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Papers by Adriana Peña-romero
Pediatric Dermatology, Oct 21, 2020
Dermatología Revista Mexicana, Oct 15, 2016
BACKGROUND: culiar characteristics contrasting with the clinical features of the classical form. ... more BACKGROUND: culiar characteristics contrasting with the clinical features of the classical form. OBJECTIVE: To compare histopathologic and clinical features of patients with the diagnosis of HMF with those of the classical form MATERIAL AND METHOD: An observational, descriptive and retrospective study was done, records of clinicopathologic notes over a 15-year period ranging from January 2000 up to July 2015 were a comparative analysis of demographic, clinical and histopathologic data was performed. RESULTS: the average age at diagnosis (24.6 vs motropism (22 vs focal. About the percentage of patients with relapse and response
![Research paper thumbnail of [Leukemia cutis: clinical features of 27 mexican patients and a review of the literature]](https://attachments.academia-assets.com/120824935/thumbnails/1.jpg)
](PubMed, Oct 30, 2016
Background: Leukemia Cutis (LC) consists in neoplastic leukocytic infiltration of the skin and is... more Background: Leukemia Cutis (LC) consists in neoplastic leukocytic infiltration of the skin and is strongly associated with the presence of extramedullary disease and poor prognosis. However, there are few studies in the literature regarding this entity. We perform a retrospective study of 27 mexican patients in order to analyze the clinical features and prognosis of LC in Mexico, and a brief review of the literature. Methods: Cases diagnosed as LC by skin biopsy were selected from the database of the Department of Dermatology of National Institute of Medical Science and Nutrition Salvador Zubirán. Cases were searched between the dates of January 1993 and December 2013. Results: Twenty-seven cases which were histologically confirmed with cutaneous leukemic infiltrate were included. Of these patients 60% were male and the mean age at diagnosis was 42 yr (19 to 80 yr). The predominant tipe of LC was acute myeloid leukemia (AML) with 48% of the cases. Nodular neoformations were the main clinical manifestation with 63% of the cases. The mean interval between the diagnosis of LC and death was 10 months (CI 95%). Conclusions: The presence of LC is a marker of poor prognosis and can precede the relapse of systemic leukemia. Cutaneous infiltration may be the first or the only sign of progression, so doctors should be familiar with the clinical manifestations of this disease.
American Journal of Dermatopathology, Dec 1, 2017
Transient reactive aquagenic pseudokeratoderma is characterized by transient whitish and transluc... more Transient reactive aquagenic pseudokeratoderma is characterized by transient whitish and translucent papules after water exposure in palms and soles. We report 5 additional cases and their histopathologic features. Patient 5 showed a topography that had not been reported before; this demonstrates that it is not an exclusive condition of palms and soles. Patient 2 presents very subtle clinical findings, making difficult the diagnosis. And the other 3 patients have a typical presentation. Transient reactive aquagenic pseudokeratoderma has heterogeneous clinical features; in some cases, histopathologic findings, although subtle, help to confirm the diagnosis.
Dermatología Revista Mexicana, Oct 15, 2016
Case reports in critical care, 2015
Indian Journal of Dermatology, 2015
Erythema multiforme is an acute muco-cutaneous hypersensitivity reaction with a variety of etiolo... more Erythema multiforme is an acute muco-cutaneous hypersensitivity reaction with a variety of etiologies. It is characterized by a skin eruption, with or without oral or other mucous membrane lesions. General characteristics and treatmet have been described, but nail findings are rarely reported Here we present a 26-year-old patient with acral erythema multiforme and erythronychia adjacent to skin lesions on the back of the hands. To our knowledge this association had not been reported before.
American Journal of Dermatopathology, Sep 1, 2017
To the Editor: Circumscribed hypokeratosis is a rare and under recognized condition characterized... more To the Editor: Circumscribed hypokeratosis is a rare and under recognized condition characterized by oval, depressed, and erythematous lesions in palms and soles. The histopathological features of this condition are well defined but the etiology is still unknown. Herein, we present a case of circumscribed hypokeratosis on the back of right index finger with a brief discussion about the histopathological findings in Periodic acid-Schiff (PAS) stain. An otherwise healthy 33-year-old man presented with a chronic and asymptomatic depressed area on the back of the right index finger (Fig. 1). The physical examination revealed an abrupt low-lying round area of 15 · 7 mm with clear-cut edges. A skin biopsy was taken from the edge of the lesion and showed hyperkeratosis with an abrupt hypokeratosis in hematoxylin and eosin stain (Fig. 2). Periodic acidSchiff (PAS) stain demonstrated scale crusts in the stratum corneum and these scales define the beginning of the hypokeratosis (Fig. 3). Circumscribed hypokeratosis was first described in 2002 by Amparo Pérez. The clinical feature is an abrupt lowering, erythematous, and well-defined area. The sites more frequently affected are palms and soles but also other regions like fingers and trunk have been reported. Histologically, the diagnostic hallmark is the abrupt thinning of the stratum corneum, other features are hyperkeratotic edge, hypereosinophilic frayed keratin in the edge, parakeratosis, and dilated blood vessels in the dermis. There are several theories about its pathogenesis, the most accepted hypothesis consists of abnormal genetic clone of keratinocytes; other theories are local trauma, viral infection (HPV type 4), decreased levels of keratin-2E, low FIGURE 1. Depressed plaque on the back of the right index finger.
Copyright © 2015 Erika P. Plata-Menchaca et al.This is an open access article distributed under t... more Copyright © 2015 Erika P. Plata-Menchaca et al.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in anymedium, provided the originalwork is properly cited. Introduction. Pulmonary hemorrhage secondary to disseminated strongyloidiasis is an unusual, well-recognized entity in immunocompromised patients with autoimmune disease, which is associated with the hyperinfection syndrome, sepsis, and a high mortality rate. Case Presentation. We present a case of a 44-year-old Mexican woman with systemic lupus erythematosus and acute bacterial meningitis who developed pulmonary hemorrhage with acute respiratory failure requiring mechanical ventilation, treated with broad spectrum systemic antibiotics and high dose methylprednisolone, who subsequently developed a characteristic
BACKGROUND: culiar characteristics contrasting with the clinical features of the classical form. ... more BACKGROUND: culiar characteristics contrasting with the clinical features of the classical form. OBJECTIVE: To compare histopathologic and clinical features of patients with the diagnosis of HMF with those of the classical form MATERIAL AND METHOD: An observational, descriptive and retrospective study was done, records of clinicopathologic notes over a 15-year period ranging from January 2000 up to July 2015 were a comparative analysis of demographic, clinical and histopathologic data was performed. RESULTS: the average age at diagnosis (24.6 vs motropism (22 vs focal. About the percentage of patients with relapse and response
Dermatologia Cosmetica Medica Y Quirurgica, 2013
Current Opinion in Pediatrics, 2019
Pediatric Dermatology, 2020
Hypohidrotic ectodermal dysplasia (HED) is a genetic condition typified by alterations in skin st... more Hypohidrotic ectodermal dysplasia (HED) is a genetic condition typified by alterations in skin structures including sweat glands, hair, nails, and teeth. Hair findings in HED have been poorly characterized in larger series.
![Research paper thumbnail of [Leukemia cutis: clinical features of 27 mexican patients and a review of the literature]](https://attachments.academia-assets.com/87471986/thumbnails/1.jpg)
](Gaceta medica de Mexico
Leukemia Cutis (LC) consists in neoplastic leukocytic infiltration of the skin and is strongly as... more Leukemia Cutis (LC) consists in neoplastic leukocytic infiltration of the skin and is strongly associated with the presence of extramedullary disease and poor prognosis. However, there are few studies in the literature regarding this entity. We perform a retrospective study of 27 mexican patients in order to analyze the clinical features and prognosis of LC in Mexico, and a brief review of the literature. Cases diagnosed as LC by skin biopsy were selected from the database of the Department of Dermatology of National Institute of Medical Science and Nutrition Salvador Zubirán. Cases were searched between the dates of January 1993 and December 2013. Twenty-seven cases which were histologically confirmed with cutaneous leukemic infiltrate were included. Of these patients 60% were male and the mean age at diagnosis was 42 yr (19 to 80 yr). The predominant tipe of LC was acute myeloid leukemia (AML) with 48% of the cases. Nodular neoformations were the main clinical manifestation with 6...
The American Journal of Dermatopathology, 2017
To the Editor: Circumscribed hypokeratosis is a rare and under recognized condition characterized... more To the Editor: Circumscribed hypokeratosis is a rare and under recognized condition characterized by oval, depressed, and erythematous lesions in palms and soles. The histopathological features of this condition are well defined but the etiology is still unknown. Herein, we present a case of circumscribed hypokeratosis on the back of right index finger with a brief discussion about the histopathological findings in Periodic acid-Schiff (PAS) stain. An otherwise healthy 33-year-old man presented with a chronic and asymptomatic depressed area on the back of the right index finger (Fig. 1). The physical examination revealed an abrupt low-lying round area of 15 · 7 mm with clear-cut edges. A skin biopsy was taken from the edge of the lesion and showed hyperkeratosis with an abrupt hypokeratosis in hematoxylin and eosin stain (Fig. 2). Periodic acidSchiff (PAS) stain demonstrated scale crusts in the stratum corneum and these scales define the beginning of the hypokeratosis (Fig. 3). Circumscribed hypokeratosis was first described in 2002 by Amparo Pérez. The clinical feature is an abrupt lowering, erythematous, and well-defined area. The sites more frequently affected are palms and soles but also other regions like fingers and trunk have been reported. Histologically, the diagnostic hallmark is the abrupt thinning of the stratum corneum, other features are hyperkeratotic edge, hypereosinophilic frayed keratin in the edge, parakeratosis, and dilated blood vessels in the dermis. There are several theories about its pathogenesis, the most accepted hypothesis consists of abnormal genetic clone of keratinocytes; other theories are local trauma, viral infection (HPV type 4), decreased levels of keratin-2E, low FIGURE 1. Depressed plaque on the back of the right index finger.
Pediatric Dermatology, Oct 21, 2020
Dermatología Revista Mexicana, Oct 15, 2016
BACKGROUND: culiar characteristics contrasting with the clinical features of the classical form. ... more BACKGROUND: culiar characteristics contrasting with the clinical features of the classical form. OBJECTIVE: To compare histopathologic and clinical features of patients with the diagnosis of HMF with those of the classical form MATERIAL AND METHOD: An observational, descriptive and retrospective study was done, records of clinicopathologic notes over a 15-year period ranging from January 2000 up to July 2015 were a comparative analysis of demographic, clinical and histopathologic data was performed. RESULTS: the average age at diagnosis (24.6 vs motropism (22 vs focal. About the percentage of patients with relapse and response
PubMed, Oct 30, 2016
Background: Leukemia Cutis (LC) consists in neoplastic leukocytic infiltration of the skin and is... more Background: Leukemia Cutis (LC) consists in neoplastic leukocytic infiltration of the skin and is strongly associated with the presence of extramedullary disease and poor prognosis. However, there are few studies in the literature regarding this entity. We perform a retrospective study of 27 mexican patients in order to analyze the clinical features and prognosis of LC in Mexico, and a brief review of the literature. Methods: Cases diagnosed as LC by skin biopsy were selected from the database of the Department of Dermatology of National Institute of Medical Science and Nutrition Salvador Zubirán. Cases were searched between the dates of January 1993 and December 2013. Results: Twenty-seven cases which were histologically confirmed with cutaneous leukemic infiltrate were included. Of these patients 60% were male and the mean age at diagnosis was 42 yr (19 to 80 yr). The predominant tipe of LC was acute myeloid leukemia (AML) with 48% of the cases. Nodular neoformations were the main clinical manifestation with 63% of the cases. The mean interval between the diagnosis of LC and death was 10 months (CI 95%). Conclusions: The presence of LC is a marker of poor prognosis and can precede the relapse of systemic leukemia. Cutaneous infiltration may be the first or the only sign of progression, so doctors should be familiar with the clinical manifestations of this disease.
American Journal of Dermatopathology, Dec 1, 2017
Transient reactive aquagenic pseudokeratoderma is characterized by transient whitish and transluc... more Transient reactive aquagenic pseudokeratoderma is characterized by transient whitish and translucent papules after water exposure in palms and soles. We report 5 additional cases and their histopathologic features. Patient 5 showed a topography that had not been reported before; this demonstrates that it is not an exclusive condition of palms and soles. Patient 2 presents very subtle clinical findings, making difficult the diagnosis. And the other 3 patients have a typical presentation. Transient reactive aquagenic pseudokeratoderma has heterogeneous clinical features; in some cases, histopathologic findings, although subtle, help to confirm the diagnosis.
Dermatología Revista Mexicana, Oct 15, 2016
Case reports in critical care, 2015
Indian Journal of Dermatology, 2015
Erythema multiforme is an acute muco-cutaneous hypersensitivity reaction with a variety of etiolo... more Erythema multiforme is an acute muco-cutaneous hypersensitivity reaction with a variety of etiologies. It is characterized by a skin eruption, with or without oral or other mucous membrane lesions. General characteristics and treatmet have been described, but nail findings are rarely reported Here we present a 26-year-old patient with acral erythema multiforme and erythronychia adjacent to skin lesions on the back of the hands. To our knowledge this association had not been reported before.
American Journal of Dermatopathology, Sep 1, 2017
To the Editor: Circumscribed hypokeratosis is a rare and under recognized condition characterized... more To the Editor: Circumscribed hypokeratosis is a rare and under recognized condition characterized by oval, depressed, and erythematous lesions in palms and soles. The histopathological features of this condition are well defined but the etiology is still unknown. Herein, we present a case of circumscribed hypokeratosis on the back of right index finger with a brief discussion about the histopathological findings in Periodic acid-Schiff (PAS) stain. An otherwise healthy 33-year-old man presented with a chronic and asymptomatic depressed area on the back of the right index finger (Fig. 1). The physical examination revealed an abrupt low-lying round area of 15 · 7 mm with clear-cut edges. A skin biopsy was taken from the edge of the lesion and showed hyperkeratosis with an abrupt hypokeratosis in hematoxylin and eosin stain (Fig. 2). Periodic acidSchiff (PAS) stain demonstrated scale crusts in the stratum corneum and these scales define the beginning of the hypokeratosis (Fig. 3). Circumscribed hypokeratosis was first described in 2002 by Amparo Pérez. The clinical feature is an abrupt lowering, erythematous, and well-defined area. The sites more frequently affected are palms and soles but also other regions like fingers and trunk have been reported. Histologically, the diagnostic hallmark is the abrupt thinning of the stratum corneum, other features are hyperkeratotic edge, hypereosinophilic frayed keratin in the edge, parakeratosis, and dilated blood vessels in the dermis. There are several theories about its pathogenesis, the most accepted hypothesis consists of abnormal genetic clone of keratinocytes; other theories are local trauma, viral infection (HPV type 4), decreased levels of keratin-2E, low FIGURE 1. Depressed plaque on the back of the right index finger.
Copyright © 2015 Erika P. Plata-Menchaca et al.This is an open access article distributed under t... more Copyright © 2015 Erika P. Plata-Menchaca et al.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in anymedium, provided the originalwork is properly cited. Introduction. Pulmonary hemorrhage secondary to disseminated strongyloidiasis is an unusual, well-recognized entity in immunocompromised patients with autoimmune disease, which is associated with the hyperinfection syndrome, sepsis, and a high mortality rate. Case Presentation. We present a case of a 44-year-old Mexican woman with systemic lupus erythematosus and acute bacterial meningitis who developed pulmonary hemorrhage with acute respiratory failure requiring mechanical ventilation, treated with broad spectrum systemic antibiotics and high dose methylprednisolone, who subsequently developed a characteristic
BACKGROUND: culiar characteristics contrasting with the clinical features of the classical form. ... more BACKGROUND: culiar characteristics contrasting with the clinical features of the classical form. OBJECTIVE: To compare histopathologic and clinical features of patients with the diagnosis of HMF with those of the classical form MATERIAL AND METHOD: An observational, descriptive and retrospective study was done, records of clinicopathologic notes over a 15-year period ranging from January 2000 up to July 2015 were a comparative analysis of demographic, clinical and histopathologic data was performed. RESULTS: the average age at diagnosis (24.6 vs motropism (22 vs focal. About the percentage of patients with relapse and response
Dermatologia Cosmetica Medica Y Quirurgica, 2013
Current Opinion in Pediatrics, 2019
Pediatric Dermatology, 2020
Hypohidrotic ectodermal dysplasia (HED) is a genetic condition typified by alterations in skin st... more Hypohidrotic ectodermal dysplasia (HED) is a genetic condition typified by alterations in skin structures including sweat glands, hair, nails, and teeth. Hair findings in HED have been poorly characterized in larger series.
Gaceta medica de Mexico
Leukemia Cutis (LC) consists in neoplastic leukocytic infiltration of the skin and is strongly as... more Leukemia Cutis (LC) consists in neoplastic leukocytic infiltration of the skin and is strongly associated with the presence of extramedullary disease and poor prognosis. However, there are few studies in the literature regarding this entity. We perform a retrospective study of 27 mexican patients in order to analyze the clinical features and prognosis of LC in Mexico, and a brief review of the literature. Cases diagnosed as LC by skin biopsy were selected from the database of the Department of Dermatology of National Institute of Medical Science and Nutrition Salvador Zubirán. Cases were searched between the dates of January 1993 and December 2013. Twenty-seven cases which were histologically confirmed with cutaneous leukemic infiltrate were included. Of these patients 60% were male and the mean age at diagnosis was 42 yr (19 to 80 yr). The predominant tipe of LC was acute myeloid leukemia (AML) with 48% of the cases. Nodular neoformations were the main clinical manifestation with 6...
The American Journal of Dermatopathology, 2017
To the Editor: Circumscribed hypokeratosis is a rare and under recognized condition characterized... more To the Editor: Circumscribed hypokeratosis is a rare and under recognized condition characterized by oval, depressed, and erythematous lesions in palms and soles. The histopathological features of this condition are well defined but the etiology is still unknown. Herein, we present a case of circumscribed hypokeratosis on the back of right index finger with a brief discussion about the histopathological findings in Periodic acid-Schiff (PAS) stain. An otherwise healthy 33-year-old man presented with a chronic and asymptomatic depressed area on the back of the right index finger (Fig. 1). The physical examination revealed an abrupt low-lying round area of 15 · 7 mm with clear-cut edges. A skin biopsy was taken from the edge of the lesion and showed hyperkeratosis with an abrupt hypokeratosis in hematoxylin and eosin stain (Fig. 2). Periodic acidSchiff (PAS) stain demonstrated scale crusts in the stratum corneum and these scales define the beginning of the hypokeratosis (Fig. 3). Circumscribed hypokeratosis was first described in 2002 by Amparo Pérez. The clinical feature is an abrupt lowering, erythematous, and well-defined area. The sites more frequently affected are palms and soles but also other regions like fingers and trunk have been reported. Histologically, the diagnostic hallmark is the abrupt thinning of the stratum corneum, other features are hyperkeratotic edge, hypereosinophilic frayed keratin in the edge, parakeratosis, and dilated blood vessels in the dermis. There are several theories about its pathogenesis, the most accepted hypothesis consists of abnormal genetic clone of keratinocytes; other theories are local trauma, viral infection (HPV type 4), decreased levels of keratin-2E, low FIGURE 1. Depressed plaque on the back of the right index finger.