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Papers by Adriana Talangescu

Research paper thumbnail of COVID-19 Pandemic: Challenges, Controversies and What we have Learned

Annals. Series of Medicine., Jun 28, 2024

Research paper thumbnail of HLA Gene Polymorphism in Patients with Chronic HBV Infection. Fundeni Clinical Institute Experience

Annals. Series of Medicine., Jun 28, 2024

Research paper thumbnail of HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic Leukemia

Genetical research, Feb 28, 2024

Research paper thumbnail of Immunogenetic Background of Chronic Lymphoproliferative Disorders in Romanian Patients—Case Control Study

Medical sciences, Feb 23, 2024

Research paper thumbnail of HLA Genotyping in Romanian Adult Patients with Celiac Disease, their First-degree Relatives and Healthy Persons

Journal of Gastrointestinal and Liver Diseases

Background and Aims: Celiac disease is characterized by an inappropriate T-cell-mediated response... more Background and Aims: Celiac disease is characterized by an inappropriate T-cell-mediated response to gluten in small bowel in genetically predisposed individuals, carriers of the DQ2 and/or DQ8 haplotypes of the human leukocyte antigen. The aim of our study was to asses HLA typing in adult patients with celiac disease, in their first degree relatives and in a healthy control group. Methods: We conducted a prospective observational study on three cohorts: 117 patients diagnosed with celiac disease, 41 first-degree relatives of celiac patients and 57 asymptomatic healthy volunteers. Low resolution HLA typing for DQ alleles was performed in all study subjects with DNA extracted from peripheral blood, using SSP HLA-DQB1 kit (Innotrain Diagnostik GmbH, Germany). Next Generation Sequencing (NGS) was used only in 18 patients for typing confirmation of DQB1 and DQA1 loci and whole gene sequencing. Results: Prevalence of HLA-DQ2 was significantly higher in the CD group compared to the healt...

Research paper thumbnail of Molecular Analysis of HLA Genes in Romanian Patients with Chronic Hepatitis B Virus Infection

Current issues in molecular biology, Jan 24, 2024

Research paper thumbnail of COVID-19 Pandemic: Challenges, Controversies and What we have Learned

Annals. Series of Medicine., Jun 28, 2024

Research paper thumbnail of HLA Gene Polymorphism in Patients with Chronic HBV Infection. Fundeni Clinical Institute Experience

Annals. Series of Medicine., Jun 28, 2024

Research paper thumbnail of HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic Leukemia

Genetical research, Feb 28, 2024

Research paper thumbnail of Immunogenetic Background of Chronic Lymphoproliferative Disorders in Romanian Patients—Case Control Study

Medical sciences, Feb 23, 2024

Research paper thumbnail of HLA Genotyping in Romanian Adult Patients with Celiac Disease, their First-degree Relatives and Healthy Persons

Journal of Gastrointestinal and Liver Diseases

Background and Aims: Celiac disease is characterized by an inappropriate T-cell-mediated response... more Background and Aims: Celiac disease is characterized by an inappropriate T-cell-mediated response to gluten in small bowel in genetically predisposed individuals, carriers of the DQ2 and/or DQ8 haplotypes of the human leukocyte antigen. The aim of our study was to asses HLA typing in adult patients with celiac disease, in their first degree relatives and in a healthy control group. Methods: We conducted a prospective observational study on three cohorts: 117 patients diagnosed with celiac disease, 41 first-degree relatives of celiac patients and 57 asymptomatic healthy volunteers. Low resolution HLA typing for DQ alleles was performed in all study subjects with DNA extracted from peripheral blood, using SSP HLA-DQB1 kit (Innotrain Diagnostik GmbH, Germany). Next Generation Sequencing (NGS) was used only in 18 patients for typing confirmation of DQB1 and DQA1 loci and whole gene sequencing. Results: Prevalence of HLA-DQ2 was significantly higher in the CD group compared to the healt...

Research paper thumbnail of Molecular Analysis of HLA Genes in Romanian Patients with Chronic Hepatitis B Virus Infection

Current issues in molecular biology, Jan 24, 2024

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