more FDG-uptake than the non-dilated aortic wall (2,4±0,4 vs. 2,0± 0,5 respectively; p=0,004). The amount of FDG-uptake is not correlated with maximal aneurysm diameter (r=-0,14 CI;-0,58 < r < 0.36). Conclusions: FDG-uptake is increased in the wall of AAA. The amount of FDG-uptake in the aneurysm is irrespective of maximal diameter. FDG-PET is a promising technique to identify AAA with an increased risk of growth and rupture due to inflammation and provides a new target for future medical therapy.

Circulation, 2017

Introduction: Endothelin receptor antagonists (ERA) have shown to be beneficial in improving clin... more Introduction: Endothelin receptor antagonists (ERA) have shown to be beneficial in improving clinical, haemodynamic and echocardiographic variables in patients with group 1 pulmonary hypertension. ...